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Q8BHL5

- ELMO2_MOUSE

UniProt

Q8BHL5 - ELMO2_MOUSE

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Protein
Engulfment and cell motility protein 2
Gene
Elmo2, Kiaa1834
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell chemotaxis Source: UniProtKB
  3. phagocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Phagocytosis

Enzyme and pathway databases

ReactomeiREACT_198374. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 2
Alternative name(s):
Protein ced-12 homolog A
Gene namesi
Name:Elmo2
Synonyms:Kiaa1834
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2153045. Elmo2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytosol By similarity. Membrane By similarity

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. cytosol Source: UniProtKB
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Engulfment and cell motility protein 2
PRO_0000153715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphotyrosine2 Publications
Modified residuei729 – 7291Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BHL5.
PaxDbiQ8BHL5.
PRIDEiQ8BHL5.

PTM databases

PhosphoSiteiQ8BHL5.

Expressioni

Gene expression databases

BgeeiQ8BHL5.
GenevestigatoriQ8BHL5.

Interactioni

Subunit structurei

Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Probably forms a heterotrimeric complex with DOCK1 and RAC1. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2 By similarity.

Protein-protein interaction databases

IntActiQ8BHL5. 2 interactions.
MINTiMINT-270694.

Structurei

3D structure databases

ProteinModelPortaliQ8BHL5.
SMRiQ8BHL5. Positions 535-729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 497175ELMO
Add
BLAST
Domaini565 – 686122PH
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi712 – 7198SH3-binding

Sequence similaritiesi

Contains 1 ELMO domain.
Contains 1 PH domain.

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG295208.
GeneTreeiENSGT00390000014155.
HOVERGENiHBG051463.
InParanoidiA2A5A6.
OMAiYLAKFHQ.
OrthoDBiEOG7D85VW.
PhylomeDBiQ8BHL5.
TreeFamiTF312966.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR006816. Engulfment_cell_motility_ELMO.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BHL5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT    50
LRYADGPQLY VTEQTRNDIK NGTILQLAVS PSRAARQLME RTQSSSMETR 100
LDAMKELAKL SADVTFATEF INMDGIIVLT RLVESGTKLL SHYSEMLAFT 150
LTAFLELMDH GIVSWDMVSV TFIKQIAGYV SQPMVDVSIL QRSLAILESM 200
VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN ALFLKAPEDK 250
RQDKHLNPLD LPVTDMANAF AQKHLRSIIL NHVIRGNRPI KTEMAHQLYV 300
LQVLTFNLLE ERMMTKMDPN DQAQRDIIFE LRRIAFDAES DPSNVPGSGT 350
EKRKAMYTKD YKMLGFTNHI NPALDFTQTP PGMLALDNML YLAKVHQDTY 400
IRIVLENSSR EDKHECPFGR SAIELTKMLC EILQVGELPN EGRNDYHPMF 450
FTHDRAFEEL FGICIQLLNK TWKEMRATAE DFNKVMQVVR EQITRALPSK 500
PNSLDQFKSK LRSLSYSEIL RLRQSERMSQ DDFQSPPIVE LREKIQPEIL 550
ELIKQQRLNR LCEGSSFRKI GNRRRQERFW HCRLALNHKV LHYGDLDDNP 600
QGEVTFESLQ EKIPVADIKA IVTGKDCPHM KEKSALKQNK EVLELAFSIL 650
YDPDETLNFI APNKYEYCIW IDGLSALLGK DMSSELTKSD LDTLLSMEMK 700
LRLLDLENIQ IPEAPPPVPK EPSSYDFVYH YG 732
Length:732
Mass (Da):83,887
Last modified:March 1, 2003 - v1
Checksum:i087A80728DC43A23
GO
Isoform 2 (identifier: Q8BHL5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-264: Missing.

Show »
Length:720
Mass (Da):82,543
Checksum:i04C6F4357F82F1F9
GO
Isoform 3 (identifier: Q8BHL5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-264: Missing.
     667-732: YCIWIDGLSA...SSYDFVYHYG → VSSVPHCLEH...PLLTRDSQFT

Note: No experimental confirmation available.

Show »
Length:798
Mass (Da):91,251
Checksum:i93E26AA789067C39
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei253 – 26412Missing in isoform 2 and isoform 3.
VSP_007488Add
BLAST
Alternative sequencei667 – 73266YCIWI…VYHYG → VSSVPHCLEHQCPHCEEVSV PHCLEHQCSHCEEVWPAQRY PHKPGSQNGSLSLWTFYHWA GLPTSHRGLSSSAFRGLGLE LCATTPNLSLCALEQLAWHR EGFPLCNLAVTFPRRVESQL PGANLVRLWSQMDLPLLTRD SQFT in isoform 3.
VSP_007489Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021D → G in BAC28514. 1 Publication
Sequence conflicti143 – 1442Missing in AAL14465. 1 Publication
Sequence conflicti519 – 5235ILRLR → NSAVA in BAC29162. 1 Publication
Sequence conflicti613 – 6131I → V in BAC41483. 1 Publication
Sequence conflicti682 – 6821M → I in BAC34424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF398884 mRNA. Translation: AAL14465.1.
AK004448 mRNA. Translation: BAB23307.1.
AK032033 mRNA. Translation: BAC27662.1.
AK033918 mRNA. Translation: BAC28514.1.
AK035710 mRNA. Translation: BAC29162.1.
AK038455 mRNA. Translation: BAC30007.1.
AK045428 mRNA. Translation: BAC32361.1.
AK047040 mRNA. Translation: BAC32945.1.
AK050823 mRNA. Translation: BAC34424.1.
AK053574 mRNA. Translation: BAC35433.1.
AL591430 Genomic DNA. Translation: CAI51618.2.
AL591430 Genomic DNA. Translation: CAM23849.1.
BC023954 mRNA. Translation: AAH23954.1.
AB093301 Transcribed RNA. Translation: BAC41483.3.
CCDSiCCDS17075.1. [Q8BHL5-2]
CCDS17076.1. [Q8BHL5-1]
CCDS17077.1. [Q8BHL5-3]
RefSeqiNP_525026.2. NM_080287.2. [Q8BHL5-2]
NP_997588.1. NM_207705.1. [Q8BHL5-3]
NP_997589.1. NM_207706.1. [Q8BHL5-1]
XP_006498804.1. XM_006498741.1. [Q8BHL5-3]
XP_006498805.1. XM_006498742.1. [Q8BHL5-3]
XP_006498808.1. XM_006498745.1. [Q8BHL5-2]
UniGeneiMm.35064.

