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Protein

Chloride intracellular channel protein 6

Gene

Clic6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 6
Gene namesi
Name:Clic6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146607. Clic6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei381 – 40121Helical; Note=After insertion into the membraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Chloride intracellular channel protein 6PRO_0000144218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401PhosphoserineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHB9.
MaxQBiQ8BHB9.
PaxDbiQ8BHB9.
PRIDEiQ8BHB9.

PTM databases

iPTMnetiQ8BHB9.
PhosphoSiteiQ8BHB9.

Expressioni

Gene expression databases

BgeeiQ8BHB9.
CleanExiMM_CLIC6.
ExpressionAtlasiQ8BHB9. baseline and differential.
GenevisibleiQ8BHB9. MM.

Interactioni

Subunit structurei

Interacts with dopamine receptors DRD2, DRD3 and DRD4.By similarity

Protein-protein interaction databases

IntActiQ8BHB9. 1 interaction.
MINTiMINT-4091042.
STRINGi10090.ENSMUSP00000023670.

Structurei

3D structure databases

ProteinModelPortaliQ8BHB9.
SMRiQ8BHB9. Positions 363-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 596149GST C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 354352Glu-richAdd
BLAST

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated
Contains 1 GST C-terminal domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000013008.
HOVERGENiHBG050996.
InParanoidiQ8BHB9.
KOiK05026.
OMAiCSRIAIK.
OrthoDBiEOG7X3QR3.
PhylomeDBiQ8BHB9.
TreeFamiTF315438.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030263. CLIC-6.
IPR010987. Glutathione-S-Trfase_C-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF142. PTHR11260:SF142. 2 hits.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEATEPKEV APGSQGQPEG ATIEGPGEPG AADLEGREAS EEAAEAPRDL
60 70 80 90 100
GAGVEARASG KEEGGCGQDE GTGGAQAQDP RTGPEAETPG ASGAPGEAEA
110 120 130 140 150
AERDPEGAIP QGAEEAPSAQ QVQGMSSGLD SQGEAPEVPG DSRREPEDPT
160 170 180 190 200
ASEAGEEAES GQEAQGGGAL GLQINPEVQG LAGDNMDTEA PAGGPLGSES
210 220 230 240 250
EPQGGGESSP QPQDEAIEIV TTEIGGNESG ELAGASAADA AGEGETLGKD
260 270 280 290 300
GSEEAASEDA RVDAHENGDQ GKLQEETGEE EARPEPELKG PCEGAIQEKP
310 320 330 340 350
PDGSLDGEEA KSTEHEEESQ AELSNHLAEE PSVQGGEELG RVNGRRENGP
360 370 380 390 400
ALEEGDPGQE HDITLFVKAG YDGESIGNCP FSQRLFMILW LKGVIFNVTT
410 420 430 440 450
VDLKRKPADL QNLAPGTNPP FMTFDGEVKT DVNKIEEFLE EKLVPPRYPK
460 470 480 490 500
LGTQHPESNS AGNDVFAKFS AFIKNTKKDA NEIYEKNLLR ALKKLDSYLN
510 520 530 540 550
SPLPDEIDAD SSEDVTVSQR KFLDGDELTL ADCNLLPKLH IIKIVAKKYR
560 570 580 590
DFEFPSEMTG IWRYLNNAYA RDEFTNTCPA DREIEHAYSD AAKRMK
Length:596
Mass (Da):62,886
Last modified:March 1, 2003 - v1
Checksum:i34B57EDC543841DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448440 mRNA. Translation: AAN76731.1.
AK077599 mRNA. Translation: BAC36890.1.
BC075706 mRNA. Translation: AAH75706.1.
CCDSiCCDS28338.1.
RefSeqiNP_766057.1. NM_172469.3.
UniGeneiMm.44747.

Genome annotation databases

EnsembliENSMUST00000023670; ENSMUSP00000023670; ENSMUSG00000022949.
GeneIDi209195.
KEGGimmu:209195.
UCSCiuc007zzg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448440 mRNA. Translation: AAN76731.1.
AK077599 mRNA. Translation: BAC36890.1.
BC075706 mRNA. Translation: AAH75706.1.
CCDSiCCDS28338.1.
RefSeqiNP_766057.1. NM_172469.3.
UniGeneiMm.44747.

3D structure databases

ProteinModelPortaliQ8BHB9.
SMRiQ8BHB9. Positions 363-595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BHB9. 1 interaction.
MINTiMINT-4091042.
STRINGi10090.ENSMUSP00000023670.

PTM databases

iPTMnetiQ8BHB9.
PhosphoSiteiQ8BHB9.

Proteomic databases

EPDiQ8BHB9.
MaxQBiQ8BHB9.
PaxDbiQ8BHB9.
PRIDEiQ8BHB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023670; ENSMUSP00000023670; ENSMUSG00000022949.
GeneIDi209195.
KEGGimmu:209195.
UCSCiuc007zzg.1. mouse.

Organism-specific databases

CTDi54102.
MGIiMGI:2146607. Clic6.

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000013008.
HOVERGENiHBG050996.
InParanoidiQ8BHB9.
KOiK05026.
OMAiCSRIAIK.
OrthoDBiEOG7X3QR3.
PhylomeDBiQ8BHB9.
TreeFamiTF315438.

Miscellaneous databases

ChiTaRSiClic6. mouse.
NextBioi372576.
PROiQ8BHB9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BHB9.
CleanExiMM_CLIC6.
ExpressionAtlasiQ8BHB9. baseline and differential.
GenevisibleiQ8BHB9. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030263. CLIC-6.
IPR010987. Glutathione-S-Trfase_C-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF142. PTHR11260:SF142. 2 hits.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12."
    Friedli M., Guipponi M., Bertrand S., Bertrand D., Neerman-Arbez M., Scott H.S., Antonarakis S.E., Reymond A.
    Gene 320:31-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCLIC6_MOUSE
AccessioniPrimary (citable) accession number: Q8BHB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.