Q8BHB2 (Q8BHB2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC33756.1

Gene names

Name:

Ehmt1 MGI 1924933

Organism

Mus musculus (Mouse) EMBL BAC33756.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	917 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS007728 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. RuleBase RU004542
Subcellular location	Nucleus By similarity RuleBase RU004542.
Sequence similarities	Contains 1 SET domain. SAAS SAAS007728 RuleBase RU004538 Contains 1 pre-SET domain. SAAS SAAS007728 RuleBase RU004542

Ontologies

Keywords
Cellular component	Chromosome SAAS SAAS007728 Nucleus SAAS SAAS007728 RuleBase RU004542
Domain	ANK repeat RuleBase RU003321 Repeat RuleBase RU003536
Molecular function	Methyltransferase SAAS SAAS007728 RuleBase RU004542 Transferase
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 17392792. Source: MGI peptidyl-lysine dimethylation Inferred from electronic annotation. Source: Compara
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone-lysine N-methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BHB2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3925B0891108F2F8	FASTA	917	101,018
	10 20 30 40 50 60 MSETDRAAKM DGDSEEEQES PDTGEDEDGG DESDLSSESS IKKKFLKRRG KTDSPWIKPA 70 80 90 100 110 120 RKRRRRSRKK PSSMLGSEAC KSSPGSMEQA ALGDSAGYME VSLDSLDLRV RGILSSQTEN 130 140 150 160 170 180 EGLASGPDVL GTDGLQEVPL CSCRMETPKS REISTLANNQ CMATESVDHE LGRCTNSVVK 190 200 210 220 230 240 YELMRPSNKA PLLVLCEDHR GRMVKHQCCP GCGYFCTAGN FMECQPESSI SHRFHKDCAS 250 260 270 280 290 300 RVNNASYCPH CGEEASKAKE VTIAKADTTS TVTLAPGQEK SLAAEGRADT TTGSIAGAPE 310 320 330 340 350 360 DERSQSTAPQ APECFDPAGP AGLVRPTSGL SQGPGKETLE SALIALDSEK PKKLRFHPKQ 370 380 390 400 410 420 LYFSARQGEL QKVLLMLVDG IDPNFKMEHQ SKRSPLHAAA EAGHVDICHM LVQAGANIDT 430 440 450 460 470 480 CSEDQRTPLM EAAENNHLDA VKYLIKAGAQ VDPKDAEGST CLHLAAKKGH YDVVQYLLSN 490 500 510 520 530 540 GQMDVNCQDD GGWTPMIWAT EYKHVELVKL LLSKGSDINI RDNEENICLH WAAFSGCVDI 550 560 570 580 590 600 AEILLAAKCD LHAVNIHGDS PLHIAARENR YDCVVLFLSR DSDVTLKNKE GETPLQCASL 610 620 630 640 650 660 SSQVWSALQM SKALRDSAPD KPVAVEKTVS RDIARGYERI PIPCVNAVDS ELCPTNYKYV 670 680 690 700 710 720 SQNCVTSPMN IDRNITHLQY CVCVDDCSSS TCMCGQLSMR CWYDKDGRLL PEFNMAEPPL 730 740 750 760 770 780 IFECNHACSC WRNCRNRVVQ NGLRARLQLY RTQDMGWGVR SLQDIPLGTF VCEYVGELIS 790 800 810 820 830 840 DSEADVREED SYLFDLDNKD GEVYCIDARF YGNVSRFINH HCEPNLVPVR VFMSHQDLRF 850 860 870 880 890 900 PRIAFFSTRL IQAGEQLGFD YGERFWDVKG KLFSCRCGSS KCRHSSAALA QRQASAAQEP 910 QENGLPDTSS AAAADPL

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[7]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC38402.1. Tissue: Head EMBL BAC38402.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
[9]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33756.1. Tissue: Head EMBL BAC38402.1, Heart EMBL BAC34869.1 and Whole body EMBL BAC33756.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK049454 mRNA. Translation: BAC33756.1. AK052174 mRNA. Translation: BAC34869.1. AK082062 mRNA. Translation: BAC38402.1.
IPI	IPI00268926.
UniGene	Mm.24176.
3D structure databases
HSSP	HSSP built from PDB template 1PEG based on UniProtKB Q8X225.
SMR	Q8BHB2. Positions 384-617, 625-885.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8BHB2. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
KEGG	mmu:77683.
Organism-specific databases
CTD	79813.
MGI	MGI:1924933. Ehmt1.
Phylogenomic databases
HOGENOM	HOG000231216.
HOVERGEN	HBG028394.
InParanoid	Q8BHB2.
KO	K11420.
Gene expression databases
Genevestigator	Q8BHB2.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR007728. Pre-SET_dom. IPR003606. Pre-SET_Zn-bd_sub. IPR001214. SET_dom. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 7 hits. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	347359.
SOURCE	Search...

Entry information

Entry name

Q8BHB2_MOUSE

Accession

Primary (citable) accession number: Q8BHB2

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)