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Q8BHT6 (B3GLT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-1,3-glucosyltransferase

Short name=Beta3Glc-T
EC=2.4.1.-
Alternative name(s):
Beta-3-glycosyltransferase-like
Gene names
Name:B3galtl
Synonyms:Gm1057
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BHT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BHT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Beta-1,3-glucosyltransferase
PRO_0000252400

Regions

Topological domain11Cytoplasmic Potential
Transmembrane2 – 2221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain23 – 489467Lumenal Potential
Motif486 – 4894Prevents secretion from ER Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 386386Missing in isoform 2.
VSP_020936

Experimental info

Sequence conflict1281L → I in BAF02833. Ref.1
Sequence conflict2531V → I in BAF02833. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 3FAD6846B25DB080

FASTA48955,358
        10         20         30         40         50         60 
MRPPALLALF SCSAAFALMS EEIKEKVTPS QDLRQSSLPG RHDIDLKEIV FVIQSQSNSF 

        70         80         90        100        110        120 
HAKRAEQLKK NILKQAANLT QDLPRVLLLH QLAKQEGAWT ILPLLPHFSV TYSKNSAWIF 

       130        140        150        160        170        180 
FCEEETRLQI PRLLDTLRRY DPSKEWFLGK ALYDEESTII HHYAFSENPT VFKYPDFAAG 

       190        200        210        220        230        240 
WALSIPLVNK LAKRLKSEAL KSDFTIDLKH EIALYIWDKG GGPALTPVPE FCTEDVDPRC 

       250        260        270        280        290        300 
VTTFHSFLPL CGVPVKKEEI FVAVKTCKKF HADRIPIVKK TWAAQASLIE YYSDYAETAI 

       310        320        330        340        350        360 
PTVDLGIPNT DRGHCGKTFA ILEKFLNHSH NKISWLVIVD DDTLISISRL RHLLSCYDSS 

       370        380        390        400        410        420 
DPVFLGERYG YGLGTGGYSY VTGGGGMVFS REAIRRLLVS SCRCYSNDAP DDMVLGMCFS 

       430        440        450        460        470        480 
GLGVPVTHSP LFHQARPVDY PKDYLAHQIP VSFHKHWHID PVKVYLTWLA PSEEDQATQE 


TQKDPREEL 

« Hide

Isoform 2 [UniParc].

Checksum: CB1B1F4685D61F40
Show »

FASTA10311,881

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain."
Sato T., Sato M., Kiyohara K., Sogabe M., Shikanai T., Kikuchi N., Togayachi A., Ishida H., Ito H., Kameyama A., Gotoh M., Narimatsu H.
Glycobiology 16:1194-1206(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352 (ISOFORM 1).
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB253762 mRNA. Translation: BAF02833.1.
AC114342 Genomic DNA. No translation available.
BC115781 mRNA. Translation: AAI15782.1.
BC117522 mRNA. Translation: AAI17523.1.
AK089440 mRNA. Translation: BAC40885.1.
CCDSCCDS39410.1. [Q8BHT6-1]
RefSeqNP_001074673.1. NM_001081204.1. [Q8BHT6-1]
UniGeneMm.45060.

3D structure databases

ProteinModelPortalQ8BHT6.
SMRQ8BHT6. Positions 259-433.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteQ8BHT6.

Proteomic databases

MaxQBQ8BHT6.
PaxDbQ8BHT6.
PRIDEQ8BHT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100404; ENSMUSP00000097972; ENSMUSG00000051950. [Q8BHT6-1]
GeneID381694.
KEGGmmu:381694.
UCSCuc009aqc.1. mouse. [Q8BHT6-1]
uc009aqd.1. mouse. [Q8BHT6-2]

Organism-specific databases

CTD381694.
MGIMGI:2685903. B3galtl.

Phylogenomic databases

eggNOGNOG150034.
GeneTreeENSGT00390000000060.
HOGENOMHOG000007375.
HOVERGENHBG059386.
InParanoidQ8BHT6.
KOK13675.
OMATGGYSYV.
OrthoDBEOG75XGMG.
TreeFamTF313496.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

BgeeQ8BHT6.
CleanExMM_B3GALTL.
GenevestigatorQ8BHT6.

Family and domain databases

InterProIPR003378. Fringe-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF02434. Fringe. 2 hits.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio402439.
PROQ8BHT6.
SOURCESearch...

Entry information

Entry nameB3GLT_MOUSE
AccessionPrimary (citable) accession number: Q8BHT6
Secondary accession number(s): E9QMK8, Q0PCR7, Q149S5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot