Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-39A

Gene

Rab39a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (By similarity). May be involved in multiple neurite formation (PubMed:23624502).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-39A
Short name:
Rab-39
Gene namesi
Name:Rab39a
Synonyms:Rab39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442855 Rab39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212541 – 217Ras-related protein Rab-39AAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi215S-geranylgeranyl cysteineBy similarity1
Modified residuei217Cysteine methyl esterBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ8BHD0
MaxQBiQ8BHD0
PaxDbiQ8BHD0
PRIDEiQ8BHD0

PTM databases

iPTMnetiQ8BHD0
PhosphoSitePlusiQ8BHD0

Expressioni

Gene expression databases

BgeeiENSMUSG00000055069
CleanExiMM_RAB39
ExpressionAtlasiQ8BHD0 baseline and differential
GenevisibleiQ8BHD0 MM

Interactioni

Subunit structurei

Interacts with BECN1. Probably associates with the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity). Interacts with UACA.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UacaQ8CGB3-33EBI-10767908,EBI-10767725

Protein-protein interaction databases

IntActiQ8BHD0, 2 interactors
STRINGi10090.ENSMUSP00000063804

Structurei

3D structure databases

ProteinModelPortaliQ8BHD0
SMRiQ8BHD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0091 Eukaryota
ENOG410ZQFG LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ8BHD0
KOiK07924
OMAiKIQDGWE
OrthoDBiEOG091G0RUB
PhylomeDBiQ8BHD0
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLHSPA CDPTVGVDFF
60 70 80 90 100
SRLLEIEPGK RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS
110 120 130 140 150
FEHVKDWLEE AKMHVQPFQI VFLLVGHKCD LASQRQVSRE EAERLSTDCG
160 170 180 190 200
MKYIETSAKD ATNVEESFTI LTRDIYELIK KGEICIQDGW EGVKSGFVPN
210
TVHSSEEAVK PRKECFC
Length:217
Mass (Da):24,978
Last modified:March 1, 2003 - v1
Checksum:i311A00AC545C4CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049038 mRNA Translation: BAC33522.1
AK053487 mRNA Translation: BAC35399.1
BC049787 mRNA Translation: AAH49787.1
CCDSiCCDS23185.1
RefSeqiNP_780771.1, NM_175562.3
UniGeneiMm.290285

Genome annotation databases

EnsembliENSMUST00000068449; ENSMUSP00000063804; ENSMUSG00000055069
GeneIDi270160
KEGGimmu:270160
UCSCiuc009pmm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRB39A_MOUSE
AccessioniPrimary (citable) accession number: Q8BHD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health