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Protein

HAUS augmin-like complex subunit 1

Gene

Haus1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 1
Alternative name(s):
Coiled-coil domain-containing protein 5
Gene namesi
Name:Haus1
Synonyms:Ccdc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2385076. Haus1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278HAUS augmin-like complex subunit 1PRO_0000089396Add
BLAST

Proteomic databases

EPDiQ8BHX1.
MaxQBiQ8BHX1.
PaxDbiQ8BHX1.
PeptideAtlasiQ8BHX1.
PRIDEiQ8BHX1.

PTM databases

iPTMnetiQ8BHX1.
PhosphoSiteiQ8BHX1.

Expressioni

Gene expression databases

BgeeiQ8BHX1.
CleanExiMM_CCDC5.
GenevisibleiQ8BHX1. MM.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity).By similarity

Protein-protein interaction databases

BioGridi230424. 42 interactions.
IntActiQ8BHX1. 42 interactions.
STRINGi10090.ENSMUSP00000035826.

Structurei

3D structure databases

ProteinModelPortaliQ8BHX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 7931Sequence analysisAdd
BLAST
Coiled coili128 – 17851Sequence analysisAdd
BLAST
Coiled coili249 – 27729Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEUK. Eukaryota.
ENOG4111SPA. LUCA.
GeneTreeiENSGT00390000006029.
HOGENOMiHOG000220811.
InParanoidiQ8BHX1.
KOiK16584.
OMAiPQYEVNA.
OrthoDBiEOG75F4GD.
PhylomeDBiQ8BHX1.
TreeFamiTF331717.

Family and domain databases

InterProiIPR026243. HAUS1.
[Graphical view]
PRINTSiPR02087. HAUSAUGMINL1.

Sequencei

Sequence statusi: Complete.

Q8BHX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEEKALQ VAEWLKKVFG DHPIPQYEMN SRTTEILYHL SERNRVRDRD
60 70 80 90 100
ISLVIEDLKQ KASEYESEAK RLEDFLMESV NFSPANLSKS GSRFLNALVD
110 120 130 140 150
SAIALEIKDT SLASFIPAVN DLTSDLFRTK SKSEEMKLEL GKLEKNLTAT
160 170 180 190 200
LVLEKCLRED LKKAELQLSA EKAKVDSRLQ NMDFLKAKAA EFRFGIKAAE
210 220 230 240 250
EQLSARGMDA SLSHRSLAAL SEKLSELKEQ TIPLKKKLES YLDLMPSPSL
260 270
AQLKIEEAKR ELDAIEAELT KKVDMMGL
Length:278
Mass (Da):31,379
Last modified:July 19, 2004 - v2
Checksum:iEE77CE588774E92A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591E → K in BAC36526 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076912 mRNA. Translation: BAC36526.1.
AK146923 mRNA. Translation: BAE27534.1.
BC024400 mRNA. Translation: AAH24400.1.
CCDSiCCDS29357.1.
RefSeqiNP_666201.1. NM_146089.2.
UniGeneiMm.39293.

Genome annotation databases

EnsembliENSMUST00000048192; ENSMUSP00000035826; ENSMUSG00000041840.
GeneIDi225745.
KEGGimmu:225745.
UCSCiuc008frs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076912 mRNA. Translation: BAC36526.1.
AK146923 mRNA. Translation: BAE27534.1.
BC024400 mRNA. Translation: AAH24400.1.
CCDSiCCDS29357.1.
RefSeqiNP_666201.1. NM_146089.2.
UniGeneiMm.39293.

3D structure databases

ProteinModelPortaliQ8BHX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230424. 42 interactions.
IntActiQ8BHX1. 42 interactions.
STRINGi10090.ENSMUSP00000035826.

PTM databases

iPTMnetiQ8BHX1.
PhosphoSiteiQ8BHX1.

Proteomic databases

EPDiQ8BHX1.
MaxQBiQ8BHX1.
PaxDbiQ8BHX1.
PeptideAtlasiQ8BHX1.
PRIDEiQ8BHX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048192; ENSMUSP00000035826; ENSMUSG00000041840.
GeneIDi225745.
KEGGimmu:225745.
UCSCiuc008frs.1. mouse.

Organism-specific databases

CTDi115106.
MGIiMGI:2385076. Haus1.

Phylogenomic databases

eggNOGiENOG410IEUK. Eukaryota.
ENOG4111SPA. LUCA.
GeneTreeiENSGT00390000006029.
HOGENOMiHOG000220811.
InParanoidiQ8BHX1.
KOiK16584.
OMAiPQYEVNA.
OrthoDBiEOG75F4GD.
PhylomeDBiQ8BHX1.
TreeFamiTF331717.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ8BHX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHX1.
CleanExiMM_CCDC5.
GenevisibleiQ8BHX1. MM.

Family and domain databases

InterProiIPR026243. HAUS1.
[Graphical view]
PRINTSiPR02087. HAUSAUGMINL1.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiHAUS1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHX1
Secondary accession number(s): Q3UIH2, Q8R1M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.