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Protein

Serine incorporator 5

Gene

Serinc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 5
Alternative name(s):
Axotomy-induced glycoprotein 31 Publication
Short name:
AIGP-31 Publication
Gene namesi
Name:Serinc5
Synonyms:Aigp31 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2444223 Serinc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 90CytoplasmicSequence analysisAdd BLAST33
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 125ExtracellularSequence analysisAdd BLAST14
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 157CytoplasmicSequence analysisAdd BLAST11
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 200ExtracellularSequence analysisAdd BLAST22
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 260ExtracellularSequence analysis8
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 312CytoplasmicSequence analysisAdd BLAST31
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 392ExtracellularSequence analysisAdd BLAST59
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 422CytoplasmicSequence analysis9
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306321 – 461Serine incorporator 5Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BHJ6
PeptideAtlasiQ8BHJ6
PRIDEiQ8BHJ6

PTM databases

iPTMnetiQ8BHJ6
PhosphoSitePlusiQ8BHJ6
SwissPalmiQ8BHJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021703
GenevisibleiQ8BHJ6 MM

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 26Cys-richAdd BLAST22
Compositional biasi132 – 135Poly-Leu4

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ8BHJ6
OMAiTVTNWFN
OrthoDBiEOG091G06BW
PhylomeDBiQ8BHJ6
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029555 Serinc5
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF16 PTHR10383:SF16, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC
60 70 80 90 100
CVMMTPSVMK QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA
110 120 130 140 150
CFFALFCLLT LKVNNSKSCR AYIHNGFWFF KLLLLGAMCS GAFFIPDQET
160 170 180 190 200
FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK WNKNWTAGTV RNKLWYASLS
210 220 230 240 250
LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL CVLISLVAIS
260 270 280 290 300
PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA
310 320 330 340 350
PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE
360 370 380 390 400
LEVARCCFCF GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL
410 420 430 440 450
ASLYVMMTLT SWFHYENATI KTFFSGWSVF WVKMASCWMC VLLYLQTLVA
460
PLCCPSRQFS V
Length:461
Mass (Da):51,831
Last modified:March 1, 2003 - v1
Checksum:i13698C24FFEFEBD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68F → S in BAC44829 (PubMed:12486168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA Translation: BAC44829.1
AK037699 mRNA Translation: BAC29851.1
AK054475 mRNA Translation: BAC35794.1
AK136799 mRNA Translation: BAE23132.1
AK165334 mRNA Translation: BAE38139.1
BC049189 mRNA Translation: AAH49189.2
BC062131 mRNA Translation: AAH62131.1
CCDSiCCDS36744.1
RefSeqiNP_766176.1, NM_172588.2
UniGeneiMm.297970

Genome annotation databases

EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703
GeneIDi218442
KEGGimmu:218442
UCSCiuc007rkt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSERC5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ6
Secondary accession number(s): Q80ZH8, Q8CHM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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