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Q8BHT6

- B3GLT_MOUSE

UniProt

Q8BHT6 - B3GLT_MOUSE

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Protein
Beta-1,3-glucosyltransferase
Gene
B3galtl, Gm1057
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan By similarity.

Pathwayi

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. fucose metabolic process Source: UniProtKB-KW
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Enzyme and pathway databases

ReactomeiREACT_211817. O-glycosylation of TSR domain-containing proteins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-glucosyltransferase (EC:2.4.1.-)
Short name:
Beta3Glc-T
Alternative name(s):
Beta-3-glycosyltransferase-like
Gene namesi
Name:B3galtl
Synonyms:Gm1057
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2685903. B3galtl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Cytoplasmic Reviewed prediction
Transmembranei2 – 2221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini23 – 489467Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Beta-1,3-glucosyltransferase
PRO_0000252400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BHT6.
PaxDbiQ8BHT6.
PRIDEiQ8BHT6.

PTM databases

PhosphoSiteiQ8BHT6.

Expressioni

Gene expression databases

BgeeiQ8BHT6.
CleanExiMM_B3GALTL.
GenevestigatoriQ8BHT6.

Structurei

3D structure databases

ProteinModelPortaliQ8BHT6.
SMRiQ8BHT6. Positions 259-433.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi486 – 4894Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150034.
GeneTreeiENSGT00390000000060.
HOGENOMiHOG000007375.
HOVERGENiHBG059386.
InParanoidiQ8BHT6.
KOiK13675.
OMAiTGGYSYV.
OrthoDBiEOG75XGMG.
TreeFamiTF313496.

Family and domain databases

InterProiIPR003378. Fringe-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02434. Fringe. 2 hits.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BHT6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRPPALLALF SCSAAFALMS EEIKEKVTPS QDLRQSSLPG RHDIDLKEIV    50
FVIQSQSNSF HAKRAEQLKK NILKQAANLT QDLPRVLLLH QLAKQEGAWT 100
ILPLLPHFSV TYSKNSAWIF FCEEETRLQI PRLLDTLRRY DPSKEWFLGK 150
ALYDEESTII HHYAFSENPT VFKYPDFAAG WALSIPLVNK LAKRLKSEAL 200
KSDFTIDLKH EIALYIWDKG GGPALTPVPE FCTEDVDPRC VTTFHSFLPL 250
CGVPVKKEEI FVAVKTCKKF HADRIPIVKK TWAAQASLIE YYSDYAETAI 300
PTVDLGIPNT DRGHCGKTFA ILEKFLNHSH NKISWLVIVD DDTLISISRL 350
RHLLSCYDSS DPVFLGERYG YGLGTGGYSY VTGGGGMVFS REAIRRLLVS 400
SCRCYSNDAP DDMVLGMCFS GLGVPVTHSP LFHQARPVDY PKDYLAHQIP 450
VSFHKHWHID PVKVYLTWLA PSEEDQATQE TQKDPREEL 489
Length:489
Mass (Da):55,358
Last modified:July 27, 2011 - v3
Checksum:i3FAD6846B25DB080
GO
Isoform 2 (identifier: Q8BHT6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.

Note: No experimental confirmation available.

Show »
Length:103
Mass (Da):11,881
Checksum:iCB1B1F4685D61F40
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 386386Missing in isoform 2.
VSP_020936Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281L → I in BAF02833. 1 Publication
Sequence conflicti253 – 2531V → I in BAF02833. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB253762 mRNA. Translation: BAF02833.1.
AC114342 Genomic DNA. No translation available.
BC115781 mRNA. Translation: AAI15782.1.
BC117522 mRNA. Translation: AAI17523.1.
AK089440 mRNA. Translation: BAC40885.1.
CCDSiCCDS39410.1. [Q8BHT6-1]
RefSeqiNP_001074673.1. NM_001081204.1. [Q8BHT6-1]
UniGeneiMm.45060.

Genome annotation databases

EnsembliENSMUST00000100404; ENSMUSP00000097972; ENSMUSG00000051950. [Q8BHT6-1]
GeneIDi381694.
KEGGimmu:381694.
UCSCiuc009aqc.1. mouse. [Q8BHT6-1]
uc009aqd.1. mouse. [Q8BHT6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB253762 mRNA. Translation: BAF02833.1 .
AC114342 Genomic DNA. No translation available.
BC115781 mRNA. Translation: AAI15782.1 .
BC117522 mRNA. Translation: AAI17523.1 .
AK089440 mRNA. Translation: BAC40885.1 .
CCDSi CCDS39410.1. [Q8BHT6-1 ]
RefSeqi NP_001074673.1. NM_001081204.1. [Q8BHT6-1 ]
UniGenei Mm.45060.

3D structure databases

ProteinModelPortali Q8BHT6.
SMRi Q8BHT6. Positions 259-433.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei Q8BHT6.

Proteomic databases

MaxQBi Q8BHT6.
PaxDbi Q8BHT6.
PRIDEi Q8BHT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100404 ; ENSMUSP00000097972 ; ENSMUSG00000051950 . [Q8BHT6-1 ]
GeneIDi 381694.
KEGGi mmu:381694.
UCSCi uc009aqc.1. mouse. [Q8BHT6-1 ]
uc009aqd.1. mouse. [Q8BHT6-2 ]

Organism-specific databases

CTDi 381694.
MGIi MGI:2685903. B3galtl.

Phylogenomic databases

eggNOGi NOG150034.
GeneTreei ENSGT00390000000060.
HOGENOMi HOG000007375.
HOVERGENi HBG059386.
InParanoidi Q8BHT6.
KOi K13675.
OMAi TGGYSYV.
OrthoDBi EOG75XGMG.
TreeFami TF313496.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_211817. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

NextBioi 402439.
PROi Q8BHT6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BHT6.
CleanExi MM_B3GALTL.
Genevestigatori Q8BHT6.

Family and domain databases

InterProi IPR003378. Fringe-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF02434. Fringe. 2 hits.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain."
    Sato T., Sato M., Kiyohara K., Sogabe M., Shikanai T., Kikuchi N., Togayachi A., Ishida H., Ito H., Kameyama A., Gotoh M., Narimatsu H.
    Glycobiology 16:1194-1206(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-352 (ISOFORM 1).
    Strain: C57BL/6J.

Entry informationi

Entry nameiB3GLT_MOUSE
AccessioniPrimary (citable) accession number: Q8BHT6
Secondary accession number(s): E9QMK8, Q0PCR7, Q149S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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