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Protein

Protein MAL2

Gene

Mal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAL2
Gene namesi
Name:Mal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146021. Mal2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 65LumenalSequence analysisAdd BLAST11
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 101CytoplasmicSequence analysisAdd BLAST15
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 148LumenalSequence analysisAdd BLAST26
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 175CytoplasmicSequence analysis6

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568091 – 175Protein MAL2Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BI08.
PaxDbiQ8BI08.
PRIDEiQ8BI08.

PTM databases

iPTMnetiQ8BI08.
PhosphoSitePlusiQ8BI08.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024479.
CleanExiMM_MAL2.
ExpressionAtlasiQ8BI08. baseline and differential.
GenevisibleiQ8BI08. MM.

Interactioni

Subunit structurei

Interacts with TPD52L2.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 174MARVELPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ8BI08.
OMAiFVTTACY.
OrthoDBiEOG091G0OS1.
PhylomeDBiQ8BI08.
TreeFamiTF316174.

Family and domain databases

InterProiView protein in InterPro
IPR013295. MAL.
IPR033240. MAL2.
IPR008253. Marvel.
PANTHERiPTHR22776:SF42. PTHR22776:SF42. 1 hit.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PRINTSiPR01884. MALPROTEIN.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BI08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGAVPPP PNPAVSFPAP RVTLPAGPDI LRTYSGAFVC LEIVLGGLVW
60 70 80 90 100
ILVASSNVPL PLLQGWVMFV SVTAFFFSLL FLGLFLSGMV TQIDANWNFL
110 120 130 140 150
DFVYHFIVFV FYFGAFLLEA AATSLHDLQC NTTMTVKPLL NDNQYNINVA
160 170
ATVFAFMTTA CYGCSLGLAL RRWRP
Length:175
Mass (Da):19,094
Last modified:March 1, 2003 - v1
Checksum:iCE28C15CD9B6FA15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035986 mRNA. Translation: BAC29268.1.
CCDSiCCDS27470.1.
RefSeqiNP_849251.1. NM_178920.4.
UniGeneiMm.410994.

Genome annotation databases

EnsembliENSMUST00000025356; ENSMUSP00000025356; ENSMUSG00000024479.
GeneIDi105853.
KEGGimmu:105853.
UCSCiuc007vrm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiMAL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BI08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome