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Protein

Sodium channel subunit beta-3

Gene

Scn3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).By similarity

GO - Molecular functioni

  1. ion channel binding Source: BHF-UCL
  2. sodium channel regulator activity Source: MGI
  3. voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI

GO - Biological processi

  1. atrial cardiac muscle cell action potential Source: MGI
  2. cardiac conduction Source: MGI
  3. cardiac muscle cell action potential involved in contraction Source: MGI
  4. cardiac muscle contraction Source: MGI
  5. membrane depolarization Source: MGI
  6. membrane depolarization during action potential Source: MGI
  7. membrane depolarization during cardiac muscle cell action potential Source: MGI
  8. nervous system development Source: Ensembl
  9. positive regulation of heart rate Source: BHF-UCL
  10. positive regulation of sodium ion transport Source: MGI
  11. protein localization to plasma membrane Source: MGI
  12. regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
  13. regulation of heart rate by cardiac conduction Source: MGI
  14. regulation of sodium ion transmembrane transporter activity Source: MGI
  15. regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
  16. SA node cell to atrial cardiac muscle cell communication Source: BHF-UCL
  17. sensory perception of pain Source: Ensembl
  18. sodium ion transmembrane transport Source: MGI
  19. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-3
Gene namesi
Name:Scn3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1918882. Scn3b.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 159135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 21535CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: MGI
  2. voltage-gated sodium channel complex Source: MGI
  3. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 215191Sodium channel subunit beta-3PRO_0000014935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48PROSITE-ProRule annotation
Disulfide bondi45 ↔ 120PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHK2.
PaxDbiQ8BHK2.
PRIDEiQ8BHK2.

PTM databases

PhosphoSiteiQ8BHK2.

Expressioni

Gene expression databases

BgeeiQ8BHK2.
CleanExiMM_SCN3B.
ExpressionAtlasiQ8BHK2. baseline and differential.
GenevestigatoriQ8BHK2.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BHK2.
SMRiQ8BHK2. Positions 25-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 138114Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40812.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ8BHK2.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
TreeFamiTF332097.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHK2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNS MKLRCISCMK
60 70 80 90 100
REEVEATTVV EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL
110 120 130 140 150
QDVSITVLNV TLNDSGLYTC NVSREFEFEA HRPFVKTTRL IPLRVTEEAG
160 170 180 190 200
EDFTSVVSEI MMYILLVFLT LWLFIEMIYC YRKVSKAEEA AQENASDYLA
210
IPSENKENSV VPVEE
Length:215
Mass (Da):24,789
Last modified:March 1, 2003 - v1
Checksum:i0E07B4704178A423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049036 mRNA. Translation: AAL07512.1.
AK049747 mRNA. Translation: BAC33901.1.
AK076466 mRNA. Translation: BAC36356.1.
BC053919 mRNA. Translation: AAH53919.1.
BC058636 mRNA. Translation: AAH58636.1.
CCDSiCCDS23080.1.
RefSeqiNP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGeneiMm.290083.

Genome annotation databases

EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneIDi235281.
KEGGimmu:235281.
UCSCiuc009ozj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049036 mRNA. Translation: AAL07512.1.
AK049747 mRNA. Translation: BAC33901.1.
AK076466 mRNA. Translation: BAC36356.1.
BC053919 mRNA. Translation: AAH53919.1.
BC058636 mRNA. Translation: AAH58636.1.
CCDSiCCDS23080.1.
RefSeqiNP_001077386.1. NM_001083917.1.
NP_001273543.1. NM_001286614.1.
NP_839941.1. NM_178227.4.
XP_006510297.1. XM_006510234.1.
UniGeneiMm.290083.

3D structure databases

ProteinModelPortaliQ8BHK2.
SMRiQ8BHK2. Positions 25-145.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BHK2.

Proteomic databases

MaxQBiQ8BHK2.
PaxDbiQ8BHK2.
PRIDEiQ8BHK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049941; ENSMUSP00000051627; ENSMUSG00000049281.
ENSMUST00000114956; ENSMUSP00000110606; ENSMUSG00000049281.
ENSMUST00000171835; ENSMUSP00000132933; ENSMUSG00000049281.
GeneIDi235281.
KEGGimmu:235281.
UCSCiuc009ozj.1. mouse.

Organism-specific databases

CTDi55800.
MGIiMGI:1918882. Scn3b.

Phylogenomic databases

eggNOGiNOG40812.
GeneTreeiENSGT00390000018560.
HOGENOMiHOG000276881.
HOVERGENiHBG056582.
InParanoidiQ8BHK2.
KOiK04847.
OMAiLLIEMVY.
OrthoDBiEOG7M3J19.
TreeFamiTF332097.

Miscellaneous databases

NextBioi382555.
PROiQ8BHK2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHK2.
CleanExiMM_SCN3B.
ExpressionAtlasiQ8BHK2. baseline and differential.
GenevestigatoriQ8BHK2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027098. Na_channel_b1/b3.
IPR027096. Na_channel_b3.
[Graphical view]
PANTHERiPTHR10546. PTHR10546. 1 hit.
PTHR10546:SF1. PTHR10546:SF1. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse brain and heart beta 3 sodium channel cDNA."
    Chen C., Avery C., Kazen-Gillespie K., Isom L.L.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Olfactory epithelium.

Entry informationi

Entry nameiSCN3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHK2
Secondary accession number(s): Q91Z99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.