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Protein

Ras-related protein Rab-9B

Gene

Rab9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans Golgi network.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi33 – 34GTPBy similarity2
Nucleotide bindingi38 – 39GTPBy similarity2
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi155 – 156GTPBy similarity2

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9B
Gene namesi
Name:Rab9b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442454 Rab9b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211431 – 201Ras-related protein Rab-9BAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ8BHH2
PaxDbiQ8BHH2
PRIDEiQ8BHH2

PTM databases

iPTMnetiQ8BHH2
PhosphoSitePlusiQ8BHH2

Expressioni

Gene expression databases

BgeeiENSMUSG00000043463
CleanExiMM_RAB9B
ExpressionAtlasiQ8BHH2 baseline and differential
GenevisibleiQ8BHH2 MM

Interactioni

Subunit structurei

Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:25220469). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-61069N
IntActiQ8BHH2, 12 interactors
STRINGi10090.ENSMUSP00000049739

Structurei

3D structure databases

ProteinModelPortaliQ8BHH2
SMRiQ8BHH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8BHH2
KOiK07900
OMAiRAWCEEN
OrthoDBiEOG091G0JIV
PhylomeDBiQ8BHH2
TreeFamiTF326442

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKSLLLKV ILLGDGGVGK SSLMNRYVTN KFDSQAFHTI GVEFLNRDLE
60 70 80 90 100
VDGRFVTLQI WDTAGQERFK SLRTPFYRGA DCCLLTFSVD DRQSFENLGN
110 120 130 140 150
WQKEFIYYAD VKDPDHFPFV VLGNKVDKED RQVTTEEAQA WCMENGNYPY
160 170 180 190 200
LETSAKDDTN VTVAFEEAVR QVLAVEEQLE HCMLGHTIDL NSGSKASSSC

C
Length:201
Mass (Da):22,704
Last modified:March 1, 2003 - v1
Checksum:i1E28B18F8F8DDDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034442 mRNA Translation: BAC28710.1
AK049693 mRNA Translation: BAC33876.1
CCDSiCCDS30425.1
RefSeqiNP_795945.1, NM_176971.2
UniGeneiMm.44557

Genome annotation databases

EnsembliENSMUST00000058814; ENSMUSP00000049739; ENSMUSG00000043463
GeneIDi319642
KEGGimmu:319642
UCSCiuc009uje.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB9B_MOUSE
AccessioniPrimary (citable) accession number: Q8BHH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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