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Q8BHK2

- SCN3B_MOUSE

UniProt

Q8BHK2 - SCN3B_MOUSE

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Protein

Sodium channel subunit beta-3

Gene
Scn3b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons By similarity.

GO - Molecular functioni

  1. ion channel binding Source: BHF-UCL
  2. sodium channel regulator activity Source: InterPro
  3. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI

GO - Biological processi

  1. atrial cardiac muscle cell action potential Source: Ensembl
  2. cardiac conduction Source: MGI
  3. cardiac muscle contraction Source: Ensembl
  4. nervous system development Source: Ensembl
  5. positive regulation of heart rate Source: BHF-UCL
  6. positive regulation of sodium ion transport Source: Ensembl
  7. protein localization to plasma membrane Source: Ensembl
  8. regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
  9. regulation of heart rate by cardiac conduction Source: Ensembl
  10. regulation of sodium ion transmembrane transporter activity Source: Ensembl
  11. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
  12. SA node cell to atrial cardiac muscle cell communication Source: BHF-UCL
  13. sensory perception of pain Source: Ensembl
  14. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:Scn3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1918882. Scn3b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 159135Extracellular Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Topological domaini181 – 21535Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. voltage-gated sodium channel complex Source: InterPro
  2. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 215191Sodium channel subunit beta-3PRO_0000014935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48 Reviewed prediction
Disulfide bondi45 ↔ 120 Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BHK2.
PRIDEiQ8BHK2.

PTM databases

PhosphoSiteiQ8BHK2.

Expressioni

Gene expression databases

ArrayExpressiQ8BHK2.
BgeeiQ8BHK2.
CleanExiMM_SCN3B.
GenevestigatoriQ8BHK2.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BHK2.
SMRiQ8BHK2. Positions 25-145.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 138114Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40812.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ8BHK2.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHK2-1 [UniParc]FASTAAdd to Basket

« Hide

MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNS MKLRCISCMK    50
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL 100
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG 150
EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA 200
IPSENKENSV VPVEE 215
Length:215
Mass (Da):24,789
Last modified:March 1, 2003 - v1
Checksum:i0E07B4704178A423
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049036 mRNA. Translation: AAL07512.1.
AK049747 mRNA. Translation: BAC33901.1.
AK076466 mRNA. Translation: BAC36356.1.
BC053919 mRNA. Translation: AAH53919.1.
BC058636 mRNA. Translation: AAH58636.1.
CCDSiCCDS23080.1.
RefSeqiNP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGeneiMm.290083.

Genome annotation databases

EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneIDi235281.
KEGGimmu:235281.
UCSCiuc009ozj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049036 mRNA. Translation: AAL07512.1 .
AK049747 mRNA. Translation: BAC33901.1 .
AK076466 mRNA. Translation: BAC36356.1 .
BC053919 mRNA. Translation: AAH53919.1 .
BC058636 mRNA. Translation: AAH58636.1 .
CCDSi CCDS23080.1.
RefSeqi NP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGenei Mm.290083.

3D structure databases

ProteinModelPortali Q8BHK2.
SMRi Q8BHK2. Positions 25-145.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BHK2.

Proteomic databases

PaxDbi Q8BHK2.
PRIDEi Q8BHK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049941 ; ENSMUSP00000051627 ; ENSMUSG00000049281 .
ENSMUST00000114956 ; ENSMUSP00000110606 ; ENSMUSG00000049281 .
ENSMUST00000171835 ; ENSMUSP00000132933 ; ENSMUSG00000049281 .
GeneIDi 235281.
KEGGi mmu:235281.
UCSCi uc009ozj.1. mouse.

Organism-specific databases

CTDi 55800.
MGIi MGI:1918882. Scn3b.

Phylogenomic databases

eggNOGi NOG40812.
GeneTreei ENSGT00390000018560.
HOGENOMi HOG000276881.
HOVERGENi HBG056582.
InParanoidi Q8BHK2.
KOi K04847.
OMAi LLIEMVY.
OrthoDBi EOG7M3J19.
TreeFami TF332097.

Miscellaneous databases

NextBioi 382555.
PROi Q8BHK2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BHK2.
Bgeei Q8BHK2.
CleanExi MM_SCN3B.
Genevestigatori Q8BHK2.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view ]
PANTHERi PTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse brain and heart beta 3 sodium channel cDNA."
    Chen C., Avery C., Kazen-Gillespie K., Isom L.L.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Olfactory epithelium.

Entry informationi

Entry nameiSCN3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHK2
Secondary accession number(s): Q91Z99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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