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Protein

F-box-like/WD repeat-containing protein TBL1XR1

Gene

Tbl1xr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • protein N-terminus binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • adipose tissue development Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • fat pad development Source: MGI
  • histone deacetylation Source: GO_Central
  • lipid catabolic process Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  • regulation of cAMP metabolic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of triglyceride metabolic process Source: MGI
  • response to dietary excess Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1XR1
Alternative name(s):
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1
TBL1-related protein 1
Transducin beta-like 1X-related protein 1
Gene namesi
Name:Tbl1xr1
Synonyms:Ira1, Tblr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441730. Tbl1xr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 514513F-box-like/WD repeat-containing protein TBL1XR1PRO_0000051267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei102 – 1021N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BHJ5.
MaxQBiQ8BHJ5.
PaxDbiQ8BHJ5.
PeptideAtlasiQ8BHJ5.
PRIDEiQ8BHJ5.

PTM databases

iPTMnetiQ8BHJ5.
PhosphoSiteiQ8BHJ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027630.
CleanExiMM_TBL1XR1.
ExpressionAtlasiQ8BHJ5. baseline and differential.
GenevisibleiQ8BHJ5. MM.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219863. 4 interactions.
IntActiQ8BHJ5. 4 interactions.
MINTiMINT-4137157.
STRINGi10090.ENSMUSP00000067164.

Structurei

3D structure databases

ProteinModelPortaliQ8BHJ5.
SMRiQ8BHJ5. Positions 1-68, 88-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3633LisHPROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8646F-box-likeAdd
BLAST
Repeati167 – 20640WD 1Add
BLAST
Repeati223 – 26240WD 2Add
BLAST
Repeati264 – 30340WD 3Add
BLAST
Repeati306 – 34439WD 4Add
BLAST
Repeati347 – 38640WD 5Add
BLAST
Repeati389 – 43749WD 6Add
BLAST
Repeati440 – 47940WD 7Add
BLAST
Repeati481 – 51333WD 8Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 11710Poly-Ala

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated
Contains 1 F-box-like domain.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQU2. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
HOVERGENiHBG050240.
InParanoidiQ8BHJ5.
KOiK04508.
OMAiEPRTEKT.
OrthoDBiEOG091G04MW.
PhylomeDBiQ8BHJ5.
TreeFamiTF323190.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI
60 70 80 90 100
SIIQKGLQYV EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR
110 120 130 140 150
DKLAQQHAAA AAAAAAATNQ QGSAKNGENT ANGEENGAHT IANNHTDMME
160 170 180 190 200
VDGDVEIPSN KAVVLRGHES EVFICAWNPV SDLLASGSGD STARIWNLSE
210 220 230 240 250
NSTSGPTQLV LRHCIREGGQ DVPSNKDVTS LDWNSEGTLL ATGSYDGFAR
260 270 280 290 300
IWTKDGNLAS TLGQHKGPIF ALKWNKKGNF ILSAGVDKTT IIWDAHTGEA
310 320 330 340 350
KQQFPFHSAP ALDVDWQSNN TFASCSTDMC IHVCKLGQDR PIKTFQGHTN
360 370 380 390 400
EVNAIKWDPT GNLLASCSDD MTLKIWSMKQ DNCVHDLQAH NKEIYTIKWS
410 420 430 440 450
PTGPGTNNPN ANLMLASASF DSTVRLWDVD RGICIHTLTK HQEPVYSVAF
460 470 480 490 500
SPDGRYLASG SFDKCVHIWN TQTGALVHSY RGTGGIFEVC WNAAGDKVGA
510
SASDGSVCVL DLRK
Length:514
Mass (Da):55,661
Last modified:March 1, 2003 - v1
Checksum:i13BEC1C2C7F8BF14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851A → V in AAG44738 (PubMed:11063877).Curated
Sequence conflicti374 – 3741K → R in BAC29294 (PubMed:16141072).Curated
Sequence conflicti480 – 4801Y → C in AAH18512 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268195 mRNA. Translation: AAG44738.1.
AK029595 mRNA. Translation: BAC26526.1.
AK033347 mRNA. Translation: BAC28241.1.
AK036064 mRNA. Translation: BAC29294.1.
AK136255 mRNA. Translation: BAE22898.1.
BC018512 mRNA. Translation: AAH18512.1.
CCDSiCCDS17266.1.
RefSeqiNP_109657.2. NM_030732.3.
XP_006535642.1. XM_006535579.2.
XP_006535643.1. XM_006535580.2.
XP_011248020.1. XM_011249718.1.
XP_011248021.1. XM_011249719.1.
XP_011248022.1. XM_011249720.1.
XP_011248023.1. XM_011249721.1.
XP_011248024.1. XM_011249722.1.
UniGeneiMm.202966.
Mm.446265.

