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Protein

Armadillo repeat-containing X-linked protein 3

Gene

Armcx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates mitochondrial aggregation and transport in axons in living neurons (PubMed:22569362, PubMed:23844091). May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2 (PubMed:22569362). Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1 (PubMed:23844091). Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters (PubMed:19304657).3 Publications

GO - Biological processi

  • cellular protein localization Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 3
Gene namesi
Name:Armcx3
Synonyms:Alex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1918953 Armcx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembrane1 Publication6
Transmembranei7 – 29Helical; Signal-anchorSequence analysisAdd BLAST23
Topological domaini30 – 379Cytoplasmic1 PublicationAdd BLAST350

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913681 – 379Armadillo repeat-containing X-linked protein 3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHS6
MaxQBiQ8BHS6
PaxDbiQ8BHS6
PeptideAtlasiQ8BHS6
PRIDEiQ8BHS6

PTM databases

iPTMnetiQ8BHS6
PhosphoSitePlusiQ8BHS6

Expressioni

Tissue specificityi

Highly expressed in the developing neural tissues, neural crest derivatives and hind limbs. Also widely expressed in the adult nervous tissue, especially in the forebrain, including the cerebral cortex, hippocampus and thalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000049047
CleanExiMM_ARMCX3
GenevisibleiQ8BHS6 MM

Interactioni

Subunit structurei

Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent (PubMed:22569362). Interacts with Sox10 (PubMed:19304657).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080518

Structurei

3D structure databases

ProteinModelPortaliQ8BHS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 151ARM 1Sequence analysisAdd BLAST41
Repeati153 – 192ARM 2Sequence analysisAdd BLAST40
Repeati233 – 272ARM 3Sequence analysisAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequence1 Publication6
Regioni26 – 37Mitochondrion outer membrane (MOM)-targeting sequence1 PublicationAdd BLAST12
Regioni89 – 98Nuclear localization signal1 Publication10

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU Eukaryota
ENOG4112958 LUCA
GeneTreeiENSGT00550000074488
HOGENOMiHOG000231611
HOVERGENiHBG080349
InParanoidiQ8BHS6
OMAiRRLKIYM
OrthoDBiEOG091G0PCU
PhylomeDBiQ8BHS6
TreeFamiTF335652

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KVYMNQVCDD TVTSRLNSSV QLAGLRLLTN MTVTNEYQHI LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKEYKE
310 320 330 340 350
VILKLLIIFE NINDNFKWEE NEPAQNHFSE GSLFFFLKEF QVCADKVLGI
360 370
ESRHDFQVRV KVGKFVAKLT ERMFPKSQE
Length:379
Mass (Da):42,620
Last modified:March 1, 2003 - v1
Checksum:i6EA7B87544652055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → T in AAH11101 (PubMed:15489334).Curated1
Sequence conflicti53S → P in BAB23399 (PubMed:16141072).Curated1
Sequence conflicti68N → Y in BAB23399 (PubMed:16141072).Curated1
Sequence conflicti333L → P in BAB23399 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004598 mRNA Translation: BAB23399.1
AK030729 mRNA Translation: BAC27102.1
AL772348 Genomic DNA No translation available.
BC011101 mRNA Translation: AAH11101.1
BC051113 mRNA Translation: AAH51113.1
CCDSiCCDS30400.1
RefSeqiNP_082146.2, NM_027870.3
XP_006528672.1, XM_006528609.2
XP_017174115.1, XM_017318626.1
UniGeneiMm.67949

Genome annotation databases

EnsembliENSMUST00000081834; ENSMUSP00000080518; ENSMUSG00000049047
ENSMUST00000086880; ENSMUSP00000084093; ENSMUSG00000049047
ENSMUST00000086884; ENSMUSP00000084097; ENSMUSG00000049047
GeneIDi71703
KEGGimmu:71703
UCSCiuc009ugo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiARMX3_MOUSE
AccessioniPrimary (citable) accession number: Q8BHS6
Secondary accession number(s): A2AKS4, Q91VP8, Q9DC32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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