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Q8BH97

- RCN3_MOUSE

UniProt

Q8BH97 - RCN3_MOUSE

Protein

Reticulocalbin-3

Gene

Rcn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi90 – 101121; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi126 – 137122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi176 – 187123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi213 – 224124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi254 – 265125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi290 – 301126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-3
    Gene namesi
    Name:Rcn3
    Synonyms:D7Ertd671e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1277122. Rcn3.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 328308Reticulocalbin-3PRO_0000004152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8BH97.
    PaxDbiQ8BH97.
    PRIDEiQ8BH97.

    PTM databases

    PhosphoSiteiQ8BH97.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BH97.
    BgeeiQ8BH97.
    CleanExiMM_RCN3.
    GenevestigatoriQ8BH97.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8BH97. 2 interactions.
    MINTiMINT-4132067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH97.
    SMRiQ8BH97. Positions 71-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 11236EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 14836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini163 – 19836EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini200 – 23536EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 27636EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 31236EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi325 – 3284Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG286499.
    GeneTreeiENSGT00550000074546.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    InParanoidiQ8BH97.
    OMAiSDAPHDD.
    OrthoDBiEOG73Z2TD.
    PhylomeDBiQ8BH97.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BH97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWRWSFLLL LLLLRHWALG KPSPDAGPHG QDRVHHGTPL SEAPHDDAHG    50
    NFQYDHEAFL GRDVAKEFDK LSPEESQARL GRIVDRMDLA GDSDGWVSLA 100
    ELRAWIAHTQ QRHIRDSVSA AWHTYDTDRD GRVGWEELRN ATYGHYEPGE 150
    EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM 200
    RDIVVAETLE DLDKNKDGYV QVEEYIADLY SEEPGEEEPA WVQTERQQFR 250
    EFRDLNKDGR LDGSEVGYWV LPPSQDQPLV EANHLLHESD TDKDGRLSKA 300
    EILSNWNMFV GSQATNYGED LTRHHDEL 328
    Length:328
    Mass (Da):38,002
    Last modified:March 1, 2003 - v1
    Checksum:i3DF05C6F0D5A6314
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211A → R in BAB23076. (PubMed:16141072)Curated
    Sequence conflicti260 – 2601R → Q in AAH05487. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003918 mRNA. Translation: BAB23076.1.
    AK077943 mRNA. Translation: BAC37077.1.
    AK082762 mRNA. Translation: BAC38608.1.
    BC005487 mRNA. Translation: AAH05487.1.
    BC025602 mRNA. Translation: AAH25602.1.
    BC055903 mRNA. Translation: AAH55903.1.
    BC092069 mRNA. Translation: AAH92069.1.
    CCDSiCCDS21229.1.
    RefSeqiNP_080831.2. NM_026555.2.
    XP_006541049.1. XM_006540986.1.
    XP_006541050.1. XM_006540987.1.
    UniGeneiMm.29997.

    Genome annotation databases

    EnsembliENSMUST00000019683; ENSMUSP00000019683; ENSMUSG00000019539.
    ENSMUST00000117546; ENSMUSP00000112739; ENSMUSG00000019539.
    GeneIDi52377.
    KEGGimmu:52377.
    UCSCiuc009gta.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003918 mRNA. Translation: BAB23076.1 .
    AK077943 mRNA. Translation: BAC37077.1 .
    AK082762 mRNA. Translation: BAC38608.1 .
    BC005487 mRNA. Translation: AAH05487.1 .
    BC025602 mRNA. Translation: AAH25602.1 .
    BC055903 mRNA. Translation: AAH55903.1 .
    BC092069 mRNA. Translation: AAH92069.1 .
    CCDSi CCDS21229.1.
    RefSeqi NP_080831.2. NM_026555.2.
    XP_006541049.1. XM_006540986.1.
    XP_006541050.1. XM_006540987.1.
    UniGenei Mm.29997.

    3D structure databases

    ProteinModelPortali Q8BH97.
    SMRi Q8BH97. Positions 71-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BH97. 2 interactions.
    MINTi MINT-4132067.

    PTM databases

    PhosphoSitei Q8BH97.

    Proteomic databases

    MaxQBi Q8BH97.
    PaxDbi Q8BH97.
    PRIDEi Q8BH97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019683 ; ENSMUSP00000019683 ; ENSMUSG00000019539 .
    ENSMUST00000117546 ; ENSMUSP00000112739 ; ENSMUSG00000019539 .
    GeneIDi 52377.
    KEGGi mmu:52377.
    UCSCi uc009gta.2. mouse.

    Organism-specific databases

    CTDi 57333.
    MGIi MGI:1277122. Rcn3.

    Phylogenomic databases

    eggNOGi NOG286499.
    GeneTreei ENSGT00550000074546.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    InParanoidi Q8BH97.
    OMAi SDAPHDD.
    OrthoDBi EOG73Z2TD.
    PhylomeDBi Q8BH97.
    TreeFami TF314849.

    Miscellaneous databases

    NextBioi 308862.
    PROi Q8BH97.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BH97.
    Bgeei Q8BH97.
    CleanExi MM_RCN3.
    Genevestigatori Q8BH97.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6, Czech II and FVB/N.
      Tissue: Colon and Mammary gland.

    Entry informationi

    Entry nameiRCN3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH97
    Secondary accession number(s): Q58E50
    , Q8R137, Q99K35, Q9CTD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3