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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

Pgs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Enzyme regulationi

Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (Pgs1)
  2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (Ptpmt1)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171PROSITE-ProRule annotation
Active sitei219 – 2191PROSITE-ProRule annotation
Active sitei224 – 2241PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1288ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Silencer-associated factor
Gene namesi
Name:Pgs1
Synonyms:Saf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921701. Pgs1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence analysisAdd
BLAST
Chaini26 – 553528CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPRO_0000337107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHF7.
MaxQBiQ8BHF7.
PaxDbiQ8BHF7.
PRIDEiQ8BHF7.

PTM databases

iPTMnetiQ8BHF7.
PhosphoSiteiQ8BHF7.

Expressioni

Tissue specificityi

Widely expressed with higher expression in testis, liver and brain.1 Publication

Gene expression databases

BgeeiQ8BHF7.
ExpressionAtlasiQ8BHF7. baseline and differential.
GenevisibleiQ8BHF7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121973.

Structurei

3D structure databases

ProteinModelPortaliQ8BHF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 23827PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini457 – 49034PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3964. Eukaryota.
COG1502. LUCA.
GeneTreeiENSGT00390000002373.
HOVERGENiHBG057228.
InParanoidiQ8BHF7.
KOiK00995.
OMAiEGWGTWH.
OrthoDBiEOG718KCF.
PhylomeDBiQ8BHF7.
TreeFamiTF314768.

Family and domain databases

InterProiIPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAAGPVF WRRLLGLLPG RPGLAALLGR LSDRLGRSRE RRRRRSPWLL
60 70 80 90 100
LAPLLSPTVP QVTSPPCCLC PEGVHRFQWI RNLVPEFGVS SSHVRVLSSP
110 120 130 140 150
AEFFELMKGQ IKIAKRRVVM ASLYLGTGPL EQELVDCLES SLEKSLQAKF
160 170 180 190 200
PSDLKVSILL DFTRGSRGRK NSRTMLLPLL QRFPERVRVS LFHTPNLRGL
210 220 230 240 250
LRLLIPERFN ETIGLQHIKV YLFDNNVILS GANLSDSYFT NRQDRYVFLQ
260 270 280 290 300
DCAEIADFFT ELVDAVGDVS LQLQGDDTVE VVDGMVHPYK GDRAAYCRAA
310 320 330 340 350
NKRVMDVIHS ARARQQMLHA QTFHSDSLLS QEEAAAAGDR RPAPDTWIYP
360 370 380 390 400
LIQMKPFEIQ IDEIVTETLL TEAERGAKVF LTTGYFNLTQ AYMDLVLGTR
410 420 430 440 450
AEYQILLASP EVNGFFGAKG VAGAIPAAYV HIERQFYSEV CSLGQQDRVQ
460 470 480 490 500
LQEYWRRGWT FHAKGLWLYL AGSSLPCLTL IGSPNFGYRS VHRDLEAQIA
510 520 530 540 550
IVTESRSLQQ QLHQEQEQLY LRSGVVTSAT FEQPGRQVKL WVKMVTPLIK

NFF
Length:553
Mass (Da):62,489
Last modified:March 1, 2003 - v1
Checksum:i23373FEE4E47CD46
GO

Sequence cautioni

The sequence AAH22918.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL87040.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti371 – 3711T → M in AAH22918 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046174 mRNA. Translation: BAC32619.1.
AK049359 mRNA. Translation: BAC33708.1.
AK053905 mRNA. Translation: BAC35584.1.
AL591433 Genomic DNA. Translation: CAM19106.1.
AF411101 mRNA. Translation: AAL87040.1. Sequence problems.
BC022918 mRNA. Translation: AAH22918.1. Different initiation.
CCDSiCCDS25698.1.
RefSeqiNP_598518.1. NM_133757.2.
UniGeneiMm.28864.

Genome annotation databases

EnsembliENSMUST00000132676; ENSMUSP00000121973; ENSMUSG00000017715.
GeneIDi74451.
KEGGimmu:74451.
UCSCiuc007moj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046174 mRNA. Translation: BAC32619.1.
AK049359 mRNA. Translation: BAC33708.1.
AK053905 mRNA. Translation: BAC35584.1.
AL591433 Genomic DNA. Translation: CAM19106.1.
AF411101 mRNA. Translation: AAL87040.1. Sequence problems.
BC022918 mRNA. Translation: AAH22918.1. Different initiation.
CCDSiCCDS25698.1.
RefSeqiNP_598518.1. NM_133757.2.
UniGeneiMm.28864.

3D structure databases

ProteinModelPortaliQ8BHF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121973.

PTM databases

iPTMnetiQ8BHF7.
PhosphoSiteiQ8BHF7.

Proteomic databases

EPDiQ8BHF7.
MaxQBiQ8BHF7.
PaxDbiQ8BHF7.
PRIDEiQ8BHF7.

Protocols and materials databases

DNASUi74451.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132676; ENSMUSP00000121973; ENSMUSG00000017715.
GeneIDi74451.
KEGGimmu:74451.
UCSCiuc007moj.1. mouse.

Organism-specific databases

CTDi9489.
MGIiMGI:1921701. Pgs1.

Phylogenomic databases

eggNOGiKOG3964. Eukaryota.
COG1502. LUCA.
GeneTreeiENSGT00390000002373.
HOVERGENiHBG057228.
InParanoidiQ8BHF7.
KOiK00995.
OMAiEGWGTWH.
OrthoDBiEOG718KCF.
PhylomeDBiQ8BHF7.
TreeFamiTF314768.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Miscellaneous databases

ChiTaRSiPgs1. mouse.
NextBioi340799.
PROiQ8BHF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHF7.
ExpressionAtlasiQ8BHF7. baseline and differential.
GenevisibleiQ8BHF7. MM.

Family and domain databases

InterProiIPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Embryonic stem cell and Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Siu G., Arsov I.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-553.
    Strain: BALB/cJ.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-553.
    Strain: FVB/N.
    Tissue: Salivary gland.
  5. "Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells."
    Kawasaki K., Kuge O., Chang S.-C., Heacock P.N., Rho M., Suzuki K., Nishijima M., Dowhan W.
    J. Biol. Chem. 274:1828-1834(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Pancreas and Testis.

Entry informationi

Entry nameiPGPS1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHF7
Secondary accession number(s): Q8QZT9, Q8R4R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.