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Q8BH97

- RCN3_MOUSE

UniProt

Q8BH97 - RCN3_MOUSE

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Protein

Reticulocalbin-3

Gene

Rcn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi90 – 101121; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi126 – 137122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi176 – 187123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi213 – 224124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi254 – 265125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi290 – 301126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Gene namesi
Name:Rcn3
Synonyms:D7Ertd671e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1277122. Rcn3.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 328308Reticulocalbin-3PRO_0000004152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BH97.
PaxDbiQ8BH97.
PRIDEiQ8BH97.

PTM databases

PhosphoSiteiQ8BH97.

Expressioni

Gene expression databases

BgeeiQ8BH97.
CleanExiMM_RCN3.
ExpressionAtlasiQ8BH97. baseline and differential.
GenevestigatoriQ8BH97.

Interactioni

Protein-protein interaction databases

IntActiQ8BH97. 2 interactions.
MINTiMINT-4132067.

Structurei

3D structure databases

ProteinModelPortaliQ8BH97.
SMRiQ8BH97. Positions 78-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 11236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini113 – 14836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini163 – 19836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini200 – 23536EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 27636EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 31236EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi325 – 3284Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG286499.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ8BH97.
OMAiSDAPHDD.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ8BH97.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMWRWSFLLL LLLLRHWALG KPSPDAGPHG QDRVHHGTPL SEAPHDDAHG
60 70 80 90 100
NFQYDHEAFL GRDVAKEFDK LSPEESQARL GRIVDRMDLA GDSDGWVSLA
110 120 130 140 150
ELRAWIAHTQ QRHIRDSVSA AWHTYDTDRD GRVGWEELRN ATYGHYEPGE
160 170 180 190 200
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM
210 220 230 240 250
RDIVVAETLE DLDKNKDGYV QVEEYIADLY SEEPGEEEPA WVQTERQQFR
260 270 280 290 300
EFRDLNKDGR LDGSEVGYWV LPPSQDQPLV EANHLLHESD TDKDGRLSKA
310 320
EILSNWNMFV GSQATNYGED LTRHHDEL
Length:328
Mass (Da):38,002
Last modified:March 1, 2003 - v1
Checksum:i3DF05C6F0D5A6314
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211A → R in BAB23076. (PubMed:16141072)Curated
Sequence conflicti260 – 2601R → Q in AAH05487. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003918 mRNA. Translation: BAB23076.1.
AK077943 mRNA. Translation: BAC37077.1.
AK082762 mRNA. Translation: BAC38608.1.
BC005487 mRNA. Translation: AAH05487.1.
BC025602 mRNA. Translation: AAH25602.1.
BC055903 mRNA. Translation: AAH55903.1.
BC092069 mRNA. Translation: AAH92069.1.
CCDSiCCDS21229.1.
RefSeqiNP_080831.2. NM_026555.2.
XP_006541049.1. XM_006540986.1.
XP_006541050.1. XM_006540987.1.
UniGeneiMm.29997.

Genome annotation databases

EnsembliENSMUST00000019683; ENSMUSP00000019683; ENSMUSG00000019539.
ENSMUST00000117546; ENSMUSP00000112739; ENSMUSG00000019539.
GeneIDi52377.
KEGGimmu:52377.
UCSCiuc009gta.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003918 mRNA. Translation: BAB23076.1 .
AK077943 mRNA. Translation: BAC37077.1 .
AK082762 mRNA. Translation: BAC38608.1 .
BC005487 mRNA. Translation: AAH05487.1 .
BC025602 mRNA. Translation: AAH25602.1 .
BC055903 mRNA. Translation: AAH55903.1 .
BC092069 mRNA. Translation: AAH92069.1 .
CCDSi CCDS21229.1.
RefSeqi NP_080831.2. NM_026555.2.
XP_006541049.1. XM_006540986.1.
XP_006541050.1. XM_006540987.1.
UniGenei Mm.29997.

3D structure databases

ProteinModelPortali Q8BH97.
SMRi Q8BH97. Positions 78-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BH97. 2 interactions.
MINTi MINT-4132067.

PTM databases

PhosphoSitei Q8BH97.

Proteomic databases

MaxQBi Q8BH97.
PaxDbi Q8BH97.
PRIDEi Q8BH97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019683 ; ENSMUSP00000019683 ; ENSMUSG00000019539 .
ENSMUST00000117546 ; ENSMUSP00000112739 ; ENSMUSG00000019539 .
GeneIDi 52377.
KEGGi mmu:52377.
UCSCi uc009gta.2. mouse.

Organism-specific databases

CTDi 57333.
MGIi MGI:1277122. Rcn3.

Phylogenomic databases

eggNOGi NOG286499.
GeneTreei ENSGT00550000074546.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
InParanoidi Q8BH97.
OMAi SDAPHDD.
OrthoDBi EOG73Z2TD.
PhylomeDBi Q8BH97.
TreeFami TF314849.

Miscellaneous databases

NextBioi 308862.
PROi Q8BH97.
SOURCEi Search...

Gene expression databases

Bgeei Q8BH97.
CleanExi MM_RCN3.
ExpressionAtlasi Q8BH97. baseline and differential.
Genevestigatori Q8BH97.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6, Czech II and FVB/N.
    Tissue: Colon and Mammary gland.

Entry informationi

Entry nameiRCN3_MOUSE
AccessioniPrimary (citable) accession number: Q8BH97
Secondary accession number(s): Q58E50
, Q8R137, Q99K35, Q9CTD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3