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Protein

Engulfment and cell motility protein 2

Gene

Elmo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Phagocytosis

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 2
Alternative name(s):
Protein ced-12 homolog A
Gene namesi
Name:Elmo2
Synonyms:Kiaa1834
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2153045 Elmo2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537151 – 732Engulfment and cell motility protein 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphotyrosineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei729PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BHL5
PeptideAtlasiQ8BHL5
PRIDEiQ8BHL5

PTM databases

iPTMnetiQ8BHL5
PhosphoSitePlusiQ8BHL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000017670
ExpressionAtlasiQ8BHL5 baseline and differential
GenevisibleiQ8BHL5 MM

Interactioni

Subunit structurei

Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site (PubMed:25533347). Probably forms a heterotrimeric complex with DOCK1 and RAC1. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2 (By similarity). Interacts with ADGRB3 (By similarity). Interacts with AUTS2; the interaction is direct (PubMed:25533347).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BHL5, 2 interactors
STRINGi10090.ENSMUSP00000071619

Structurei

3D structure databases

ProteinModelPortaliQ8BHL5
SMRiQ8BHL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini323 – 497ELMOPROSITE-ProRule annotationAdd BLAST175
Domaini565 – 686PHAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi712 – 719SH3-binding8

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOVERGENiHBG051463
InParanoidiQ8BHL5
KOiK18985
OMAiYLAKFHQ
OrthoDBiEOG091G03JJ
PhylomeDBiQ8BHL5
TreeFamiTF312966

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030713 ELMO2
IPR006816 ELMO_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12771:SF8 PTHR12771:SF8, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
PF04727 ELMO_CED12, 1 hit
PF16457 PH_12, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BHL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT
60 70 80 90 100
LRYADGPQLY VTEQTRNDIK NGTILQLAVS PSRAARQLME RTQSSSMETR
110 120 130 140 150
LDAMKELAKL SADVTFATEF INMDGIIVLT RLVESGTKLL SHYSEMLAFT
160 170 180 190 200
LTAFLELMDH GIVSWDMVSV TFIKQIAGYV SQPMVDVSIL QRSLAILESM
210 220 230 240 250
VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN ALFLKAPEDK
260 270 280 290 300
RQDKHLNPLD LPVTDMANAF AQKHLRSIIL NHVIRGNRPI KTEMAHQLYV
310 320 330 340 350
LQVLTFNLLE ERMMTKMDPN DQAQRDIIFE LRRIAFDAES DPSNVPGSGT
360 370 380 390 400
EKRKAMYTKD YKMLGFTNHI NPALDFTQTP PGMLALDNML YLAKVHQDTY
410 420 430 440 450
IRIVLENSSR EDKHECPFGR SAIELTKMLC EILQVGELPN EGRNDYHPMF
460 470 480 490 500
FTHDRAFEEL FGICIQLLNK TWKEMRATAE DFNKVMQVVR EQITRALPSK
510 520 530 540 550
PNSLDQFKSK LRSLSYSEIL RLRQSERMSQ DDFQSPPIVE LREKIQPEIL
560 570 580 590 600
ELIKQQRLNR LCEGSSFRKI GNRRRQERFW HCRLALNHKV LHYGDLDDNP
610 620 630 640 650
QGEVTFESLQ EKIPVADIKA IVTGKDCPHM KEKSALKQNK EVLELAFSIL
660 670 680 690 700
YDPDETLNFI APNKYEYCIW IDGLSALLGK DMSSELTKSD LDTLLSMEMK
710 720 730
LRLLDLENIQ IPEAPPPVPK EPSSYDFVYH YG
Length:732
Mass (Da):83,887
Last modified:March 1, 2003 - v1
Checksum:i087A80728DC43A23
GO
Isoform 2 (identifier: Q8BHL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-264: Missing.

Show »
Length:720
Mass (Da):82,543
Checksum:i04C6F4357F82F1F9
GO
Isoform 3 (identifier: Q8BHL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-264: Missing.
     667-732: YCIWIDGLSA...SSYDFVYHYG → VSSVPHCLEH...PLLTRDSQFT

Note: No experimental confirmation available.
Show »
Length:798
Mass (Da):91,251
Checksum:i93E26AA789067C39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102D → G in BAC28514 (PubMed:16141072).Curated1
Sequence conflicti143 – 144Missing in AAL14465 (PubMed:11595183).Curated2
Sequence conflicti519 – 523ILRLR → NSAVA in BAC29162 (PubMed:16141072).Curated5
Sequence conflicti613I → V in BAC41483 (PubMed:12465718).Curated1
Sequence conflicti682M → I in BAC34424 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007488253 – 264Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_007489667 – 732YCIWI…VYHYG → VSSVPHCLEHQCPHCEEVSV PHCLEHQCSHCEEVWPAQRY PHKPGSQNGSLSLWTFYHWA GLPTSHRGLSSSAFRGLGLE LCATTPNLSLCALEQLAWHR EGFPLCNLAVTFPRRVESQL PGANLVRLWSQMDLPLLTRD SQFT in isoform 3. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398884 mRNA Translation: AAL14465.1
AK004448 mRNA Translation: BAB23307.1
AK032033 mRNA Translation: BAC27662.1
AK033918 mRNA Translation: BAC28514.1
AK035710 mRNA Translation: BAC29162.1
AK038455 mRNA Translation: BAC30007.1
AK045428 mRNA Translation: BAC32361.1
AK047040 mRNA Translation: BAC32945.1
AK050823 mRNA Translation: BAC34424.1
AK053574 mRNA Translation: BAC35433.1
AL591430 Genomic DNA No translation available.
BC023954 mRNA Translation: AAH23954.1
AB093301 Transcribed RNA Translation: BAC41483.3
CCDSiCCDS17075.1 [Q8BHL5-2]
CCDS17076.1 [Q8BHL5-1]
RefSeqiNP_001289681.1, NM_001302752.1 [Q8BHL5-2]
NP_001289683.1, NM_001302754.1
NP_525026.2, NM_080287.2 [Q8BHL5-2]
NP_997589.1, NM_207706.1 [Q8BHL5-1]
XP_011237586.1, XM_011239284.1 [Q8BHL5-1]
XP_011237587.1, XM_011239285.1 [Q8BHL5-1]
XP_011237588.1, XM_011239286.2 [Q8BHL5-2]
XP_017170976.1, XM_017315487.1 [Q8BHL5-1]
UniGeneiMm.35064

Genome annotation databases

EnsembliENSMUST00000071699; ENSMUSP00000071619; ENSMUSG00000017670 [Q8BHL5-3]
ENSMUST00000074046; ENSMUSP00000073691; ENSMUSG00000017670 [Q8BHL5-1]
ENSMUST00000094329; ENSMUSP00000091887; ENSMUSG00000017670 [Q8BHL5-2]
ENSMUST00000103088; ENSMUSP00000099377; ENSMUSG00000017670 [Q8BHL5-3]
ENSMUST00000103091; ENSMUSP00000099380; ENSMUSG00000017670 [Q8BHL5-2]
GeneIDi140579
KEGGimmu:140579
UCSCiuc008nxj.1 mouse [Q8BHL5-2]
uc008nxk.1 mouse [Q8BHL5-1]
uc008nxm.2 mouse [Q8BHL5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELMO2_MOUSE
AccessioniPrimary (citable) accession number: Q8BHL5
Secondary accession number(s): A2A5A6
, Q5GMG3, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health