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Protein

Ras-related protein Rab-9B

Gene

Rab9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans Golgi network.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi33 – 34GTPBy similarity2
Nucleotide bindingi38 – 39GTPBy similarity2
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi155 – 156GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9B
Gene namesi
Name:Rab9b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442454. Rab9b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211431 – 201Ras-related protein Rab-9BAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ8BHH2.
PaxDbiQ8BHH2.
PRIDEiQ8BHH2.

PTM databases

iPTMnetiQ8BHH2.
PhosphoSitePlusiQ8BHH2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043463.
CleanExiMM_RAB9B.
ExpressionAtlasiQ8BHH2. baseline and differential.
GenevisibleiQ8BHH2. MM.

Interactioni

Subunit structurei

Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:25220469). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity).By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-61069N.
IntActiQ8BHH2. 10 interactors.
STRINGi10090.ENSMUSP00000049739.

Structurei

3D structure databases

ProteinModelPortaliQ8BHH2.
SMRiQ8BHH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ8BHH2.
KOiK07900.
OMAiLSNWQKE.
OrthoDBiEOG091G0JIV.
PhylomeDBiQ8BHH2.
TreeFamiTF326442.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKSLLLKV ILLGDGGVGK SSLMNRYVTN KFDSQAFHTI GVEFLNRDLE
60 70 80 90 100
VDGRFVTLQI WDTAGQERFK SLRTPFYRGA DCCLLTFSVD DRQSFENLGN
110 120 130 140 150
WQKEFIYYAD VKDPDHFPFV VLGNKVDKED RQVTTEEAQA WCMENGNYPY
160 170 180 190 200
LETSAKDDTN VTVAFEEAVR QVLAVEEQLE HCMLGHTIDL NSGSKASSSC

C
Length:201
Mass (Da):22,704
Last modified:March 1, 2003 - v1
Checksum:i1E28B18F8F8DDDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034442 mRNA. Translation: BAC28710.1.
AK049693 mRNA. Translation: BAC33876.1.
CCDSiCCDS30425.1.
RefSeqiNP_795945.1. NM_176971.2.
UniGeneiMm.44557.

Genome annotation databases

EnsembliENSMUST00000058814; ENSMUSP00000049739; ENSMUSG00000043463.
GeneIDi319642.
KEGGimmu:319642.
UCSCiuc009uje.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034442 mRNA. Translation: BAC28710.1.
AK049693 mRNA. Translation: BAC33876.1.
CCDSiCCDS30425.1.
RefSeqiNP_795945.1. NM_176971.2.
UniGeneiMm.44557.

3D structure databases

ProteinModelPortaliQ8BHH2.
SMRiQ8BHH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61069N.
IntActiQ8BHH2. 10 interactors.
STRINGi10090.ENSMUSP00000049739.

PTM databases

iPTMnetiQ8BHH2.
PhosphoSitePlusiQ8BHH2.

Proteomic databases

MaxQBiQ8BHH2.
PaxDbiQ8BHH2.
PRIDEiQ8BHH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058814; ENSMUSP00000049739; ENSMUSG00000043463.
GeneIDi319642.
KEGGimmu:319642.
UCSCiuc009uje.1. mouse.

Organism-specific databases

CTDi51209.
MGIiMGI:2442454. Rab9b.

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ8BHH2.
KOiK07900.
OMAiLSNWQKE.
OrthoDBiEOG091G0JIV.
PhylomeDBiQ8BHH2.
TreeFamiTF326442.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ8BHH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043463.
CleanExiMM_RAB9B.
ExpressionAtlasiQ8BHH2. baseline and differential.
GenevisibleiQ8BHH2. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.