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Protein

TBC1 domain family member 10B

Gene

Tbc1d10b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 10B
Alternative name(s):
Protein wz3-85
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915699. Tbc1d10b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157171 – 798TBC1 domain family member 10BAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei136PhosphothreonineCombined sources1
Modified residuei170Omega-N-methylarginineCombined sources1
Modified residuei644PhosphoserineBy similarity1
Modified residuei647PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BHL3.
MaxQBiQ8BHL3.
PaxDbiQ8BHL3.
PeptideAtlasiQ8BHL3.
PRIDEiQ8BHL3.

PTM databases

iPTMnetiQ8BHL3.
PhosphoSitePlusiQ8BHL3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042492.
CleanExiMM_TBC1D10B.
ExpressionAtlasiQ8BHL3. baseline and differential.
GenevisibleiQ8BHL3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113307.

Structurei

3D structure databases

ProteinModelPortaliQ8BHL3.
SMRiQ8BHL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 534Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili702 – 769Sequence analysisAdd BLAST68

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8BHL3.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8BHL3.
TreeFamiTF313293.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGPAPLVA PPRRHGAPAA PSPPPRGSRA GSHLVVEPGP PVTTATSAPV
60 70 80 90 100
ELVAPGEARP ACVPGSSQTS ASTPTTATSS TVVMLTLEAS PEAAKTQEFP
110 120 130 140 150
APAAETGAET SVALALGTDT QKTEEVRASP VPGPGTPTRT PSRMAPGALT
160 170 180 190 200
AKPPLAPKPG TTVASGVTAR GGVGQVAGGH EAATSASAGS VPEDPSGPVT
210 220 230 240 250
GPPGTCEAPA PTPVAVVTVT PAPEPVENFQ DLGSTSSLGP GISGPRGQAP
260 270 280 290 300
DTLSYLDSVS LMSGTLESLP DDVSSMGSDS EINGMALRKT DKYGFLGGSQ
310 320 330 340 350
YSGSLESSIP VDVARQRELK WLEMFSNWDK WLSRRFQKVK LRCRKGIPSS
360 370 380 390 400
LRAKAWQYLS NSKELLEQNP GKFEELERAA GDPKWLDVIE KDLHRQFPFH
410 420 430 440 450
EMFAARGGHG QQDLYRILKA YTIYRPDEGY CQAQAPVAAV LLMHMPAEQA
460 470 480 490 500
FWCLVQICDK YLPGYYSAGL EAIQLDGEIF FALLRRVSPL AHRHLRRQRI
510 520 530 540 550
DPVLYMTEWF MCIFARTLPW ASVLRVWDMF FCEGVKIIFR VALVLLRHTL
560 570 580 590 600
GSVEKLRSCQ GMYETMEQLR NLPQQCMQED FLVHEVTNLP VTEAWIEREN
610 620 630 640 650
AAQLKKWRET RGELQYRPSR RLHGSRAIHE ERRRQQPPLG PSSSLLSLPS
660 670 680 690 700
LKSRGSRAVG GAPSPPPPVR RASAGPVPGA VVIAEGLHPS LPSPTGNSTP
710 720 730 740 750
LGTSKEIRRQ EKERQKQEKD REKERQRQEK ERERQEKERQ KWEKEQEKEQ
760 770 780 790
QKQEKERQKL EKKGQGRKLS LRRRADGPPA SHDGGDRSAA EARQDAYF
Length:798
Mass (Da):87,275
Last modified:April 20, 2010 - v2
Checksum:iB9CB616C2BA01913
GO

Sequence cautioni

The sequence AAH25889 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH72576 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK82984 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC33022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC33025 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31G → R in BAC33022 (PubMed:16141072).Curated1
Sequence conflicti31G → R in BAC33025 (PubMed:16141072).Curated1
Sequence conflicti221P → S in AAK82984 (Ref. 3) Curated1
Sequence conflicti697N → S in AAK82984 (Ref. 3) Curated1
Sequence conflicti751Q → R in AAK82984 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047320 mRNA. Translation: BAC33022.1. Different initiation.
AK047327 mRNA. Translation: BAC33025.1. Different initiation.
AC122537 Genomic DNA. No translation available.
AF285112 mRNA. Translation: AAK82984.1. Different initiation.
BC025889 mRNA. Translation: AAH25889.1. Different initiation.
BC072576 mRNA. Translation: AAH72576.2. Different initiation.
CCDSiCCDS40139.2.
RefSeqiNP_653105.3. NM_144522.5.
UniGeneiMm.41420.

Genome annotation databases

EnsembliENSMUST00000120705; ENSMUSP00000113307; ENSMUSG00000042492.
GeneIDi68449.
KEGGimmu:68449.
UCSCiuc009juo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047320 mRNA. Translation: BAC33022.1. Different initiation.
AK047327 mRNA. Translation: BAC33025.1. Different initiation.
AC122537 Genomic DNA. No translation available.
AF285112 mRNA. Translation: AAK82984.1. Different initiation.
BC025889 mRNA. Translation: AAH25889.1. Different initiation.
BC072576 mRNA. Translation: AAH72576.2. Different initiation.
CCDSiCCDS40139.2.
RefSeqiNP_653105.3. NM_144522.5.
UniGeneiMm.41420.

3D structure databases

ProteinModelPortaliQ8BHL3.
SMRiQ8BHL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113307.

PTM databases

iPTMnetiQ8BHL3.
PhosphoSitePlusiQ8BHL3.

Proteomic databases

EPDiQ8BHL3.
MaxQBiQ8BHL3.
PaxDbiQ8BHL3.
PeptideAtlasiQ8BHL3.
PRIDEiQ8BHL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120705; ENSMUSP00000113307; ENSMUSG00000042492.
GeneIDi68449.
KEGGimmu:68449.
UCSCiuc009juo.3. mouse.

Organism-specific databases

CTDi26000.
MGIiMGI:1915699. Tbc1d10b.

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8BHL3.
KOiK19944.
OMAiTGPSGTC.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8BHL3.
TreeFamiTF313293.

Miscellaneous databases

ChiTaRSiTbc1d10b. mouse.
PROiQ8BHL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042492.
CleanExiMM_TBC1D10B.
ExpressionAtlasiQ8BHL3. baseline and differential.
GenevisibleiQ8BHL3. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTB10B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHL3
Secondary accession number(s): Q6GQW9, Q6PIZ5, Q91XR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.