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Protein

Zinc finger and BTB domain-containing protein 46

Gene

Zbtb46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Function as a transcriptional repressor for PRDM1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of dendritic cell differentiation Source: MGI
  • negative regulation of granulocyte differentiation Source: MGI
  • negative regulation of macrophage differentiation Source: MGI
  • negative regulation of monocyte differentiation Source: MGI
  • positive regulation of dendritic cell differentiation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 46
Alternative name(s):
BTB-ZF protein expressed in effector lymphocytes
Short name:
BZEL
BTB/POZ domain-containing protein 4
Gene namesi
Name:Zbtb46
Synonyms:Btbd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919397. Zbtb46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477471 – 600Zinc finger and BTB domain-containing protein 46Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei234PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BID6.
PRIDEiQ8BID6.

PTM databases

iPTMnetiQ8BID6.
PhosphoSitePlusiQ8BID6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027583.
CleanExiMM_ZBTB46.
ExpressionAtlasiQ8BID6. baseline and differential.
GenevisibleiQ8BID6. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Desi1Q9CQT72EBI-7768990,EBI-7768710

Protein-protein interaction databases

IntActiQ8BID6. 2 interactors.
MINTiMINT-8361942.
STRINGi10090.ENSMUSP00000029106.

Structurei

3D structure databases

ProteinModelPortaliQ8BID6.
SMRiQ8BID6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 99BTBPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri418 – 436C2H2-type 1PROSITE-ProRule annotationAdd BLAST19
Zinc fingeri446 – 468C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000231953.
HOVERGENiHBG079368.
InParanoidiQ8BID6.
KOiK10517.
OMAiTSGWPFS.
OrthoDBiEOG091G05WK.
PhylomeDBiQ8BID6.
TreeFamiTF341953.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BID6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDACVVVEGK VFKAHKNVLL
60 70 80 90 100
GSSRYFKTLY CQVQKTSDQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR
110 120 130 140 150
NVIEVMSAAS FLQMTDIVQA CHDFIKAALD ISIKSDASDE LSEFEIGTPA
160 170 180 190 200
SNSTEALISA VMAGRSISPW LARRTSPANS SGDSAIASCH EGGSSYGKED
210 220 230 240 250
QEPKADGPDD VSSQSLWPGD VGYGSLRIKE EQISPSHYGG SELPSSKDTA
260 270 280 290 300
IQNSLSEQGS GDGWQPTGRR KNRKNKETVR HITQQVEEDS QAGSPVPSFL
310 320 330 340 350
PTSGWPFSSR DSNVDLTVTE ASSLDSRGER AELYAHIDEG LLGGETSYLG
360 370 380 390 400
PPLTPEKEEA LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP
410 420 430 440 450
KGAHSLSLNE FTVIRKKFKC PYCSFSAMHQ CILKRHMRSH TGERPYPCEI
460 470 480 490 500
CGKKFTRREH MKRHTLVHSK DKKYVCKVCS RVFMSAASVG IKHGSRRHGV
510 520 530 540 550
CADCAGRGVG TPLDHGGGGE GSPEALFAGE GPYLEDPDDP RGEAEEELVE
560 570 580 590 600
DEDEDVAKWK DDVGLAHEDA LLGDDKDDED SPQGPHSPSG EPDKDFAWIS
Length:600
Mass (Da):65,499
Last modified:February 16, 2004 - v2
Checksum:iC89E77D5B7C1C0B3
GO
Isoform 2 (identifier: Q8BID6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-434: LNEFTVIRKKFKCPYCSFSAMHQCILK → RKCKFWCVTVSSFGLSTSVQPFRPWSH
     435-600: Missing.

