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Protein

Sorting nexin-14

Gene

Snx14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (PubMed:24859318). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-14
Gene namesi
Name:Snx14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2155664. Snx14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Sorting nexin-14PRO_0000236201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki223 – 223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei566 – 5661PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BHY8.
PaxDbiQ8BHY8.
PRIDEiQ8BHY8.

PTM databases

iPTMnetiQ8BHY8.

Expressioni

Tissue specificityi

Expressed at high levels in the brain, testes, and lung and is present in diverse brain regions. Increases significantly during neuron development and maturation.1 Publication

Gene expression databases

BgeeiQ8BHY8.
CleanExiMM_SNX14.
ExpressionAtlasiQ8BHY8. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ8BHY8. 1 interaction.
MINTiMINT-4110650.
STRINGi10090.ENSMUSP00000130116.

Structurei

3D structure databases

ProteinModelPortaliQ8BHY8.
SMRiQ8BHY8. Positions 577-711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 331175PXAPROSITE-ProRule annotationAdd
BLAST
Domaini363 – 495133RGSPROSITE-ProRule annotationAdd
BLAST
Domaini588 – 708121PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 PXA domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMHX. Eukaryota.
ENOG410XS0F. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000043107.
HOVERGENiHBG056713.
InParanoidiQ8BHY8.
KOiK17926.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLRRRGLGV PSASASEGGT SSPAWTEMGS WVRTICGRLK QRLRLDVGRE
60 70 80 90 100
ICRQYPLFCF LLLCLSVASL LLNRYLHVLM IFWSFVAGVV TFYCSLGPDS
110 120 130 140 150
LLPNIFFTIK YKPKQLGLQE LFPQGHSCAV CGKVKCKRHR PSLLLENYQP
160 170 180 190 200
WLDLKVSSKV DASLSEVLEL VLENFVYPWY RDVTDDESFV DELRITLRFF
210 220 230 240 250
ASVLVRRIHK VDIPSIITKK LLKAAMKHIE VIVKARQKVK NTEYLQQAAL
260 270 280 290 300
EEYGPELHVA LRSRRDELQY LRKLTELLFP YILPPKATDC RSLTLLIREI
310 320 330 340 350
LSGSVLLPSL DFLADPDTVN HLLIIFIDDS PPEKATEPAS PLVPFLQKFA
360 370 380 390 400
EPRNKKPSVL KLELKQIREQ QDLLFRFMNF LKQEGAVHVL QFCLTVEEFN
410 420 430 440 450
DRILRPELSN DEMLSLHEEL QKIYKTYCLD ESIDKIRFDP FIVEEIQRIA
460 470 480 490 500
EGPYIDVVKL QTMRCLFEAY EHVLSLLENV FTPMFCHSDE YFRQLLRGAE
510 520 530 540 550
SPTRNSKFNR STQKRGESFG ISRIGSKIKG VFKSTTMEGA VLPNYGVAEG
560 570 580 590 600
EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL AAWKISIPYV DFFEDPSSER
610 620 630 640 650
KEKKERIPVF CIDVERNDRR AVGHEPEHWS VYRRYLEFYV LESKLTEFHG
660 670 680 690 700
TFPDAQLPSK RIIGPKNYEF LKSKREEFQE YLQKLVQHPE LSNSQLLADF
710 720 730 740 750
LSPNGGETQF LDKILPDVNL GKIIKSVPGK LMKEKGQHLE PFIMSFINSC
760 770 780 790 800
ESPKPKPSRP ELTILSPTSE NNKKLFNDLF KNNANRAENT ERKQNQNYFM
810 820 830 840 850
EVMTVDGVYD YLMYVGRVVF QVPDWLHHLL MGTRILFKNT LEMYTDYYLQ
860 870 880 890 900
CKLEQLFQEH RLVSLITLLR DAIFCENTEP RSLQDKQKGA KQTFEEMMNY
910 920 930 940 950
IPDLIVKCIG EETKYESIRL LFDGLQQPVL NKQLTYVLLD IVIQELFPEL
960
NKVQKEATSM TSWM
Length:964
Mass (Da):111,865
Last modified:June 24, 2015 - v2
Checksum:i3FF60D12EF8FBBC4
GO

Sequence cautioni

The sequence AAH80799.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC33716.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → R in AAH80799 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049371 mRNA. Translation: BAC33716.1. Different initiation.
AC116713 Genomic DNA. No translation available.
CT025673 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL26530.1.
BC080799 mRNA. Translation: AAH80799.1. Different initiation.
CCDSiCCDS23387.2.
RefSeqiNP_766514.2. NM_172926.3.
UniGeneiMm.439873.

Genome annotation databases

EnsembliENSMUST00000165315; ENSMUSP00000130116; ENSMUSG00000032422.
GeneIDi244962.
KEGGimmu:244962.
UCSCiuc009qyl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049371 mRNA. Translation: BAC33716.1. Different initiation.
AC116713 Genomic DNA. No translation available.
CT025673 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL26530.1.
BC080799 mRNA. Translation: AAH80799.1. Different initiation.
CCDSiCCDS23387.2.
RefSeqiNP_766514.2. NM_172926.3.
UniGeneiMm.439873.

3D structure databases

ProteinModelPortaliQ8BHY8.
SMRiQ8BHY8. Positions 577-711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHY8. 1 interaction.
MINTiMINT-4110650.
STRINGi10090.ENSMUSP00000130116.

PTM databases

iPTMnetiQ8BHY8.

Proteomic databases

EPDiQ8BHY8.
PaxDbiQ8BHY8.
PRIDEiQ8BHY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165315; ENSMUSP00000130116; ENSMUSG00000032422.
GeneIDi244962.
KEGGimmu:244962.
UCSCiuc009qyl.2. mouse.

Organism-specific databases

CTDi57231.
MGIiMGI:2155664. Snx14.

Phylogenomic databases

eggNOGiENOG410IMHX. Eukaryota.
ENOG410XS0F. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000043107.
HOVERGENiHBG056713.
InParanoidiQ8BHY8.
KOiK17926.

Miscellaneous databases

ChiTaRSiSnx14. mouse.
PROiQ8BHY8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHY8.
CleanExiMM_SNX14.
ExpressionAtlasiQ8BHY8. baseline and differential.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  6. "Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice."
    Huang H.S., Yoon B.J., Brooks S., Bakal R., Berrios J., Larsen R.S., Wallace M.L., Han J.E., Chung E.H., Zylka M.J., Philpot B.D.
    PLoS ONE 9:E98383-E98383(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPRINTING, SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSNX14_MOUSE
AccessioniPrimary (citable) accession number: Q8BHY8
Secondary accession number(s): B0V2Q4, G3UWA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 24, 2015
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The SNX14 locus is maternally imprinted.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.