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Protein

Gamma-taxilin

Gene

Txlng

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.By similarity3 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • syntaxin binding Source: InterPro

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • regulation of bone mineralization Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB
  • regulation of cell cycle process Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-taxilin
Alternative name(s):
Factor inhibiting ATF4-mediated transcription
Short name:
FIAT
Lipopolysaccharide-responsive gene protein
Gene namesi
Name:Txlng
Synonyms:Lrg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3590652 Txlng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894271 – 524Gamma-taxilinAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Omega-N-methylarginineBy similarity1
Modified residuei24Omega-N-methylarginineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei86PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei283PhosphotyrosineBy similarity1
Modified residuei512PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BHN1
PaxDbiQ8BHN1
PeptideAtlasiQ8BHN1
PRIDEiQ8BHN1

PTM databases

iPTMnetiQ8BHN1
PhosphoSitePlusiQ8BHN1

Expressioni

Developmental stagei

At E16.5, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells, and also strongly expressed in osteocytes. By postnatal week 4, strongly expressed in osteocytes (at protein level).1 Publication

Inductioni

By LPS.1 Publication

Gene expression databases

BgeeiENSMUSG00000038344
CleanExiMM_4932441K18RIK
ExpressionAtlasiQ8BHN1 baseline and differential
GenevisibleiQ8BHN1 MM

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A (By similarity). Forms a heterodimer with ATF4 in osteoblasts.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TBK1Q9UHD22EBI-6116854,EBI-356402From Homo sapiens.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • syntaxin binding Source: InterPro

Protein-protein interaction databases

IntActiQ8BHN1, 3 interactors
STRINGi10090.ENSMUSP00000038615

Structurei

3D structure databases

ProteinModelPortaliQ8BHN1
SMRiQ8BHN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 465Sequence analysisAdd BLAST313

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ8BHN1
OMAiWRKKSHH
OrthoDBiEOG091G0GVB
PhylomeDBiQ8BHN1
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BHN1-1) [UniParc]FASTAAdd to basket
Also known as: LrgW

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRLEEVTR GRGGGTEEAS EGGRGGRRRS PPQKFEIGTM EEARICGLGV
60 70 80 90 100
KADMVCNSQA NDILQHQDPS CGGTTKKHSL EGDEGSDFIT KNRNLVSSVF
110 120 130 140 150
CTQEKREEIP GREARTGPPD GQQDSECSRN KEKTLGKEVL LLMQALNTLS
160 170 180 190 200
TPEEKLAALC KKYADLLEES RNVQKQMKIL QKKQAQIVKE KVHLQSEHSK
210 220 230 240 250
AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA TAHFQITLNE
260 270 280 290 300
IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ
310 320 330 340 350
QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL
360 370 380 390 400
KQQLSLYMDK FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR
410 420 430 440 450
TKWENNNKAL LQMAEEKTVR DKEYKAFQIK LERLEKLCRA LQTERNELNE
460 470 480 490 500
KVEVLKEQVS IKAADGDLVS PATQPCAVLD SFKETSRRTL GMHLEARAKS
510 520
VCEKSAAQKP SSSGSPAQGI ESVD
Length:524
Mass (Da):60,309
Last modified:March 1, 2003 - v1
Checksum:i0228777633E4ED7C
GO
Isoform 2 (identifier: Q8BHN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     289-290: HI → VI
     291-524: Missing.

Note: No experimental confirmation available.
Show »
Length:241
Mass (Da):27,598
Checksum:i1E0C7A38E169F31A
GO
Isoform 3 (identifier: Q8BHN1-3) [UniParc]FASTAAdd to basket
Also known as: LrgS

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.

Show »
Length:475
Mass (Da):55,016
Checksum:iF504425EAC95774A
GO

Sequence cautioni

The sequence ABC47035 differs from that shown. Reason: Frameshift at position 520.Curated
The sequence ABC47035 differs from that shown. Reason: Erroneous termination at position 518. Translated as Gln.Curated
The sequence ABC60327 differs from that shown. Reason: Frameshift at position 520.Curated
The sequence ABC60327 differs from that shown. Reason: Erroneous termination at position 518. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72G → D in ABC47035 (PubMed:19913514).Curated1
Sequence conflicti84E → D in ABC47035 (PubMed:19913514).Curated1
Sequence conflicti306A → G in ABC47035 (PubMed:19913514).Curated1
Sequence conflicti306A → G in ABC60327 (PubMed:19913514).Curated1
Sequence conflicti446N → T in ABC60327 (PubMed:19913514).Curated1
Sequence conflicti494L → W in ABC47035 (PubMed:19913514).Curated1
Sequence conflicti514G → S in ABC60327 (PubMed:19913514).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01183555 – 103Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST49
Alternative sequenceiVSP_011836289 – 290HI → VI in isoform 2. 1 Publication2
Alternative sequenceiVSP_011837291 – 524Missing in isoform 2. 1 PublicationAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ316984 mRNA Translation: ABC47035.1 Sequence problems.
DQ320011 mRNA Translation: ABC60327.1 Sequence problems.
AK030100 mRNA Translation: BAC26785.1
AK031783 mRNA Translation: BAC27547.1
AK044130 mRNA Translation: BAC31791.1
AK078477 mRNA Translation: BAC37296.1
AL672123 Genomic DNA No translation available.
BC117898 mRNA Translation: AAI17899.1
BC117899 mRNA Translation: AAI17900.1
CCDSiCCDS30510.1 [Q8BHN1-1]
CCDS72463.1 [Q8BHN1-3]
CCDS81194.1 [Q8BHN1-2]
RefSeqiNP_001277705.1, NM_001290776.1 [Q8BHN1-3]
NP_001277706.1, NM_001290777.1 [Q8BHN1-2]
NP_849266.1, NM_178935.5 [Q8BHN1-1]
UniGeneiMm.270186
Mm.371732

Genome annotation databases

EnsembliENSMUST00000041370; ENSMUSP00000038615; ENSMUSG00000038344 [Q8BHN1-1]
ENSMUST00000112315; ENSMUSP00000107934; ENSMUSG00000038344 [Q8BHN1-2]
ENSMUST00000112316; ENSMUSP00000107935; ENSMUSG00000038344 [Q8BHN1-3]
GeneIDi353170
KEGGimmu:353170
UCSCiuc009uuh.2 mouse [Q8BHN1-1]
uc009uui.2 mouse [Q8BHN1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTXLNG_MOUSE
AccessioniPrimary (citable) accession number: Q8BHN1
Secondary accession number(s): A2AFJ5
, Q148Z8, Q2LGB1, Q2PMX1, Q8BP11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health