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Q8BHB0

- NOD1_MOUSE

UniProt

Q8BHB0 - NOD1_MOUSE

Protein

Nucleotide-binding oligomerization domain-containing protein 1

Gene

Nod1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi202 – 2098ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. defense response to bacterium Source: HGNC
    3. defense response to Gram-positive bacterium Source: MGI
    4. detection of bacterium Source: HGNC
    5. innate immune response Source: UniProtKB-KW
    6. interleukin-8 biosynthetic process Source: HGNC
    7. intracellular signal transduction Source: HGNC
    8. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    9. positive regulation of ERK1 and ERK2 cascade Source: MGI
    10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    11. positive regulation of interleukin-6 production Source: MGI
    12. positive regulation of JNK cascade Source: MGI
    13. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    14. positive regulation of stress-activated MAPK cascade Source: MGI
    15. positive regulation of tumor necrosis factor production Source: MGI

    Keywords - Biological processi

    Apoptosis, Immunity, Innate immunity

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleotide-binding oligomerization domain-containing protein 1
    Alternative name(s):
    Caspase recruitment domain-containing protein 4
    Gene namesi
    Name:Nod1
    Synonyms:Card4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1341839. Nod1.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity. Apical cell membrane By similarity. Basolateral cell membrane By similarity
    Note: Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. basolateral plasma membrane Source: UniProtKB
    3. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 953953Nucleotide-binding oligomerization domain-containing protein 1PRO_0000144078Add
    BLAST

    Proteomic databases

    PaxDbiQ8BHB0.
    PRIDEiQ8BHB0.

    PTM databases

    PhosphoSiteiQ8BHB0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BHB0.
    BgeeiQ8BHB0.
    GenevestigatoriQ8BHB0.

    Interactioni

    Subunit structurei

    Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection By similarity.By similarity

    Protein-protein interaction databases

    BioGridi223435. 3 interactions.
    DIPiDIP-59535N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BHB0.
    SMRiQ8BHB0. Positions 17-101, 193-218, 660-946.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10793CARDPROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 531336NACHTPROSITE-ProRule annotationAdd
    BLAST
    Repeati702 – 72524LRR 1Add
    BLAST
    Repeati727 – 75024LRR 2Add
    BLAST
    Repeati755 – 77824LRR 3Add
    BLAST
    Repeati783 – 80624LRR 4Add
    BLAST
    Repeati839 – 86224LRR 5Add
    BLAST
    Repeati867 – 89024LRR 6Add
    BLAST
    Repeati895 – 91824LRR 7Add
    BLAST
    Repeati923 – 94624LRR 8Add
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation
    Contains 8 LRR (leucine-rich) repeats.Curated
    Contains 1 NACHT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG275503.
    GeneTreeiENSGT00710000106284.
    HOGENOMiHOG000113813.
    HOVERGENiHBG050793.
    InParanoidiQ8BHB0.
    KOiK08727.
    OMAiLCYAQKE.
    OrthoDBiEOG7H4DV9.
    PhylomeDBiQ8BHB0.
    TreeFamiTF352118.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BHB0-1 [UniParc]FASTAAdd to Basket

