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Protein

Anoctamin-1

Gene

Ano1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.5 Publications

Enzyme regulationi

ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) (By similarity).By similarity

GO - Molecular functioni

  • calcium activated cation channel activity Source: MGI
  • chloride channel activity Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: UniProtKB
  • iodide transmembrane transporter activity Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • voltage-gated chloride channel activity Source: UniProtKB

GO - Biological processi

  • cation transmembrane transport Source: MGI
  • cation transport Source: MGI
  • cellular response to heat Source: UniProtKB
  • chloride transmembrane transport Source: UniProtKB
  • chloride transport Source: UniProtKB
  • detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
  • iodide transport Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  • regulation of anion transmembrane transport Source: GOC
  • regulation of membrane potential Source: MGI
  • trachea development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Developmental protein, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-1
Alternative name(s):
Transmembrane protein 16A
Gene namesi
Name:Ano1
Synonyms:Tmem16a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142149. Ano1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 333333CytoplasmicSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Topological domaini355 – 40248ExtracellularSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Topological domaini424 – 49370CytoplasmicSequence analysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence analysisAdd
BLAST
Topological domaini515 – 53925ExtracellularSequence analysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence analysisAdd
BLAST
Topological domaini561 – 58121CytoplasmicSequence analysisAdd
BLAST
Transmembranei582 – 60221HelicalSequence analysisAdd
BLAST
Topological domaini603 – 705103ExtracellularSequence analysisAdd
BLAST
Transmembranei706 – 72621HelicalSequence analysisAdd
BLAST
Topological domaini727 – 76539CytoplasmicSequence analysisAdd
BLAST
Transmembranei766 – 78621HelicalSequence analysisAdd
BLAST
Topological domaini787 – 85670ExtracellularSequence analysisAdd
BLAST
Transmembranei857 – 87721HelicalSequence analysisAdd
BLAST
Topological domaini878 – 96083CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • chloride channel complex Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display severe tracheomalacia with gaps in the tracheal cartilage rings along the entire length of the trachea. 90% of mutants die within the first nine days of postnatal life and no mutants survive longer than 30 days postpartum. Knockdown of Ano1 reduces calcium-activated chloride currents and saliva production.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi588 – 5881K → Q: Decreased permeability to chloride ions. 1 Publication
Mutagenesisi621 – 6211R → E: Reduced anion permeability and increased cation permeability. 1 Publication
Mutagenesisi625 – 6251C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication
Mutagenesisi630 – 6301C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication
Mutagenesisi635 – 6351C → A: No effect of cysteine-modifying agent MTSET on ion permeability in contrast to wild-type where MTSET blocks current. 1 Publication
Mutagenesisi645 – 6451K → E: Reduced anion permeability and increased cation permeability. 1 Publication
Mutagenesisi668 – 6681K → E: Reduced anion permeability and increased cation permeability. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Anoctamin-1PRO_0000288436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961PhosphoserineBy similarity
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8BHY3.
MaxQBiQ8BHY3.
PaxDbiQ8BHY3.
PRIDEiQ8BHY3.

PTM databases

iPTMnetiQ8BHY3.

Expressioni

Tissue specificityi

Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.3 Publications

Developmental stagei

In the developing respiratory system, expressed in epithelium of trachea and lung at E12.5 and E14.5 but not detected in distal epithelial tips. Expressed in the mesenchyme adjacent to the proximal conducting airway epithelium at E14.5 but not at E16.5. Epithelial expression persists at E16.5. At E18.5, high levels detected only in epithelial cells of terminal sacules. In the developing gastrointestinal tract, expressed in the esophageal mesenchyme and epithelium of posterior stomach and intestine. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at E14.5 and E16.5. In developing skin, expression is restricted to basal layers of the epidermis at E16.5.1 Publication

Gene expression databases

BgeeiQ8BHY3.
ExpressionAtlasiQ8BHY3. baseline and differential.
GenevisibleiQ8BHY3. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with CFTR (By similarity). Interacts with TRPV4 (PubMed:24509911).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113899.

Structurei

3D structure databases

ProteinModelPortaliQ8BHY3.
SMRiQ8BHY3. Positions 281-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ8BHY3.
KOiK19496.
OrthoDBiEOG7BS48W.
PhylomeDBiQ8BHY3.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031287. Anoctamin-1.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF13. PTHR12308:SF13. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BHY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVPEKYSTL PAEDRSVHIV NICAIEDLGY LPSEGTLLNS LSVDPDAECK
60 70 80 90 100
YGLYFRDGKR KVDYILVYHH KRASGSRTLA RRGLQNDMVL GTRSVRQDQP
110 120 130 140 150
LPGKGSPVDA GSPEVPMDYH EDDKRFRREE YEGNLLEAGL ELENDEDTKI
160 170 180 190 200
HGVGFVKIHA PWHVLCREAE FLKLKMPTKK VYHISETRGL LKTINSVLQK
210 220 230 240 250
ITDPIQPKVA EHRPQTTKRL SYPFSREKQH LFDLTDRDSF FDSKTRSTIV
260 270 280 290 300
YEILKRTTCT KAKYSMGITS LLANGVYSAA YPLHDGDYEG DNVEFNDRKL
310 320 330 340 350
LYEEWASYGV FYKYQPIDLV RKYFGEKVGL YFAWLGAYTQ MLIPASIVGV
360 370 380 390 400
IVFLYGCATV DENIPSMEMC DQRYNITMCP LCDKTCSYWK MSSACATARA
410 420 430 440 450
SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV
460 470 480 490 500
KDHPRAEYEA RVLEKSLRKE SRNKETDKVK LTWRDRFPAY FTNLVSIIFM
510 520 530 540 550
IAVTFAIVLG VIIYRISTAA ALAMNSSPSV RSNIRVTVTA TAVIINLVVI
560 570 580 590 600
ILLDEVYGCI ARWLTKIEVP KTEKSFEERL TFKAFLLKFV NSYTPIFYVA
610 620 630 640 650
FFKGRFVGRP GDYVYIFRSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN
660 670 680 690 700
NLFEIGIPKM KKFIRYLKLR RQSPSDREEY VKRKQRYEVD FNLEPFAGLT
710 720 730 740 750
PEYMEMIIQF GFVTLFVASF PLAPLFALLN NIIEIRLDAK KFVTELRRPV
760 770 780 790 800
AIRAKDIGIW YNILRGVGKL AVIINAFVIS FTSDFIPRLV YLYMYSQNGT
810 820 830 840 850
MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVQICRYKD YREPPWSEHK
860 870 880 890 900
YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE
910 920 930 940 950
KVLMVELFMR EEQGKQQLLD TWMEKEKPRD VPCNNHSPTT HPEAGDGSPV
960
PSYEYHGDAL
Length:960
Mass (Da):110,916
Last modified:May 29, 2007 - v2
Checksum:iBFD0112FD310CE88
GO
Isoform 2 (identifier: Q8BHY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-451: Missing.

