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Protein

Caytaxin

Gene

Atcay

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Caytaxin
Gene namesi
Name:Atcay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2448730. Atcay.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • mitochondrial membrane Source: UniProtKB
  • neuron projection Source: UniProtKB
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Mitochondrion, Synapse

Pathology & Biotechi

Involvement in diseasei

Defects in Atcay are the cause of jittery phenotype, which is characterized by severe truncal and limb ataxia and death due to starvation and dehydration by 3-4 weeks of age.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372CaytaxinPRO_0000210769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineCombined sources

Post-translational modificationi

Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2.1 Publication
May be ubiquitinated by STUB1.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei105 – 1062Cleavage; by CASP3By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BHE3.
PaxDbiQ8BHE3.
PeptideAtlasiQ8BHE3.
PRIDEiQ8BHE3.

PTM databases

iPTMnetiQ8BHE3.
PhosphoSiteiQ8BHE3.

Expressioni

Tissue specificityi

Neuronal tissues specific. Strongly expressed in brain. Expressed in virtually all parts of the adult brain, including cortex, cerebellum and olfactory bulbs. Enriched in hippocampus, cerebellar cortex, deep cerebellar nuclei, and pontine nuclei (at protein level).3 Publications

Developmental stagei

Expressed in embryo, where it is also completely restricted to neuronal tissues, including brain, dorsal root ganglia and enteric nervous system. MRNA and protein expressions are not correlated during development.2 Publications

Gene expression databases

BgeeiENSMUSG00000034958.
CleanExiMM_ATCAY.
ExpressionAtlasiQ8BHE3. baseline and differential.
GenevisibleiQ8BHE3. MM.

Interactioni

Subunit structurei

Interacts with KLC1; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts with GLS; the interaction is direct and may control GLS localization, negatively regulating its activity. Interacts with PIN1 (via WW domain); upon NGF stimulation (By similarity). The interaction with PIN1 and GLS is competitive (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036721.

Structurei

3D structure databases

ProteinModelPortaliQ8BHE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 328158CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1206Required for interaction with KLC1
Regioni190 – 372183Mediates interaction with GLSBy similarityAdd
BLAST

Domaini

The CRAL-TRIO domain is known to bind small hydrophobic molecules.By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFIP. Eukaryota.
ENOG410ZS9Z. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiQ8BHE3.
KOiK18450.
OMAiMRVVTHG.
OrthoDBiEOG091G0E88.
PhylomeDBiQ8BHE3.
TreeFamiTF324164.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTEATLRM ENVDVRDEWQ DEDLPRPLPE DTGVERLGGA VEDSSSPPST
60 70 80 90 100
LNLSGAHRKR KTLVAPEINI SLDQSEGSLL SDDFLDTPDD LDINVDDIET
110 120 130 140 150
PDETDSLEFL GNGNELEWED DTPVATAKNM PGDSADLFGD GSAEDGSAAN
160 170 180 190 200
GRLWRTVIIG EQEHRIDLHM IRPYMKVVTH GGYYGEGLNA IIVFAACFLP
210 220 230 240 250
DSSSPDYHYI MENLFLYVIS SLELLVAEDY MIVYLNGATP RRRMPGIGWL
260 270 280 290 300
KKCYHMIDRR LRKNLKSLII VHPSWFIRTV LAISRPFISV KFISKIQYVH
310 320 330 340 350
SLEELERLIP MEHVQLPDCV LQYEEQRLRA KRESTRPPQP EFLLPRSEEK
360 370
PETVEEEDRA AEATEDQETS MS
Length:372
Mass (Da):42,178
Last modified:March 1, 2003 - v1
Checksum:i299146667F722C11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349150 mRNA. Translation: AAQ90064.1.
AK028298 mRNA. Translation: BAC25867.1.
AK038483 mRNA. Translation: BAC30014.1.
AK038990 mRNA. Translation: BAC30195.1.
AK039411 mRNA. Translation: BAC30342.1.
AK162959 mRNA. Translation: BAE37136.1.
BC048903 mRNA. Translation: AAH48903.1.
CCDSiCCDS24047.1.
RefSeqiNP_848777.1. NM_178662.3.
UniGeneiMm.127681.

Genome annotation databases

EnsembliENSMUST00000047408; ENSMUSP00000036721; ENSMUSG00000034958.
GeneIDi16467.
KEGGimmu:16467.
UCSCiuc007ggo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349150 mRNA. Translation: AAQ90064.1.
AK028298 mRNA. Translation: BAC25867.1.
AK038483 mRNA. Translation: BAC30014.1.
AK038990 mRNA. Translation: BAC30195.1.
AK039411 mRNA. Translation: BAC30342.1.
AK162959 mRNA. Translation: BAE37136.1.
BC048903 mRNA. Translation: AAH48903.1.
CCDSiCCDS24047.1.
RefSeqiNP_848777.1. NM_178662.3.
UniGeneiMm.127681.

3D structure databases

ProteinModelPortaliQ8BHE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036721.

PTM databases

iPTMnetiQ8BHE3.
PhosphoSiteiQ8BHE3.

Proteomic databases

MaxQBiQ8BHE3.
PaxDbiQ8BHE3.
PeptideAtlasiQ8BHE3.
PRIDEiQ8BHE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047408; ENSMUSP00000036721; ENSMUSG00000034958.
GeneIDi16467.
KEGGimmu:16467.
UCSCiuc007ggo.1. mouse.

Organism-specific databases

CTDi85300.
MGIiMGI:2448730. Atcay.

Phylogenomic databases

eggNOGiENOG410IFIP. Eukaryota.
ENOG410ZS9Z. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiQ8BHE3.
KOiK18450.
OMAiMRVVTHG.
OrthoDBiEOG091G0E88.
PhylomeDBiQ8BHE3.
TreeFamiTF324164.

Miscellaneous databases

PROiQ8BHE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034958.
CleanExiMM_ATCAY.
ExpressionAtlasiQ8BHE3. baseline and differential.
GenevisibleiQ8BHE3. MM.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATCAY_MOUSE
AccessioniPrimary (citable) accession number: Q8BHE3
Secondary accession number(s): Q3TR94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.