Sodium channel subunit beta-3 precursor

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Q8BHK2 (SCN3B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium channel subunit beta-3

Gene names

Name:

Scn3b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons By similarity.
Subunit structure	The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and/or beta-3 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. [View classification] Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Ligand	Sodium
Molecular function	Ion channel Sodium channel Voltage-gated channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SA node cell to atrial cardiac muscle cell communication Inferred from mutant phenotype PubMed 19796257. Source: BHF-UCL cardiac muscle contraction Inferred from electronic annotation. Source: Compara nervous system development Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from mutant phenotype PubMed 19796257. Source: BHF-UCL positive regulation of sodium ion transport Inferred from electronic annotation. Source: Compara protein localization to plasma membrane Inferred from electronic annotation. Source: Compara regulation of atrial cardiac muscle cell action potential Inferred from electronic annotation. Source: Compara regulation of atrial cardiac muscle cell membrane depolarization Inferred from mutant phenotype PubMed 19796257. Source: BHF-UCL regulation of heart rate by cardiac conduction Inferred from electronic annotation. Source: Compara regulation of sodium ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara regulation of ventricular cardiac muscle cell action potential Inferred from mutant phenotype PubMed 19351516. Source: MGI regulation of ventricular cardiac muscle cell membrane depolarization Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from direct assay PubMed 17884088. Source: BHF-UCL voltage-gated sodium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	sodium channel regulator activity Inferred from electronic annotation. Source: Compara voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential Inferred from mutant phenotype PubMed 19351516. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 215

191

Sodium channel subunit beta-3

PRO_0000014935

Regions

Topological domain

25 – 159

135

Extracellular Potential

Transmembrane

160 – 180

Helical; Potential

Topological domain

181 – 215

Cytoplasmic Potential

Domain

25 – 138

114

Ig-like C2-type

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

109

N-linked (GlcNAc...) Potential

Glycosylation

113

N-linked (GlcNAc...) Potential

Glycosylation

121

N-linked (GlcNAc...) Potential

Disulfide bond

26 ↔ 48

Potential

Disulfide bond

45 ↔ 120

Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8BHK2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0E07B4704178A423
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FASTA

215

24,789

        10         20         30         40         50         60 
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNS MKLRCISCMK REEVEATTVV 

        70         80         90        100        110        120 
EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC 

       130        140        150        160        170        180 
NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLFIEMIYC 

       190        200        210 
YRKVSKAEEA AQENASDYLA IPSENKENSV VPVEE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse brain and heart beta 3 sodium channel cDNA." Chen C., Avery C., Kazen-Gillespie K., Isom L.L. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head and Spinal cord.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY049036 mRNA. Translation: AAL07512.1. AK049747 mRNA. Translation: BAC33901.1. AK076466 mRNA. Translation: BAC36356.1. BC053919 mRNA. Translation: AAH53919.1. BC058636 mRNA. Translation: AAH58636.1.
IPI	IPI00221885.
RefSeq	NP_001077386.1. NM_001083917.1. NP_705742.2. NM_153522.2. NP_839941.1. NM_178227.4.
UniGene	Mm.290083.
3D structure databases
ProteinModelPortal	Q8BHK2.
SMR	Q8BHK2. Positions 25-122.
ModBase	Search...
PTM databases
PhosphoSite	Q8BHK2.
Proteomic databases
PaxDb	Q8BHK2.
PRIDE	Q8BHK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281. ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281. ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneID	235281.
KEGG	mmu:235281.
Organism-specific databases
CTD	55800.
MGI	MGI:1918882. Scn3b.
Phylogenomic databases
eggNOG	NOG40812.
GeneTree	ENSGT00390000018560.
HOGENOM	HOG000276881.
HOVERGEN	HBG056582.
InParanoid	Q8BHK2.
KO	K04847.
OMA	LLIEMVY.
OrthoDB	EOG4JDH7P.
Gene expression databases
ArrayExpress	Q8BHK2.
Bgee	Q8BHK2.
CleanEx	MM_SCN3B.
Genevestigator	Q8BHK2.
GermOnline	ENSMUSG00000049281. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR027098. Na_channel_b1/b3. IPR027096. Na_channel_b3. [Graphical view]
PANTHER	PTHR10546. PTHR10546. 1 hit. PTHR10546:SF1. PTHR10546:SF1. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	382555.
SOURCE	Search...

Entry information

Entry name

SCN3B_MOUSE

Accession

Primary (citable) accession number: Q8BHK2
Secondary accession number(s): Q91Z99

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents