Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 10B

Gene

Tbc1d10b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 10B
Alternative name(s):
Protein wz3-85
Gene namesi
Name:Tbc1d10b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915699. Tbc1d10b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 798798TBC1 domain family member 10BPRO_0000315717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei129 – 1291PhosphoserineCombined sources
Modified residuei136 – 1361PhosphothreonineCombined sources
Modified residuei644 – 6441PhosphoserineBy similarity
Modified residuei647 – 6471PhosphoserineCombined sources
Modified residuei650 – 6501PhosphoserineCombined sources
Modified residuei664 – 6641PhosphoserineCombined sources
Modified residuei673 – 6731PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHL3.
MaxQBiQ8BHL3.
PaxDbiQ8BHL3.
PRIDEiQ8BHL3.

PTM databases

iPTMnetiQ8BHL3.
PhosphoSiteiQ8BHL3.

Expressioni

Gene expression databases

BgeeiQ8BHL3.
CleanExiMM_TBC1D10B.
GenevisibleiQ8BHL3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113307.

Structurei

3D structure databases

ProteinModelPortaliQ8BHL3.
SMRiQ8BHL3. Positions 312-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini346 – 534189Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili702 – 76968Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8BHL3.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG7RJPR8.
PhylomeDBiQ8BHL3.
TreeFamiTF313293.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGPAPLVA PPRRHGAPAA PSPPPRGSRA GSHLVVEPGP PVTTATSAPV
60 70 80 90 100
ELVAPGEARP ACVPGSSQTS ASTPTTATSS TVVMLTLEAS PEAAKTQEFP
110 120 130 140 150
APAAETGAET SVALALGTDT QKTEEVRASP VPGPGTPTRT PSRMAPGALT
160 170 180 190 200
AKPPLAPKPG TTVASGVTAR GGVGQVAGGH EAATSASAGS VPEDPSGPVT
210 220 230 240 250
GPPGTCEAPA PTPVAVVTVT PAPEPVENFQ DLGSTSSLGP GISGPRGQAP
260 270 280 290 300
DTLSYLDSVS LMSGTLESLP DDVSSMGSDS EINGMALRKT DKYGFLGGSQ
310 320 330 340 350
YSGSLESSIP VDVARQRELK WLEMFSNWDK WLSRRFQKVK LRCRKGIPSS
360 370 380 390 400
LRAKAWQYLS NSKELLEQNP GKFEELERAA GDPKWLDVIE KDLHRQFPFH
410 420 430 440 450
EMFAARGGHG QQDLYRILKA YTIYRPDEGY CQAQAPVAAV LLMHMPAEQA
460 470 480 490 500
FWCLVQICDK YLPGYYSAGL EAIQLDGEIF FALLRRVSPL AHRHLRRQRI
510 520 530 540 550
DPVLYMTEWF MCIFARTLPW ASVLRVWDMF FCEGVKIIFR VALVLLRHTL
560 570 580 590 600
GSVEKLRSCQ GMYETMEQLR NLPQQCMQED FLVHEVTNLP VTEAWIEREN
610 620 630 640 650
AAQLKKWRET RGELQYRPSR RLHGSRAIHE ERRRQQPPLG PSSSLLSLPS
660 670 680 690 700
LKSRGSRAVG GAPSPPPPVR RASAGPVPGA VVIAEGLHPS LPSPTGNSTP
710 720 730 740 750
LGTSKEIRRQ EKERQKQEKD REKERQRQEK ERERQEKERQ KWEKEQEKEQ
760 770 780 790
QKQEKERQKL EKKGQGRKLS LRRRADGPPA SHDGGDRSAA EARQDAYF
Length:798
Mass (Da):87,275
Last modified:April 20, 2010 - v2
Checksum:iB9CB616C2BA01913
GO

Sequence cautioni

The sequence AAH25889.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH72576.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK82984.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC33022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC33025.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311G → R in BAC33022 (PubMed:16141072).Curated
Sequence conflicti31 – 311G → R in BAC33025 (PubMed:16141072).Curated
Sequence conflicti221 – 2211P → S in AAK82984 (Ref. 3) Curated
Sequence conflicti697 – 6971N → S in AAK82984 (Ref. 3) Curated
Sequence conflicti751 – 7511Q → R in AAK82984 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047320 mRNA. Translation: BAC33022.1. Different initiation.
AK047327 mRNA. Translation: BAC33025.1. Different initiation.
AC122537 Genomic DNA. No translation available.
AF285112 mRNA. Translation: AAK82984.1. Different initiation.
BC025889 mRNA. Translation: AAH25889.1. Different initiation.
BC072576 mRNA. Translation: AAH72576.2. Different initiation.
CCDSiCCDS40139.2.
RefSeqiNP_653105.3. NM_144522.5.
UniGeneiMm.41420.

Genome annotation databases

EnsembliENSMUST00000120705; ENSMUSP00000113307; ENSMUSG00000042492.
GeneIDi68449.
KEGGimmu:68449.
UCSCiuc009juo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047320 mRNA. Translation: BAC33022.1. Different initiation.
AK047327 mRNA. Translation: BAC33025.1. Different initiation.
AC122537 Genomic DNA. No translation available.
AF285112 mRNA. Translation: AAK82984.1. Different initiation.
BC025889 mRNA. Translation: AAH25889.1. Different initiation.
BC072576 mRNA. Translation: AAH72576.2. Different initiation.
CCDSiCCDS40139.2.
RefSeqiNP_653105.3. NM_144522.5.
UniGeneiMm.41420.

3D structure databases

ProteinModelPortaliQ8BHL3.
SMRiQ8BHL3. Positions 312-583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113307.

PTM databases

iPTMnetiQ8BHL3.
PhosphoSiteiQ8BHL3.

Proteomic databases

EPDiQ8BHL3.
MaxQBiQ8BHL3.
PaxDbiQ8BHL3.
PRIDEiQ8BHL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120705; ENSMUSP00000113307; ENSMUSG00000042492.
GeneIDi68449.
KEGGimmu:68449.
UCSCiuc009juo.3. mouse.

Organism-specific databases

CTDi26000.
MGIiMGI:1915699. Tbc1d10b.

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8BHL3.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG7RJPR8.
PhylomeDBiQ8BHL3.
TreeFamiTF313293.

Miscellaneous databases

ChiTaRSiTbc1d10b. mouse.
PROiQ8BHL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHL3.
CleanExiMM_TBC1D10B.
GenevisibleiQ8BHL3. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Characterization of an unknown wz3-85 gene."
    Tian W., Chua K., Strober W., Chu C.C.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-798.
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-798.
    Strain: C57BL/6J and FVB/N.
    Tissue: Kidney.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664 AND SER-673, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; THR-136; SER-647; SER-650 AND SER-673, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTB10B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHL3
Secondary accession number(s): Q6GQW9, Q6PIZ5, Q91XR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.