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Protein

Lymphatic vessel endothelial hyaluronic acid receptor 1

Gene

Lyve1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.1 Publication

GO - Molecular functioni

  • hyaluronic acid binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cell adhesion Source: InterPro
  • glycosaminoglycan catabolic process Source: MGI
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-2160916. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphatic vessel endothelial hyaluronic acid receptor 1
Short name:
LYVE-1
Alternative name(s):
Cell surface retention sequence-binding protein 1
Short name:
CRSBP-1
Extracellular link domain-containing protein 1
Gene namesi
Name:Lyve1
Synonyms:Crsbp1, Xlkd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2136348. Lyve1.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

  • Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 234211ExtracellularSequence analysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 31863CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell periphery Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 318295Lymphatic vessel endothelial hyaluronic acid receptor 1PRO_0000252134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)1 Publication
Disulfide bondi60 ↔ 127PROSITE-ProRule annotation
Disulfide bondi84 ↔ 105PROSITE-ProRule annotation
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BHC0.
PaxDbiQ8BHC0.
PeptideAtlasiQ8BHC0.
PRIDEiQ8BHC0.

PTM databases

iPTMnetiQ8BHC0.
PhosphoSiteiQ8BHC0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030787.
GenevisibleiQ8BHC0. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033050.

Structurei

3D structure databases

ProteinModelPortaliQ8BHC0.
SMRiQ8BHC0. Positions 29-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12991LinkPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ8BHC0.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG091G09EL.
PhylomeDBiQ8BHC0.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQHTSLVLL LASIWTTRHP VQGADLVQDL SISTCRIMGV ALVGRNKNPQ
60 70 80 90 100
MNFTEANEAC KMLGLTLASR DQVESAQKSG FETCSYGWVG EQFSVIPRIF
110 120 130 140 150
SNPRCGKNGK GVLIWNAPSS QKFKAYCHNS SDTWVNSCIP EIVTTFYPVL
160 170 180 190 200
DTQTPATEFS VSSSAYLASS PDSTTPVSAT TRAPPLTSMA RKTKKICITE
210 220 230 240 250
VYTEPITMAT ETEAFVASGA AFKNEAAGFG GVPTALLVLA LLFFGAAAVL
260 270 280 290 300
AVCYVKRYVK AFPFTTKNQQ KEMIETKVVK EEKADDVNAN EESKKTIKNP
310
EEAKSPPKTT VRCLEAEV
Length:318
Mass (Da):34,574
Last modified:March 1, 2003 - v1
Checksum:i34AA31AEF5430B08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 102LL → FF in CAC33082 (PubMed:10037799).Curated
Sequence conflicti60 – 601C → G in BAE36050 (PubMed:16141072).Curated
Sequence conflicti124 – 1241K → E in BAE36050 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311501 mRNA. Translation: CAC33082.1.
AK004726 mRNA. Translation: BAC25094.1.
AK160857 mRNA. Translation: BAE36050.1.
BC038653 mRNA. Translation: AAH38653.1.
BC038892 mRNA. Translation: AAH38892.1.
CCDSiCCDS21748.1.
RefSeqiNP_444477.2. NM_053247.4.
UniGeneiMm.396078.

Genome annotation databases

EnsembliENSMUST00000033050; ENSMUSP00000033050; ENSMUSG00000030787.
GeneIDi114332.
KEGGimmu:114332.
UCSCiuc009jfr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311501 mRNA. Translation: CAC33082.1.
AK004726 mRNA. Translation: BAC25094.1.
AK160857 mRNA. Translation: BAE36050.1.
BC038653 mRNA. Translation: AAH38653.1.
BC038892 mRNA. Translation: AAH38892.1.
CCDSiCCDS21748.1.
RefSeqiNP_444477.2. NM_053247.4.
UniGeneiMm.396078.

3D structure databases

ProteinModelPortaliQ8BHC0.
SMRiQ8BHC0. Positions 29-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033050.

PTM databases

iPTMnetiQ8BHC0.
PhosphoSiteiQ8BHC0.

Proteomic databases

MaxQBiQ8BHC0.
PaxDbiQ8BHC0.
PeptideAtlasiQ8BHC0.
PRIDEiQ8BHC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033050; ENSMUSP00000033050; ENSMUSG00000030787.
GeneIDi114332.
KEGGimmu:114332.
UCSCiuc009jfr.1. mouse.

Organism-specific databases

CTDi10894.
MGIiMGI:2136348. Lyve1.

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ8BHC0.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG091G09EL.
PhylomeDBiQ8BHC0.
TreeFamiTF334173.

Enzyme and pathway databases

ReactomeiR-MMU-2160916. Hyaluronan uptake and degradation.

Miscellaneous databases

PROiQ8BHC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030787.
GenevisibleiQ8BHC0. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYVE1_MOUSE
AccessioniPrimary (citable) accession number: Q8BHC0
Secondary accession number(s): Q3TUC1, Q99NE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.