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Q8BHT6

- B3GLT_MOUSE

UniProt

Q8BHT6 - B3GLT_MOUSE

Protein

Beta-1,3-glucosyltransferase

Gene

B3galtl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. fucose metabolic process Source: UniProtKB-KW
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Enzyme and pathway databases

    ReactomeiREACT_211817. O-glycosylation of TSR domain-containing proteins.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-glucosyltransferase (EC:2.4.1.-)
    Short name:
    Beta3Glc-T
    Alternative name(s):
    Beta-3-glycosyltransferase-like
    Gene namesi
    Name:B3galtl
    Synonyms:Gm1057
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2685903. B3galtl.

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Single-pass type II membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Beta-1,3-glucosyltransferasePRO_0000252400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8BHT6.
    PaxDbiQ8BHT6.
    PRIDEiQ8BHT6.

    PTM databases

    PhosphoSiteiQ8BHT6.

    Expressioni

    Gene expression databases

    BgeeiQ8BHT6.
    CleanExiMM_B3GALTL.
    GenevestigatoriQ8BHT6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BHT6.
    SMRiQ8BHT6. Positions 259-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11CytoplasmicSequence Analysis
    Topological domaini23 – 489467LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi486 – 4894Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150034.
    GeneTreeiENSGT00390000000060.
    HOGENOMiHOG000007375.
    HOVERGENiHBG059386.
    InParanoidiQ8BHT6.
    KOiK13675.
    OMAiTGGYSYV.
    OrthoDBiEOG75XGMG.
    TreeFamiTF313496.

    Family and domain databases

    InterProiIPR003378. Fringe-like.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF02434. Fringe. 2 hits.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BHT6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPPALLALF SCSAAFALMS EEIKEKVTPS QDLRQSSLPG RHDIDLKEIV    50
    FVIQSQSNSF HAKRAEQLKK NILKQAANLT QDLPRVLLLH QLAKQEGAWT 100
    ILPLLPHFSV TYSKNSAWIF FCEEETRLQI PRLLDTLRRY DPSKEWFLGK 150
    ALYDEESTII HHYAFSENPT VFKYPDFAAG WALSIPLVNK LAKRLKSEAL 200
    KSDFTIDLKH EIALYIWDKG GGPALTPVPE FCTEDVDPRC VTTFHSFLPL 250
    CGVPVKKEEI FVAVKTCKKF HADRIPIVKK TWAAQASLIE YYSDYAETAI 300
    PTVDLGIPNT DRGHCGKTFA ILEKFLNHSH NKISWLVIVD DDTLISISRL 350
    RHLLSCYDSS DPVFLGERYG YGLGTGGYSY VTGGGGMVFS REAIRRLLVS 400
    SCRCYSNDAP DDMVLGMCFS GLGVPVTHSP LFHQARPVDY PKDYLAHQIP 450
    VSFHKHWHID PVKVYLTWLA PSEEDQATQE TQKDPREEL 489
    Length:489
    Mass (Da):55,358
    Last modified:July 27, 2011 - v3
    Checksum:i3FAD6846B25DB080
    GO
    Isoform 2 (identifier: Q8BHT6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-386: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:103
    Mass (Da):11,881
    Checksum:iCB1B1F4685D61F40
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281L → I in BAF02833. (PubMed:16899492)Curated
    Sequence conflicti253 – 2531V → I in BAF02833. (PubMed:16899492)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 386386Missing in isoform 2. 1 PublicationVSP_020936Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB253762 mRNA. Translation: BAF02833.1.
    AC114342 Genomic DNA. No translation available.
    BC115781 mRNA. Translation: AAI15782.1.
    BC117522 mRNA. Translation: AAI17523.1.
    AK089440 mRNA. Translation: BAC40885.1.
    CCDSiCCDS39410.1. [Q8BHT6-1]
    RefSeqiNP_001074673.1. NM_001081204.1. [Q8BHT6-1]
    UniGeneiMm.45060.

    Genome annotation databases

    EnsembliENSMUST00000100404; ENSMUSP00000097972; ENSMUSG00000051950. [Q8BHT6-1]
    GeneIDi381694.
    KEGGimmu:381694.
    UCSCiuc009aqc.1. mouse. [Q8BHT6-1]
    uc009aqd.1. mouse. [Q8BHT6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB253762 mRNA. Translation: BAF02833.1 .
    AC114342 Genomic DNA. No translation available.
    BC115781 mRNA. Translation: AAI15782.1 .
    BC117522 mRNA. Translation: AAI17523.1 .
    AK089440 mRNA. Translation: BAC40885.1 .
    CCDSi CCDS39410.1. [Q8BHT6-1 ]
    RefSeqi NP_001074673.1. NM_001081204.1. [Q8BHT6-1 ]
    UniGenei Mm.45060.

    3D structure databases

    ProteinModelPortali Q8BHT6.
    SMRi Q8BHT6. Positions 259-433.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q8BHT6.

    Proteomic databases

    MaxQBi Q8BHT6.
    PaxDbi Q8BHT6.
    PRIDEi Q8BHT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100404 ; ENSMUSP00000097972 ; ENSMUSG00000051950 . [Q8BHT6-1 ]
    GeneIDi 381694.
    KEGGi mmu:381694.
    UCSCi uc009aqc.1. mouse. [Q8BHT6-1 ]
    uc009aqd.1. mouse. [Q8BHT6-2 ]

    Organism-specific databases

    CTDi 381694.
    MGIi MGI:2685903. B3galtl.

    Phylogenomic databases

    eggNOGi NOG150034.
    GeneTreei ENSGT00390000000060.
    HOGENOMi HOG000007375.
    HOVERGENi HBG059386.
    InParanoidi Q8BHT6.
    KOi K13675.
    OMAi TGGYSYV.
    OrthoDBi EOG75XGMG.
    TreeFami TF313496.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_211817. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    NextBioi 402439.
    PROi Q8BHT6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BHT6.
    CleanExi MM_B3GALTL.
    Genevestigatori Q8BHT6.

    Family and domain databases

    InterProi IPR003378. Fringe-like.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF02434. Fringe. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain."
      Sato T., Sato M., Kiyohara K., Sogabe M., Shikanai T., Kikuchi N., Togayachi A., Ishida H., Ito H., Kameyama A., Gotoh M., Narimatsu H.
      Glycobiology 16:1194-1206(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352 (ISOFORM 1).
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiB3GLT_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHT6
    Secondary accession number(s): E9QMK8, Q0PCR7, Q149S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3