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Protein

WD repeat-containing protein 3

Gene

Wdr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 3
Gene namesi
Name:Wdr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2443143 Wdr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309411 – 942WD repeat-containing protein 3Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineCombined sources1
Cross-linki473Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei725PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BHB4
MaxQBiQ8BHB4
PaxDbiQ8BHB4
PeptideAtlasiQ8BHB4
PRIDEiQ8BHB4

PTM databases

iPTMnetiQ8BHB4
PhosphoSitePlusiQ8BHB4
SwissPalmiQ8BHB4

Expressioni

Gene expression databases

BgeeiENSMUSG00000033285
ExpressionAtlasiQ8BHB4 baseline and differential
GenevisibleiQ8BHB4 MM

Interactioni

Protein-protein interaction databases

BioGridi234655, 3 interactors
STRINGi10090.ENSMUSP00000060613

Structurei

3D structure databases

ProteinModelPortaliQ8BHB4
SMRiQ8BHB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 60WD 1Add BLAST40
Repeati63 – 102WD 2Add BLAST40
Repeati105 – 144WD 3Add BLAST40
Repeati147 – 186WD 4Add BLAST40
Repeati189 – 228WD 5Add BLAST40
Repeati277 – 316WD 6Add BLAST40
Repeati412 – 450WD 7Add BLAST39
Repeati452 – 490WD 8Add BLAST39
Repeati493 – 532WD 9Add BLAST40
Repeati546 – 585WD 10Add BLAST40
Repeati588 – 629WD 11Add BLAST42
Repeati630 – 669WD 12Add BLAST40
Repeati672 – 711WD 13Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi927 – 932Poly-Lys6

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0306 Eukaryota
ENOG410XR1C LUCA
GeneTreeiENSGT00910000144238
HOGENOMiHOG000212524
HOVERGENiHBG013192
InParanoidiQ8BHB4
KOiK14556
OMAiDTMVKWW
OrthoDBiEOG091G023R
PhylomeDBiQ8BHB4
TreeFamiTF300427

Family and domain databases

Gene3Di2.130.10.10, 4 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 8 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50998 SSF50998, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 9 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BHB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTKQYLRY VASAVFGLIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW
60 70 80 90 100
DLRKGEKILI LQGNKQEVTC LCPSPDGLHL AVGYEDGAIR IFSLLSGEGN
110 120 130 140 150
ITFNGHKAAV TSLKYDQLGG RLASGSKDTD VIIWDVINES GLYRLKGHKD
160 170 180 190 200
AVTQALFLRE RNLLVTSGKD TMVKWWDLDN QHCFKTMVGH RTEVWGLVLV
210 220 230 240 250
SEEKRLITGA ADSELRAWDI DYLQEIDDPE EPEPKKIKEC PGIQDTPESE
260 270 280 290 300
DSTLEADDEK SEDRILSCSK AGSIMREGRD RVVNLAVDKT GRILACHGTD
310 320 330 340 350
SVLEVFCILS KAEVQKKMDK KLKKARKKAR LNSANEEEDP ETSVSMTLQD
360 370 380 390 400
EILRVAKIKT SAKIKSFDLI HSPQGELKAV FLLQNNLVEL YSLNASLPAP
410 420 430 440 450
QPVRTSRITI GGHRSDVRTL SFSSDNIAVL SAAADSIKIW NRSTLQCIRT
460 470 480 490 500
MPCEYALCSF FVPGDRQVVI GTKTGNLQLY DLASGTLLET IAAHDGALWS
510 520 530 540 550
MSLSPDQRGF VTGGADKAVK FWDFELVTDK NSTQKRLSVK QTRTLQLDED
560 570 580 590 600
VLCVSYSPNQ KLLAVSLLDC TVKVFYVDTL KFFLSLYGHK LPVLCMDISH
610 620 630 640 650
DGALIATGSA DRNVKIWGLD FGDCHRSLFA HDDSVMYLRF VPKSHLFFTA
660 670 680 690 700
GKDHKIKQWD ADKFEHIQTL EGHHQEIWCL AVSPSGDYVV SASHDKSLRL
710 720 730 740 750
WERTREPLIL EEEREMQREA EYEESVAKED QPAVPGETQG DNYFTGKKTI
760 770 780 790 800
ETVKAAERIM EAIELHREET AKMKEHRAIC KAAGKEVPLP VNPILMAHGN
810 820 830 840 850
ISPSAYVLET FKGIRSSELE EALLVLPFSY VPDVLTLFNE FIQTGLDVEL
860 870 880 890 900
LCRCLFFLLR IHFGQITSNQ MLVPVIEKLK ETTISKVRQV QDAIGFNMAG
910 920 930 940
LDYLKRECEA KSEVMFFAEA TSHLEEKKKK RKNRKRMILT LT
Length:942
Mass (Da):105,775
Last modified:March 1, 2003 - v1
Checksum:i36F2E83AD4FF85C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050738 mRNA Translation: BAC34400.1
AK050797 mRNA Translation: BAC34414.1
BC063100 mRNA Translation: AAH63100.1
CCDSiCCDS17674.1
RefSeqiNP_780761.1, NM_175552.4
UniGeneiMm.24591

Genome annotation databases

EnsembliENSMUST00000052120; ENSMUSP00000060613; ENSMUSG00000033285
GeneIDi269470
KEGGimmu:269470
UCSCiuc008qqo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWDR3_MOUSE
AccessioniPrimary (citable) accession number: Q8BHB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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