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Q8BHA9 (ACPL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acid phosphatase-like protein 2

EC=3.1.3.2
Gene names
Name:Acpl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 480446Acid phosphatase-like protein 2
PRO_0000314925

Sites

Active site971Nucleophile By similarity
Active site3791Proton donor By similarity

Amino acid modifications

Glycosylation3051N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1231K → N in BAC29653. Ref.1
Sequence conflict3741L → H in BAC29653. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BHA9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 3A8E2476B9E10BB4

FASTA48054,937
        10         20         30         40         50         60 
MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD PVTEPPTVDP 

        70         80         90        100        110        120 
VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR YPLYAIPKTK RPEIDCTLVA 

       130        140        150        160        170        180 
SRKPYHPKLE AFISHMLKGS GASFESPLNS LPLYPNHPLC ETGELTQTGV VQHLLNGQLL 

       190        200        210        220        230        240 
RDIYLRKHKL LPNNWSSDQL YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF 

       250        260        270        280        290        300 
CSGSCYCPLR NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 

       310        320        330        340        350        360 
HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH PILNQTVNRM 

       370        380        390        400        410        420 
QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA ARLVFELWQD RQKPSEHSVR 

       430        440        450        460        470        480 
ILYNGADVTF HTSFCHDFHK RSPKPMCPLE NLVRFVKRDM FVALDGSSTN YYDACHGEGA 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung and Vagina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK036973 mRNA. Translation: BAC29653.1.
AK043758 mRNA. Translation: BAC31644.1.
AK082059 mRNA. Translation: BAC38400.1.
AK083712 mRNA. Translation: BAC39001.1.
AK084605 mRNA. Translation: BAC39227.1.
AK144699 mRNA. Translation: BAE26021.1.
AK164254 mRNA. Translation: BAE37705.1.
BC023960 mRNA. Translation: AAH23960.1.
BC036342 mRNA. Translation: AAH36342.1.
RefSeqNP_700469.1. NM_153420.3.
XP_006511200.1. XM_006511137.1.
XP_006511201.1. XM_006511138.1.
UniGeneMm.233031.

3D structure databases

ProteinModelPortalQ8BHA9.
SMRQ8BHA9. Positions 87-456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000108574.

PTM databases

PhosphoSiteQ8BHA9.

Proteomic databases

PRIDEQ8BHA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078478; ENSMUSP00000077571; ENSMUSG00000043587.
ENSMUST00000112951; ENSMUSP00000108574; ENSMUSG00000043587.
ENSMUST00000119141; ENSMUSP00000113489; ENSMUSG00000043587.
ENSMUST00000120101; ENSMUSP00000113210; ENSMUSG00000043587.
GeneID235534.
KEGGmmu:235534.
UCSCuc009rcu.1. mouse.

Organism-specific databases

CTD92370.
MGIMGI:2442444. Acpl2.

Phylogenomic databases

eggNOGNOG321954.
GeneTreeENSGT00390000016324.
HOGENOMHOG000033787.
HOVERGENHBG106056.
InParanoidQ8BHA9.
OMACHNVSFP.
OrthoDBEOG747PJ2.
PhylomeDBQ8BHA9.
TreeFamTF318821.

Gene expression databases

ArrayExpressQ8BHA9.
BgeeQ8BHA9.
CleanExMM_ACPL2.
GenevestigatorQ8BHA9.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSACPL2. mouse.
NextBio382737.
PROQ8BHA9.
SOURCESearch...

Entry information

Entry nameACPL2_MOUSE
AccessionPrimary (citable) accession number: Q8BHA9
Secondary accession number(s): Q8BZ12
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot