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Protein

HAUS augmin-like complex subunit 1

Gene

Haus1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 1
Alternative name(s):
Coiled-coil domain-containing protein 5
Gene namesi
Name:Haus1
Synonyms:Ccdc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2385076 Haus1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893961 – 278HAUS augmin-like complex subunit 1Add BLAST278

Proteomic databases

EPDiQ8BHX1
MaxQBiQ8BHX1
PaxDbiQ8BHX1
PeptideAtlasiQ8BHX1
PRIDEiQ8BHX1

PTM databases

iPTMnetiQ8BHX1
PhosphoSitePlusiQ8BHX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000041840
CleanExiMM_CCDC5
GenevisibleiQ8BHX1 MM

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity).By similarity

Protein-protein interaction databases

BioGridi230424, 42 interactors
IntActiQ8BHX1, 42 interactors
MINTiQ8BHX1
STRINGi10090.ENSMUSP00000035826

Structurei

3D structure databases

ProteinModelPortaliQ8BHX1
SMRiQ8BHX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 79Sequence analysisAdd BLAST31
Coiled coili128 – 178Sequence analysisAdd BLAST51
Coiled coili249 – 277Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the HAUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEUK Eukaryota
ENOG4111SPA LUCA
GeneTreeiENSGT00390000006029
HOGENOMiHOG000220811
InParanoidiQ8BHX1
KOiK16584
OMAiPQYEVNA
OrthoDBiEOG091G0I5X
PhylomeDBiQ8BHX1
TreeFamiTF331717

Family and domain databases

InterProiView protein in InterPro
IPR026243 HAUS1
PRINTSiPR02087 HAUSAUGMINL1

Sequencei

Sequence statusi: Complete.

Q8BHX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEEKALQ VAEWLKKVFG DHPIPQYEMN SRTTEILYHL SERNRVRDRD
60 70 80 90 100
ISLVIEDLKQ KASEYESEAK RLEDFLMESV NFSPANLSKS GSRFLNALVD
110 120 130 140 150
SAIALEIKDT SLASFIPAVN DLTSDLFRTK SKSEEMKLEL GKLEKNLTAT
160 170 180 190 200
LVLEKCLRED LKKAELQLSA EKAKVDSRLQ NMDFLKAKAA EFRFGIKAAE
210 220 230 240 250
EQLSARGMDA SLSHRSLAAL SEKLSELKEQ TIPLKKKLES YLDLMPSPSL
260 270
AQLKIEEAKR ELDAIEAELT KKVDMMGL
Length:278
Mass (Da):31,379
Last modified:July 19, 2004 - v2
Checksum:iEE77CE588774E92A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159E → K in BAC36526 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076912 mRNA Translation: BAC36526.1
AK146923 mRNA Translation: BAE27534.1
BC024400 mRNA Translation: AAH24400.1
CCDSiCCDS29357.1
RefSeqiNP_666201.1, NM_146089.2
UniGeneiMm.39293

Genome annotation databases

EnsembliENSMUST00000048192; ENSMUSP00000035826; ENSMUSG00000041840
GeneIDi225745
KEGGimmu:225745
UCSCiuc008frs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHAUS1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHX1
Secondary accession number(s): Q3UIH2, Q8R1M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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