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Protein

Aquaporin-11

Gene

Aqp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

  • water channel activity Source: MGI

GO - Biological processi

  • endosomal lumen acidification Source: MGI
  • kidney development Source: MGI
  • protein homooligomerization Source: Ensembl
  • proximal tubule development Source: MGI
  • water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:Aqp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913583. Aqp11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • dendrite Source: Ensembl
  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639691 – 271Aquaporin-11Add BLAST271

Proteomic databases

PaxDbiQ8BHH1.
PRIDEiQ8BHH1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042797.
CleanExiMM_AQP11.
ExpressionAtlasiQ8BHH1. baseline and differential.
GenevisibleiQ8BHH1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082054.

Structurei

3D structure databases

ProteinModelPortaliQ8BHH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 101NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8BHH1.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG091G0JBQ.
PhylomeDBiQ8BHH1.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BHH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLGLRPE VQDTCISLGL MLLFVLFVGL ARVIARQQLH RPVVHAFVLE
60 70 80 90 100
FLATFQLCCC THELQVLSEQ DSAHPTWTLT LIYFFSLVHG LTLVGTASNP
110 120 130 140 150
CGVMMQMILG GMSPEMGAVR LLAQLVSALC SRYCISALWS LSLTKYHYDE
160 170 180 190 200
RILACRNPIH TDMSKAIIIE AICSFIFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLAYAGGSL TGALFNPALA LSLHFPCFDE LFYKFFVVYW LAPSVGVLMM
260 270
ILMFSFFLPW LHNNQMTNKK E
Length:271
Mass (Da):30,481
Last modified:March 1, 2003 - v1
Checksum:i1E88F989B3889226
GO

Sequence cautioni

The sequence AAH37088 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028148 mRNA. Translation: BAC45005.1.
AK075757 mRNA. Translation: BAC35935.1.
BC037088 mRNA. Translation: AAH37088.1. Different initiation.
CCDSiCCDS21463.1.
RefSeqiNP_780314.1. NM_175105.3.
UniGeneiMm.29756.

Genome annotation databases

EnsembliENSMUST00000206389; ENSMUSP00000146215; ENSMUSG00000042797.
GeneIDi66333.
KEGGimmu:66333.
UCSCiuc009ijs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028148 mRNA. Translation: BAC45005.1.
AK075757 mRNA. Translation: BAC35935.1.
BC037088 mRNA. Translation: AAH37088.1. Different initiation.
CCDSiCCDS21463.1.
RefSeqiNP_780314.1. NM_175105.3.
UniGeneiMm.29756.

3D structure databases

ProteinModelPortaliQ8BHH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082054.

Proteomic databases

PaxDbiQ8BHH1.
PRIDEiQ8BHH1.

Protocols and materials databases

DNASUi66333.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000206389; ENSMUSP00000146215; ENSMUSG00000042797.
GeneIDi66333.
KEGGimmu:66333.
UCSCiuc009ijs.1. mouse.

Organism-specific databases

CTDi282679.
MGIiMGI:1913583. Aqp11.

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8BHH1.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG091G0JBQ.
PhylomeDBiQ8BHH1.
TreeFamiTF320251.

Miscellaneous databases

PROiQ8BHH1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042797.
CleanExiMM_AQP11.
ExpressionAtlasiQ8BHH1. baseline and differential.
GenevisibleiQ8BHH1. MM.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAQP11_MOUSE
AccessioniPrimary (citable) accession number: Q8BHH1
Secondary accession number(s): Q8JZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.