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Protein

Homeobox protein Mohawk

Gene

Mkx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi71 – 13262Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • collagen fibril organization Source: MGI
  • muscle organ development Source: HGNC
  • negative regulation of myoblast differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of collagen biosynthetic process Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of gene expression Source: MGI
  • tendon cell differentiation Source: MGI
  • tendon formation Source: MGI
  • tendon sheath development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Mohawk
Gene namesi
Name:Mkx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2687286. Mkx.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Homeobox protein MohawkPRO_0000268857Add
BLAST

Proteomic databases

PaxDbiQ8BIA3.
PRIDEiQ8BIA3.

PTM databases

iPTMnetiQ8BIA3.
PhosphoSiteiQ8BIA3.

Expressioni

Developmental stagei

Transcribed in developmentally important regions that give rise to skeletal muscle, tendons, cartilage, male gonads, and the ureteric buds of the kidney. Expressed in discrete premyogenic cell populations of the somite, in the condensing prechondrogenic mesenchymal cells of the axial skeleton, in the pretendenous cells of the tail and limbs, the testis cords of the developing male gonad, and in the metanephric kidney.1 Publication

Gene expression databases

BgeeiQ8BIA3.
CleanExiMM_MKX.

Interactioni

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078718.

Structurei

3D structure databases

ProteinModelPortaliQ8BIA3.
SMRiQ8BIA3. Positions 85-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOVERGENiHBG057105.
InParanoidiQ8BIA3.
PhylomeDBiQ8BIA3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BIA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP
60 70 80 90 100
LKDNLSLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK
110 120 130 140 150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV
160 170 180 190 200
QGNAERLSVS SDGDSCSEDG ENPPRNHMNE EGYSTPAHHT VIKGESSAIK
210 220 230 240 250
AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST AMMGKTRRRN
260 270 280 290 300
HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS
310 320 330 340 350
KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV

QRF
Length:353
Mass (Da):39,401
Last modified:March 1, 2003 - v1
Checksum:iC0301988D7DBAFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034675 mRNA. Translation: BAC28793.1.
RefSeqiNP_808263.2. NM_177595.4.
UniGeneiMm.257186.

Genome annotation databases

GeneIDi210719.
KEGGimmu:210719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034675 mRNA. Translation: BAC28793.1.
RefSeqiNP_808263.2. NM_177595.4.
UniGeneiMm.257186.

3D structure databases

ProteinModelPortaliQ8BIA3.
SMRiQ8BIA3. Positions 85-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078718.

PTM databases

iPTMnetiQ8BIA3.
PhosphoSiteiQ8BIA3.

Proteomic databases

PaxDbiQ8BIA3.
PRIDEiQ8BIA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi210719.
KEGGimmu:210719.

Organism-specific databases

CTDi283078.
MGIiMGI:2687286. Mkx.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOVERGENiHBG057105.
InParanoidiQ8BIA3.
PhylomeDBiQ8BIA3.

Miscellaneous databases

PROiQ8BIA3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BIA3.
CleanExiMM_MKX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "Mohawk is a novel homeobox gene expressed in the developing mouse embryo."
    Anderson D.M., Arredondo J., Hahn K., Valente G., Martin J.F., Wilson-Rawls J., Rawls A.
    Dev. Dyn. 235:792-801(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMKX_MOUSE
AccessioniPrimary (citable) accession number: Q8BIA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.