Show »
Length:434
Mass (Da):47,245
Checksum:i50C4070F07566B7B
GO

Sequence cautioni

The sequence BAB30386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30190 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363Q → K in BAC30190 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009387408 – 434LNEFT…QCILK → RKCKFWCVTVSSFGLSTSVQ PFRPWSH in isoform 2. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_009388435 – 600Missing in isoform 2. 2 PublicationsAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011461 mRNA. Translation: BAB27633.1.
AK016700 mRNA. Translation: BAB30386.1. Different initiation.
AK038975 mRNA. Translation: BAC30190.1. Different initiation.
AK155148 mRNA. Translation: BAE33078.1.
AL929094 Genomic DNA. Translation: CAM21496.1.
BC058179 mRNA. Translation: AAH58179.1.
CCDSiCCDS17212.1. [Q8BID6-2]
CCDS50854.1. [Q8BID6-1]
RefSeqiNP_081932.1. NM_027656.2. [Q8BID6-1]
NP_082401.1. NM_028125.3. [Q8BID6-2]
XP_006500775.1. XM_006500712.3. [Q8BID6-1]
XP_006500776.1. XM_006500713.2. [Q8BID6-1]
UniGeneiMm.486504.

Genome annotation databases

EnsembliENSMUST00000029106; ENSMUSP00000029106; ENSMUSG00000027583. [Q8BID6-1]
ENSMUST00000087409; ENSMUSP00000084672; ENSMUSG00000027583. [Q8BID6-2]
ENSMUST00000180222; ENSMUSP00000137014; ENSMUSG00000027583. [Q8BID6-1]
GeneIDi72147.
KEGGimmu:72147.
UCSCiuc008omh.2. mouse. [Q8BID6-2]
uc008omi.1. mouse. [Q8BID6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011461 mRNA. Translation: BAB27633.1.
AK016700 mRNA. Translation: BAB30386.1. Different initiation.
AK038975 mRNA. Translation: BAC30190.1. Different initiation.
AK155148 mRNA. Translation: BAE33078.1.
AL929094 Genomic DNA. Translation: CAM21496.1.
BC058179 mRNA. Translation: AAH58179.1.
CCDSiCCDS17212.1. [Q8BID6-2]
CCDS50854.1. [Q8BID6-1]
RefSeqiNP_081932.1. NM_027656.2. [Q8BID6-1]
NP_082401.1. NM_028125.3. [Q8BID6-2]
XP_006500775.1. XM_006500712.3. [Q8BID6-1]
XP_006500776.1. XM_006500713.2. [Q8BID6-1]
UniGeneiMm.486504.

3D structure databases

ProteinModelPortaliQ8BID6.
SMRiQ8BID6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BID6. 2 interactors.
MINTiMINT-8361942.
STRINGi10090.ENSMUSP00000029106.

PTM databases

iPTMnetiQ8BID6.
PhosphoSitePlusiQ8BID6.

Proteomic databases

PaxDbiQ8BID6.
PRIDEiQ8BID6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029106; ENSMUSP00000029106; ENSMUSG00000027583. [Q8BID6-1]
ENSMUST00000087409; ENSMUSP00000084672; ENSMUSG00000027583. [Q8BID6-2]
ENSMUST00000180222; ENSMUSP00000137014; ENSMUSG00000027583. [Q8BID6-1]
GeneIDi72147.
KEGGimmu:72147.
UCSCiuc008omh.2. mouse. [Q8BID6-2]
uc008omi.1. mouse. [Q8BID6-1]

Organism-specific databases

CTDi140685.
MGIiMGI:1919397. Zbtb46.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000231953.
HOVERGENiHBG079368.
InParanoidiQ8BID6.
KOiK10517.
OMAiTSGWPFS.
OrthoDBiEOG091G05WK.
PhylomeDBiQ8BID6.
TreeFamiTF341953.

Miscellaneous databases

PROiQ8BID6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027583.
CleanExiMM_ZBTB46.
ExpressionAtlasiQ8BID6. baseline and differential.
GenevisibleiQ8BID6. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT46_MOUSE
AccessioniPrimary (citable) accession number: Q8BID6
Secondary accession number(s): A2AUD2
, Q3U2R2, Q9D0G6, Q9D492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.