Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-39A

Gene

Rab39a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (By similarity). May be involved in multiple neurite formation (PubMed:23624502).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-39A
Short name:
Rab-39
Gene namesi
Name:Rab39a
Synonyms:Rab39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442855. Rab39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Ras-related protein Rab-39APRO_0000121254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051PhosphoserineBy similarity
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
Modified residuei217 – 2171Cysteine methyl esterBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ8BHD0.
MaxQBiQ8BHD0.
PaxDbiQ8BHD0.
PRIDEiQ8BHD0.

PTM databases

iPTMnetiQ8BHD0.
PhosphoSiteiQ8BHD0.

Expressioni

Gene expression databases

BgeeiQ8BHD0.
CleanExiMM_RAB39.
ExpressionAtlasiQ8BHD0. baseline and differential.
GenevisibleiQ8BHD0. MM.

Interactioni

Subunit structurei

Interacts with BECN1. Probably associates with the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity). Interacts with UACA.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UacaQ8CGB3-33EBI-10767908,EBI-10767725

Protein-protein interaction databases

IntActiQ8BHD0. 2 interactions.
STRINGi10090.ENSMUSP00000063804.

Structurei

3D structure databases

ProteinModelPortaliQ8BHD0.
SMRiQ8BHD0. Positions 5-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0091. Eukaryota.
ENOG410ZQFG. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ8BHD0.
KOiK07924.
OMAiACGMKYI.
OrthoDBiEOG7JHM6Q.
PhylomeDBiQ8BHD0.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLHSPA CDPTVGVDFF
60 70 80 90 100
SRLLEIEPGK RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS
110 120 130 140 150
FEHVKDWLEE AKMHVQPFQI VFLLVGHKCD LASQRQVSRE EAERLSTDCG
160 170 180 190 200
MKYIETSAKD ATNVEESFTI LTRDIYELIK KGEICIQDGW EGVKSGFVPN
210
TVHSSEEAVK PRKECFC
Length:217
Mass (Da):24,978
Last modified:March 1, 2003 - v1
Checksum:i311A00AC545C4CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049038 mRNA. Translation: BAC33522.1.
AK053487 mRNA. Translation: BAC35399.1.
BC049787 mRNA. Translation: AAH49787.1.
CCDSiCCDS23185.1.
RefSeqiNP_780771.1. NM_175562.3.
UniGeneiMm.290285.

Genome annotation databases

EnsembliENSMUST00000068449; ENSMUSP00000063804; ENSMUSG00000055069.
GeneIDi270160.
KEGGimmu:270160.
UCSCiuc009pmm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049038 mRNA. Translation: BAC33522.1.
AK053487 mRNA. Translation: BAC35399.1.
BC049787 mRNA. Translation: AAH49787.1.
CCDSiCCDS23185.1.
RefSeqiNP_780771.1. NM_175562.3.
UniGeneiMm.290285.

3D structure databases

ProteinModelPortaliQ8BHD0.
SMRiQ8BHD0. Positions 5-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHD0. 2 interactions.
STRINGi10090.ENSMUSP00000063804.

PTM databases

iPTMnetiQ8BHD0.
PhosphoSiteiQ8BHD0.

Proteomic databases

EPDiQ8BHD0.
MaxQBiQ8BHD0.
PaxDbiQ8BHD0.
PRIDEiQ8BHD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068449; ENSMUSP00000063804; ENSMUSG00000055069.
GeneIDi270160.
KEGGimmu:270160.
UCSCiuc009pmm.1. mouse.

Organism-specific databases

CTDi270160.
MGIiMGI:2442855. Rab39.

Phylogenomic databases

eggNOGiKOG0091. Eukaryota.
ENOG410ZQFG. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ8BHD0.
KOiK07924.
OMAiACGMKYI.
OrthoDBiEOG7JHM6Q.
PhylomeDBiQ8BHD0.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiQ8BHD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHD0.
CleanExiMM_RAB39.
ExpressionAtlasiQ8BHD0. baseline and differential.
GenevisibleiQ8BHD0. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  3. "Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells."
    Mori Y., Matsui T., Omote D., Fukuda M.
    Biochem. Biophys. Res. Commun. 435:113-119(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UACA.

Entry informationi

Entry nameiRB39A_MOUSE
AccessioniPrimary (citable) accession number: Q8BHD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.