Show »
Length:956
Mass (Da):110,489
Checksum:i150FACCDBDA4AF25
GO

Sequence cautioni

The sequence AAH06062.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26230.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26398.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC35051.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei448 – 4514Missing in isoform 2. 1 PublicationVSP_025672

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028991 mRNA. Translation: BAC26230.1. Different initiation.
AK029329 mRNA. Translation: BAC26398.1. Different initiation.
AK052589 mRNA. Translation: BAC35051.1. Sequence problems.
BC006062 mRNA. Translation: AAH06062.1. Different initiation.
BC062959 mRNA. Translation: AAH62959.1.
RefSeqiNP_001229278.1. NM_001242349.1.
NP_848757.4. NM_178642.5.
UniGeneiMm.26700.

Genome annotation databases

EnsembliENSMUST00000033393; ENSMUSP00000033393; ENSMUSG00000031075. [Q8BHY3-2]
GeneIDi101772.
KEGGimmu:101772.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028991 mRNA. Translation: BAC26230.1. Different initiation.
AK029329 mRNA. Translation: BAC26398.1. Different initiation.
AK052589 mRNA. Translation: BAC35051.1. Sequence problems.
BC006062 mRNA. Translation: AAH06062.1. Different initiation.
BC062959 mRNA. Translation: AAH62959.1.
RefSeqiNP_001229278.1. NM_001242349.1.
NP_848757.4. NM_178642.5.
UniGeneiMm.26700.

3D structure databases

ProteinModelPortaliQ8BHY3.
SMRiQ8BHY3. Positions 281-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113899.

PTM databases

iPTMnetiQ8BHY3.

Proteomic databases

EPDiQ8BHY3.
MaxQBiQ8BHY3.
PaxDbiQ8BHY3.
PRIDEiQ8BHY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033393; ENSMUSP00000033393; ENSMUSG00000031075. [Q8BHY3-2]
GeneIDi101772.
KEGGimmu:101772.

Organism-specific databases

CTDi55107.
MGIiMGI:2142149. Ano1.

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ8BHY3.
KOiK19496.
OrthoDBiEOG7BS48W.
PhylomeDBiQ8BHY3.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

PROiQ8BHY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHY3.
ExpressionAtlasiQ8BHY3. baseline and differential.
GenevisibleiQ8BHY3. MM.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031287. Anoctamin-1.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF13. PTHR12308:SF13. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TMEM16A confers receptor-activated calcium-dependent chloride conductance."
    Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.-S., Park S.P., Lee J., Lee B., Kim B.-M., Raouf R., Shin Y.K., Oh U.
    Nature 455:1210-1215(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, PORE-FORMING REGION, KNOCKDOWN, MUTAGENESIS OF ARG-621; CYS-625; CYS-630; CYS-635; LYS-645 AND LYS-668.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head, Kidney and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and Czech II.
    Tissue: Eye and Mammary tumor.
  4. "The transmembrane protein TMEM16A is required for normal development of the murine trachea."
    Rock J.R., Futtner C.R., Harfe B.D.
    Dev. Biol. 321:141-149(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  5. "Expression of TMEM16 paralogs during murine embryogenesis."
    Rock J.R., Harfe B.D.
    Dev. Dyn. 237:2566-2574(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Lung and Testis.
  7. Cited for: TISSUE SPECIFICITY.
  8. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
    Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
    Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "TMEM16F forms a Ca(2+)-activated cation channel required for lipid scrambling in platelets during blood coagulation."
    Yang H., Kim A., David T., Palmer D., Jin T., Tien J., Huang F., Cheng T., Coughlin S.R., Jan Y.N., Jan L.Y.
    Cell 151:111-122(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LYS-588.
  10. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. Cited for: REVIEW, FUNCTION.
  12. "Anoctamins and gastrointestinal smooth muscle excitability."
    Sanders K.M., Zhu M.H., Britton F., Koh S.D., Ward S.M.
    Exp. Physiol. 97:200-206(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.
  13. "Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1."
    Takayama Y., Shibasaki K., Suzuki Y., Yamanaka A., Tominaga M.
    FASEB J. 28:2238-2248(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRPV4.

Entry informationi

Entry nameiANO1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHY3
Secondary accession number(s): Q6P5C6, Q8BI26, Q99JK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.