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Q8BHJ6

- SERC5_MOUSE

UniProt

Q8BHJ6 - SERC5_MOUSE

Protein

Serine incorporator 5

Gene

Serinc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes By similarity.By similarity

    GO - Biological processi

    1. myelination Source: MGI
    2. phosphatidylserine metabolic process Source: HGNC
    3. phospholipid biosynthetic process Source: UniProtKB-KW
    4. positive regulation of transferase activity Source: HGNC

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine incorporator 5
    Alternative name(s):
    Axotomy-induced glycoprotein 3
    Short name:
    AIGP-3
    Gene namesi
    Name:Serinc5
    Synonyms:Aigp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2444223. Serinc5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi apparatus Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. myelin sheath Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Serine incorporator 5PRO_0000330632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8BHJ6.
    PRIDEiQ8BHJ6.

    PTM databases

    PhosphoSiteiQ8BHJ6.

    Expressioni

    Gene expression databases

    BgeeiQ8BHJ6.
    GenevestigatoriQ8BHJ6.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini58 – 9033CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 12514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 15711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 20022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 23110CytoplasmicSequence Analysis
    Topological domaini253 – 2608ExtracellularSequence Analysis
    Topological domaini282 – 31231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 39259ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini414 – 4229CytoplasmicSequence Analysis
    Topological domaini444 – 46118ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 2622Cys-richAdd
    BLAST
    Compositional biasi132 – 1354Poly-Leu

    Sequence similaritiesi

    Belongs to the TDE1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247442.
    GeneTreeiENSGT00550000074522.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    InParanoidiQ8BHJ6.
    OMAiFWVKMAS.
    OrthoDBiEOG7N8ZWM.
    PhylomeDBiQ8BHJ6.
    TreeFamiTF312881.

    Family and domain databases

    InterProiIPR029555. Serinc5.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF16. PTHR10383:SF16. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BHJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSARCCAGQL ACCCGSAGCS LCCGCCPKFR QSRTTRFMYL FYFILVIALC    50
    CVMMTPSVMK QVKDHIPFFE EFCKKTQAGG DACENLVGYS AVYRVCFGMA 100
    CFFALFCLLT LKVNNSKSCR AYIHNGFWFF KLLLLGAMCS GAFFIPDQET 150
    FLKVWRYVGA GGSFLFICIQ LLLIVQFAHK WNKNWTAGTV RNKLWYASLS 200
    LVTLIMYSVA VGGLALMAVF YTQWDDCMDN KILLGVHGGL CVLISLVAIS 250
    PCVQNRQPHS GLLQSGLISC YVTYLTFSAL TSKPEKKVLD EHGKNVTICA 300
    PDFGQDLHRD ENMVTWLGTL LLIVCISYSC LTSTTRSSSD ALQSRYGAPE 350
    LEVARCCFCF GPDGEDTEEQ QNVKKGPRVI YDEKKGTVYS YSYFHFVFFL 400
    ASLYVMMTLT SWFHYENATI KTFFSGWSVF WVKMASCWMC VLLYLQTLVA 450
    PLCCPSRQFS V 461
    Length:461
    Mass (Da):51,831
    Last modified:March 1, 2003 - v1
    Checksum:i13698C24FFEFEBD9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681F → S in BAC44829. (PubMed:12486168)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029501 mRNA. Translation: BAC44829.1.
    AK037699 mRNA. Translation: BAC29851.1.
    AK054475 mRNA. Translation: BAC35794.1.
    AK136799 mRNA. Translation: BAE23132.1.
    AK165334 mRNA. Translation: BAE38139.1.
    BC049189 mRNA. Translation: AAH49189.2.
    BC062131 mRNA. Translation: AAH62131.1.
    CCDSiCCDS36744.1.
    RefSeqiNP_766176.1. NM_172588.2.
    UniGeneiMm.297970.

    Genome annotation databases

    EnsembliENSMUST00000049488; ENSMUSP00000047547; ENSMUSG00000021703.
    GeneIDi218442.
    KEGGimmu:218442.
    UCSCiuc007rkt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029501 mRNA. Translation: BAC44829.1 .
    AK037699 mRNA. Translation: BAC29851.1 .
    AK054475 mRNA. Translation: BAC35794.1 .
    AK136799 mRNA. Translation: BAE23132.1 .
    AK165334 mRNA. Translation: BAE38139.1 .
    BC049189 mRNA. Translation: AAH49189.2 .
    BC062131 mRNA. Translation: AAH62131.1 .
    CCDSi CCDS36744.1.
    RefSeqi NP_766176.1. NM_172588.2.
    UniGenei Mm.297970.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BHJ6.

    Proteomic databases

    PaxDbi Q8BHJ6.
    PRIDEi Q8BHJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049488 ; ENSMUSP00000047547 ; ENSMUSG00000021703 .
    GeneIDi 218442.
    KEGGi mmu:218442.
    UCSCi uc007rkt.1. mouse.

    Organism-specific databases

    CTDi 256987.
    MGIi MGI:2444223. Serinc5.

    Phylogenomic databases

    eggNOGi NOG247442.
    GeneTreei ENSGT00550000074522.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    InParanoidi Q8BHJ6.
    OMAi FWVKMAS.
    OrthoDBi EOG7N8ZWM.
    PhylomeDBi Q8BHJ6.
    TreeFami TF312881.

    Miscellaneous databases

    NextBioi 376292.
    PROi Q8BHJ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BHJ6.
    Genevestigatori Q8BHJ6.

    Family and domain databases

    InterProi IPR029555. Serinc5.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF16. PTHR10383:SF16. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress."
      Aoki S., Su Q., Li H., Nishikawa K., Ayukawa K., Hara Y., Namikawa K., Kiryu-Seo S., Kiyama H., Wada K.
      J. Neurosci. 22:10751-10760(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon, Ovary, Spleen and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb and Olfactory epithelium.

    Entry informationi

    Entry nameiSERC5_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHJ6
    Secondary accession number(s): Q80ZH8, Q8CHM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3