Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor SLU7

Gene

Slu7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 13518CCHC-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SLU7
Gene namesi
Name:Slu7
Synonyms:D11Ertd730e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2385598. Slu7.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 585584Pre-mRNA-splicing factor SLU7PRO_0000289196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei215 – 2151PhosphoserineCombined sources
Modified residuei227 – 2271PhosphoserineBy similarity
Modified residuei235 – 2351PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BHJ9.
MaxQBiQ8BHJ9.
PaxDbiQ8BHJ9.
PeptideAtlasiQ8BHJ9.
PRIDEiQ8BHJ9.

PTM databases

iPTMnetiQ8BHJ9.
PhosphoSiteiQ8BHJ9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020409.
CleanExiMM_SLU7.
ExpressionAtlasiQ8BHJ9. baseline and differential.
GenevisibleiQ8BHJ9. MM.

Interactioni

Subunit structurei

Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I (By similarity).By similarity

Protein-protein interaction databases

BioGridi228728. 1 interaction.
IntActiQ8BHJ9. 1 interaction.
MINTiMINT-4110579.
STRINGi10090.ENSMUSP00000020681.

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi129 – 16941Bipartite nuclear localization signalBy similarityAdd
BLAST

Domaini

The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.By similarity

Sequence similaritiesi

Belongs to the SLU7 family.Curated
Contains 1 CCHC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 13518CCHC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2560. Eukaryota.
ENOG410XPPP. LUCA.
GeneTreeiENSGT00390000002292.
HOVERGENiHBG053287.
InParanoidiQ8BHJ9.
KOiK12819.
OMAiIANSEEC.
OrthoDBiEOG091G05PK.
PhylomeDBiQ8BHJ9.
TreeFamiTF105691.

Family and domain databases

InterProiIPR021715. Slu7.
[Graphical view]
PfamiPF11708. Slu7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAVDPVS ATPMTGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA
60 70 80 90 100
EVDEEGKDIN PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE
110 120 130 140 150
WYKRGVKENS ITTKYRKGAC ENCGAMTHKR KDCFERPRRV GAKFTGTNIA
160 170 180 190 200
PDEHVQPQLM FDYDGKRDRW NGYNPEEHMK IVEEYAKVDL AKRTLKAQKL
210 220 230 240 250
QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE DKYADDIDMP
260 270 280 290 300
GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA
310 320 330 340 350
GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL
360 370 380 390 400
ELLYKSFKVK KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY
410 420 430 440 450
SRHGTVIKGQ ERAVACSKYE EDVKINNHTH IWGSYWKEGR WGYKCCHSFF
460 470 480 490 500
KYSYCTGEAG KESVNSEECI ITGATAEESV KKPQALLELH QEKLKEEKKK
510 520 530 540 550
KKKKKKHRKS SSDSDDEERK QEKLKKALNA EEARLLHVKE IMQIDERKRP
560 570 580
YNSIYETREP TEEEMEAYRM KRQRPDDPMA SFLGQ
Length:585
Mass (Da):68,080
Last modified:March 1, 2003 - v1
Checksum:i1020FE4B6D65668B
GO

Sequence cautioni

The sequence AAH13810 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI24831 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431R → K in BAC32662 (PubMed:16141072).Curated
Sequence conflicti102 – 1021Y → H in BAC33093 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029117 mRNA. Translation: BAC26306.1.
AK046262 mRNA. Translation: BAC32662.1.
AK047597 mRNA. Translation: BAC33093.1.
AK049178 mRNA. Translation: BAC33589.1.
AL670472 Genomic DNA. Translation: CAI24830.1.
AL670472 Genomic DNA. Translation: CAI24831.1. Sequence problems.
BC013810 mRNA. Translation: AAH13810.1. Different initiation.
BC023057 mRNA. Translation: AAH23057.1.
BC060954 mRNA. Translation: AAH60954.1.
BC082780 mRNA. Translation: AAH82780.1. Different termination.
BC106099 mRNA. Translation: AAI06100.1.
CCDSiCCDS24557.1.
RefSeqiNP_683514.2. NM_148673.3.
NP_945174.1. NM_198936.1.
XP_011247125.1. XM_011248823.1.
UniGeneiMm.28200.

Genome annotation databases

EnsembliENSMUST00000020681; ENSMUSP00000020681; ENSMUSG00000020409.
ENSMUST00000178622; ENSMUSP00000137281; ENSMUSG00000020409.
GeneIDi193116.
KEGGimmu:193116.
UCSCiuc007imp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029117 mRNA. Translation: BAC26306.1.
AK046262 mRNA. Translation: BAC32662.1.
AK047597 mRNA. Translation: BAC33093.1.
AK049178 mRNA. Translation: BAC33589.1.
AL670472 Genomic DNA. Translation: CAI24830.1.
AL670472 Genomic DNA. Translation: CAI24831.1. Sequence problems.
BC013810 mRNA. Translation: AAH13810.1. Different initiation.
BC023057 mRNA. Translation: AAH23057.1.
BC060954 mRNA. Translation: AAH60954.1.
BC082780 mRNA. Translation: AAH82780.1. Different termination.
BC106099 mRNA. Translation: AAI06100.1.
CCDSiCCDS24557.1.
RefSeqiNP_683514.2. NM_148673.3.
NP_945174.1. NM_198936.1.
XP_011247125.1. XM_011248823.1.
UniGeneiMm.28200.

3D structure databases

ProteinModelPortaliQ8BHJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228728. 1 interaction.
IntActiQ8BHJ9. 1 interaction.
MINTiMINT-4110579.
STRINGi10090.ENSMUSP00000020681.

PTM databases

iPTMnetiQ8BHJ9.
PhosphoSiteiQ8BHJ9.

Proteomic databases

EPDiQ8BHJ9.
MaxQBiQ8BHJ9.
PaxDbiQ8BHJ9.
PeptideAtlasiQ8BHJ9.
PRIDEiQ8BHJ9.

Protocols and materials databases

DNASUi193116.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020681; ENSMUSP00000020681; ENSMUSG00000020409.
ENSMUST00000178622; ENSMUSP00000137281; ENSMUSG00000020409.
GeneIDi193116.
KEGGimmu:193116.
UCSCiuc007imp.1. mouse.

Organism-specific databases

CTDi10569.
MGIiMGI:2385598. Slu7.

Phylogenomic databases

eggNOGiKOG2560. Eukaryota.
ENOG410XPPP. LUCA.
GeneTreeiENSGT00390000002292.
HOVERGENiHBG053287.
InParanoidiQ8BHJ9.
KOiK12819.
OMAiIANSEEC.
OrthoDBiEOG091G05PK.
PhylomeDBiQ8BHJ9.
TreeFamiTF105691.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiSlu7. mouse.
PROiQ8BHJ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020409.
CleanExiMM_SLU7.
ExpressionAtlasiQ8BHJ9. baseline and differential.
GenevisibleiQ8BHJ9. MM.

Family and domain databases

InterProiIPR021715. Slu7.
[Graphical view]
PfamiPF11708. Slu7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLU7_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ9
Secondary accession number(s): Q3KQQ3
, Q5SRU1, Q63ZX3, Q6P923, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.