ID   Q8BHB2_MOUSE            Unreviewed;       917 AA.
AC   Q8BHB2;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=Histone-lysine N-methyltransferase EHMT1 {ECO:0008006|Google:ProtNLM};
GN   Name=Ehmt1 {ECO:0000313|MGI:MGI:1924933};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC33756.1};
RN   [1] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAC33756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC33756.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAC38402.1}, Heart
RC   {ECO:0000313|EMBL:BAC34869.1}, and Whole body
RC   {ECO:0000313|EMBL:BAC33756.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
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DR   EMBL; AK049454; BAC33756.1; -; mRNA.
DR   EMBL; AK052174; BAC34869.1; -; mRNA.
DR   EMBL; AK082062; BAC38402.1; -; mRNA.
DR   RefSeq; NP_766133.2; NM_172545.4.
DR   AlphaFoldDB; Q8BHB2; -.
DR   IntAct; Q8BHB2; 1.
DR   PeptideAtlas; Q8BHB2; -.
DR   DNASU; 77683; -.
DR   GeneID; 77683; -.
DR   AGR; MGI:1924933; -.
DR   CTD; 79813; -.
DR   MGI; MGI:1924933; Ehmt1.
DR   OrthoDB; 5481936at2759; -.
DR   BioGRID-ORCS; 77683; 20 hits in 86 CRISPR screens.
DR   ChiTaRS; Ehmt1; mouse.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0046974; F:histone H3K9 methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0008168; F:methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR   CDD; cd20905; EHMT_ZBD; 1.
DR   CDD; cd10535; SET_EHMT1; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR043550; EHMT1/EHMT2.
DR   InterPro; IPR047762; EHMT_CRR.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR038035; SET_EHMT1.
DR   PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR   PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF21533; EHMT1-2_CRR; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 7.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 5.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454}.
FT   REPEAT          391..423
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          424..456
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          457..481
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          491..523
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          557..589
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          679..742
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          745..862
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..34
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        892..908
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   917 AA;  101018 MW;  3925B0891108F2F8 CRC64;
     MSETDRAAKM DGDSEEEQES PDTGEDEDGG DESDLSSESS IKKKFLKRRG KTDSPWIKPA
     RKRRRRSRKK PSSMLGSEAC KSSPGSMEQA ALGDSAGYME VSLDSLDLRV RGILSSQTEN
     EGLASGPDVL GTDGLQEVPL CSCRMETPKS REISTLANNQ CMATESVDHE LGRCTNSVVK
     YELMRPSNKA PLLVLCEDHR GRMVKHQCCP GCGYFCTAGN FMECQPESSI SHRFHKDCAS
     RVNNASYCPH CGEEASKAKE VTIAKADTTS TVTLAPGQEK SLAAEGRADT TTGSIAGAPE
     DERSQSTAPQ APECFDPAGP AGLVRPTSGL SQGPGKETLE SALIALDSEK PKKLRFHPKQ
     LYFSARQGEL QKVLLMLVDG IDPNFKMEHQ SKRSPLHAAA EAGHVDICHM LVQAGANIDT
     CSEDQRTPLM EAAENNHLDA VKYLIKAGAQ VDPKDAEGST CLHLAAKKGH YDVVQYLLSN
     GQMDVNCQDD GGWTPMIWAT EYKHVELVKL LLSKGSDINI RDNEENICLH WAAFSGCVDI
     AEILLAAKCD LHAVNIHGDS PLHIAARENR YDCVVLFLSR DSDVTLKNKE GETPLQCASL
     SSQVWSALQM SKALRDSAPD KPVAVEKTVS RDIARGYERI PIPCVNAVDS ELCPTNYKYV
     SQNCVTSPMN IDRNITHLQY CVCVDDCSSS TCMCGQLSMR CWYDKDGRLL PEFNMAEPPL
     IFECNHACSC WRNCRNRVVQ NGLRARLQLY RTQDMGWGVR SLQDIPLGTF VCEYVGELIS
     DSEADVREED SYLFDLDNKD GEVYCIDARF YGNVSRFINH HCEPNLVPVR VFMSHQDLRF
     PRIAFFSTRL IQAGEQLGFD YGERFWDVKG KLFSCRCGSS KCRHSSAALA QRQASAAQEP
     QENGLPDTSS AAAADPL
//