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Q8BHK2

- SCN3B_MOUSE

UniProt

Q8BHK2 - SCN3B_MOUSE

Protein

Sodium channel subunit beta-3

Gene

Scn3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons By similarity.By similarity

    GO - Molecular functioni

    1. ion channel binding Source: BHF-UCL
    2. sodium channel regulator activity Source: InterPro
    3. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI

    GO - Biological processi

    1. atrial cardiac muscle cell action potential Source: Ensembl
    2. cardiac conduction Source: MGI
    3. cardiac muscle contraction Source: Ensembl
    4. nervous system development Source: Ensembl
    5. positive regulation of heart rate Source: BHF-UCL
    6. positive regulation of sodium ion transport Source: Ensembl
    7. protein localization to plasma membrane Source: Ensembl
    8. regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
    9. regulation of heart rate by cardiac conduction Source: Ensembl
    10. regulation of sodium ion transmembrane transporter activity Source: Ensembl
    11. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
    12. SA node cell to atrial cardiac muscle cell communication Source: BHF-UCL
    13. sensory perception of pain Source: Ensembl
    14. ventricular cardiac muscle cell action potential Source: MGI

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel subunit beta-3
    Gene namesi
    Name:Scn3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1918882. Scn3b.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. voltage-gated sodium channel complex Source: InterPro
    2. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 215191Sodium channel subunit beta-3PRO_0000014935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
    Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8BHK2.
    PRIDEiQ8BHK2.

    PTM databases

    PhosphoSiteiQ8BHK2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BHK2.
    BgeeiQ8BHK2.
    CleanExiMM_SCN3B.
    GenevestigatoriQ8BHK2.

    Interactioni

    Subunit structurei

    The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BHK2.
    SMRiQ8BHK2. Positions 25-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 159135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 21535CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 138114Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40812.
    GeneTreeiENSGT00390000018560.
    HOGENOMiHOG000276881.
    HOVERGENiHBG056582.
    InParanoidiQ8BHK2.
    KOiK04847.
    OMAiLLIEMVY.
    OrthoDBiEOG7M3J19.
    TreeFamiTF332097.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR027098. Na_channel_b1/b3.
    IPR027096. Na_channel_b3.
    [Graphical view]
    PANTHERiPTHR10546. PTHR10546. 1 hit.
    PTHR10546:SF1. PTHR10546:SF1. 1 hit.
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BHK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNS MKLRCISCMK    50
    REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL 100
    QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG 150
    EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA 200
    IPSENKENSV VPVEE 215
    Length:215
    Mass (Da):24,789
    Last modified:March 1, 2003 - v1
    Checksum:i0E07B4704178A423
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049036 mRNA. Translation: AAL07512.1.
    AK049747 mRNA. Translation: BAC33901.1.
    AK076466 mRNA. Translation: BAC36356.1.
    BC053919 mRNA. Translation: AAH53919.1.
    BC058636 mRNA. Translation: AAH58636.1.
    CCDSiCCDS23080.1.
    RefSeqiNP_001077386.1. NM_001083917.1.
    NP_001273543.1. NM_001286614.1.
    NP_839941.1. NM_178227.4.
    XP_006510297.1. XM_006510234.1.
    UniGeneiMm.290083.

    Genome annotation databases

    EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
    ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
    ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
    GeneIDi235281.
    KEGGimmu:235281.
    UCSCiuc009ozj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049036 mRNA. Translation: AAL07512.1 .
    AK049747 mRNA. Translation: BAC33901.1 .
    AK076466 mRNA. Translation: BAC36356.1 .
    BC053919 mRNA. Translation: AAH53919.1 .
    BC058636 mRNA. Translation: AAH58636.1 .
    CCDSi CCDS23080.1.
    RefSeqi NP_001077386.1. NM_001083917.1.
    NP_001273543.1. NM_001286614.1.
    NP_839941.1. NM_178227.4.
    XP_006510297.1. XM_006510234.1.
    UniGenei Mm.290083.

    3D structure databases

    ProteinModelPortali Q8BHK2.
    SMRi Q8BHK2. Positions 25-145.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BHK2.

    Proteomic databases

    PaxDbi Q8BHK2.
    PRIDEi Q8BHK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049941 ; ENSMUSP00000051627 ; ENSMUSG00000049281 .
    ENSMUST00000114956 ; ENSMUSP00000110606 ; ENSMUSG00000049281 .
    ENSMUST00000171835 ; ENSMUSP00000132933 ; ENSMUSG00000049281 .
    GeneIDi 235281.
    KEGGi mmu:235281.
    UCSCi uc009ozj.1. mouse.

    Organism-specific databases

    CTDi 55800.
    MGIi MGI:1918882. Scn3b.

    Phylogenomic databases

    eggNOGi NOG40812.
    GeneTreei ENSGT00390000018560.
    HOGENOMi HOG000276881.
    HOVERGENi HBG056582.
    InParanoidi Q8BHK2.
    KOi K04847.
    OMAi LLIEMVY.
    OrthoDBi EOG7M3J19.
    TreeFami TF332097.

    Miscellaneous databases

    NextBioi 382555.
    PROi Q8BHK2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BHK2.
    Bgeei Q8BHK2.
    CleanExi MM_SCN3B.
    Genevestigatori Q8BHK2.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR027098. Na_channel_b1/b3.
    IPR027096. Na_channel_b3.
    [Graphical view ]
    PANTHERi PTHR10546. PTHR10546. 1 hit.
    PTHR10546:SF1. PTHR10546:SF1. 1 hit.
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse brain and heart beta 3 sodium channel cDNA."
      Chen C., Avery C., Kazen-Gillespie K., Isom L.L.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Spinal cord.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Olfactory epithelium.

    Entry informationi

    Entry nameiSCN3B_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHK2
    Secondary accession number(s): Q91Z99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3