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Protein

Alpha-(1,3)-fucosyltransferase 11

Gene

Fut11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable fucosyltransferase.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 11 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase XI
Short name:
Fuc-TXI
Short name:
FucT-XI
Galactoside 3-L-fucosyltransferase 11
Short name:
Fucosyltransferase 11
Gene namesi
Name:Fut11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1920318. Fut11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini25 – 489LumenalSequence analysisAdd BLAST465

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990101 – 489Alpha-(1,3)-fucosyltransferase 11Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 99By similarity
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi385 ↔ 388By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8BHC9.
MaxQBiQ8BHC9.
PaxDbiQ8BHC9.
PRIDEiQ8BHC9.

PTM databases

iPTMnetiQ8BHC9.
PhosphoSitePlusiQ8BHC9.

Expressioni

Tissue specificityi

Widely expressed. Expressed at slightly higher level in heart, kidney and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000039357.
CleanExiMM_FUT11.
ExpressionAtlasiQ8BHC9. baseline and differential.
GenevisibleiQ8BHC9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BHC9. 1 interactor.
MINTiMINT-4110519.
STRINGi10090.ENSMUSP00000040370.

Structurei

3D structure databases

ProteinModelPortaliQ8BHC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000006538.
HOVERGENiHBG055521.
InParanoidiQ8BHC9.
KOiK11257.
OMAiKFWDYLH.
OrthoDBiEOG091G064Z.
PhylomeDBiQ8BHC9.
TreeFamiTF316348.

Family and domain databases

InterProiIPR017176. Alpha-1_3-FUT_met.
IPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF037332. Alpha1_3FUT_met. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BHC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCTEAVL AALGVLSVCS ASSSGSEASG EAEREEPWDG AVFRPPAALG
60 70 80 90 100
AVGIARGPGS PPPGNREAVD LPVLLWWSPG LFPHFPGDSE RIQCAHGACV
110 120 130 140 150
ASRDRRARAD PRTRALLFYG TDFRAADAPL PRLAHQSWAL LHEESPLNNF
160 170 180 190 200
LLSHGPGIRL FNLTATFSRH SDYPLPLQWL PGAAYLRRPA PPPRERAEWR
210 220 230 240 250
RRGYAPLLYL QSHCDVPSDR DRYVRELMRY IPVDSYGKCL QNREPPTVRL
260 270 280 290 300
QDTATATTED PELMAFLSRY KFHLALENAI CNDYMTEKLW RPMHLGAVPV
310 320 330 340 350
YRGSPSVRDW MPNNHSVILI DDFESPQKLA EFIDFLDKND DEYMKYLAYK
360 370 380 390 400
QPGGITNQFL LDNLEHREWG VNDPMLPNYL NGFECFVCDH ELARLNAEKA
410 420 430 440 450
HASSHGDIPV PEPRIAQSSH MNCPVPTPGF GKVEEIPEND SWKEMWLQDY
460 470 480
WQGLYQGEAL TAMIHNNETQ QRKFWDYVHE IFMKRNKNL
Length:489
Mass (Da):55,533
Last modified:March 1, 2003 - v1
Checksum:i313E8EB8AE3A1345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → V in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti25G → R in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti80G → S in BAB29123 (PubMed:16141072).Curated1
Sequence conflicti97G → R in BAB29123 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ542393 mRNA. Translation: CAD62573.1.
AK014029 mRNA. Translation: BAB29123.1.
AK030310 mRNA. Translation: BAC26892.1.
AK046461 mRNA. Translation: BAC32740.1.
BC145735 mRNA. Translation: AAI45736.1.
CCDSiCCDS26851.1.
RefSeqiNP_082704.1. NM_028428.2.
UniGeneiMm.277552.

Genome annotation databases

EnsembliENSMUST00000048016; ENSMUSP00000040370; ENSMUSG00000039357.
GeneIDi73068.
KEGGimmu:73068.
UCSCiuc007skk.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ542393 mRNA. Translation: CAD62573.1.
AK014029 mRNA. Translation: BAB29123.1.
AK030310 mRNA. Translation: BAC26892.1.
AK046461 mRNA. Translation: BAC32740.1.
BC145735 mRNA. Translation: AAI45736.1.
CCDSiCCDS26851.1.
RefSeqiNP_082704.1. NM_028428.2.
UniGeneiMm.277552.

3D structure databases

ProteinModelPortaliQ8BHC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHC9. 1 interactor.
MINTiMINT-4110519.
STRINGi10090.ENSMUSP00000040370.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

PTM databases

iPTMnetiQ8BHC9.
PhosphoSitePlusiQ8BHC9.

Proteomic databases

EPDiQ8BHC9.
MaxQBiQ8BHC9.
PaxDbiQ8BHC9.
PRIDEiQ8BHC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048016; ENSMUSP00000040370; ENSMUSG00000039357.
GeneIDi73068.
KEGGimmu:73068.
UCSCiuc007skk.1. mouse.

Organism-specific databases

CTDi170384.
MGIiMGI:1920318. Fut11.

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000006538.
HOVERGENiHBG055521.
InParanoidiQ8BHC9.
KOiK11257.
OMAiKFWDYLH.
OrthoDBiEOG091G064Z.
PhylomeDBiQ8BHC9.
TreeFamiTF316348.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ8BHC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039357.
CleanExiMM_FUT11.
ExpressionAtlasiQ8BHC9. baseline and differential.
GenevisibleiQ8BHC9. MM.

Family and domain databases

InterProiIPR017176. Alpha-1_3-FUT_met.
IPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF037332. Alpha1_3FUT_met. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUT11_MOUSE
AccessioniPrimary (citable) accession number: Q8BHC9
Secondary accession number(s): Q9CXS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.