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Q8BHB0 (NOD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleotide-binding oligomerization domain-containing protein 1
Alternative name(s):
Caspase recruitment domain-containing protein 4
Gene names
Name:Nod1
Synonyms:Card4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection By similarity.

Subunit structure

Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection By similarity.

Subcellular location

Cytoplasm By similarity. Cell membrane By similarity. Apical cell membrane By similarity. Basolateral cell membrane By similarity. Note: Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells By similarity.

Sequence similarities

Contains 1 CARD domain.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.

Ontologies

Keywords
   Biological processApoptosis
Immunity
Innate immunity
   Cellular componentCell membrane
Cytoplasm
Membrane
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 18261938. Source: MGI

defense response to bacterium

Inferred from sequence or structural similarity. Source: HGNC

detection of bacterium

Inferred from sequence or structural similarity. Source: HGNC

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-8 biosynthetic process

Inferred from sequence or structural similarity. Source: HGNC

intracellular signal transduction

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of JNK cascade

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of NF-kappaB transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of dendritic cell antigen processing and presentation

Inferred from mutant phenotype PubMed 20008287. Source: BHF-UCL

positive regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 18261938. Source: MGI

positive regulation of stress-activated MAPK cascade

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 18261938. Source: MGI

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

basolateral plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 20534456. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 953953Nucleotide-binding oligomerization domain-containing protein 1
PRO_0000144078

Regions

Domain15 – 10793CARD
Domain196 – 531336NACHT
Repeat702 – 72524LRR 1
Repeat727 – 75024LRR 2
Repeat755 – 77824LRR 3
Repeat783 – 80624LRR 4
Repeat839 – 86224LRR 5
Repeat867 – 89024LRR 6
Repeat895 – 91824LRR 7
Repeat923 – 94624LRR 8
Nucleotide binding202 – 2098ATP Potential

Natural variations

Natural variant8841S → A in strain: Czech II. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BHB0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 39C639621CEB1A58

FASTA953107,740
        10         20         30         40         50         60 
MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF SAEDAEIVCA 

        70         80         90        100        110        120 
CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL RLWLSEIGFS PSQLIRTKTI 

       130        140        150        160        170        180 
VNTDPVSRYT QQLRHQLGRD SKFMLCYAQK EDLLLEETYM DTLMELVGFN NENLGSLGGL 

       190        200        210        220        230        240 
DCLLDHSTGV LNEHGETVFV FGDAGVGKSM LLQRLQSLWA SGRLTSTAKF FFHFRCRMFS 

       250        260        270        280        290        300 
CFKESDMLSL QDLLFKHFCY PEQDPEEVFS FLLRFPHTAL FTFDGLDELH SDFDLSRVPD 

       310        320        330        340        350        360 
SCCPWEPAHP LVLLANLLSG RLLKGAGKLL TARTGVEVPR QLLRKKVLLR GFSPSHLRAY 

       370        380        390        400        410        420 
ARRMFPERTA QEHLLQQLDA NPNLCSLCGV PLFCWIIFRC FQHFQTVFEG SSSQLPDCAV 

       430        440        450        460        470        480 
TLTDVFLLVT EVHLNRPQPS SLVQRNTRSP AETLRAGWRT LHALGEVAHR GTDKSLFVFG 

       490        500        510        520        530        540 
QEEVQASKLQ EGDLQLGFLR ALPDVGPEQG QSYEFFHLTL QAFFTAFFLV ADDKVSTREL 

       550        560        570        580        590        600 
LRFFREWTSP GEATSSSCHS SFFSFQCLGG RSRLGPDPFR NKDHFQFTNL FLCGLLAKAR 

       610        620        630        640        650        660 
QKLLRQLVPK AILRRKRKAL WAHLFASLRS YLKSLPRVQS GGFNQVHAMP TFLWMLRCIY 

       670        680        690        700        710        720 
ETQSQKVGRL AARGISADYL KLAFCNACSA DCSALSFVLH HFHRQLALDL DNNNLNDYGV 

       730        740        750        760        770        780 
QELQPCFSRL TVIRLSVNQI TDTGVKVLCE ELTKYKIVTF LGLYNNQITD IGARYVAQIL 

       790        800        810        820        830        840 
DECRGLKHLK LGKNRITSEG GKCVALAVKN STSIVDVGMW GNQIGDEGAK AFAEALKDHP 

       850        860        870        880        890        900 
SLTTLSLAFN GISPEGGKSL AQALKQNTTL TVIWLTKNEL NDESAECFAE MLRVNQTLRH 

       910        920        930        940        950 
LWLIQNRITA KGTAQLARAL QKNTAITEIC LNGNLIKPEE AKVFENEKRI ICF 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Cerebellum and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-884.
Strain: Czech II and FVB/N.
Tissue: Mammary cancer.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK082663 mRNA. Translation: BAC38566.1.
AK089662 mRNA. Translation: BAC40940.1.
BC042670 mRNA. Translation: AAH42670.1.
BC043670 mRNA. Translation: AAH43670.1.
CCDSCCDS20160.1.
RefSeqNP_001164478.1. NM_001171007.1.
NP_766317.1. NM_172729.3.
XP_006505340.1. XM_006505277.1.
UniGeneMm.28498.

3D structure databases

ProteinModelPortalQ8BHB0.
SMRQ8BHB0. Positions 17-101, 193-218, 660-946.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid223435. 3 interactions.
DIPDIP-59535N.

PTM databases

PhosphoSiteQ8BHB0.

Proteomic databases

PaxDbQ8BHB0.
PRIDEQ8BHB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060655; ENSMUSP00000055747; ENSMUSG00000038058.
ENSMUST00000168172; ENSMUSP00000130487; ENSMUSG00000038058.
GeneID107607.
KEGGmmu:107607.
UCSCuc009caf.2. mouse.

Organism-specific databases

CTD10392.
MGIMGI:1341839. Nod1.

Phylogenomic databases

eggNOGNOG275503.
GeneTreeENSGT00710000106284.
HOGENOMHOG000113813.
HOVERGENHBG050793.
InParanoidQ8BHB0.
KOK08727.
OMALCYAQKE.
OrthoDBEOG7H4DV9.
PhylomeDBQ8BHB0.
TreeFamTF352118.

Gene expression databases

ArrayExpressQ8BHB0.
BgeeQ8BHB0.
GenevestigatorQ8BHB0.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR007111. NACHT_NTPase.
[Graphical view]
PfamPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio359142.
PROQ8BHB0.
SOURCESearch...

Entry information

Entry nameNOD1_MOUSE
AccessionPrimary (citable) accession number: Q8BHB0
Secondary accession number(s): Q8BUT6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot