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Protein

Bone morphogenetic protein 3

Gene

Bmp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Gene namesi
Name:Bmp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88179. Bmp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 358336By similarityPRO_0000033838Add
BLAST
Chaini359 – 468110Bone morphogenetic protein 3PRO_0000033839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi366 ↔ 433By similarity
Disulfide bondi395 ↔ 465By similarity
Disulfide bondi399 ↔ 467By similarity
Disulfide bondi432 – 432InterchainBy similarity
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHE5.
PaxDbiQ8BHE5.
PRIDEiQ8BHE5.

PTM databases

PhosphoSiteiQ8BHE5.

Expressioni

Gene expression databases

BgeeiQ8BHE5.
CleanExiMM_BMP3.
ExpressionAtlasiQ8BHE5. baseline and differential.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031278.

Structurei

3D structure databases

ProteinModelPortaliQ8BHE5.
SMRiQ8BHE5. Positions 362-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiQ8BHE5.
KOiK05496.
OrthoDBiEOG70CR76.
PhylomeDBiQ8BHE5.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARGLLCL WLGYFCLNLA QGQRPNLHLP GLRETEPSDR ATGGSPSPDL
60 70 80 90 100
RPHDKVSEHM LWLYDRYSGS SRVQATRTPG SQLPGPQPLR GGNTVRSFRA
110 120 130 140 150
AAAGTPQTKG LHTFNLTSLT KSENILSATL YFYVGELVNI SLSCPEPQGC
160 170 180 190 200
SHHTQRQHIQ IDLSAWILKS NQSQLLGHLS VDVVRPYRDS VSWLSKDITQ
210 220 230 240 250
LLRKAKQNEE FLIGFNITSR AHELPKRMLF FPEPYILVYA NDAAISEPES
260 270 280 290 300
VVSSLQRHRD FTAGTGPRLD SHVREALSVE RRKKRSTGIL LPLQNNELPG
310 320 330 340 350
AEYQYKEEGA WEERKPYKSL QTQPPEKSRN KKKQRKGSHQ KGQTLQFDEQ
360 370 380 390 400
TLKKARRKQW VEPRNCARRY LKVDFADIGW SEWIISPKSF DAFYCSGACQ
410 420 430 440 450
FPMPKSLKPS NHATIQSIVR AVGVVSGIPE PCCVPEKMSS LSILFFDENK
460
NVVLKVYPNM TVDSCACR
Length:468
Mass (Da):52,774
Last modified:March 1, 2003 - v1
Checksum:i28E34717E15C76E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037225 mRNA. Translation: BAC29764.1.
AK040389 mRNA. Translation: BAC30581.1.
CCDSiCCDS19458.1.
RefSeqiNP_775580.1. NM_173404.5.
UniGeneiMm.136461.
Mm.209571.

Genome annotation databases

EnsembliENSMUST00000031278; ENSMUSP00000031278; ENSMUSG00000029335.
GeneIDi110075.
KEGGimmu:110075.
UCSCiuc008ygg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037225 mRNA. Translation: BAC29764.1.
AK040389 mRNA. Translation: BAC30581.1.
CCDSiCCDS19458.1.
RefSeqiNP_775580.1. NM_173404.5.
UniGeneiMm.136461.
Mm.209571.

3D structure databases

ProteinModelPortaliQ8BHE5.
SMRiQ8BHE5. Positions 362-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031278.

PTM databases

PhosphoSiteiQ8BHE5.

Proteomic databases

MaxQBiQ8BHE5.
PaxDbiQ8BHE5.
PRIDEiQ8BHE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031278; ENSMUSP00000031278; ENSMUSG00000029335.
GeneIDi110075.
KEGGimmu:110075.
UCSCiuc008ygg.1. mouse.

Organism-specific databases

CTDi651.
MGIiMGI:88179. Bmp3.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiQ8BHE5.
KOiK05496.
OrthoDBiEOG70CR76.
PhylomeDBiQ8BHE5.
TreeFamiTF316134.

Miscellaneous databases

NextBioi363271.
PROiQ8BHE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHE5.
CleanExiMM_BMP3.
ExpressionAtlasiQ8BHE5. baseline and differential.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Thymus.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 260-268, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "Bone morphogenetic protein-3 is a negative regulator of bone density."
    Daluiski A., Engstrand T., Bahamonde M.E., Gamer L.W., Agius E., Stevenson S.L., Cox K., Rosen V., Lyons K.M.
    Nat. Genet. 27:84-88(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiBMP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BHE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.