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    MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF    50
    SAEDAEIVCA CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL 100
    RLWLSEIGFS PSQLIRTKTI VNTDPVSRYT QQLRHQLGRD SKFMLCYAQK 150
    EDLLLEETYM DTLMELVGFN NENLGSLGGL DCLLDHSTGV LNEHGETVFV 200
    FGDAGVGKSM LLQRLQSLWA SGRLTSTAKF FFHFRCRMFS CFKESDMLSL 250
    QDLLFKHFCY PEQDPEEVFS FLLRFPHTAL FTFDGLDELH SDFDLSRVPD 300
    SCCPWEPAHP LVLLANLLSG RLLKGAGKLL TARTGVEVPR QLLRKKVLLR 350
    GFSPSHLRAY ARRMFPERTA QEHLLQQLDA NPNLCSLCGV PLFCWIIFRC 400
    FQHFQTVFEG SSSQLPDCAV TLTDVFLLVT EVHLNRPQPS SLVQRNTRSP 450
    AETLRAGWRT LHALGEVAHR GTDKSLFVFG QEEVQASKLQ EGDLQLGFLR 500
    ALPDVGPEQG QSYEFFHLTL QAFFTAFFLV ADDKVSTREL LRFFREWTSP 550
    GEATSSSCHS SFFSFQCLGG RSRLGPDPFR NKDHFQFTNL FLCGLLAKAR 600
    QKLLRQLVPK AILRRKRKAL WAHLFASLRS YLKSLPRVQS GGFNQVHAMP 650
    TFLWMLRCIY ETQSQKVGRL AARGISADYL KLAFCNACSA DCSALSFVLH 700
    HFHRQLALDL DNNNLNDYGV QELQPCFSRL TVIRLSVNQI TDTGVKVLCE 750
    ELTKYKIVTF LGLYNNQITD IGARYVAQIL DECRGLKHLK LGKNRITSEG 800
    GKCVALAVKN STSIVDVGMW GNQIGDEGAK AFAEALKDHP SLTTLSLAFN 850
    GISPEGGKSL AQALKQNTTL TVIWLTKNEL NDESAECFAE MLRVNQTLRH 900
    LWLIQNRITA KGTAQLARAL QKNTAITEIC LNGNLIKPEE AKVFENEKRI 950
    ICF 953
    Length:953
    Mass (Da):107,740
    Last modified:March 1, 2003 - v1
    Checksum:i39C639621CEB1A58
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti884 – 8841S → A in strain: Czech II. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK082663 mRNA. Translation: BAC38566.1.
    AK089662 mRNA. Translation: BAC40940.1.
    BC042670 mRNA. Translation: AAH42670.1.
    BC043670 mRNA. Translation: AAH43670.1.
    CCDSiCCDS20160.1.
    RefSeqiNP_001164478.1. NM_001171007.1.
    NP_766317.1. NM_172729.3.
    XP_006505340.1. XM_006505277.1.
    UniGeneiMm.28498.

    Genome annotation databases

    EnsembliENSMUST00000060655; ENSMUSP00000055747; ENSMUSG00000038058.
    ENSMUST00000168172; ENSMUSP00000130487; ENSMUSG00000038058.
    GeneIDi107607.
    KEGGimmu:107607.
    UCSCiuc009caf.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK082663 mRNA. Translation: BAC38566.1 .
    AK089662 mRNA. Translation: BAC40940.1 .
    BC042670 mRNA. Translation: AAH42670.1 .
    BC043670 mRNA. Translation: AAH43670.1 .
    CCDSi CCDS20160.1.
    RefSeqi NP_001164478.1. NM_001171007.1.
    NP_766317.1. NM_172729.3.
    XP_006505340.1. XM_006505277.1.
    UniGenei Mm.28498.

    3D structure databases

    ProteinModelPortali Q8BHB0.
    SMRi Q8BHB0. Positions 17-101, 193-218, 660-946.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223435. 3 interactions.
    DIPi DIP-59535N.

    PTM databases

    PhosphoSitei Q8BHB0.

    Proteomic databases

    PaxDbi Q8BHB0.
    PRIDEi Q8BHB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060655 ; ENSMUSP00000055747 ; ENSMUSG00000038058 .
    ENSMUST00000168172 ; ENSMUSP00000130487 ; ENSMUSG00000038058 .
    GeneIDi 107607.
    KEGGi mmu:107607.
    UCSCi uc009caf.2. mouse.

    Organism-specific databases

    CTDi 10392.
    MGIi MGI:1341839. Nod1.

    Phylogenomic databases

    eggNOGi NOG275503.
    GeneTreei ENSGT00710000106284.
    HOGENOMi HOG000113813.
    HOVERGENi HBG050793.
    InParanoidi Q8BHB0.
    KOi K08727.
    OMAi LCYAQKE.
    OrthoDBi EOG7H4DV9.
    PhylomeDBi Q8BHB0.
    TreeFami TF352118.

    Enzyme and pathway databases

    Reactomei REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    NextBioi 359142.
    PROi Q8BHB0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BHB0.
    Bgeei Q8BHB0.
    Genevestigatori Q8BHB0.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Cerebellum and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-884.
      Strain: Czech II and FVB/N.
      Tissue: Mammary cancer.

    Entry informationi

    Entry nameiNOD1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHB0
    Secondary accession number(s): Q8BUT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3