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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene

Dyrk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible non-essential role in spermiogenesis.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPPROSITE-ProRule annotationBy similarity1
Active sitei345Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi225 – 233ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi298 – 301ATPPROSITE-ProRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
Gene namesi
Name:Dyrk4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1330292. Dyrk4.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915391 – 632Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei379Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylation on Tyr-379 in the activation loop is required for kinase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BI55.
PeptideAtlasiQ8BI55.
PRIDEiQ8BI55.

PTM databases

iPTMnetiQ8BI55.
PhosphoSitePlusiQ8BI55.

Expressioni

Tissue specificityi

Highly expressed in testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000030345.
ExpressionAtlasiQ8BI55. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077606.

Structurei

3D structure databases

ProteinModelPortaliQ8BI55.
SMRiQ8BI55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 515Protein kinasePROSITE-ProRule annotationAdd BLAST297

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ8BI55.
KOiK18669.
OMAiPPAGFIQ.
OrthoDBiEOG091G0Q46.
PhylomeDBiQ8BI55.
TreeFamiTF314624.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8BI55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLLRLPALT RTETSMDTNK ARKRSLTTFP ILKARKKQSF TSVKVESKPL
60 70 80 90 100
GHLQKPSSKN KKLRVNRCPQ KIPSNTAFPF VDTKGKRNTV NFPQIGNKVP
110 120 130 140 150
SKGPMQYQEN QIHNQVLSSE LKTSEIPFNI NTKAQDTKPH PELQKKHKVP
160 170 180 190 200
LTVAEALKFF KNQLSPYEQS EILGYSELWF LGLEAKKLNV VPEKFSKTSF
210 220 230 240 250
DDEHGSYMKV LHDHIAYRYE VLEMIGKGSF GQVAKCLDHK NNELVALKII
260 270 280 290 300
RNKKRFHHQA LVELKILEAL RRKDKDNNHN VVHMKDFFYF RNHLCITFEL
310 320 330 340 350
LGINLYELMK NNSFHGFNLS IVRRFTFSIL KCLHMLYVEK IIHCDLKPEN
360 370 380 390 400
IVLYQRGQVT VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYNMAI
410 420 430 440 450
DMWSLGCIMA ELYTGYPLFP GENEVEQLAC IMEVLGLPPA HFTQTASRRQ
460 470 480 490 500
VFFDSKGLPK NINNNRGGKR YPDSKDLTMV VKTYDSSFLD FLRRCLVWEP
510 520 530 540 550
SLRMTPEQAL KHAWIHEPRK FKPRPKPQIL RKPGASISSE ISTEKAEEQQ
560 570 580 590 600
ASKGKKDEAT KETTDKLKDE AEKHLENSGK QQSSVEHTAD TIQLPHLTEA
610 620 630
SGKSETVAGS EMSAEQQSTS SPKSTNILPP IV
Note: No experimental confirmation available.Curated
Length:632
Mass (Da):72,561
Last modified:March 1, 2003 - v1
Checksum:i2F2F74C6695833DD
GO
Isoform 21 Publication (identifier: Q8BI55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-44: KKQSFTSVK → MRTSKAQSE

Note: No experimental confirmation available.Curated
Show »
Length:597
Mass (Da):68,504
Checksum:iD20C6AAF9BC7AB48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495 – 497Missing in AAH52324 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524561 – 35Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_05245736 – 44KKQSFTSVK → MRTSKAQSE in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077117 mRNA. Translation: BAC36621.1.
BC052324 mRNA. Translation: AAH52324.1.
CCDSiCCDS20559.2. [Q8BI55-1]
RefSeqiNP_997093.2. NM_207210.2. [Q8BI55-1]
UniGeneiMm.44896.

Genome annotation databases

EnsembliENSMUST00000078521; ENSMUSP00000077606; ENSMUSG00000030345. [Q8BI55-1]
GeneIDi101320.
KEGGimmu:101320.
UCSCiuc009dvg.1. mouse. [Q8BI55-2]
uc009dvh.1. mouse. [Q8BI55-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077117 mRNA. Translation: BAC36621.1.
BC052324 mRNA. Translation: AAH52324.1.
CCDSiCCDS20559.2. [Q8BI55-1]
RefSeqiNP_997093.2. NM_207210.2. [Q8BI55-1]
UniGeneiMm.44896.

3D structure databases

ProteinModelPortaliQ8BI55.
SMRiQ8BI55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077606.

PTM databases

iPTMnetiQ8BI55.
PhosphoSitePlusiQ8BI55.

Proteomic databases

PaxDbiQ8BI55.
PeptideAtlasiQ8BI55.
PRIDEiQ8BI55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078521; ENSMUSP00000077606; ENSMUSG00000030345. [Q8BI55-1]
GeneIDi101320.
KEGGimmu:101320.
UCSCiuc009dvg.1. mouse. [Q8BI55-2]
uc009dvh.1. mouse. [Q8BI55-1]

Organism-specific databases

CTDi8798.
MGIiMGI:1330292. Dyrk4.

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ8BI55.
KOiK18669.
OMAiPPAGFIQ.
OrthoDBiEOG091G0Q46.
PhylomeDBiQ8BI55.
TreeFamiTF314624.

Miscellaneous databases

PROiQ8BI55.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030345.
ExpressionAtlasiQ8BI55. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYRK4_MOUSE
AccessioniPrimary (citable) accession number: Q8BI55
Secondary accession number(s): Q80WP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.