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Protein

Aquaporin-11

Gene

Aqp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

  • water channel activity Source: MGI

GO - Biological processi

  • endosomal lumen acidification Source: MGI
  • kidney development Source: MGI
  • protein homooligomerization Source: Ensembl
  • proximal tubule development Source: MGI
  • water transport Source: MGI

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:Aqp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913583 Aqp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639691 – 271Aquaporin-11Add BLAST271

Proteomic databases

PaxDbiQ8BHH1
PRIDEiQ8BHH1

PTM databases

SwissPalmiQ8BHH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042797
CleanExiMM_AQP11
ExpressionAtlasiQ8BHH1 baseline and differential
GenevisibleiQ8BHH1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082054

Structurei

3D structure databases

ProteinModelPortaliQ8BHH1
SMRiQ8BHH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 101NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS Eukaryota
ENOG4111GCP LUCA
GeneTreeiENSGT00530000063816
HOGENOMiHOG000034024
HOVERGENiHBG050556
InParanoidiQ8BHH1
KOiK09870
OMAiCCTHELQ
OrthoDBiEOG091G0JBQ
PhylomeDBiQ8BHH1
TreeFamiTF320251

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023266 Aquaporin_11
IPR016697 Aquaporin_11/12
IPR000425 MIP
PANTHERiPTHR21191:SF7 PTHR21191:SF7, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PIRSFiPIRSF017529 Aquaporin_11/12, 1 hit
PRINTSiPR02024 AQUAPORIN11
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLGLRPE VQDTCISLGL MLLFVLFVGL ARVIARQQLH RPVVHAFVLE
60 70 80 90 100
FLATFQLCCC THELQVLSEQ DSAHPTWTLT LIYFFSLVHG LTLVGTASNP
110 120 130 140 150
CGVMMQMILG GMSPEMGAVR LLAQLVSALC SRYCISALWS LSLTKYHYDE
160 170 180 190 200
RILACRNPIH TDMSKAIIIE AICSFIFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLAYAGGSL TGALFNPALA LSLHFPCFDE LFYKFFVVYW LAPSVGVLMM
260 270
ILMFSFFLPW LHNNQMTNKK E
Length:271
Mass (Da):30,481
Last modified:March 1, 2003 - v1
Checksum:i1E88F989B3889226
GO

Sequence cautioni

The sequence AAH37088 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028148 mRNA Translation: BAC45005.1
AK075757 mRNA Translation: BAC35935.1
BC037088 mRNA Translation: AAH37088.1 Different initiation.
CCDSiCCDS21463.1
RefSeqiNP_780314.1, NM_175105.3
UniGeneiMm.29756

Genome annotation databases

EnsembliENSMUST00000206389; ENSMUSP00000146215; ENSMUSG00000042797
GeneIDi66333
KEGGimmu:66333
UCSCiuc009ijs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAQP11_MOUSE
AccessioniPrimary (citable) accession number: Q8BHH1
Secondary accession number(s): Q8JZU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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