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Protein

Zinc finger protein 592

Gene

Znf592

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri587 – 61226C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63925C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73121C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri799 – 82224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri827 – 85024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri892 – 91524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri983 – 100624C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1013 – 103624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1043 – 106927C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1124 – 114623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1153 – 117624C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 592
Short name:
Zfp-592
Gene namesi
Name:Znf592
Synonyms:Kiaa0211, Zfp592
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443541. Zfp592.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12621262Zinc finger protein 592PRO_0000047683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei145 – 1451PhosphoserineCombined sources
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei529 – 5291PhosphoserineBy similarity
Modified residuei573 – 5731PhosphoserineCombined sources
Modified residuei691 – 6911PhosphoserineBy similarity
Modified residuei1089 – 10891PhosphoserineBy similarity
Modified residuei1198 – 11981PhosphoserineCombined sources
Modified residuei1202 – 12021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHZ4.
MaxQBiQ8BHZ4.
PaxDbiQ8BHZ4.
PRIDEiQ8BHZ4.

PTM databases

iPTMnetiQ8BHZ4.
PhosphoSiteiQ8BHZ4.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Developmental stagei

Expressed in the embryo at least from 10 dpc until birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000005621.
CleanExiMM_ZFP592.
GenevisibleiQ8BHZ4. MM.

Interactioni

Protein-protein interaction databases

BioGridi231411. 4 interactions.
IntActiQ8BHZ4. 2 interactions.
MINTiMINT-1540719.
STRINGi10090.ENSMUSP00000102976.

Structurei

3D structure databases

ProteinModelPortaliQ8BHZ4.
SMRiQ8BHZ4. Positions 604-642, 712-849, 1000-1047, 1142-1172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 1734Poly-Pro

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri587 – 61226C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63925C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73121C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri799 – 82224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri827 – 85024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri892 – 91524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri983 – 100624C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1013 – 103624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1043 – 106927C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1124 – 114623C2H2-type 12; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1153 – 117624C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063261.
HOGENOMiHOG000010306.
HOVERGENiHBG062228.
InParanoidiQ8BHZ4.
KOiK19325.
OMAiCGALCRS.
OrthoDBiEOG091G0AA1.
PhylomeDBiQ8BHZ4.
TreeFamiTF329009.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF16622. zf-C2H2_11. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QAPSEENESP LKSSGMCIDE
60 70 80 90 100
NVSLSHSGSA PDVPAVSVIV KNTSRQESFE AEKDHIAPSL LHNGFRGSDL
110 120 130 140 150
PPDSHHCGKF DSTFINGDSA RSFTSKLEPS KSEPLPTFNQ FSPISSPEPE
160 170 180 190 200
DPVKDNGFGI KSKHSDSYFP PPPGTVGGPV LEALSKFPVP ELHMFDHFCK
210 220 230 240 250
KEPKPEPLPL ESQQEHEQGG QKVVEPHKDL DSSRFFGEAL EFNSHPSNSI
260 270 280 290 300
GEPKKLAPEL SACSSVPPRQ RLKPAHSKLS SCVAALVALQ AKRVANVTKE
310 320 330 340 350
DQPGHTKDSS GPTKEGSKGS PKMPKSPKSP RSPLEATRKS IKPSDSPRSI
360 370 380 390 400
CSDSSSKGSP SVAASSPPAI PKVRIKTIKT SSGEIKRTVT RILPDPDDPS
410 420 430 440 450
KSPAESPAGS TITEAPSEAP GDEGTAMPVE EHFSEAGIHS GSPQGDRKGD
460 470 480 490 500
ENMIKTSDSS SPCRISGSRV PKGSALNSQA SKKQQSTAPQ ASTPAASLLP
510 520 530 540 550
KAVHLANLNL VPHSVAASVT AKSSAQRRSQ PQVTQMTVPL VHQVKKAAPL
560 570 580 590 600
IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK
610 620 630 640 650
SLSQHYSRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ
660 670 680 690 700
LLVKPISADQ MFVAAPVNST APATPAASSS PKPSPTLDNA SSVIPALPLY
710 720 730 740 750
PDPVRLIRYG TKCPECHKQM RDYMVLATHF QRTTEETEGL TCQVCQMLLP
760 770 780 790 800
NQCSFCAHQR IHAHKSPYCC PECGVLCRSA YFQTHVKENC LHYARKVGYR
810 820 830 840 850
CIHCGVIHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS STMDHSTTQH
860 870 880 890 900
PTQPHKPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQAG VFKCPECPLL
910 920 930 940 950
FLQKPELMQH VKNTHGVPRN VEELSSLQSS TDTSSNRPGS RAPAEPPATN
960 970 980 990 1000
VAARGSSLTA GRWGRPEAHR RAEARPRMRS TGWTCQECQE WVPDRESYVS
1010 1020 1030 1040 1050
HMKKSHGRTL KRYPCRQCEQ SFHNPSSLRK HIRNNHDTVK KVYTCGYCTE
1060 1070 1080 1090 1100
DSPSFPRPSL LESHISLMHG IRNPDLSQTS KVRHPGGPSP QVNHLKRPVS
1110 1120 1130 1140 1150
RMADAPGTSN GATVSSTKRH KSLFQCAKCT FATDSELEFQ SHIPQHQVDS
1160 1170 1180 1190 1200
STAQCLLCGL CYTSTSSLNR HLFIVHKVRD QEEGGEDIVE VKVEAPDSEA
1210 1220 1230 1240 1250
CSGEEVAMET KENGLEECAS EPLVTDLGGQ QGLALDEDSA QDPQNQPQAS
1260
QDQNSHALSP QV
Length:1,262
Mass (Da):137,514
Last modified:May 5, 2009 - v3
Checksum:i5C3FD264D0330B96
GO

