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Protein

Nardilysin

Gene

Nrdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Catalytic activityi

Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi244ZincPROSITE-ProRule annotation1
Active sitei247Proton acceptorPROSITE-ProRule annotation1
Metal bindingi248ZincPROSITE-ProRule annotation1
Metal bindingi325ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM16.987.

Names & Taxonomyi

Protein namesi
Recommended name:
Nardilysin (EC:3.4.24.61)
Alternative name(s):
N-arginine dibasic convertase
Short name:
NRD convertase
Short name:
NRD-C
Nardilysin convertaseBy similarity
Gene namesi
Name:NrdcBy similarity
Synonyms:Nrd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1201386. Nrd1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002675619 – 1161NardilysinAdd BLAST1143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHG1.
MaxQBiQ8BHG1.
PaxDbiQ8BHG1.
PRIDEiQ8BHG1.

PTM databases

iPTMnetiQ8BHG1.
PhosphoSitePlusiQ8BHG1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053510.
ExpressionAtlasiQ8BHG1. baseline and differential.
GenevisibleiQ8BHG1. MM.

Interactioni

Protein-protein interaction databases

BioGridi230982. 1 interactor.
IntActiQ8BHG1. 1 interactor.
MINTiMINT-4104130.
STRINGi10090.ENSMUSP00000068328.

Structurei

3D structure databases

ProteinModelPortaliQ8BHG1.
SMRiQ8BHG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 209Asp/Glu-rich (highly acidic)Add BLAST71
Compositional biasi140 – 151Poly-GluAdd BLAST12
Compositional biasi152 – 165Poly-AspAdd BLAST14
Compositional biasi185 – 190Poly-Asp6
Compositional biasi193 – 196Poly-Asp4

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.
HOGENOMiHOG000231160.
HOVERGENiHBG006530.
InParanoidiQ8BHG1.
KOiK01411.
PhylomeDBiQ8BHG1.
TreeFamiTF106274.

Family and domain databases

Gene3Di3.30.830.10. 5 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 5 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRVAVAAV CVTGRKLRCE AGRELTALGR IEARGLCEES SKPFPTLTMP
60 70 80 90 100
GRNKAKSTCS CPDLQPNGQD LGESGRLARL GADESEEEGR SFSNVGDPEI
110 120 130 140 150
IKSPSDPKQY RYIKLQNGLQ ALLISDLSNV EGKTGNATDE EEEEEEEEEE
160 170 180 190 200
EDDDDDDDDD DDDEDSGAEI QDDDEEGFDD EEEFDDDDDD EHDDDDLENE
210 220 230 240 250
ENELEELEER VEARKKTTEK QSAAALCVGV GSFADPDDLP GLAHFLEHMV
260 270 280 290 300
FMGSLKYPDE NGFDAFLKKH GGSDNASTDC ERTVFQFDVQ RKYFKEALDR
310 320 330 340 350
WAQFFIHPLM IRDAIDREVE AVDSEYQLAR PSDANRKEML FGSLARPGHP
360 370 380 390 400
MGKFFWGNAE TLKHEPKKNN IDTHARLREF WMRYYSAHYM TLVVQSKETL
410 420 430 440 450
DTLEKWVTEI FSQIPNNGLP KPNFSHLTDP FDTPAFNKLY RVVPIRKIHA
460 470 480 490 500
LTITWALPPQ QQHYRVKPLH YISWLVGHEG KGSILSYLRK KCWALALFGG
510 520 530 540 550
NGETGFEQNS TYSVFSISIT LTDEGYEHFY EVAHTVFQYL KMLQKLGPEK
560 570 580 590 600
RVFEEIQKIE DNEFHYQEQT DPVEYVENMC ENMQLYPRQD FLTGDQLLFE
610 620 630 640 650
YKPEVIAEAL NQLVPQKANL VLLSGANEGR CDLKEKWFGT QYSIEDIENS
660 670 680 690 700
WTELWKSNFD LNPDLHLPAE NKYIATDFTL KAFDCPETEY PAKIVNTAQG
710 720 730 740 750
CLWYKKDNKF KIPKAYIRFH LISPLIQKSA ANVVLFDIFV NILTHNLAEP
760 770 780 790 800
AYEADVAQLE YKLVAGEHGL IIRVKGFNHK LPLLFQLIID YLTEFSSTPA
810 820 830 840 850
VFTMITEQLK KTYFNILIKP ETLAKDVRLL ILEYSRWSMI DKYQALMDGL
860 870 880 890 900
SLDSLLNFVK DFKSQLFVEG LVQGNVTSTE SMDFLKYVVD KLNFAPLERE
910 920 930 940 950
MPVQFQVVEL PSGHHLCKVR ALNKGDANSE VTVYYQSGTR SLREYTLMEL
960 970 980 990 1000
LVMHMEEPCF DFLRTKQTLG YHVYPTCRNT SGILGFSVTV GTQATKYNSE
1010 1020 1030 1040 1050
TVDKKIEEFL SSFEEKIENL TEDAFNTQVT ALIKLKECED THLGEEVDRN
1060 1070 1080 1090 1100
WNEVVTQQYL FDRLAHEIEA LKSFSKSDLV SWFKAHRGPG SKMLSVHVVG
1110 1120 1130 1140 1150
YGKYELEEDG APFGEDSNSR EGMQLTYLPP SPVLAESTTP ITDIRAFTAT
1160
LSLFPYHKIV K
Length:1,161
Mass (Da):132,891
Last modified:March 1, 2003 - v1
Checksum:i21334221632A5122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031548 mRNA. Translation: BAC27445.1.
BC036128 mRNA. Translation: AAH36128.1.
CCDSiCCDS18460.1.
RefSeqiNP_666262.2. NM_146150.2.
UniGeneiMm.274950.
Mm.442231.

Genome annotation databases

EnsembliENSMUST00000065977; ENSMUSP00000068328; ENSMUSG00000053510.
GeneIDi230598.
KEGGimmu:230598.
UCSCiuc008ubw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031548 mRNA. Translation: BAC27445.1.
BC036128 mRNA. Translation: AAH36128.1.
CCDSiCCDS18460.1.
RefSeqiNP_666262.2. NM_146150.2.
UniGeneiMm.274950.
Mm.442231.

3D structure databases

ProteinModelPortaliQ8BHG1.
SMRiQ8BHG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230982. 1 interactor.
IntActiQ8BHG1. 1 interactor.
MINTiMINT-4104130.
STRINGi10090.ENSMUSP00000068328.

Protein family/group databases

MEROPSiM16.987.

PTM databases

iPTMnetiQ8BHG1.
PhosphoSitePlusiQ8BHG1.

Proteomic databases

EPDiQ8BHG1.
MaxQBiQ8BHG1.
PaxDbiQ8BHG1.
PRIDEiQ8BHG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065977; ENSMUSP00000068328; ENSMUSG00000053510.
GeneIDi230598.
KEGGimmu:230598.
UCSCiuc008ubw.1. mouse.

Organism-specific databases

CTDi230598.
MGIiMGI:1201386. Nrd1.

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.
HOGENOMiHOG000231160.
HOVERGENiHBG006530.
InParanoidiQ8BHG1.
KOiK01411.
PhylomeDBiQ8BHG1.
TreeFamiTF106274.

Miscellaneous databases

ChiTaRSiNrd1. mouse.
PROiQ8BHG1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053510.
ExpressionAtlasiQ8BHG1. baseline and differential.
GenevisibleiQ8BHG1. MM.

Family and domain databases

Gene3Di3.30.830.10. 5 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 5 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRDC_MOUSE
AccessioniPrimary (citable) accession number: Q8BHG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.