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Q8BHJ6 (SERC5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine incorporator 5
Alternative name(s):
Axotomy-induced glycoprotein 3
Short name=AIGP-3
Gene names
Name:Serinc5
Synonyms:Aigp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the TDE1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Serine incorporator 5
PRO_0000330632

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 9033Cytoplasmic Potential
Transmembrane91 – 11121Helical; Potential
Topological domain112 – 12514Extracellular Potential
Transmembrane126 – 14621Helical; Potential
Topological domain147 – 15711Cytoplasmic Potential
Transmembrane158 – 17821Helical; Potential
Topological domain179 – 20022Extracellular Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 23110Cytoplasmic Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 2608Extracellular Potential
Transmembrane261 – 28121Helical; Potential
Topological domain282 – 31231Cytoplasmic Potential
Transmembrane313 – 33321Helical; Potential
Topological domain334 – 39259Extracellular Potential
Transmembrane393 – 41321Helical; Potential
Topological domain414 – 4229Cytoplasmic Potential
Transmembrane423 – 44321Helical; Potential
Topological domain444 – 46118Extracellular Potential
Compositional bias5 – 2622Cys-rich
Compositional bias132 – 1354Poly-Leu

Amino acid modifications

Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict681F → S in BAC44829. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BHJ6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 13698C24FFEFEBD9

FASTA46151,831
        10         20         30         40         50         60 
MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC CVMMTPSVMK 

        70         80         90        100        110        120 
QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA CFFALFCLLT LKVNNSKSCR 

       130        140        150        160        170        180 
AYIHNGFWFF KLLLLGAMCS GAFFIPDQET FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK 

       190        200        210        220        230        240 
WNKNWTAGTV RNKLWYASLS LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL 

       250        260        270        280        290        300 
CVLISLVAIS PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA 

       310        320        330        340        350        360 
PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE LEVARCCFCF 

       370        380        390        400        410        420 
GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL ASLYVMMTLT SWFHYENATI 

       430        440        450        460 
KTFFSGWSVF WVKMASCWMC VLLYLQTLVA PLCCPSRQFS V 

« Hide

References

« Hide 'large scale' references
[1]"Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress."
Aoki S., Su Q., Li H., Nishikawa K., Ayukawa K., Hara Y., Namikawa K., Kiryu-Seo S., Kiyama H., Wada K.
J. Neurosci. 22:10751-10760(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Diencephalon, Ovary, Spleen and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb and Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029501 mRNA. Translation: BAC44829.1.
AK037699 mRNA. Translation: BAC29851.1.
AK054475 mRNA. Translation: BAC35794.1.
AK136799 mRNA. Translation: BAE23132.1.
AK165334 mRNA. Translation: BAE38139.1.
BC049189 mRNA. Translation: AAH49189.2.
BC062131 mRNA. Translation: AAH62131.1.
RefSeqNP_766176.1. NM_172588.2.
UniGeneMm.297970.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BHJ6.

Proteomic databases

PaxDbQ8BHJ6.
PRIDEQ8BHJ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703.
GeneID218442.
KEGGmmu:218442.
UCSCuc007rkt.1. mouse.

Organism-specific databases

CTD256987.
MGIMGI:2444223. Serinc5.

Phylogenomic databases

eggNOGNOG247442.
GeneTreeENSGT00550000074522.
HOGENOMHOG000165463.
HOVERGENHBG025699.
InParanoidQ8BHJ6.
OMAFWVKMAS.
OrthoDBEOG7N8ZWM.
PhylomeDBQ8BHJ6.
TreeFamTF312881.

Gene expression databases

BgeeQ8BHJ6.
GenevestigatorQ8BHJ6.

Family and domain databases

InterProIPR005016. TMS_TDE.
[Graphical view]
PANTHERPTHR10383. PTHR10383. 1 hit.
PfamPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio376292.
PROQ8BHJ6.
SOURCESearch...

Entry information

Entry nameSERC5_MOUSE
AccessionPrimary (citable) accession number: Q8BHJ6
Secondary accession number(s): Q80ZH8, Q8CHM0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot