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Protein

CGG triplet repeat-binding protein 1

Gene

Cggbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter (By similarity).By similarity

Miscellaneous

Binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CGG triplet repeat-binding protein 1
Short name:
CGG-binding protein 1
Alternative name(s):
20 kDa CGG-binding protein
p20-CGGBP DNA-binding protein
Gene namesi
Name:Cggbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146370 Cggbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524161 – 167CGG triplet repeat-binding protein 1Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1
Modified residuei164PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHG9
MaxQBiQ8BHG9
PaxDbiQ8BHG9
PeptideAtlasiQ8BHG9
PRIDEiQ8BHG9

PTM databases

iPTMnetiQ8BHG9
PhosphoSitePlusiQ8BHG9

Expressioni

Gene expression databases

BgeeiENSMUSG00000054604
CleanExiMM_CGGBP1
GenevisibleiQ8BHG9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222999, 1 interactor
IntActiQ8BHG9, 2 interactors
MINTiQ8BHG9
STRINGi10090.ENSMUSP00000065845

Structurei

3D structure databases

SMRiQ8BHG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 84Nuclear localization signalSequence analysis5

Phylogenomic databases

eggNOGiENOG410IE4P Eukaryota
ENOG41111EK LUCA
GeneTreeiENSGT00390000017898
HOGENOMiHOG000000684
HOVERGENiHBG081129
InParanoidiQ8BHG9
OMAiFGSELHE
OrthoDBiEOG091G0O2H
PhylomeDBiQ8BHG9
TreeFamiTF335518

Family and domain databases

InterProiView protein in InterPro
IPR033375 Cggbp1
PANTHERiPTHR32344 PTHR32344, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERFVVTAPP ARNRSKTALY VTPLDRVTEF GGELHEDGGK LFCTSCNVVL
60 70 80 90 100
NHVRKSAISD HLKSKTHTKR KAEFEEQNVR KKQRPLTASL QCNSPAQTEK
110 120 130 140 150
ASVIQDFVKM CLEANIPLEK ADHPAVRAFL SRHVKNGGSI PKSDQLRRAY
160
LPDGYENENQ LLSSQDC
Length:167
Mass (Da):18,761
Last modified:March 1, 2003 - v1
Checksum:i1FE797D198A0B7BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189895 Genomic DNA Translation: AAO32829.1
AK049631 mRNA Translation: BAC33847.1
AK052195 mRNA Translation: BAC34877.1
AK083450 mRNA Translation: BAC38920.1
BC031191 mRNA Translation: AAH31191.1
BC043097 mRNA Translation: AAH43097.1
BC057053 mRNA Translation: AAH57053.1
CCDSiCCDS28266.1
RefSeqiNP_848762.1, NM_178647.2
XP_006521721.1, XM_006521658.2
UniGeneiMm.10160

Genome annotation databases

EnsembliENSMUST00000067744; ENSMUSP00000065845; ENSMUSG00000054604
GeneIDi106143
KEGGimmu:106143
UCSCiuc007zqe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCGBP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHG9
Secondary accession number(s): Q8K2K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health