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Protein

CDKN2A-interacting protein

Gene

Cdkn2aip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CDKN2A-interacting protein
Alternative name(s):
Collaborator of ARF
Gene namesi
Name:Cdkn2aip
Synonyms:Carf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918175. Cdkn2aip.

Subcellular locationi

  • Nucleusnucleoplasm By similarity

GO - Cellular componenti

  • granular component Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 563562CDKN2A-interacting proteinPRO_0000324340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei124 – 1241PhosphoserineCombined sources
Cross-linki177 – 177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei234 – 2341PhosphoserineCombined sources
Modified residuei340 – 3401PhosphothreonineBy similarity
Modified residuei371 – 3711PhosphoserineBy similarity

Post-translational modificationi

May be ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BI72.
MaxQBiQ8BI72.
PaxDbiQ8BI72.
PeptideAtlasiQ8BI72.
PRIDEiQ8BI72.

PTM databases

iPTMnetiQ8BI72.
PhosphoSiteiQ8BI72.

Expressioni

Gene expression databases

BgeeiQ8BI72.
CleanExiMM_CARF.
MM_CDKN2AIP.
GenevisibleiQ8BI72. MM.

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214348. 18 interactions.
IntActiQ8BI72. 17 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8BI72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 52076DRBMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 403236Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the CARF family.Curated
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000111305.
HOVERGENiHBG101830.
InParanoidiQ8BI72.
OMAiRCEGETD.
OrthoDBiEOG7HQNBG.
PhylomeDBiQ8BI72.
TreeFamiTF333807.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BI72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEVSEYLS QNPRVAAWVE TLRCEGETDK HWRHRREFLL RNAGDLVPAT
60 70 80 90 100
DETADAESGA RTRQLQQLVS FSMAWANHVF LGCRYPQKVM DKILSMAEGI
110 120 130 140 150
KVTDAPIHTT RDELVAKVKK RGISSSNEGV EEPSKKRAVE GKNNSSVERD
160 170 180 190 200
HGKKSAKTDR SAAQQENSSP SRGSSTKSES GGTSARSSSS GSHQDSATSE
210 220 230 240 250
GDRSVCSQSS SNSSQVTAGS GKALESEAPH KRGSASFVSS LLKSSMNSHM
260 270 280 290 300
TQSTDNRQQS GSPKKGALEG SSGSASQSSS EIEVPLLGSS GSAEVELPLL
310 320 330 340 350
SCKSSSETAS SGLTSKSSSE ANISSSVSKN SSSSGSSLLT PQSSSTNPSL
360 370 380 390 400
LTSKSTAQVA ASLLATKSGA SLGSVSQLAA KSGSQSSTSQ LPSKSTSQAS
410 420 430 440 450
ESSVKFACRK LTNEDIKQKQ PFFNRLYKTV AWKLVAVGGF SPTVNHGELL
460 470 480 490 500
NAAIEALKAT LDVFFVPLKE LADLPQNKSS QESIVCELRC KSVYLGTGCG
510 520 530 540 550
KSKENAKAVA SREALKLFLK KKVVVKICKR KYRGSEIEDL VLLDEEARPV
560
NLPPALKHPQ ELL
Length:563
Mass (Da):59,745
Last modified:March 1, 2003 - v1
Checksum:i277B979F01EB43C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048437 mRNA. Translation: BAC33336.1.
CCDSiCCDS22299.1.
RefSeqiNP_765995.1. NM_172407.3.
UniGeneiMm.393807.

Genome annotation databases

EnsembliENSMUST00000038738; ENSMUSP00000043713; ENSMUSG00000038069.
GeneIDi70925.
KEGGimmu:70925.
UCSCiuc009lrh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048437 mRNA. Translation: BAC33336.1.
CCDSiCCDS22299.1.
RefSeqiNP_765995.1. NM_172407.3.
UniGeneiMm.393807.

3D structure databases

ProteinModelPortaliQ8BI72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214348. 18 interactions.
IntActiQ8BI72. 17 interactions.

PTM databases

iPTMnetiQ8BI72.
PhosphoSiteiQ8BI72.

Proteomic databases

EPDiQ8BI72.
MaxQBiQ8BI72.
PaxDbiQ8BI72.
PeptideAtlasiQ8BI72.
PRIDEiQ8BI72.

Protocols and materials databases

DNASUi70925.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038738; ENSMUSP00000043713; ENSMUSG00000038069.
GeneIDi70925.
KEGGimmu:70925.
UCSCiuc009lrh.2. mouse.

Organism-specific databases

CTDi55602.
MGIiMGI:1918175. Cdkn2aip.

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000111305.
HOVERGENiHBG101830.
InParanoidiQ8BI72.
OMAiRCEGETD.
OrthoDBiEOG7HQNBG.
PhylomeDBiQ8BI72.
TreeFamiTF333807.

Miscellaneous databases

PROiQ8BI72.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BI72.
CleanExiMM_CARF.
MM_CDKN2AIP.
GenevisibleiQ8BI72. MM.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: IDENTIFICATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCARF_MOUSE
AccessioniPrimary (citable) accession number: Q8BI72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.