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Protein

Phosphodiesterase

Gene

Pde8b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde8bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2443999 Pde8b

PTM / Processingi

Proteomic databases

PRIDEiQ8BI47

Expressioni

Gene expression databases

GenevisibleiQ8BI47 MM

Structurei

3D structure databases

ProteinModelPortaliQ8BI47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini390 – 726PDEaseInterPro annotationAdd BLAST337

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
HOGENOMiHOG000008068
HOVERGENiHBG053544

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BI47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSRAAGPP GAVRVRRSRA ELGSGSSTGS SGPATTTCRG RRRHCCSSAE
60 70 80 90 100
AETQTSYTSV KQVSSAEVRI GPMRLTQDPI QVLLIFAKED SQSDGFWWAC
110 120 130 140 150
DRAGYRCNIA RTPESALECF LDKHHEIIVI DHRQSRNFDA EAVCRSIRAT
160 170 180 190 200
NPSEHTVILA VVSQASDDHE EASVLPLLHA GFNRRFMENS SIIACYNELI
210 220 230 240 250
QIEHGEVRSQ FKLRACNSVF TALDHCHEAI EITSDDHVIQ IHRIHRDSGD
260 270 280 290 300
NSQTEPHSFR HKSRRKESID VKSISSRGSD APSLQNRRYP SMARIHSMTI
310 320 330 340 350
EAPITKVINI INAAQENSPV TVAEALDRVL EILRTTELYS PQLGTKDEDP
360 370 380 390 400
HTSDLVGGLM TDGLRRLSGN EYVFTKNVHH SHSHLSMPIT INDVPPSIAQ
410 420 430 440 450
LLDNEESWDF NIFELEAVTH KRPLVYLGLK VFSRFGVCEF LNCTETTLRA
460 470 480 490 500
WLQVIEANYH SSNAYHNSTH AADVLHATAF FLGKERVKGS LDQLDEVAAL
510 520 530 540 550
IAATVHDVDH PGRTNSFLCN AGSELAVLYN DTAVLESHHT ALAFQLTVKD
560 570 580 590 600
TKCNIFKNID RNHYRTLRQA IIDMVLATEM TKHFEHVNKF VNSINKPLAA
610 620 630 640 650
ESEGSDCECN PTGKNFPENQ ILIKRMMIKC ADVANPCRPL DLCIEWAGRI
660 670 680 690 700
SEEYFAQTDE EKRQGLPVVM PVFDRNTCSI PKSQISFIDY FITDMFDAWD
710 720 730
AFAHLPALMQ HLADNYKHWK TLDDLKCKTL RLPSDS
Length:736
Mass (Da):82,610
Last modified:March 1, 2003 - v1
Checksum:i375577078FECA2D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083166 mRNA Translation: BAC38791.1
RefSeqiNP_758467.2, NM_172263.2
UniGeneiMm.100167

Genome annotation databases

GeneIDi218461

Similar proteinsi

Entry informationi

Entry nameiQ8BI47_MOUSE
AccessioniPrimary (citable) accession number: Q8BI47
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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