Reviewed, UniProtKB/Swiss-Prot Q8BHA9 (ACPL2_MOUSE)

Names and origin

Protein names

Recommended name:
    Acid phosphatase-like protein 2
    EC=3.1.3.2

Gene names

Name:

Acpl2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 480	446	Acid phosphatase-like protein 2		PRO_0000314925
Sites
	Active site	97	1	Nucleophile By similarity
	Active site	379	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	305	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	123	1	K → N in BAC29653. Ref.1
	Sequence conflict	374	1	L → H in BAC29653. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BHA9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3A8E2476B9E10BB4	FASTA	480	54,937
	10 20 30 40 50 60 MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD PVTEPPTVDP 70 80 90 100 110 120 VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR YPLYAIPKTK RPEIDCTLVA 130 140 150 160 170 180 SRKPYHPKLE AFISHMLKGS GASFESPLNS LPLYPNHPLC ETGELTQTGV VQHLLNGQLL 190 200 210 220 230 240 RDIYLRKHKL LPNNWSSDQL YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF 250 260 270 280 290 300 CSGSCYCPLR NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 310 320 330 340 350 360 HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH PILNQTVNRM 370 380 390 400 410 420 QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA ARLVFELWQD RQKPSEHSVR 430 440 450 460 470 480 ILYNGADVTF HTSFCHDFHK RSPKPMCPLE NLVRFVKRDM FVALDGSSTN YYDACHGEGA

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung and Vagina.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK036973 mRNA. Translation: BAC29653.1. AK043758 mRNA. Translation: BAC31644.1. AK082059 mRNA. Translation: BAC38400.1. AK083712 mRNA. Translation: BAC39001.1. AK084605 mRNA. Translation: BAC39227.1. AK144699 mRNA. Translation: BAE26021.1. AK164254 mRNA. Translation: BAE37705.1. BC023960 mRNA. Translation: AAH23960.1. BC036342 mRNA. Translation: AAH36342.1.
IPI	IPI00221818.
RefSeq	NP_700469.1.
UniGene	Mm.233031
3D structure databases
HSSP	HSSP built from PDB template 1ND5 based on UniProtKB P15309.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000043587. Mus musculus. [Contig view]
GeneID	235534.
KEGG	mmu:235534.
Organism-specific databases
MGI	MGI:2442444. Acpl2.
Phylogenomic databases
HOGENOM	Q8BHA9.
HOVERGEN	Q8BHA9.
OMA	Q8BHA9. RAANPID.
Enzyme and pathway databases
BRENDA	3.1.3.2. 244.
Gene expression databases
ArrayExpress	Q8BHA9.
Bgee	Q8BHA9.
CleanEx	MM_ACPL2.
Family and domain databases
InterPro	IPR000560. Histidine_acid_Pase. [Graphical view]
Pfam	PF00328. Acid_phosphat_A. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. False negative. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	382737.
SOURCE	Search...

Entry information

Entry name

ACPL2_MOUSE

Accession

Primary (citable) accession number: Q8BHA9
Secondary accession number(s): Q8BZ12

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)