Reviewed, UniProtKB/Swiss-Prot Q8BHG2 (CA123_MOUSE)

Names and origin

Protein names	Recommended name:     UPF0587 protein C1orf123 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the UPF0587 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BHG2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BHG2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     136-160: DWTDYDEKAQESVGIFEVTHQFVKC → AHVFSSYNCFLQEGTQVWENDMIFLVRRPRDGV

Isoform 3 (identifier: Q8BHG2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MG → MEGVRLGWRGLSREGRGGAWHAAERTRPCTQRVPPSSQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	UPF0587 protein C1orf123 homolog		PRO_0000264152
Natural variations
	Alternative sequence	1 – 2	2	MG → MEGVRLGWRGLSREGRGGAW HAAERTRPCTQRVPPSSQ in isoform 3.		VSP_021887
	Alternative sequence	136 – 160	25	DWTDY…QFVKC → AHVFSSYNCFLQEGTQVWEN DMIFLVRRPRDGV in isoform 2.		VSP_021888
Experimental info
	Sequence conflict	25	1	F → L in BAC34312. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 21329F78F4777F07	FASTA	160	18,020
	10 20 30 40 50 60 MGKIALQLKA TLENVTNLRP VGEDFRWYLK MKCGNCGEIS EKWQYIRLMD SVALKGGRGS 70 80 90 100 110 120 ASMVQKCKLC ARENSIDILS STIKAYNAED NEKFKTIVEF ECRGLEPVDF QPQAGFAADG 130 140 150 160 VESGTVFSDI NLQEKDWTDY DEKAQESVGI FEVTHQFVKC
	Isoform 2. Checksum: 08070CBA77EB6676	FASTA	168	18,961
	10 20 30 40 50 60 MGKIALQLKA TLENVTNLRP VGEDFRWYLK MKCGNCGEIS EKWQYIRLMD SVALKGGRGS 70 80 90 100 110 120 ASMVQKCKLC ARENSIDILS STIKAYNAED NEKFKTIVEF ECRGLEPVDF QPQAGFAADG 130 140 150 160 VESGTVFSDI NLQEKAHVFS SYNCFLQEGT QVWENDMIFL VRRPRDGV
	Isoform 3. Checksum: FE17E8EA2F429118	FASTA	196	22,048
	10 20 30 40 50 60 MEGVRLGWRG LSREGRGGAW HAAERTRPCT QRVPPSSQKI ALQLKATLEN VTNLRPVGED 70 80 90 100 110 120 FRWYLKMKCG NCGEISEKWQ YIRLMDSVAL KGGRGSASMV QKCKLCAREN SIDILSSTIK 130 140 150 160 170 180 AYNAEDNEKF KTIVEFECRG LEPVDFQPQA GFAADGVESG TVFSDINLQE KDWTDYDEKA 190 QESVGIFEVT HQFVKC

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6J. Tissue: Hippocampus, Kidney, Olfactory bulb and Pancreas.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: FVB/N. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002776 mRNA. Translation: BAB22350.1. AK003575 mRNA. Translation: BAB22867.1. AK032590 mRNA. Translation: BAC27937.1. AK050486 mRNA. Translation: BAC34284.1. AK050533 mRNA. Translation: BAC34312.1. AK160674 mRNA. Translation: BAE35952.1. AL611936 Genomic DNA. Translation: CAM23586.1. AL611936 Genomic DNA. Translation: CAM23588.1. BC019215 mRNA. Translation: AAH19215.1.
IPI	IPI00120915. IPI00133735. IPI00649435.
RefSeq	NP_083030.1.
UniGene	Mm.274853
3D structure databases
ModBase	Search...
2-D gel databases
REPRODUCTION-2DPAGE	Q8BHG2.
Proteomic databases
PRIDE	Q8BHG2.
Genome annotation databases
Ensembl	ENSMUST00000030346; ENSMUSP00000030346; ENSMUSG00000028608; Mus musculus. [Genome view] ENSMUST00000030347; ENSMUSP00000030347; ENSMUSG00000028608; Mus musculus. [Genome view] ENSMUST00000106727; ENSMUSP00000102338; ENSMUSG00000028608; Mus musculus. [Genome view]
GeneID	74098.
KEGG	mmu:74098.
UCSC	uc008uak.1. mouse. uc008ual.1. mouse. uc008uam.1. mouse.
Organism-specific databases
MGI	MGI:1921348. 0610037L13Rik.
Phylogenomic databases
HOVERGEN	Q8BHG2.
Gene expression databases
ArrayExpress	Q8BHG2.
Bgee	Q8BHG2.
CleanEx	MM_0610037L13RIK.
Genevestigator	Q8BHG2.
GermOnline	ENSMUSG00000028608. Mus musculus.
Family and domain databases
InterPro	IPR008584. DUF866_euk. [Graphical view]
PANTHER	PTHR12857. DUF866_euk. 1 hit.
Pfam	PF05907. DUF866. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CA123_MOUSE

Accession

Primary (citable) accession number: Q8BHG2
Secondary accession number(s): A2A8E3 , A2A8E5, Q8C7D6, Q9D1H2, Q9DCH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)