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Q8BHJ7

- GBRA5_MOUSE

UniProt

Q8BHJ7 - GBRA5_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit alpha-5

Gene

Gabra5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: Ensembl
    4. protein binding Source: IntAct

    GO - Biological processi

    1. associative learning Source: MGI
    2. behavioral fear response Source: MGI
    3. brain development Source: Ensembl
    4. cochlea development Source: DFLAT
    5. gamma-aminobutyric acid signaling pathway Source: InterPro
    6. inner ear receptor cell development Source: DFLAT
    7. innervation Source: DFLAT
    8. negative regulation of neuron apoptotic process Source: DFLAT
    9. neuron development Source: DFLAT
    10. regulation of neuron apoptotic process Source: DFLAT
    11. sensory perception of sound Source: DFLAT
    12. synaptic transmission Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-5
    Alternative name(s):
    GABA(A) receptor subunit alpha-5
    Gene namesi
    Name:Gabra5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95617. Gabra5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: MGI
    2. cell junction Source: UniProtKB-KW
    3. chloride channel complex Source: UniProtKB-KW
    4. dendrite Source: MGI
    5. neuronal cell body membrane Source: Ensembl
    6. postsynaptic membrane Source: UniProtKB-SubCell
    7. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 463438Gamma-aminobutyric acid receptor subunit alpha-5PRO_0000000445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi173 ↔ 187By similarity
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Cross-linki355 – 355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ8BHJ7.
    PRIDEiQ8BHJ7.

    PTM databases

    PhosphoSiteiQ8BHJ7.

    Expressioni

    Gene expression databases

    BgeeiQ8BHJ7.
    GenevestigatoriQ8BHJ7.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RdxQ5WQV54EBI-8069233,EBI-8069271From a different organism.

    Protein-protein interaction databases

    IntActiQ8BHJ7. 1 interaction.
    MINTiMINT-1789015.
    STRINGi10090.ENSMUSP00000063276.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BHJ7.
    SMRiQ8BHJ7. Positions 59-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 259234ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 42887CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei260 – 28122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei286 – 30722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 34123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 45022HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    GeneTreeiENSGT00550000074441.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiQ8BHJ7.
    KOiK05175.
    OMAiWTNGTTK.
    OrthoDBiEOG7JX342.
    PhylomeDBiQ8BHJ7.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005435. GABBAa5_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01618. GABAARALPHA5.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BHJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNGMLSRFI MTQTLLVFCI SMTLSSHFGF SQMPTSSVQD ETNDNITIFT    50
    RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF 100
    RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN 150
    KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE 200
    VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH 250
    FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM 300
    TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA 350
    WDGKKALEAA KIKKKERELI LNKSTNAFTT GKLTHPPNIP KEQPPAGTAN 400
    APTVSIKASE EKTAESKKTY NSISKIDKMS RIVFPILFGT FNLVYWATYL 450
    NREPVIKGAT SPK 463
    Length:463
    Mass (Da):52,274
    Last modified:March 1, 2003 - v1
    Checksum:i12C677403D326378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK038476 mRNA. Translation: BAC30012.1.
    AK083185 mRNA. Translation: BAC38799.1.
    BC062112 mRNA. Translation: AAH62112.1.
    CCDSiCCDS21322.1.
    RefSeqiNP_795916.1. NM_176942.4.
    XP_006540619.1. XM_006540556.1.
    XP_006540620.1. XM_006540557.1.
    XP_006540621.1. XM_006540558.1.
    XP_006540622.1. XM_006540559.1.
    XP_006540623.1. XM_006540560.1.
    UniGeneiMm.273114.

    Genome annotation databases

    EnsembliENSMUST00000068456; ENSMUSP00000063276; ENSMUSG00000055078.
    GeneIDi110886.
    KEGGimmu:110886.
    UCSCiuc009heb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK038476 mRNA. Translation: BAC30012.1 .
    AK083185 mRNA. Translation: BAC38799.1 .
    BC062112 mRNA. Translation: AAH62112.1 .
    CCDSi CCDS21322.1.
    RefSeqi NP_795916.1. NM_176942.4.
    XP_006540619.1. XM_006540556.1.
    XP_006540620.1. XM_006540557.1.
    XP_006540621.1. XM_006540558.1.
    XP_006540622.1. XM_006540559.1.
    XP_006540623.1. XM_006540560.1.
    UniGenei Mm.273114.

    3D structure databases

    ProteinModelPortali Q8BHJ7.
    SMRi Q8BHJ7. Positions 59-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BHJ7. 1 interaction.
    MINTi MINT-1789015.
    STRINGi 10090.ENSMUSP00000063276.

    Chemistry

    BindingDBi Q8BHJ7.
    ChEMBLi CHEMBL2304.
    GuidetoPHARMACOLOGYi 408.

    PTM databases

    PhosphoSitei Q8BHJ7.

    Proteomic databases

    PaxDbi Q8BHJ7.
    PRIDEi Q8BHJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068456 ; ENSMUSP00000063276 ; ENSMUSG00000055078 .
    GeneIDi 110886.
    KEGGi mmu:110886.
    UCSCi uc009heb.1. mouse.

    Organism-specific databases

    CTDi 2558.
    MGIi MGI:95617. Gabra5.

    Phylogenomic databases

    eggNOGi NOG238757.
    GeneTreei ENSGT00550000074441.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi Q8BHJ7.
    KOi K05175.
    OMAi WTNGTTK.
    OrthoDBi EOG7JX342.
    PhylomeDBi Q8BHJ7.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Miscellaneous databases

    NextBioi 364867.
    PROi Q8BHJ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BHJ7.
    Genevestigatori Q8BHJ7.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005435. GABBAa5_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01618. GABAARALPHA5.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus and Hypothalamus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiGBRA5_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3