Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Reticulocalbin-3

Gene

Rcn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi90 – 1011; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi126 – 1372PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi176 – 1873; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi213 – 2244PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi254 – 2655PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi290 – 3016PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Gene namesi
Name:Rcn3
Synonyms:D7Ertd671e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1277122. Rcn3.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000415221 – 328Reticulocalbin-3Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BH97.
MaxQBiQ8BH97.
PaxDbiQ8BH97.
PeptideAtlasiQ8BH97.
PRIDEiQ8BH97.

PTM databases

iPTMnetiQ8BH97.
PhosphoSitePlusiQ8BH97.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019539.
CleanExiMM_RCN3.
GenevisibleiQ8BH97. MM.

Interactioni

Protein-protein interaction databases

BioGridi206549. 1 interactor.
IntActiQ8BH97. 2 interactors.
MINTiMINT-4132067.
STRINGi10090.ENSMUSP00000019683.

Structurei

3D structure databases

ProteinModelPortaliQ8BH97.
SMRiQ8BH97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 112EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini113 – 148EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 198EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini200 – 235EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini241 – 276EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini277 – 312EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi325 – 328Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ8BH97.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ8BH97.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWRWSFLLL LLLLRHWALG KPSPDAGPHG QDRVHHGTPL SEAPHDDAHG
60 70 80 90 100
NFQYDHEAFL GRDVAKEFDK LSPEESQARL GRIVDRMDLA GDSDGWVSLA
110 120 130 140 150
ELRAWIAHTQ QRHIRDSVSA AWHTYDTDRD GRVGWEELRN ATYGHYEPGE
160 170 180 190 200
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM
210 220 230 240 250
RDIVVAETLE DLDKNKDGYV QVEEYIADLY SEEPGEEEPA WVQTERQQFR
260 270 280 290 300
EFRDLNKDGR LDGSEVGYWV LPPSQDQPLV EANHLLHESD TDKDGRLSKA
310 320
EILSNWNMFV GSQATNYGED LTRHHDEL
Length:328
Mass (Da):38,002
Last modified:March 1, 2003 - v1
Checksum:i3DF05C6F0D5A6314
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121A → R in BAB23076 (PubMed:16141072).Curated1
Sequence conflicti260R → Q in AAH05487 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003918 mRNA. Translation: BAB23076.1.
AK077943 mRNA. Translation: BAC37077.1.
AK082762 mRNA. Translation: BAC38608.1.
BC005487 mRNA. Translation: AAH05487.1.
BC025602 mRNA. Translation: AAH25602.1.
BC055903 mRNA. Translation: AAH55903.1.
BC092069 mRNA. Translation: AAH92069.1.
CCDSiCCDS21229.1.
RefSeqiNP_080831.2. NM_026555.2.
XP_006541049.1. XM_006540986.2.
XP_006541050.1. XM_006540987.2.
UniGeneiMm.29997.

Genome annotation databases

EnsembliENSMUST00000019683; ENSMUSP00000019683; ENSMUSG00000019539.
ENSMUST00000211352; ENSMUSP00000148227; ENSMUSG00000019539.
GeneIDi52377.
KEGGimmu:52377.
UCSCiuc009gta.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003918 mRNA. Translation: BAB23076.1.
AK077943 mRNA. Translation: BAC37077.1.
AK082762 mRNA. Translation: BAC38608.1.
BC005487 mRNA. Translation: AAH05487.1.
BC025602 mRNA. Translation: AAH25602.1.
BC055903 mRNA. Translation: AAH55903.1.
BC092069 mRNA. Translation: AAH92069.1.
CCDSiCCDS21229.1.
RefSeqiNP_080831.2. NM_026555.2.
XP_006541049.1. XM_006540986.2.
XP_006541050.1. XM_006540987.2.
UniGeneiMm.29997.

3D structure databases

ProteinModelPortaliQ8BH97.
SMRiQ8BH97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206549. 1 interactor.
IntActiQ8BH97. 2 interactors.
MINTiMINT-4132067.
STRINGi10090.ENSMUSP00000019683.

PTM databases

iPTMnetiQ8BH97.
PhosphoSitePlusiQ8BH97.

Proteomic databases

EPDiQ8BH97.
MaxQBiQ8BH97.
PaxDbiQ8BH97.
PeptideAtlasiQ8BH97.
PRIDEiQ8BH97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019683; ENSMUSP00000019683; ENSMUSG00000019539.
ENSMUST00000211352; ENSMUSP00000148227; ENSMUSG00000019539.
GeneIDi52377.
KEGGimmu:52377.
UCSCiuc009gta.3. mouse.

Organism-specific databases

CTDi57333.
MGIiMGI:1277122. Rcn3.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ8BH97.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ8BH97.
TreeFamiTF314849.

Miscellaneous databases

PROiQ8BH97.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019539.
CleanExiMM_RCN3.
GenevisibleiQ8BH97. MM.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN3_MOUSE
AccessioniPrimary (citable) accession number: Q8BH97
Secondary accession number(s): Q58E50
, Q8R137, Q99K35, Q9CTD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.