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Protein

Alpha-(1,3)-fucosyltransferase 11

Gene

Fut11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable fucosyltransferase.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 11 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase XI
Short name:
Fuc-TXI
Short name:
FucT-XI
Galactoside 3-L-fucosyltransferase 11
Short name:
Fucosyltransferase 11
Gene namesi
Name:Fut11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1920318 Fut11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini25 – 489LumenalSequence analysisAdd BLAST465

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990101 – 489Alpha-(1,3)-fucosyltransferase 11Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 99By similarity
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi385 ↔ 388By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8BHC9
MaxQBiQ8BHC9
PaxDbiQ8BHC9
PRIDEiQ8BHC9

PTM databases

CarbonylDBiQ8BHC9
iPTMnetiQ8BHC9
PhosphoSitePlusiQ8BHC9

Expressioni

Tissue specificityi

Widely expressed. Expressed at slightly higher level in heart, kidney and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000039357
CleanExiMM_FUT11
ExpressionAtlasiQ8BHC9 baseline and differential
GenevisibleiQ8BHC9 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BHC9, 1 interactor
MINTiQ8BHC9
STRINGi10090.ENSMUSP00000040370

Structurei

3D structure databases

ProteinModelPortaliQ8BHC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000006538
HOVERGENiHBG055521
InParanoidiQ8BHC9
KOiK11257
OMAiGLFPHFP
OrthoDBiEOG091G064Z
PhylomeDBiQ8BHC9
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR017176 Alpha-1_3-FUT_met
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
PIRSFiPIRSF037332 Alpha1_3FUT_met, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCTEAVL AALGVLSVCS ASSSGSEASG EAEREEPWDG AVFRPPAALG
60 70 80 90 100
AVGIARGPGS PPPGNREAVD LPVLLWWSPG LFPHFPGDSE RIQCAHGACV
110 120 130 140 150
ASRDRRARAD PRTRALLFYG TDFRAADAPL PRLAHQSWAL LHEESPLNNF
160 170 180 190 200
LLSHGPGIRL FNLTATFSRH SDYPLPLQWL PGAAYLRRPA PPPRERAEWR
210 220 230 240 250
RRGYAPLLYL QSHCDVPSDR DRYVRELMRY IPVDSYGKCL QNREPPTVRL
260 270 280 290 300
QDTATATTED PELMAFLSRY KFHLALENAI CNDYMTEKLW RPMHLGAVPV
310 320 330 340 350
YRGSPSVRDW MPNNHSVILI DDFESPQKLA EFIDFLDKND DEYMKYLAYK
360 370 380 390 400
QPGGITNQFL LDNLEHREWG VNDPMLPNYL NGFECFVCDH ELARLNAEKA
410 420 430 440 450
HASSHGDIPV PEPRIAQSSH MNCPVPTPGF GKVEEIPEND SWKEMWLQDY
460 470 480
WQGLYQGEAL TAMIHNNETQ QRKFWDYVHE IFMKRNKNL
Length:489
Mass (Da):55,533
Last modified:March 1, 2003 - v1
Checksum:i313E8EB8AE3A1345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → V in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti25G → R in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti80G → S in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti97G → R in BAB29123 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ542393 mRNA Translation: CAD62573.1
AK014029 mRNA Translation: BAB29123.1
AK030310 mRNA Translation: BAC26892.1
AK046461 mRNA Translation: BAC32740.1
BC145735 mRNA Translation: AAI45736.1
CCDSiCCDS26851.1
RefSeqiNP_082704.1, NM_028428.2
UniGeneiMm.277552

Genome annotation databases

EnsembliENSMUST00000048016; ENSMUSP00000040370; ENSMUSG00000039357
GeneIDi73068
KEGGimmu:73068
UCSCiuc007skk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFUT11_MOUSE
AccessioniPrimary (citable) accession number: Q8BHC9
Secondary accession number(s): Q9CXS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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