Genome annotation databases

EnsembliENSMUST00000063988; ENSMUSP00000067164; ENSMUSG00000027630.
ENSMUST00000192328; ENSMUSP00000141363; ENSMUSG00000027630.
ENSMUST00000193734; ENSMUSP00000142184; ENSMUSG00000027630.
ENSMUST00000202747; ENSMUSP00000144436; ENSMUSG00000027630.
GeneIDi81004.
KEGGimmu:81004.
UCSCiuc008osw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268195 mRNA. Translation: AAG44738.1.
AK029595 mRNA. Translation: BAC26526.1.
AK033347 mRNA. Translation: BAC28241.1.
AK036064 mRNA. Translation: BAC29294.1.
AK136255 mRNA. Translation: BAE22898.1.
BC018512 mRNA. Translation: AAH18512.1.
CCDSiCCDS17266.1.
RefSeqiNP_109657.2. NM_030732.3.
XP_006535642.1. XM_006535579.2.
XP_006535643.1. XM_006535580.2.
XP_011248020.1. XM_011249718.1.
XP_011248021.1. XM_011249719.1.
XP_011248022.1. XM_011249720.1.
XP_011248023.1. XM_011249721.1.
XP_011248024.1. XM_011249722.1.
UniGeneiMm.202966.
Mm.446265.

3D structure databases

ProteinModelPortaliQ8BHJ5.
SMRiQ8BHJ5. Positions 1-68, 88-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219863. 4 interactions.
IntActiQ8BHJ5. 4 interactions.
MINTiMINT-4137157.
STRINGi10090.ENSMUSP00000067164.

PTM databases

iPTMnetiQ8BHJ5.
PhosphoSiteiQ8BHJ5.

Proteomic databases

EPDiQ8BHJ5.
MaxQBiQ8BHJ5.
PaxDbiQ8BHJ5.
PeptideAtlasiQ8BHJ5.
PRIDEiQ8BHJ5.

Protocols and materials databases

DNASUi81004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063988; ENSMUSP00000067164; ENSMUSG00000027630.
ENSMUST00000192328; ENSMUSP00000141363; ENSMUSG00000027630.
ENSMUST00000193734; ENSMUSP00000142184; ENSMUSG00000027630.
ENSMUST00000202747; ENSMUSP00000144436; ENSMUSG00000027630.
GeneIDi81004.
KEGGimmu:81004.
UCSCiuc008osw.1. mouse.

Organism-specific databases

CTDi79718.
MGIiMGI:2441730. Tbl1xr1.

Phylogenomic databases

eggNOGiENOG410IQU2. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
HOVERGENiHBG050240.
InParanoidiQ8BHJ5.
KOiK04508.
OMAiEPRTEKT.
OrthoDBiEOG091G04MW.
PhylomeDBiQ8BHJ5.
TreeFamiTF323190.

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

ChiTaRSiTbl1xr1. mouse.
PROiQ8BHJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027630.
CleanExiMM_TBL1XR1.
ExpressionAtlasiQ8BHJ5. baseline and differential.
GenevisibleiQ8BHJ5. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBL1R_MOUSE
AccessioniPrimary (citable) accession number: Q8BHJ5
Secondary accession number(s): Q3UWL6
, Q8CBG4, Q8VEG3, Q9EQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.