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Protein

F-box-like/WD repeat-containing protein TBL1XR1

Gene

Tbl1xr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • protein N-terminus binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • adipose tissue development Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • fat pad development Source: MGI
  • histone deacetylation Source: GO_Central
  • lipid catabolic process Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  • regulation of cAMP metabolic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of triglyceride metabolic process Source: MGI
  • response to dietary excess Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • white fat cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1XR1
Alternative name(s):
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1
TBL1-related protein 1
Transducin beta-like 1X-related protein 1
Gene namesi
Name:Tbl1xr1
Synonyms:Ira1, Tblr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441730. Tbl1xr1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000512672 – 514F-box-like/WD repeat-containing protein TBL1XR1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei102N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BHJ5.
MaxQBiQ8BHJ5.
PaxDbiQ8BHJ5.
PeptideAtlasiQ8BHJ5.
PRIDEiQ8BHJ5.

PTM databases

iPTMnetiQ8BHJ5.
PhosphoSitePlusiQ8BHJ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027630.
CleanExiMM_TBL1XR1.
ExpressionAtlasiQ8BHJ5. baseline and differential.
GenevisibleiQ8BHJ5. MM.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219863. 4 interactors.
DIPiDIP-38606N.
IntActiQ8BHJ5. 4 interactors.
MINTiMINT-4137157.
STRINGi10090.ENSMUSP00000067164.

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi159 – 161Combined sources3
Beta strandi162 – 165Combined sources4
Beta strandi172 – 177Combined sources6
Beta strandi179 – 188Combined sources10
Beta strandi193 – 197Combined sources5
Beta strandi207 – 211Combined sources5
Beta strandi228 – 233Combined sources6
Beta strandi237 – 244Combined sources8
Beta strandi247 – 253Combined sources7
Beta strandi258 – 264Combined sources7
Beta strandi269 – 274Combined sources6
Beta strandi276 – 285Combined sources10
Beta strandi290 – 294Combined sources5
Turni295 – 297Combined sources3
Beta strandi299 – 304Combined sources6
Beta strandi311 – 326Combined sources16
Beta strandi329 – 335Combined sources7
Beta strandi342 – 346Combined sources5
Beta strandi352 – 357Combined sources6
Beta strandi364 – 368Combined sources5
Beta strandi373 – 376Combined sources4
Beta strandi384 – 387Combined sources4
Beta strandi394 – 399Combined sources6
Beta strandi403 – 407Combined sources5
Beta strandi414 – 419Combined sources6
Beta strandi424 – 428Combined sources5
Turni429 – 432Combined sources4
Beta strandi433 – 438Combined sources6
Beta strandi445 – 450Combined sources6
Beta strandi454 – 461Combined sources8
Beta strandi464 – 470Combined sources7
Turni471 – 473Combined sources3
Beta strandi476 – 481Combined sources6
Beta strandi486 – 491Combined sources6
Beta strandi493 – 502Combined sources10
Beta strandi507 – 511Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NAFX-ray2.49A/B/C/D134-514[»]
ProteinModelPortaliQ8BHJ5.
SMRiQ8BHJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36LisHPROSITE-ProRule annotationAdd BLAST33
Domaini41 – 86F-box-likeAdd BLAST46
Repeati167 – 206WD 1Add BLAST40
Repeati223 – 262WD 2Add BLAST40
Repeati264 – 303WD 3Add BLAST40
Repeati306 – 344WD 4Add BLAST39
Repeati347 – 386WD 5Add BLAST40
Repeati389 – 437WD 6Add BLAST49
Repeati440 – 479WD 7Add BLAST40
Repeati481 – 513WD 8Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 117Poly-Ala10

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQU2. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00880000137922.
HOGENOMiHOG000220902.
HOVERGENiHBG050240.
InParanoidiQ8BHJ5.
KOiK04508.
OMAiKWDPQGQ.
OrthoDBiEOG091G04MW.
PhylomeDBiQ8BHJ5.
TreeFamiTF323190.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI
60 70 80 90 100
SIIQKGLQYV EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR
110 120 130 140 150
DKLAQQHAAA AAAAAAATNQ QGSAKNGENT ANGEENGAHT IANNHTDMME
160 170 180 190 200
VDGDVEIPSN KAVVLRGHES EVFICAWNPV SDLLASGSGD STARIWNLSE
210 220 230 240 250
NSTSGPTQLV LRHCIREGGQ DVPSNKDVTS LDWNSEGTLL ATGSYDGFAR
260 270 280 290 300
IWTKDGNLAS TLGQHKGPIF ALKWNKKGNF ILSAGVDKTT IIWDAHTGEA
310 320 330 340 350
KQQFPFHSAP ALDVDWQSNN TFASCSTDMC IHVCKLGQDR PIKTFQGHTN
360 370 380 390 400
EVNAIKWDPT GNLLASCSDD MTLKIWSMKQ DNCVHDLQAH NKEIYTIKWS
410 420 430 440 450
PTGPGTNNPN ANLMLASASF DSTVRLWDVD RGICIHTLTK HQEPVYSVAF
460 470 480 490 500
SPDGRYLASG SFDKCVHIWN TQTGALVHSY RGTGGIFEVC WNAAGDKVGA
510
SASDGSVCVL DLRK
Length:514
Mass (Da):55,661
Last modified:March 1, 2003 - v1
Checksum:i13BEC1C2C7F8BF14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185A → V in AAG44738 (PubMed:11063877).Curated1
Sequence conflicti374K → R in BAC29294 (PubMed:16141072).Curated1
Sequence conflicti480Y → C in AAH18512 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268195 mRNA. Translation: AAG44738.1.
AK029595 mRNA. Translation: BAC26526.1.
AK033347 mRNA. Translation: BAC28241.1.
AK036064 mRNA. Translation: BAC29294.1.
AK136255 mRNA. Translation: BAE22898.1.
BC018512 mRNA. Translation: AAH18512.1.
CCDSiCCDS17266.1.
RefSeqiNP_109657.2. NM_030732.3.
XP_006535642.1. XM_006535579.3.
XP_006535643.1. XM_006535580.3.
XP_011248020.1. XM_011249718.2.
XP_011248021.1. XM_011249719.2.
XP_011248023.1. XM_011249721.2.
XP_017175306.1. XM_017319817.1.
UniGeneiMm.202966.
Mm.446265.

Genome annotation databases

EnsembliENSMUST00000063988; ENSMUSP00000067164; ENSMUSG00000027630.
ENSMUST00000192328; ENSMUSP00000141363; ENSMUSG00000027630.
ENSMUST00000193734; ENSMUSP00000142184; ENSMUSG00000027630.
ENSMUST00000202747; ENSMUSP00000144436; ENSMUSG00000027630.
GeneIDi81004.
KEGGimmu:81004.
UCSCiuc008osw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTBL1R_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ5
Secondary accession number(s): Q3UWL6
, Q8CBG4, Q8VEG3, Q9EQD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families