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Protein

WD repeat-containing protein 3

Gene

Wdr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 3
Gene namesi
Name:Wdr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2443143. Wdr3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309411 – 942WD repeat-containing protein 3Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineCombined sources1
Modified residuei725PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BHB4.
MaxQBiQ8BHB4.
PaxDbiQ8BHB4.
PeptideAtlasiQ8BHB4.
PRIDEiQ8BHB4.

PTM databases

iPTMnetiQ8BHB4.
PhosphoSitePlusiQ8BHB4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033285.
ExpressionAtlasiQ8BHB4. baseline and differential.
GenevisibleiQ8BHB4. MM.

Interactioni

Protein-protein interaction databases

BioGridi234655. 2 interactors.
STRINGi10090.ENSMUSP00000060613.

Structurei

3D structure databases

ProteinModelPortaliQ8BHB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 60WD 1Add BLAST40
Repeati63 – 102WD 2Add BLAST40
Repeati105 – 144WD 3Add BLAST40
Repeati147 – 186WD 4Add BLAST40
Repeati189 – 228WD 5Add BLAST40
Repeati277 – 316WD 6Add BLAST40
Repeati412 – 450WD 7Add BLAST39
Repeati452 – 490WD 8Add BLAST39
Repeati493 – 532WD 9Add BLAST40
Repeati546 – 585WD 10Add BLAST40
Repeati588 – 629WD 11Add BLAST42
Repeati630 – 669WD 12Add BLAST40
Repeati672 – 711WD 13Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi927 – 932Poly-Lys6

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated
Contains 13 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00860000133855.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ8BHB4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG091G023R.
PhylomeDBiQ8BHB4.
TreeFamiTF300427.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
PF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BHB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTKQYLRY VASAVFGLIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW
60 70 80 90 100
DLRKGEKILI LQGNKQEVTC LCPSPDGLHL AVGYEDGAIR IFSLLSGEGN
110 120 130 140 150
ITFNGHKAAV TSLKYDQLGG RLASGSKDTD VIIWDVINES GLYRLKGHKD
160 170 180 190 200
AVTQALFLRE RNLLVTSGKD TMVKWWDLDN QHCFKTMVGH RTEVWGLVLV
210 220 230 240 250
SEEKRLITGA ADSELRAWDI DYLQEIDDPE EPEPKKIKEC PGIQDTPESE
260 270 280 290 300
DSTLEADDEK SEDRILSCSK AGSIMREGRD RVVNLAVDKT GRILACHGTD
310 320 330 340 350
SVLEVFCILS KAEVQKKMDK KLKKARKKAR LNSANEEEDP ETSVSMTLQD
360 370 380 390 400
EILRVAKIKT SAKIKSFDLI HSPQGELKAV FLLQNNLVEL YSLNASLPAP
410 420 430 440 450
QPVRTSRITI GGHRSDVRTL SFSSDNIAVL SAAADSIKIW NRSTLQCIRT
460 470 480 490 500
MPCEYALCSF FVPGDRQVVI GTKTGNLQLY DLASGTLLET IAAHDGALWS
510 520 530 540 550
MSLSPDQRGF VTGGADKAVK FWDFELVTDK NSTQKRLSVK QTRTLQLDED
560 570 580 590 600
VLCVSYSPNQ KLLAVSLLDC TVKVFYVDTL KFFLSLYGHK LPVLCMDISH
610 620 630 640 650
DGALIATGSA DRNVKIWGLD FGDCHRSLFA HDDSVMYLRF VPKSHLFFTA
660 670 680 690 700
GKDHKIKQWD ADKFEHIQTL EGHHQEIWCL AVSPSGDYVV SASHDKSLRL
710 720 730 740 750
WERTREPLIL EEEREMQREA EYEESVAKED QPAVPGETQG DNYFTGKKTI
760 770 780 790 800
ETVKAAERIM EAIELHREET AKMKEHRAIC KAAGKEVPLP VNPILMAHGN
810 820 830 840 850
ISPSAYVLET FKGIRSSELE EALLVLPFSY VPDVLTLFNE FIQTGLDVEL
860 870 880 890 900
LCRCLFFLLR IHFGQITSNQ MLVPVIEKLK ETTISKVRQV QDAIGFNMAG
910 920 930 940
LDYLKRECEA KSEVMFFAEA TSHLEEKKKK RKNRKRMILT LT
Length:942
Mass (Da):105,775
Last modified:March 1, 2003 - v1
Checksum:i36F2E83AD4FF85C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050738 mRNA. Translation: BAC34400.1.
AK050797 mRNA. Translation: BAC34414.1.
BC063100 mRNA. Translation: AAH63100.1.
CCDSiCCDS17674.1.
RefSeqiNP_780761.1. NM_175552.4.
UniGeneiMm.24591.

Genome annotation databases

EnsembliENSMUST00000052120; ENSMUSP00000060613; ENSMUSG00000033285.
GeneIDi269470.
KEGGimmu:269470.
UCSCiuc008qqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050738 mRNA. Translation: BAC34400.1.
AK050797 mRNA. Translation: BAC34414.1.
BC063100 mRNA. Translation: AAH63100.1.
CCDSiCCDS17674.1.
RefSeqiNP_780761.1. NM_175552.4.
UniGeneiMm.24591.

3D structure databases

ProteinModelPortaliQ8BHB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234655. 2 interactors.
STRINGi10090.ENSMUSP00000060613.

PTM databases

iPTMnetiQ8BHB4.
PhosphoSitePlusiQ8BHB4.

Proteomic databases

EPDiQ8BHB4.
MaxQBiQ8BHB4.
PaxDbiQ8BHB4.
PeptideAtlasiQ8BHB4.
PRIDEiQ8BHB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052120; ENSMUSP00000060613; ENSMUSG00000033285.
GeneIDi269470.
KEGGimmu:269470.
UCSCiuc008qqo.2. mouse.

Organism-specific databases

CTDi10885.
MGIiMGI:2443143. Wdr3.

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00860000133855.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ8BHB4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG091G023R.
PhylomeDBiQ8BHB4.
TreeFamiTF300427.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ8BHB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033285.
ExpressionAtlasiQ8BHB4. baseline and differential.
GenevisibleiQ8BHB4. MM.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
PF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR3_MOUSE
AccessioniPrimary (citable) accession number: Q8BHB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.