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Protein

Gamma-aminobutyric acid receptor subunit alpha-5

Gene

Gabra5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: MGI
  • behavioral fear response Source: MGI
  • brain development Source: Ensembl
  • chemical synaptic transmission Source: Ensembl
  • cochlea development Source: DFLAT
  • gamma-aminobutyric acid signaling pathway Source: InterPro
  • inner ear receptor cell development Source: DFLAT
  • innervation Source: DFLAT
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • negative regulation of neuron apoptotic process Source: DFLAT
  • neuron development Source: DFLAT
  • positive regulation of defense response to virus by host Source: Ensembl
  • regulation of neuron apoptotic process Source: DFLAT
  • sensory perception of sound Source: DFLAT
  • xenophagy Source: Ensembl
Complete GO annotation...

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-5
Alternative name(s):
GABA(A) receptor subunit alpha-5
Gene namesi
Name:Gabra5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95617. Gabra5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 259ExtracellularSequence analysisAdd BLAST234
Transmembranei260 – 281HelicalSequence analysisAdd BLAST22
Transmembranei286 – 307HelicalSequence analysisAdd BLAST22
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Topological domaini342 – 428CytoplasmicSequence analysisAdd BLAST87
Transmembranei429 – 450HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • cell body Source: MGI
  • cell junction Source: UniProtKB-KW
  • chloride channel complex Source: UniProtKB-KW
  • dendrite Source: MGI
  • GABA-A receptor complex Source: GO_Central
  • neuronal cell body membrane Source: Ensembl
  • postsynaptic membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000044526 – 463Gamma-aminobutyric acid receptor subunit alpha-5Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi173 ↔ 187By similarity
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Cross-linki355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BHJ7.
PeptideAtlasiQ8BHJ7.
PRIDEiQ8BHJ7.

PTM databases

PhosphoSitePlusiQ8BHJ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055078.
GenevisibleiQ8BHJ7. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RdxQ5WQV54EBI-8069233,EBI-8069271From Rattus norvegicus.

Protein-protein interaction databases

IntActiQ8BHJ7. 1 interactor.
MINTiMINT-1789015.
STRINGi10090.ENSMUSP00000063276.

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ8BHJ7.
KOiK05175.
OMAiWDGKKAS.
OrthoDBiEOG091G0805.
PhylomeDBiQ8BHJ7.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005435. GABBAa5_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01618. GABAARALPHA5.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGMLSRFI MTQTLLVFCI SMTLSSHFGF SQMPTSSVQD ETNDNITIFT
60 70 80 90 100
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
110 120 130 140 150
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
160 170 180 190 200
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
210 220 230 240 250
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
260 270 280 290 300
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
310 320 330 340 350
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
360 370 380 390 400
WDGKKALEAA KIKKKERELI LNKSTNAFTT GKLTHPPNIP KEQPPAGTAN
410 420 430 440 450
APTVSIKASE EKTAESKKTY NSISKIDKMS RIVFPILFGT FNLVYWATYL
460
NREPVIKGAT SPK
Length:463
Mass (Da):52,274
Last modified:March 1, 2003 - v1
Checksum:i12C677403D326378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038476 mRNA. Translation: BAC30012.1.
AK083185 mRNA. Translation: BAC38799.1.
BC062112 mRNA. Translation: AAH62112.1.
CCDSiCCDS21322.1.
RefSeqiNP_795916.1. NM_176942.4.
XP_006540619.1. XM_006540556.3.
XP_006540620.1. XM_006540557.3.
XP_006540621.1. XM_006540558.2.
XP_006540622.1. XM_006540559.3.
XP_006540623.1. XM_006540560.3.
UniGeneiMm.273114.

Genome annotation databases

EnsembliENSMUST00000068456; ENSMUSP00000063276; ENSMUSG00000055078.
ENSMUST00000206382; ENSMUSP00000146238; ENSMUSG00000055078.
ENSMUST00000206734; ENSMUSP00000145685; ENSMUSG00000055078.
GeneIDi110886.
KEGGimmu:110886.
UCSCiuc009heb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038476 mRNA. Translation: BAC30012.1.
AK083185 mRNA. Translation: BAC38799.1.
BC062112 mRNA. Translation: AAH62112.1.
CCDSiCCDS21322.1.
RefSeqiNP_795916.1. NM_176942.4.
XP_006540619.1. XM_006540556.3.
XP_006540620.1. XM_006540557.3.
XP_006540621.1. XM_006540558.2.
XP_006540622.1. XM_006540559.3.
XP_006540623.1. XM_006540560.3.
UniGeneiMm.273114.

3D structure databases

ProteinModelPortaliQ8BHJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHJ7. 1 interactor.
MINTiMINT-1789015.
STRINGi10090.ENSMUSP00000063276.

Chemistry databases

ChEMBLiCHEMBL2304.

PTM databases

PhosphoSitePlusiQ8BHJ7.

Proteomic databases

PaxDbiQ8BHJ7.
PeptideAtlasiQ8BHJ7.
PRIDEiQ8BHJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068456; ENSMUSP00000063276; ENSMUSG00000055078.
ENSMUST00000206382; ENSMUSP00000146238; ENSMUSG00000055078.
ENSMUST00000206734; ENSMUSP00000145685; ENSMUSG00000055078.
GeneIDi110886.
KEGGimmu:110886.
UCSCiuc009heb.1. mouse.

Organism-specific databases

CTDi2558.
MGIiMGI:95617. Gabra5.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiQ8BHJ7.
KOiK05175.
OMAiWDGKKAS.
OrthoDBiEOG091G0805.
PhylomeDBiQ8BHJ7.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Miscellaneous databases

PROiQ8BHJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055078.
GenevisibleiQ8BHJ7. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005435. GABBAa5_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01618. GABAARALPHA5.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRA5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.