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Q8BHF7 (PGPS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
EC=2.7.8.5
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name=PGP synthase 1
Silencer-associated factor
Gene names
Name:Pgs1
Synonyms:Saf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.

Catalytic activity

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Enzyme regulation

Activated by calcium and magnesium and inhibited by other bivalent cations By similarity.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

Subcellular location

Mitochondrion By similarity.

Tissue specificity

Widely expressed with higher expression in testis, liver and brain. Ref.5

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

Contains 2 PLD phosphodiesterase domains.

Sequence caution

The sequence AAH22918.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAL87040.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion Potential
Chain26 – 553528CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
PRO_0000337107

Regions

Domain212 – 23827PLD phosphodiesterase 1
Domain457 – 49034PLD phosphodiesterase 2
Nucleotide binding121 – 1288ATP Potential

Sites

Active site2171 Potential
Active site2191 Potential
Active site2241 Potential

Experimental info

Sequence conflict3711T → M in AAH22918. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8BHF7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 23373FEE4E47CD46

FASTA55362,489
        10         20         30         40         50         60 
MAAPAAGPVF WRRLLGLLPG RPGLAALLGR LSDRLGRSRE RRRRRSPWLL LAPLLSPTVP 

        70         80         90        100        110        120 
QVTSPPCCLC PEGVHRFQWI RNLVPEFGVS SSHVRVLSSP AEFFELMKGQ IKIAKRRVVM 

       130        140        150        160        170        180 
ASLYLGTGPL EQELVDCLES SLEKSLQAKF PSDLKVSILL DFTRGSRGRK NSRTMLLPLL 

       190        200        210        220        230        240 
QRFPERVRVS LFHTPNLRGL LRLLIPERFN ETIGLQHIKV YLFDNNVILS GANLSDSYFT 

       250        260        270        280        290        300 
NRQDRYVFLQ DCAEIADFFT ELVDAVGDVS LQLQGDDTVE VVDGMVHPYK GDRAAYCRAA 

       310        320        330        340        350        360 
NKRVMDVIHS ARARQQMLHA QTFHSDSLLS QEEAAAAGDR RPAPDTWIYP LIQMKPFEIQ 

       370        380        390        400        410        420 
IDEIVTETLL TEAERGAKVF LTTGYFNLTQ AYMDLVLGTR AEYQILLASP EVNGFFGAKG 

       430        440        450        460        470        480 
VAGAIPAAYV HIERQFYSEV CSLGQQDRVQ LQEYWRRGWT FHAKGLWLYL AGSSLPCLTL 

       490        500        510        520        530        540 
IGSPNFGYRS VHRDLEAQIA IVTESRSLQQ QLHQEQEQLY LRSGVVTSAT FEQPGRQVKL 

       550 
WVKMVTPLIK NFF

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Corpora quadrigemina, Embryonic stem cell and Eye.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Siu G., Arsov I.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-553.
Strain: BALB/c.
Tissue: Thymus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-553.
Strain: FVB/N.
Tissue: Salivary gland.
[5]"Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells."
Kawasaki K., Kuge O., Chang S.-C., Heacock P.N., Rho M., Suzuki K., Nishijima M., Dowhan W.
J. Biol. Chem. 274:1828-1834(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK046174 mRNA. Translation: BAC32619.1.
AK049359 mRNA. Translation: BAC33708.1.
AK053905 mRNA. Translation: BAC35584.1.
AL591433 Genomic DNA. Translation: CAM19106.1.
AF411101 mRNA. Translation: AAL87040.1. Sequence problems.
BC022918 mRNA. Translation: AAH22918.1. Different initiation.
IPIIPI00221857.
RefSeqNP_598518.1. NM_133757.2.
UniGeneMm.28864.

3D structure databases

ProteinModelPortalQ8BHF7.
ModBaseSearch...

PTM databases

PhosphoSiteQ8BHF7.

Proteomic databases

PaxDbQ8BHF7.
PRIDEQ8BHF7.

Protocols and materials databases

DNASU74451.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000132676; ENSMUSP00000121973; ENSMUSG00000017715.
GeneID74451.
KEGGmmu:74451.

Organism-specific databases

CTD9489.
MGIMGI:1921701. Pgs1.

Phylogenomic databases

eggNOGCOG1502.
GeneTreeENSGT00390000002373.
HOVERGENHBG057228.
InParanoidQ8BHF7.
KOK00995.
OMAFELMKGQ.

Enzyme and pathway databases

UniPathwayUPA00084; UER00503.

Gene expression databases

ArrayExpressQ8BHF7.
BgeeQ8BHF7.
GenevestigatorQ8BHF7.

Family and domain databases

InterProIPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERPTHR12586. PTHR12586. 1 hit.
PIRSFPIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITEPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPGS1. mouse.
NextBio340799.
SOURCESearch...

Entry information

Entry namePGPS1_MOUSE
AccessionPrimary (citable) accession number: Q8BHF7
Secondary accession number(s): Q8QZT9, Q8R4R7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents