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Q8BHJ6

- SERC5_MOUSE

UniProt

Q8BHJ6 - SERC5_MOUSE

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Protein

Serine incorporator 5

Gene

Serinc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).By similarity

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. myelination Source: MGI
  2. phosphatidylserine metabolic process Source: HGNC
  3. phospholipid biosynthetic process Source: UniProtKB-KW
  4. positive regulation of transferase activity Source: HGNC
  5. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 5
Alternative name(s):
Axotomy-induced glycoprotein 3
Short name:
AIGP-3
Gene namesi
Name:Serinc5
Synonyms:Aigp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2444223. Serinc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 9033CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Topological domaini112 – 12514ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Topological domaini147 – 15711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Topological domaini179 – 20022ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Topological domaini222 – 23110CytoplasmicSequence Analysis
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 2608ExtracellularSequence Analysis
Transmembranei261 – 28121HelicalSequence AnalysisAdd
BLAST
Topological domaini282 – 31231CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 39259ExtracellularSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Topological domaini414 – 4229CytoplasmicSequence Analysis
Transmembranei423 – 44321HelicalSequence AnalysisAdd
BLAST
Topological domaini444 – 46118ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. myelin sheath Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Serine incorporator 5PRO_0000330632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BHJ6.
PRIDEiQ8BHJ6.

PTM databases

PhosphoSiteiQ8BHJ6.

Expressioni

Gene expression databases

BgeeiQ8BHJ6.
GenevestigatoriQ8BHJ6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 2622Cys-richAdd
BLAST
Compositional biasi132 – 1354Poly-Leu

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247442.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ8BHJ6.
OMAiFWVKMAS.
OrthoDBiEOG7N8ZWM.
PhylomeDBiQ8BHJ6.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC
60 70 80 90 100
CVMMTPSVMK QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA
110 120 130 140 150
CFFALFCLLT LKVNNSKSCR AYIHNGFWFF KLLLLGAMCS GAFFIPDQET
160 170 180 190 200
FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK WNKNWTAGTV RNKLWYASLS
210 220 230 240 250
LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL CVLISLVAIS
260 270 280 290 300
PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA
310 320 330 340 350
PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE
360 370 380 390 400
LEVARCCFCF GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL
410 420 430 440 450
ASLYVMMTLT SWFHYENATI KTFFSGWSVF WVKMASCWMC VLLYLQTLVA
460
PLCCPSRQFS V
Length:461
Mass (Da):51,831
Last modified:March 1, 2003 - v1
Checksum:i13698C24FFEFEBD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681F → S in BAC44829. (PubMed:12486168)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA. Translation: BAC44829.1.
AK037699 mRNA. Translation: BAC29851.1.
AK054475 mRNA. Translation: BAC35794.1.
AK136799 mRNA. Translation: BAE23132.1.
AK165334 mRNA. Translation: BAE38139.1.
BC049189 mRNA. Translation: AAH49189.2.
BC062131 mRNA. Translation: AAH62131.1.
CCDSiCCDS36744.1.
RefSeqiNP_766176.1. NM_172588.2.
UniGeneiMm.297970.

Genome annotation databases

EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703.
GeneIDi218442.
KEGGimmu:218442.
UCSCiuc007rkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA. Translation: BAC44829.1 .
AK037699 mRNA. Translation: BAC29851.1 .
AK054475 mRNA. Translation: BAC35794.1 .
AK136799 mRNA. Translation: BAE23132.1 .
AK165334 mRNA. Translation: BAE38139.1 .
BC049189 mRNA. Translation: AAH49189.2 .
BC062131 mRNA. Translation: AAH62131.1 .
CCDSi CCDS36744.1.
RefSeqi NP_766176.1. NM_172588.2.
UniGenei Mm.297970.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BHJ6.

Proteomic databases

PaxDbi Q8BHJ6.
PRIDEi Q8BHJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049488 ; ENSMUSP00000047547 ; ENSMUSG00000021703 .
GeneIDi 218442.
KEGGi mmu:218442.
UCSCi uc007rkt.1. mouse.

Organism-specific databases

CTDi 256987.
MGIi MGI:2444223. Serinc5.

Phylogenomic databases

eggNOGi NOG247442.
GeneTreei ENSGT00550000074522.
HOGENOMi HOG000165463.
HOVERGENi HBG025699.
InParanoidi Q8BHJ6.
OMAi FWVKMAS.
OrthoDBi EOG7N8ZWM.
PhylomeDBi Q8BHJ6.
TreeFami TF312881.

Miscellaneous databases

NextBioi 376292.
PROi Q8BHJ6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BHJ6.
Genevestigatori Q8BHJ6.

Family and domain databases

InterProi IPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view ]
PANTHERi PTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
Pfami PF03348. Serinc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress."
    Aoki S., Su Q., Li H., Nishikawa K., Ayukawa K., Hara Y., Namikawa K., Kiryu-Seo S., Kiyama H., Wada K.
    J. Neurosci. 22:10751-10760(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon, Ovary, Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb and Olfactory epithelium.

Entry informationi

Entry nameiSERC5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ6
Secondary accession number(s): Q80ZH8, Q8CHM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3