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Protein

Sodium channel subunit beta-3

Gene

Scn3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).By similarity

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • sodium channel regulator activity Source: MGI
  • voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:Scn3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918882. Scn3b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 159ExtracellularSequence analysisAdd BLAST135
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 215CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • plasma membrane Source: MGI
  • voltage-gated sodium channel complex Source: MGI
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001493525 – 215Sodium channel subunit beta-3Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHK2.
PaxDbiQ8BHK2.
PRIDEiQ8BHK2.

PTM databases

iPTMnetiQ8BHK2.
PhosphoSitePlusiQ8BHK2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049281.
CleanExiMM_SCN3B.
ExpressionAtlasiQ8BHK2. baseline and differential.
GenevisibleiQ8BHK2. MM.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).By similarity

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051627.

Structurei

3D structure databases

ProteinModelPortaliQ8BHK2.
SMRiQ8BHK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 138Ig-like C2-typeAdd BLAST114

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHF3. Eukaryota.
ENOG4111IPM. LUCA.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ8BHK2.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG091G0OF7.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNS MKLRCISCMK
60 70 80 90 100
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL
110 120 130 140 150
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG
160 170 180 190 200
EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA
210
IPSENKENSV VPVEE
Length:215
Mass (Da):24,789
Last modified:March 1, 2003 - v1
Checksum:i0E07B4704178A423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049036 mRNA. Translation: AAL07512.1.
AK049747 mRNA. Translation: BAC33901.1.
AK076466 mRNA. Translation: BAC36356.1.
BC053919 mRNA. Translation: AAH53919.1.
BC058636 mRNA. Translation: AAH58636.1.
CCDSiCCDS23080.1.
RefSeqiNP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGeneiMm.290083.

Genome annotation databases

EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneIDi235281.
KEGGimmu:235281.
UCSCiuc009ozj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049036 mRNA. Translation: AAL07512.1.
AK049747 mRNA. Translation: BAC33901.1.
AK076466 mRNA. Translation: BAC36356.1.
BC053919 mRNA. Translation: AAH53919.1.
BC058636 mRNA. Translation: AAH58636.1.
CCDSiCCDS23080.1.
RefSeqiNP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGeneiMm.290083.

3D structure databases

ProteinModelPortaliQ8BHK2.
SMRiQ8BHK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051627.

PTM databases

iPTMnetiQ8BHK2.
PhosphoSitePlusiQ8BHK2.

Proteomic databases

MaxQBiQ8BHK2.
PaxDbiQ8BHK2.
PRIDEiQ8BHK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneIDi235281.
KEGGimmu:235281.
UCSCiuc009ozj.1. mouse.

Organism-specific databases

CTDi55800.
MGIiMGI:1918882. Scn3b.

Phylogenomic databases

eggNOGiENOG410IHF3. Eukaryota.
ENOG4111IPM. LUCA.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ8BHK2.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG091G0OF7.
TreeFamiTF332097.

Miscellaneous databases

PROiQ8BHK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049281.
CleanExiMM_SCN3B.
ExpressionAtlasiQ8BHK2. baseline and differential.
GenevisibleiQ8BHK2. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCN3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHK2
Secondary accession number(s): Q91Z99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.