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Q8BHA9

- ACPL2_MOUSE

UniProt

Q8BHA9 - ACPL2_MOUSE

Protein

Acid phosphatase-like protein 2

Gene

Acpl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971NucleophileBy similarity
    Active sitei379 – 3791Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase-like protein 2 (EC:3.1.3.2)
    Gene namesi
    Name:Acpl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2442444. Acpl2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 480446Acid phosphatase-like protein 2PRO_0000314925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BHA9.

    PTM databases

    PhosphoSiteiQ8BHA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BHA9.
    BgeeiQ8BHA9.
    CleanExiMM_ACPL2.
    GenevestigatoriQ8BHA9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000108574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BHA9.
    SMRiQ8BHA9. Positions 87-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG321954.
    GeneTreeiENSGT00390000016324.
    HOGENOMiHOG000033787.
    HOVERGENiHBG106056.
    InParanoidiQ8BHA9.
    OMAiCHNVSFP.
    OrthoDBiEOG747PJ2.
    PhylomeDBiQ8BHA9.
    TreeFamiTF318821.

    Family and domain databases

    Gene3Di3.40.50.1240. 2 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BHA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD    50
    PVTEPPTVDP VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR 100
    YPLYAIPKTK RPEIDCTLVA SRKPYHPKLE AFISHMLKGS GASFESPLNS 150
    LPLYPNHPLC ETGELTQTGV VQHLLNGQLL RDIYLRKHKL LPNNWSSDQL 200
    YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF CSGSCYCPLR 250
    NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 300
    HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH 350
    PILNQTVNRM QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA 400
    ARLVFELWQD RQKPSEHSVR ILYNGADVTF HTSFCHDFHK RSPKPMCPLE 450
    NLVRFVKRDM FVALDGSSTN YYDACHGEGA 480
    Length:480
    Mass (Da):54,937
    Last modified:March 1, 2003 - v1
    Checksum:i3A8E2476B9E10BB4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231K → N in BAC29653. (PubMed:16141072)Curated
    Sequence conflicti374 – 3741L → H in BAC29653. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036973 mRNA. Translation: BAC29653.1.
    AK043758 mRNA. Translation: BAC31644.1.
    AK082059 mRNA. Translation: BAC38400.1.
    AK083712 mRNA. Translation: BAC39001.1.
    AK084605 mRNA. Translation: BAC39227.1.
    AK144699 mRNA. Translation: BAE26021.1.
    AK164254 mRNA. Translation: BAE37705.1.
    BC023960 mRNA. Translation: AAH23960.1.
    BC036342 mRNA. Translation: AAH36342.1.
    CCDSiCCDS23418.1.
    RefSeqiNP_001276574.1. NM_001289645.1.
    NP_001276575.1. NM_001289646.1.
    NP_001276576.1. NM_001289647.1.
    NP_700469.1. NM_153420.3.
    XP_006511200.1. XM_006511137.1.
    XP_006511201.1. XM_006511138.1.
    UniGeneiMm.233031.

    Genome annotation databases

    EnsembliENSMUST00000078478; ENSMUSP00000077571; ENSMUSG00000043587.
    ENSMUST00000112951; ENSMUSP00000108574; ENSMUSG00000043587.
    ENSMUST00000119141; ENSMUSP00000113489; ENSMUSG00000043587.
    ENSMUST00000120101; ENSMUSP00000113210; ENSMUSG00000043587.
    GeneIDi235534.
    KEGGimmu:235534.
    UCSCiuc009rcu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036973 mRNA. Translation: BAC29653.1 .
    AK043758 mRNA. Translation: BAC31644.1 .
    AK082059 mRNA. Translation: BAC38400.1 .
    AK083712 mRNA. Translation: BAC39001.1 .
    AK084605 mRNA. Translation: BAC39227.1 .
    AK144699 mRNA. Translation: BAE26021.1 .
    AK164254 mRNA. Translation: BAE37705.1 .
    BC023960 mRNA. Translation: AAH23960.1 .
    BC036342 mRNA. Translation: AAH36342.1 .
    CCDSi CCDS23418.1.
    RefSeqi NP_001276574.1. NM_001289645.1.
    NP_001276575.1. NM_001289646.1.
    NP_001276576.1. NM_001289647.1.
    NP_700469.1. NM_153420.3.
    XP_006511200.1. XM_006511137.1.
    XP_006511201.1. XM_006511138.1.
    UniGenei Mm.233031.

    3D structure databases

    ProteinModelPortali Q8BHA9.
    SMRi Q8BHA9. Positions 87-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000108574.

    PTM databases

    PhosphoSitei Q8BHA9.

    Proteomic databases

    PRIDEi Q8BHA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078478 ; ENSMUSP00000077571 ; ENSMUSG00000043587 .
    ENSMUST00000112951 ; ENSMUSP00000108574 ; ENSMUSG00000043587 .
    ENSMUST00000119141 ; ENSMUSP00000113489 ; ENSMUSG00000043587 .
    ENSMUST00000120101 ; ENSMUSP00000113210 ; ENSMUSG00000043587 .
    GeneIDi 235534.
    KEGGi mmu:235534.
    UCSCi uc009rcu.1. mouse.

    Organism-specific databases

    CTDi 92370.
    MGIi MGI:2442444. Acpl2.

    Phylogenomic databases

    eggNOGi NOG321954.
    GeneTreei ENSGT00390000016324.
    HOGENOMi HOG000033787.
    HOVERGENi HBG106056.
    InParanoidi Q8BHA9.
    OMAi CHNVSFP.
    OrthoDBi EOG747PJ2.
    PhylomeDBi Q8BHA9.
    TreeFami TF318821.

    Miscellaneous databases

    ChiTaRSi ACPL2. mouse.
    NextBioi 382737.
    PROi Q8BHA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BHA9.
    Bgeei Q8BHA9.
    CleanExi MM_ACPL2.
    Genevestigatori Q8BHA9.

    Family and domain databases

    Gene3Di 3.40.50.1240. 2 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung and Vagina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiACPL2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BHA9
    Secondary accession number(s): Q8BZ12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3