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Protein

Gamma-aminobutyric acid receptor subunit alpha-5

Gene

Gabra5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of mitophagy in response to mitochondrial depolarization Source: MGI
  • associative learning Source: MGI
  • behavioral fear response Source: MGI
  • brain development Source: Ensembl
  • cochlea development Source: DFLAT
  • gamma-aminobutyric acid signaling pathway Source: InterPro
  • inner ear receptor cell development Source: DFLAT
  • innervation Source: DFLAT
  • negative regulation of neuron apoptotic process Source: DFLAT
  • neuron development Source: DFLAT
  • positive regulation of defense response to virus by host Source: MGI
  • regulation of neuron apoptotic process Source: DFLAT
  • sensory perception of sound Source: DFLAT
  • synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_293019. Ligand-gated ion channel transport.
REACT_343799. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-5
Alternative name(s):
GABA(A) receptor subunit alpha-5
Gene namesi
Name:Gabra5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95617. Gabra5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 259234ExtracellularSequence AnalysisAdd
BLAST
Transmembranei260 – 28122HelicalSequence AnalysisAdd
BLAST
Transmembranei286 – 30722HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 34123HelicalSequence AnalysisAdd
BLAST
Topological domaini342 – 42887CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei429 – 45022HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell body Source: MGI
  • cell junction Source: UniProtKB-KW
  • chloride channel complex Source: UniProtKB-KW
  • dendrite Source: MGI
  • neuronal cell body membrane Source: Ensembl
  • postsynaptic membrane Source: UniProtKB-SubCell
  • receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 463438Gamma-aminobutyric acid receptor subunit alpha-5PRO_0000000445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi173 ↔ 187By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Cross-linki355 – 355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BHJ7.
PRIDEiQ8BHJ7.

PTM databases

PhosphoSiteiQ8BHJ7.

Expressioni

Gene expression databases

BgeeiQ8BHJ7.
ExpressionAtlasiQ8BHJ7. baseline and differential.
GenevisibleiQ8BHJ7. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RdxQ5WQV54EBI-8069233,EBI-8069271From a different organism.

Protein-protein interaction databases

IntActiQ8BHJ7. 1 interaction.
MINTiMINT-1789015.
STRINGi10090.ENSMUSP00000063276.

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ7.
SMRiQ8BHJ7. Positions 53-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238757.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ8BHJ7.
KOiK05175.
OMAiWTNGTTK.
OrthoDBiEOG7JX342.
PhylomeDBiQ8BHJ7.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005435. GABBAa5_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01618. GABAARALPHA5.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGMLSRFI MTQTLLVFCI SMTLSSHFGF SQMPTSSVQD ETNDNITIFT
60 70 80 90 100
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
110 120 130 140 150
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
160 170 180 190 200
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
210 220 230 240 250
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
260 270 280 290 300
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
310 320 330 340 350
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
360 370 380 390 400
WDGKKALEAA KIKKKERELI LNKSTNAFTT GKLTHPPNIP KEQPPAGTAN
410 420 430 440 450
APTVSIKASE EKTAESKKTY NSISKIDKMS RIVFPILFGT FNLVYWATYL
460
NREPVIKGAT SPK
Length:463
Mass (Da):52,274
Last modified:March 1, 2003 - v1
Checksum:i12C677403D326378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038476 mRNA. Translation: BAC30012.1.
AK083185 mRNA. Translation: BAC38799.1.
BC062112 mRNA. Translation: AAH62112.1.
CCDSiCCDS21322.1.
RefSeqiNP_795916.1. NM_176942.4.
XP_006540619.1. XM_006540556.2.
XP_006540620.1. XM_006540557.2.
XP_006540621.1. XM_006540558.1.
XP_006540622.1. XM_006540559.2.
XP_006540623.1. XM_006540560.2.
UniGeneiMm.273114.

Genome annotation databases

EnsembliENSMUST00000068456; ENSMUSP00000063276; ENSMUSG00000055078.
GeneIDi110886.
KEGGimmu:110886.
UCSCiuc009heb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038476 mRNA. Translation: BAC30012.1.
AK083185 mRNA. Translation: BAC38799.1.
BC062112 mRNA. Translation: AAH62112.1.
CCDSiCCDS21322.1.
RefSeqiNP_795916.1. NM_176942.4.
XP_006540619.1. XM_006540556.2.
XP_006540620.1. XM_006540557.2.
XP_006540621.1. XM_006540558.1.
XP_006540622.1. XM_006540559.2.
XP_006540623.1. XM_006540560.2.
UniGeneiMm.273114.

3D structure databases

ProteinModelPortaliQ8BHJ7.
SMRiQ8BHJ7. Positions 53-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHJ7. 1 interaction.
MINTiMINT-1789015.
STRINGi10090.ENSMUSP00000063276.

Chemistry

ChEMBLiCHEMBL2094133.
GuidetoPHARMACOLOGYi408.

PTM databases

PhosphoSiteiQ8BHJ7.

Proteomic databases

PaxDbiQ8BHJ7.
PRIDEiQ8BHJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068456; ENSMUSP00000063276; ENSMUSG00000055078.
GeneIDi110886.
KEGGimmu:110886.
UCSCiuc009heb.1. mouse.

Organism-specific databases

CTDi2558.
MGIiMGI:95617. Gabra5.

Phylogenomic databases

eggNOGiNOG238757.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ8BHJ7.
KOiK05175.
OMAiWTNGTTK.
OrthoDBiEOG7JX342.
PhylomeDBiQ8BHJ7.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiREACT_293019. Ligand-gated ion channel transport.
REACT_343799. GABA A receptor activation.

Miscellaneous databases

NextBioi364867.
PROiQ8BHJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHJ7.
ExpressionAtlasiQ8BHJ7. baseline and differential.
GenevisibleiQ8BHJ7. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005435. GABBAa5_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01618. GABAARALPHA5.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGBRA5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.