Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase NIM1

Gene

Nim1k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation at Thr-229, probably by autophosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103ATPPROSITE-ProRule annotationBy similarity1
Active sitei196Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 88ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase NIM1 (EC:2.7.11.1)
Alternative name(s):
NIM1 serine/threonine-protein kinase
Gene namesi
Name:Nim1k
Synonyms:Nim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442399. Nim1k.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476671 – 436Serine/threonine-protein kinase NIM1Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BHI9.
PRIDEiQ8BHI9.

PTM databases

iPTMnetiQ8BHI9.
PhosphoSitePlusiQ8BHI9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000095930.
CleanExiMM_E130304F04RIK.
ExpressionAtlasiQ8BHI9. baseline and differential.
GenevisibleiQ8BHI9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136377.

Structurei

3D structure databases

ProteinModelPortaliQ8BHI9.
SMRiQ8BHI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG082029.
InParanoidiQ8BHI9.
KOiK16310.
OMAiYARWDRR.
OrthoDBiEOG091G07AG.
PhylomeDBiQ8BHI9.
TreeFamiTF320558.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVFVNGGG LVNTHCDRWE RRDSVESSCQ TEGGKDSEED QQRQLTPFEK
60 70 80 90 100
LTQDMCQDEK VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV
110 120 130 140 150
AIKILDKTKL DQKTQRLLSR EISSMEKLHH PNIVRLYEVV ETLSKLHLVM
160 170 180 190 200
EYAGGGELFG KISTEGKLSE PESKLIFSQI LSAVKHMHEN QIIHRDLKAE
210 220 230 240 250
NVFYTSRTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE LFRDQHYVGV
260 270 280 290 300
YVDIWALGVL LYFMVTGTMP FRAETVAKLK KSILEGTYTI PQHVSEPCHR
310 320 330 340 350
LIRGVLQPTP TERYGINYIM SNEWMRGVPY PTPLEPFQLD PKHLSETSTL
360 370 380 390 400
KEEENEVKST LEHLGITDEH IRNNQGRDAR SSITGVYRII LHRVQRRKAL
410 420 430
ESVPIMILPE PKERDLKKGS RIYRGIRHTS KFCSIL
Length:436
Mass (Da):49,777
Last modified:March 1, 2003 - v1
Checksum:i15EF3210F49B2EC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295S → F in BAC31934 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044462 mRNA. Translation: BAC31934.1.
AK048694 mRNA. Translation: BAC33424.1.
AK053734 mRNA. Translation: BAC35497.1.
BC051189 mRNA. Translation: AAH51189.2.
BC106122 mRNA. Translation: AAI06123.1.
BC117955 mRNA. Translation: AAI17956.1.
BC117956 mRNA. Translation: AAI17957.1.
CCDSiCCDS56902.1.
RefSeqiNP_780747.1. NM_175538.3.
UniGeneiMm.403943.

Genome annotation databases

EnsembliENSMUST00000178142; ENSMUSP00000136377; ENSMUSG00000095930.
GeneIDi245269.
KEGGimmu:245269.
UCSCiuc007rzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044462 mRNA. Translation: BAC31934.1.
AK048694 mRNA. Translation: BAC33424.1.
AK053734 mRNA. Translation: BAC35497.1.
BC051189 mRNA. Translation: AAH51189.2.
BC106122 mRNA. Translation: AAI06123.1.
BC117955 mRNA. Translation: AAI17956.1.
BC117956 mRNA. Translation: AAI17957.1.
CCDSiCCDS56902.1.
RefSeqiNP_780747.1. NM_175538.3.
UniGeneiMm.403943.

3D structure databases

ProteinModelPortaliQ8BHI9.
SMRiQ8BHI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136377.

PTM databases

iPTMnetiQ8BHI9.
PhosphoSitePlusiQ8BHI9.

Proteomic databases

PaxDbiQ8BHI9.
PRIDEiQ8BHI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178142; ENSMUSP00000136377; ENSMUSG00000095930.
GeneIDi245269.
KEGGimmu:245269.
UCSCiuc007rzu.1. mouse.

Organism-specific databases

CTDi167359.
MGIiMGI:2442399. Nim1k.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG082029.
InParanoidiQ8BHI9.
KOiK16310.
OMAiYARWDRR.
OrthoDBiEOG091G07AG.
PhylomeDBiQ8BHI9.
TreeFamiTF320558.

Miscellaneous databases

PROiQ8BHI9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000095930.
CleanExiMM_E130304F04RIK.
ExpressionAtlasiQ8BHI9. baseline and differential.
GenevisibleiQ8BHI9. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIM1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHI9
Secondary accession number(s): Q148V1, Q80XC1, Q8BXQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.