ID   ACPL2_MOUSE             Reviewed;         480 AA.
AC   Q8BHA9; Q8BZ12;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Acid phosphatase-like protein 2;
DE            EC=3.1.3.2;
DE   Flags: Precursor;
GN   Name=Acpl2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RC   TISSUE=Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung,
RC   and Vagina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
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DR   EMBL; AK036973; BAC29653.1; -; mRNA.
DR   EMBL; AK043758; BAC31644.1; -; mRNA.
DR   EMBL; AK082059; BAC38400.1; -; mRNA.
DR   EMBL; AK083712; BAC39001.1; -; mRNA.
DR   EMBL; AK084605; BAC39227.1; -; mRNA.
DR   EMBL; AK144699; BAE26021.1; -; mRNA.
DR   EMBL; AK164254; BAE37705.1; -; mRNA.
DR   EMBL; BC023960; AAH23960.1; -; mRNA.
DR   EMBL; BC036342; AAH36342.1; -; mRNA.
DR   IPI; IPI00221818; -.
DR   RefSeq; NP_700469.1; -.
DR   UniGene; Mm.233031; -.
DR   HSSP; P15309; 1ND5.
DR   Ensembl; ENSMUSG00000043587; Mus musculus.
DR   GeneID; 235534; -.
DR   KEGG; mmu:235534; -.
DR   MGI; MGI:2442444; Acpl2.
DR   HOGENOM; Q8BHA9; -.
DR   HOVERGEN; Q8BHA9; -.
DR   OMA; Q8BHA9; RAANPID.
DR   BRENDA; 3.1.3.2; 244.
DR   NextBio; 382737; -.
DR   ArrayExpress; Q8BHA9; -.
DR   Bgee; Q8BHA9; -.
DR   CleanEx; MM_ACPL2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:EC.
DR   InterPro; IPR000560; Histidine_acid_Pase.
DR   Pfam; PF00328; Acid_phosphat_A; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; FALSE_NEG.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Secreted; Signal.
FT   SIGNAL        1     34       Potential.
FT   CHAIN        35    480       Acid phosphatase-like protein 2.
FT                                /FTId=PRO_0000314925.
FT   ACT_SITE     97     97       Nucleophile (By similarity).
FT   ACT_SITE    379    379       Proton donor (By similarity).
FT   CARBOHYD    305    305       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    123    123       K -> N (in Ref. 1; BAC29653).
FT   CONFLICT    374    374       L -> H (in Ref. 1; BAC29653).
SQ   SEQUENCE   480 AA;  54937 MW;  3A8E2476B9E10BB4 CRC64;
     MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD PVTEPPTVDP
     VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR YPLYAIPKTK RPEIDCTLVA
     SRKPYHPKLE AFISHMLKGS GASFESPLNS LPLYPNHPLC ETGELTQTGV VQHLLNGQLL
     RDIYLRKHKL LPNNWSSDQL YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF
     CSGSCYCPLR NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC
     HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH PILNQTVNRM
     QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA ARLVFELWQD RQKPSEHSVR
     ILYNGADVTF HTSFCHDFHK RSPKPMCPLE NLVRFVKRDM FVALDGSSTN YYDACHGEGA
//