Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BHA9

- ACPL2_MOUSE

UniProt

Q8BHA9 - ACPL2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acid phosphatase-like protein 2

Gene

Acpl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971NucleophileBy similarity
Active sitei379 – 3791Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase-like protein 2 (EC:3.1.3.2)
Gene namesi
Name:Acpl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2442444. Acpl2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 480446Acid phosphatase-like protein 2PRO_0000314925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BHA9.

PTM databases

PhosphoSiteiQ8BHA9.

Expressioni

Gene expression databases

BgeeiQ8BHA9.
CleanExiMM_ACPL2.
ExpressionAtlasiQ8BHA9. baseline and differential.
GenevestigatoriQ8BHA9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108574.

Structurei

3D structure databases

ProteinModelPortaliQ8BHA9.
SMRiQ8BHA9. Positions 87-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG321954.
GeneTreeiENSGT00390000016324.
HOGENOMiHOG000033787.
HOVERGENiHBG106056.
InParanoidiQ8BHA9.
OMAiCHNVSFP.
OrthoDBiEOG747PJ2.
PhylomeDBiQ8BHA9.
TreeFamiTF318821.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BHA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD
60 70 80 90 100
PVTEPPTVDP VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR
110 120 130 140 150
YPLYAIPKTK RPEIDCTLVA SRKPYHPKLE AFISHMLKGS GASFESPLNS
160 170 180 190 200
LPLYPNHPLC ETGELTQTGV VQHLLNGQLL RDIYLRKHKL LPNNWSSDQL
210 220 230 240 250
YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF CSGSCYCPLR
260 270 280 290 300
NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC
310 320 330 340 350
HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH
360 370 380 390 400
PILNQTVNRM QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA
410 420 430 440 450
ARLVFELWQD RQKPSEHSVR ILYNGADVTF HTSFCHDFHK RSPKPMCPLE
460 470 480
NLVRFVKRDM FVALDGSSTN YYDACHGEGA
Length:480
Mass (Da):54,937
Last modified:March 1, 2003 - v1
Checksum:i3A8E2476B9E10BB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231K → N in BAC29653. (PubMed:16141072)Curated
Sequence conflicti374 – 3741L → H in BAC29653. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036973 mRNA. Translation: BAC29653.1.
AK043758 mRNA. Translation: BAC31644.1.
AK082059 mRNA. Translation: BAC38400.1.
AK083712 mRNA. Translation: BAC39001.1.
AK084605 mRNA. Translation: BAC39227.1.
AK144699 mRNA. Translation: BAE26021.1.
AK164254 mRNA. Translation: BAE37705.1.
BC023960 mRNA. Translation: AAH23960.1.
BC036342 mRNA. Translation: AAH36342.1.
CCDSiCCDS23418.1.
RefSeqiNP_001276574.1. NM_001289645.1.
NP_001276575.1. NM_001289646.1.
NP_001276576.1. NM_001289647.1.
NP_700469.1. NM_153420.3.
XP_006511200.1. XM_006511137.1.
XP_006511201.1. XM_006511138.1.
UniGeneiMm.233031.

Genome annotation databases

EnsembliENSMUST00000078478; ENSMUSP00000077571; ENSMUSG00000043587.
ENSMUST00000112951; ENSMUSP00000108574; ENSMUSG00000043587.
ENSMUST00000119141; ENSMUSP00000113489; ENSMUSG00000043587.
ENSMUST00000120101; ENSMUSP00000113210; ENSMUSG00000043587.
GeneIDi235534.
KEGGimmu:235534.
UCSCiuc009rcu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036973 mRNA. Translation: BAC29653.1 .
AK043758 mRNA. Translation: BAC31644.1 .
AK082059 mRNA. Translation: BAC38400.1 .
AK083712 mRNA. Translation: BAC39001.1 .
AK084605 mRNA. Translation: BAC39227.1 .
AK144699 mRNA. Translation: BAE26021.1 .
AK164254 mRNA. Translation: BAE37705.1 .
BC023960 mRNA. Translation: AAH23960.1 .
BC036342 mRNA. Translation: AAH36342.1 .
CCDSi CCDS23418.1.
RefSeqi NP_001276574.1. NM_001289645.1.
NP_001276575.1. NM_001289646.1.
NP_001276576.1. NM_001289647.1.
NP_700469.1. NM_153420.3.
XP_006511200.1. XM_006511137.1.
XP_006511201.1. XM_006511138.1.
UniGenei Mm.233031.

3D structure databases

ProteinModelPortali Q8BHA9.
SMRi Q8BHA9. Positions 87-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000108574.

PTM databases

PhosphoSitei Q8BHA9.

Proteomic databases

PRIDEi Q8BHA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078478 ; ENSMUSP00000077571 ; ENSMUSG00000043587 .
ENSMUST00000112951 ; ENSMUSP00000108574 ; ENSMUSG00000043587 .
ENSMUST00000119141 ; ENSMUSP00000113489 ; ENSMUSG00000043587 .
ENSMUST00000120101 ; ENSMUSP00000113210 ; ENSMUSG00000043587 .
GeneIDi 235534.
KEGGi mmu:235534.
UCSCi uc009rcu.1. mouse.

Organism-specific databases

CTDi 92370.
MGIi MGI:2442444. Acpl2.

Phylogenomic databases

eggNOGi NOG321954.
GeneTreei ENSGT00390000016324.
HOGENOMi HOG000033787.
HOVERGENi HBG106056.
InParanoidi Q8BHA9.
OMAi CHNVSFP.
OrthoDBi EOG747PJ2.
PhylomeDBi Q8BHA9.
TreeFami TF318821.

Miscellaneous databases

ChiTaRSi ACPL2. mouse.
NextBioi 382737.
PROi Q8BHA9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BHA9.
CleanExi MM_ACPL2.
ExpressionAtlasi Q8BHA9. baseline and differential.
Genevestigatori Q8BHA9.

Family and domain databases

Gene3Di 3.40.50.1240. 2 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiACPL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BHA9
Secondary accession number(s): Q8BZ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3