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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

Pgs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Enzyme regulationi

Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (Pgs1)
  2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (Ptpmt1)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei217PROSITE-ProRule annotation1
Active sitei219PROSITE-ProRule annotation1
Active sitei224PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 128ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Silencer-associated factor
Gene namesi
Name:Pgs1
Synonyms:Saf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921701 Pgs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000033710726 – 553CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHF7
MaxQBiQ8BHF7
PaxDbiQ8BHF7
PRIDEiQ8BHF7

PTM databases

iPTMnetiQ8BHF7
PhosphoSitePlusiQ8BHF7

Expressioni

Tissue specificityi

Widely expressed with higher expression in testis, liver and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000017715
ExpressionAtlasiQ8BHF7 baseline and differential
GenevisibleiQ8BHF7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121973

Structurei

3D structure databases

ProteinModelPortaliQ8BHF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 238PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST27
Domaini457 – 490PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3964 Eukaryota
COG1502 LUCA
GeneTreeiENSGT00390000002373
HOVERGENiHBG057228
InParanoidiQ8BHF7
KOiK00995
OMAiHLKGFVI
OrthoDBiEOG091G0DQT
PhylomeDBiQ8BHF7
TreeFamiTF314768

Family and domain databases

InterProiView protein in InterPro
IPR016270 PGS1
IPR001736 PLipase_D/transphosphatidylase
PANTHERiPTHR12586 PTHR12586, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAAGPVF WRRLLGLLPG RPGLAALLGR LSDRLGRSRE RRRRRSPWLL
60 70 80 90 100
LAPLLSPTVP QVTSPPCCLC PEGVHRFQWI RNLVPEFGVS SSHVRVLSSP
110 120 130 140 150
AEFFELMKGQ IKIAKRRVVM ASLYLGTGPL EQELVDCLES SLEKSLQAKF
160 170 180 190 200
PSDLKVSILL DFTRGSRGRK NSRTMLLPLL QRFPERVRVS LFHTPNLRGL
210 220 230 240 250
LRLLIPERFN ETIGLQHIKV YLFDNNVILS GANLSDSYFT NRQDRYVFLQ
260 270 280 290 300
DCAEIADFFT ELVDAVGDVS LQLQGDDTVE VVDGMVHPYK GDRAAYCRAA
310 320 330 340 350
NKRVMDVIHS ARARQQMLHA QTFHSDSLLS QEEAAAAGDR RPAPDTWIYP
360 370 380 390 400
LIQMKPFEIQ IDEIVTETLL TEAERGAKVF LTTGYFNLTQ AYMDLVLGTR
410 420 430 440 450
AEYQILLASP EVNGFFGAKG VAGAIPAAYV HIERQFYSEV CSLGQQDRVQ
460 470 480 490 500
LQEYWRRGWT FHAKGLWLYL AGSSLPCLTL IGSPNFGYRS VHRDLEAQIA
510 520 530 540 550
IVTESRSLQQ QLHQEQEQLY LRSGVVTSAT FEQPGRQVKL WVKMVTPLIK

NFF
Length:553
Mass (Da):62,489
Last modified:March 1, 2003 - v1
Checksum:i23373FEE4E47CD46
GO

Sequence cautioni

The sequence AAH22918 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL87040 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371T → M in AAH22918 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046174 mRNA Translation: BAC32619.1
AK049359 mRNA Translation: BAC33708.1
AK053905 mRNA Translation: BAC35584.1
AL591433 Genomic DNA No translation available.
AF411101 mRNA Translation: AAL87040.1 Sequence problems.
BC022918 mRNA Translation: AAH22918.1 Different initiation.
CCDSiCCDS25698.1
RefSeqiNP_598518.1, NM_133757.2
UniGeneiMm.28864

Genome annotation databases

EnsembliENSMUST00000132676; ENSMUSP00000121973; ENSMUSG00000017715
GeneIDi74451
KEGGimmu:74451
UCSCiuc007moj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPGPS1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHF7
Secondary accession number(s): Q8QZT9, Q8R4R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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