Genome annotation databases

EnsembliENSMUST00000071699; ENSMUSP00000071619; ENSMUSG00000017670. [Q8BHL5-3]
ENSMUST00000074046; ENSMUSP00000073691; ENSMUSG00000017670. [Q8BHL5-1]
ENSMUST00000094329; ENSMUSP00000091887; ENSMUSG00000017670. [Q8BHL5-2]
ENSMUST00000103088; ENSMUSP00000099377; ENSMUSG00000017670. [Q8BHL5-3]
ENSMUST00000103091; ENSMUSP00000099380; ENSMUSG00000017670. [Q8BHL5-2]
GeneIDi140579.
KEGGimmu:140579.
UCSCiuc008nxj.1. mouse. [Q8BHL5-2]
uc008nxk.1. mouse. [Q8BHL5-1]
uc008nxm.1. mouse. [Q8BHL5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF398884 mRNA. Translation: AAL14465.1 .
AK004448 mRNA. Translation: BAB23307.1 .
AK032033 mRNA. Translation: BAC27662.1 .
AK033918 mRNA. Translation: BAC28514.1 .
AK035710 mRNA. Translation: BAC29162.1 .
AK038455 mRNA. Translation: BAC30007.1 .
AK045428 mRNA. Translation: BAC32361.1 .
AK047040 mRNA. Translation: BAC32945.1 .
AK050823 mRNA. Translation: BAC34424.1 .
AK053574 mRNA. Translation: BAC35433.1 .
AL591430 Genomic DNA. Translation: CAI51618.2 .
AL591430 Genomic DNA. Translation: CAM23849.1 .
BC023954 mRNA. Translation: AAH23954.1 .
AB093301 Transcribed RNA. Translation: BAC41483.3 .
CCDSi CCDS17075.1. [Q8BHL5-2 ]
CCDS17076.1. [Q8BHL5-1 ]
CCDS17077.1. [Q8BHL5-3 ]
RefSeqi NP_525026.2. NM_080287.2. [Q8BHL5-2 ]
NP_997588.1. NM_207705.1. [Q8BHL5-3 ]
NP_997589.1. NM_207706.1. [Q8BHL5-1 ]
XP_006498804.1. XM_006498741.1. [Q8BHL5-3 ]
XP_006498805.1. XM_006498742.1. [Q8BHL5-3 ]
XP_006498808.1. XM_006498745.1. [Q8BHL5-2 ]
UniGenei Mm.35064.

3D structure databases

ProteinModelPortali Q8BHL5.
SMRi Q8BHL5. Positions 535-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BHL5. 2 interactions.
MINTi MINT-270694.

PTM databases

PhosphoSitei Q8BHL5.

Proteomic databases

MaxQBi Q8BHL5.
PaxDbi Q8BHL5.
PRIDEi Q8BHL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071699 ; ENSMUSP00000071619 ; ENSMUSG00000017670 . [Q8BHL5-3 ]
ENSMUST00000074046 ; ENSMUSP00000073691 ; ENSMUSG00000017670 . [Q8BHL5-1 ]
ENSMUST00000094329 ; ENSMUSP00000091887 ; ENSMUSG00000017670 . [Q8BHL5-2 ]
ENSMUST00000103088 ; ENSMUSP00000099377 ; ENSMUSG00000017670 . [Q8BHL5-3 ]
ENSMUST00000103091 ; ENSMUSP00000099380 ; ENSMUSG00000017670 . [Q8BHL5-2 ]
GeneIDi 140579.
KEGGi mmu:140579.
UCSCi uc008nxj.1. mouse. [Q8BHL5-2 ]
uc008nxk.1. mouse. [Q8BHL5-1 ]
uc008nxm.1. mouse. [Q8BHL5-3 ]

Organism-specific databases

CTDi 63916.
MGIi MGI:2153045. Elmo2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG295208.
GeneTreei ENSGT00390000014155.
HOVERGENi HBG051463.
InParanoidi A2A5A6.
OMAi YLAKFHQ.
OrthoDBi EOG7D85VW.
PhylomeDBi Q8BHL5.
TreeFami TF312966.

Enzyme and pathway databases

Reactomei REACT_198374. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

NextBioi 369891.
PROi Q8BHL5.
SOURCEi Search...

Gene expression databases

Bgeei Q8BHL5.
Genevestigatori Q8BHL5.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.30.29.30. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR006816. Engulfment_cell_motility_ELMO.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS51335. ELMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C3H.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Brain, Cerebellum, Diencephalon, Embryo, Eye, Hypothalamus, Medulla oblongata and Urinary bladder.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-732.
    Tissue: Brain.
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-48 AND TYR-729, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  8. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-48, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiELMO2_MOUSE
AccessioniPrimary (citable) accession number: Q8BHL5
Secondary accession number(s): A2A5A6
, Q5GMG3, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi