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Protein

CGG triplet repeat-binding protein 1

Gene

Cggbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CGG triplet repeat-binding protein 1
Short name:
CGG-binding protein 1
Alternative name(s):
20 kDa CGG-binding protein
p20-CGGBP DNA-binding protein
Gene namesi
Name:Cggbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146370. Cggbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167CGG triplet repeat-binding protein 1PRO_0000252416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei164 – 1641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHG9.
MaxQBiQ8BHG9.
PaxDbiQ8BHG9.
PeptideAtlasiQ8BHG9.
PRIDEiQ8BHG9.

PTM databases

iPTMnetiQ8BHG9.
PhosphoSiteiQ8BHG9.

Expressioni

Gene expression databases

BgeeiQ8BHG9.
CleanExiMM_CGGBP1.
GenevisibleiQ8BHG9. MM.

Interactioni

Protein-protein interaction databases

BioGridi222999. 1 interaction.
IntActiQ8BHG9. 2 interactions.
MINTiMINT-4110542.
STRINGi10090.ENSMUSP00000065845.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 845Nuclear localization signalSequence analysis

Phylogenomic databases

eggNOGiENOG410IE4P. Eukaryota.
ENOG41111EK. LUCA.
GeneTreeiENSGT00390000017898.
HOGENOMiHOG000000684.
HOVERGENiHBG081129.
InParanoidiQ8BHG9.
OMAiTPQDRVT.
OrthoDBiEOG7SXW4N.
PhylomeDBiQ8BHG9.
TreeFamiTF335518.

Family and domain databases

InterProiIPR033375. Cggbp1.
[Graphical view]
PANTHERiPTHR32344. PTHR32344. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BHG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERFVVTAPP ARNRSKTALY VTPLDRVTEF GGELHEDGGK LFCTSCNVVL
60 70 80 90 100
NHVRKSAISD HLKSKTHTKR KAEFEEQNVR KKQRPLTASL QCNSPAQTEK
110 120 130 140 150
ASVIQDFVKM CLEANIPLEK ADHPAVRAFL SRHVKNGGSI PKSDQLRRAY
160
LPDGYENENQ LLSSQDC
Length:167
Mass (Da):18,761
Last modified:March 1, 2003 - v1
Checksum:i1FE797D198A0B7BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189895 Genomic DNA. Translation: AAO32829.1.
AK049631 mRNA. Translation: BAC33847.1.
AK052195 mRNA. Translation: BAC34877.1.
AK083450 mRNA. Translation: BAC38920.1.
BC031191 mRNA. Translation: AAH31191.1.
BC043097 mRNA. Translation: AAH43097.1.
BC057053 mRNA. Translation: AAH57053.1.
CCDSiCCDS28266.1.
RefSeqiNP_848762.1. NM_178647.2.
XP_006521721.1. XM_006521658.1.
UniGeneiMm.10160.

Genome annotation databases

EnsembliENSMUST00000067744; ENSMUSP00000065845; ENSMUSG00000054604.
GeneIDi106143.
KEGGimmu:106143.
UCSCiuc007zqe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189895 Genomic DNA. Translation: AAO32829.1.
AK049631 mRNA. Translation: BAC33847.1.
AK052195 mRNA. Translation: BAC34877.1.
AK083450 mRNA. Translation: BAC38920.1.
BC031191 mRNA. Translation: AAH31191.1.
BC043097 mRNA. Translation: AAH43097.1.
BC057053 mRNA. Translation: AAH57053.1.
CCDSiCCDS28266.1.
RefSeqiNP_848762.1. NM_178647.2.
XP_006521721.1. XM_006521658.1.
UniGeneiMm.10160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222999. 1 interaction.
IntActiQ8BHG9. 2 interactions.
MINTiMINT-4110542.
STRINGi10090.ENSMUSP00000065845.

PTM databases

iPTMnetiQ8BHG9.
PhosphoSiteiQ8BHG9.

Proteomic databases

EPDiQ8BHG9.
MaxQBiQ8BHG9.
PaxDbiQ8BHG9.
PeptideAtlasiQ8BHG9.
PRIDEiQ8BHG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067744; ENSMUSP00000065845; ENSMUSG00000054604.
GeneIDi106143.
KEGGimmu:106143.
UCSCiuc007zqe.1. mouse.

Organism-specific databases

CTDi8545.
MGIiMGI:2146370. Cggbp1.

Phylogenomic databases

eggNOGiENOG410IE4P. Eukaryota.
ENOG41111EK. LUCA.
GeneTreeiENSGT00390000017898.
HOGENOMiHOG000000684.
HOVERGENiHBG081129.
InParanoidiQ8BHG9.
OMAiTPQDRVT.
OrthoDBiEOG7SXW4N.
PhylomeDBiQ8BHG9.
TreeFamiTF335518.

Miscellaneous databases

ChiTaRSiCggbp1. mouse.
PROiQ8BHG9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHG9.
CleanExiMM_CGGBP1.
GenevisibleiQ8BHG9. MM.

Family and domain databases

InterProiIPR033375. Cggbp1.
[Graphical view]
PANTHERiPTHR32344. PTHR32344. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1)."
    Naumann F., Remus R., Schmitz B., Doerfler W.
    Genomics 83:106-118(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Heart and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and Czech II.
    Tissue: Brain and Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiCGBP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHG9
Secondary accession number(s): Q8K2K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.