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Protein

Serine incorporator 5

Gene

Serinc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-977347. Serine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 5
Alternative name(s):
Axotomy-induced glycoprotein 31 Publication
Short name:
AIGP-31 Publication
Gene namesi
Name:Serinc5
Synonyms:Aigp31 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2444223. Serinc5.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 90CytoplasmicSequence analysisAdd BLAST33
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 125ExtracellularSequence analysisAdd BLAST14
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 157CytoplasmicSequence analysisAdd BLAST11
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 200ExtracellularSequence analysisAdd BLAST22
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 260ExtracellularSequence analysis8
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 312CytoplasmicSequence analysisAdd BLAST31
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 392ExtracellularSequence analysisAdd BLAST59
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 422CytoplasmicSequence analysis9
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461ExtracellularSequence analysisAdd BLAST18

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: GO_Central
  • myelin sheath Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306321 – 461Serine incorporator 5Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BHJ6.
PeptideAtlasiQ8BHJ6.
PRIDEiQ8BHJ6.

PTM databases

iPTMnetiQ8BHJ6.
PhosphoSitePlusiQ8BHJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021703.
GenevisibleiQ8BHJ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047547.

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 26Cys-richAdd BLAST22
Compositional biasi132 – 135Poly-Leu4

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ8BHJ6.
OMAiCCPTREF.
OrthoDBiEOG091G06BW.
PhylomeDBiQ8BHJ6.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC
60 70 80 90 100
CVMMTPSVMK QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA
110 120 130 140 150
CFFALFCLLT LKVNNSKSCR AYIHNGFWFF KLLLLGAMCS GAFFIPDQET
160 170 180 190 200
FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK WNKNWTAGTV RNKLWYASLS
210 220 230 240 250
LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL CVLISLVAIS
260 270 280 290 300
PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA
310 320 330 340 350
PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE
360 370 380 390 400
LEVARCCFCF GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL
410 420 430 440 450
ASLYVMMTLT SWFHYENATI KTFFSGWSVF WVKMASCWMC VLLYLQTLVA
460
PLCCPSRQFS V
Length:461
Mass (Da):51,831
Last modified:March 1, 2003 - v1
Checksum:i13698C24FFEFEBD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68F → S in BAC44829 (PubMed:12486168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA. Translation: BAC44829.1.
AK037699 mRNA. Translation: BAC29851.1.
AK054475 mRNA. Translation: BAC35794.1.
AK136799 mRNA. Translation: BAE23132.1.
AK165334 mRNA. Translation: BAE38139.1.
BC049189 mRNA. Translation: AAH49189.2.
BC062131 mRNA. Translation: AAH62131.1.
CCDSiCCDS36744.1.
RefSeqiNP_766176.1. NM_172588.2.
UniGeneiMm.297970.

Genome annotation databases

EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703.
GeneIDi218442.
KEGGimmu:218442.
UCSCiuc007rkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029501 mRNA. Translation: BAC44829.1.
AK037699 mRNA. Translation: BAC29851.1.
AK054475 mRNA. Translation: BAC35794.1.
AK136799 mRNA. Translation: BAE23132.1.
AK165334 mRNA. Translation: BAE38139.1.
BC049189 mRNA. Translation: AAH49189.2.
BC062131 mRNA. Translation: AAH62131.1.
CCDSiCCDS36744.1.
RefSeqiNP_766176.1. NM_172588.2.
UniGeneiMm.297970.

3D structure databases

ProteinModelPortaliQ8BHJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047547.

PTM databases

iPTMnetiQ8BHJ6.
PhosphoSitePlusiQ8BHJ6.

Proteomic databases

PaxDbiQ8BHJ6.
PeptideAtlasiQ8BHJ6.
PRIDEiQ8BHJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703.
GeneIDi218442.
KEGGimmu:218442.
UCSCiuc007rkt.1. mouse.

Organism-specific databases

CTDi256987.
MGIiMGI:2444223. Serinc5.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ8BHJ6.
OMAiCCPTREF.
OrthoDBiEOG091G06BW.
PhylomeDBiQ8BHJ6.
TreeFamiTF312881.

Enzyme and pathway databases

ReactomeiR-MMU-977347. Serine biosynthesis.

Miscellaneous databases

PROiQ8BHJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021703.
GenevisibleiQ8BHJ6. MM.

Family and domain databases

InterProiIPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC5_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ6
Secondary accession number(s): Q80ZH8, Q8CHM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.