Sequence cautioni

The sequence BAC31327 differs from that shown. Reason: Frameshift at position 45. Curated
The sequence BAC97899 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti510 – 52112LVPHS…ASVTA → PRVRPRVRPRVR in AAH44728 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti625 – 6251L → F in BAC97899 (PubMed:14621295).Curated
Sequence conflicti761 – 7611I → V in BAC97899 (PubMed:14621295).Curated
Sequence conflicti761 – 7611I → V in AAH44728 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129089 mRNA. Translation: BAC97899.1. Different initiation.
AK042675 mRNA. Translation: BAC31327.1. Frameshift.
BC044728 mRNA. Translation: AAH44728.1.
BC059073 mRNA. Translation: AAH59073.1.
CCDSiCCDS40003.2.
RefSeqiNP_848822.2. NM_178707.4.
UniGeneiMm.29525.

Genome annotation databases

EnsembliENSMUST00000107353; ENSMUSP00000102976; ENSMUSG00000005621.
GeneIDi233410.
KEGGimmu:233410.
UCSCiuc009ibp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129089 mRNA. Translation: BAC97899.1. Different initiation.
AK042675 mRNA. Translation: BAC31327.1. Frameshift.
BC044728 mRNA. Translation: AAH44728.1.
BC059073 mRNA. Translation: AAH59073.1.
CCDSiCCDS40003.2.
RefSeqiNP_848822.2. NM_178707.4.
UniGeneiMm.29525.

3D structure databases

ProteinModelPortaliQ8BHZ4.
SMRiQ8BHZ4. Positions 604-642, 712-849, 1000-1047, 1142-1172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231411. 4 interactions.
IntActiQ8BHZ4. 2 interactions.
MINTiMINT-1540719.
STRINGi10090.ENSMUSP00000102976.

PTM databases

iPTMnetiQ8BHZ4.
PhosphoSiteiQ8BHZ4.

Proteomic databases

EPDiQ8BHZ4.
MaxQBiQ8BHZ4.
PaxDbiQ8BHZ4.
PRIDEiQ8BHZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107353; ENSMUSP00000102976; ENSMUSG00000005621.
GeneIDi233410.
KEGGimmu:233410.
UCSCiuc009ibp.2. mouse.

Organism-specific databases

CTDi233410.
MGIiMGI:2443541. Zfp592.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063261.
HOGENOMiHOG000010306.
HOVERGENiHBG062228.
InParanoidiQ8BHZ4.
KOiK19325.
OMAiCGALCRS.
OrthoDBiEOG091G0AA1.
PhylomeDBiQ8BHZ4.
TreeFamiTF329009.

Miscellaneous databases

PROiQ8BHZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005621.
CleanExiMM_ZFP592.
GenevisibleiQ8BHZ4. MM.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF16622. zf-C2H2_11. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN592_MOUSE
AccessioniPrimary (citable) accession number: Q8BHZ4
Secondary accession number(s): Q80XM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.