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Protein

RNA-binding protein 45

Gene

Rbm45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
Short name:
RB-1
RNA-binding motif protein 45
Gene namesi
Name:Rbm45
Synonyms:Drb1Imported, Drbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2387367. Rbm45.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476RNA-binding protein 45PRO_0000081573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHN5.
MaxQBiQ8BHN5.
PaxDbiQ8BHN5.
PRIDEiQ8BHN5.

PTM databases

iPTMnetiQ8BHN5.
PhosphoSiteiQ8BHN5.

Expressioni

Gene expression databases

BgeeiQ8BHN5.
CleanExiMM_RBM45.
GenevisibleiQ8BHN5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040420.

Structurei

3D structure databases

ProteinModelPortaliQ8BHN5.
SMRiQ8BHN5. Positions 32-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10681RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini121 – 19272RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 46473RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
GeneTreeiENSGT00680000100059.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8BHN5.
OMAiDDPPNSR.
OrthoDBiEOG7P8P83.
PhylomeDBiQ8BHN5.
TreeFamiTF324216.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDAGGLGGS GGFRPGVDSL DEPPNSRIFL VISKHTSELV LRERFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGVAF VKFARSSQAC RAMEEMHGQC LGPSDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
IIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRALLA EPKNKVSGSP
210 220 230 240 250
EQDDYSSGRQ EALGQEPRAN LFPFVGEQQS EFSTFDKNDS RGQEAVSKRL
260 270 280 290 300
SVVSRVPFTE EQLFSIFDIV PGLEYCEVPR DPYSNYGHGV VQYFNVASAI
310 320 330 340 350
YAKYKLHGFQ YPPGNRIVVS FLDDGSNMTE LIRKMATQMV AAQLASMVWS
360 370 380 390 400
TTSQQQFLQY GGNAASQAPQ IQTDVVLPSC KKKAPPETPV KERLFVVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YVKYADRKSA NEAITTLHGK
460 470
ILNGVRLKVM LADSPREESK KRQRTY
Length:476
Mass (Da):53,324
Last modified:March 1, 2003 - v1
Checksum:i00A7E233C221653F
GO

Sequence cautioni

The sequence BAC41024.1 differs from that shown. Reason: Frameshift at position 418. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211T → S in BAC41024 (PubMed:16141072).Curated
Sequence conflicti277 – 2771E → K in BAC41024 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036992 mRNA. Translation: BAC16208.1.
AY152391 mRNA. Translation: AAN41644.1.
AK089975 mRNA. Translation: BAC41024.1. Frameshift.
BC057890 mRNA. Translation: AAH57890.1.
CCDSiCCDS16157.1.
RefSeqiNP_700454.1. NM_153405.2.
UniGeneiMm.33310.

Genome annotation databases

EnsembliENSMUST00000046389; ENSMUSP00000040420; ENSMUSG00000042369.
GeneIDi241490.
KEGGimmu:241490.
UCSCiuc008kez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036992 mRNA. Translation: BAC16208.1.
AY152391 mRNA. Translation: AAN41644.1.
AK089975 mRNA. Translation: BAC41024.1. Frameshift.
BC057890 mRNA. Translation: AAH57890.1.
CCDSiCCDS16157.1.
RefSeqiNP_700454.1. NM_153405.2.
UniGeneiMm.33310.

3D structure databases

ProteinModelPortaliQ8BHN5.
SMRiQ8BHN5. Positions 32-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040420.

PTM databases

iPTMnetiQ8BHN5.
PhosphoSiteiQ8BHN5.

Proteomic databases

EPDiQ8BHN5.
MaxQBiQ8BHN5.
PaxDbiQ8BHN5.
PRIDEiQ8BHN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046389; ENSMUSP00000040420; ENSMUSG00000042369.
GeneIDi241490.
KEGGimmu:241490.
UCSCiuc008kez.1. mouse.

Organism-specific databases

CTDi129831.
MGIiMGI:2387367. Rbm45.

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
GeneTreeiENSGT00680000100059.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8BHN5.
OMAiDDPPNSR.
OrthoDBiEOG7P8P83.
PhylomeDBiQ8BHN5.
TreeFamiTF324216.

Miscellaneous databases

PROiQ8BHN5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHN5.
CleanExiMM_RBM45.
GenevisibleiQ8BHN5. MM.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein."
    Tamada H., Sakashita E., Shimazaki K., Ueno E., Hamamoto T., Kagawa Y., Endo H.
    Biochem. Biophys. Res. Commun. 297:96-104(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJImported.
    Tissue: BrainImported.
  2. Chen X.G., Li Y.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJImported.
    Tissue: Embryonic heartImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ.
    Tissue: Blood.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRIImported.
    Tissue: Mammary glandImported.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Spleen.

Entry informationi

Entry nameiRBM45_MOUSE
AccessioniPrimary (citable) accession number: Q8BHN5
Secondary accession number(s): Q8C1Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.