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Q8BH97 (RCN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulocalbin-3
Gene names
Name:Rcn3
Synonyms:D7Ertd671e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 328308Reticulocalbin-3
PRO_0000004152

Regions

Domain77 – 11236EF-hand 1
Domain113 – 14836EF-hand 2
Domain163 – 19836EF-hand 3
Domain200 – 23536EF-hand 4
Domain241 – 27636EF-hand 5
Domain277 – 31236EF-hand 6
Calcium binding90 – 101121; possibly ancestral Potential
Calcium binding126 – 137122 Potential
Calcium binding176 – 187123; possibly ancestral Potential
Calcium binding213 – 224124 Potential
Calcium binding254 – 265125 Potential
Calcium binding290 – 301126 Potential
Motif325 – 3284Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1211A → R in BAB23076. Ref.1
Sequence conflict2601R → Q in AAH05487. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BH97 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 3DF05C6F0D5A6314

FASTA32838,002
        10         20         30         40         50         60 
MMWRWSFLLL LLLLRHWALG KPSPDAGPHG QDRVHHGTPL SEAPHDDAHG NFQYDHEAFL 

        70         80         90        100        110        120 
GRDVAKEFDK LSPEESQARL GRIVDRMDLA GDSDGWVSLA ELRAWIAHTQ QRHIRDSVSA 

       130        140        150        160        170        180 
AWHTYDTDRD GRVGWEELRN ATYGHYEPGE EFHDVEDAET YKKMLARDER RFRVADQDGD 

       190        200        210        220        230        240 
SMATREELTA FLHPEEFPHM RDIVVAETLE DLDKNKDGYV QVEEYIADLY SEEPGEEEPA 

       250        260        270        280        290        300 
WVQTERQQFR EFRDLNKDGR LDGSEVGYWV LPPSQDQPLV EANHLLHESD TDKDGRLSKA 

       310        320 
EILSNWNMFV GSQATNYGED LTRHHDEL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6, Czech II and FVB/N.
Tissue: Colon and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK003918 mRNA. Translation: BAB23076.1.
AK077943 mRNA. Translation: BAC37077.1.
AK082762 mRNA. Translation: BAC38608.1.
BC005487 mRNA. Translation: AAH05487.1.
BC025602 mRNA. Translation: AAH25602.1.
BC055903 mRNA. Translation: AAH55903.1.
BC092069 mRNA. Translation: AAH92069.1.
CCDSCCDS21229.1.
RefSeqNP_080831.2. NM_026555.2.
XP_006541049.1. XM_006540986.1.
XP_006541050.1. XM_006540987.1.
UniGeneMm.29997.

3D structure databases

ProteinModelPortalQ8BH97.
SMRQ8BH97. Positions 71-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BH97. 2 interactions.
MINTMINT-4132067.

PTM databases

PhosphoSiteQ8BH97.

Proteomic databases

MaxQBQ8BH97.
PaxDbQ8BH97.
PRIDEQ8BH97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019683; ENSMUSP00000019683; ENSMUSG00000019539.
ENSMUST00000117546; ENSMUSP00000112739; ENSMUSG00000019539.
GeneID52377.
KEGGmmu:52377.
UCSCuc009gta.2. mouse.

Organism-specific databases

CTD57333.
MGIMGI:1277122. Rcn3.

Phylogenomic databases

eggNOGNOG286499.
GeneTreeENSGT00550000074546.
HOGENOMHOG000230934.
HOVERGENHBG002834.
InParanoidQ8BH97.
OMASDAPHDD.
OrthoDBEOG73Z2TD.
PhylomeDBQ8BH97.
TreeFamTF314849.

Gene expression databases

ArrayExpressQ8BH97.
BgeeQ8BH97.
CleanExMM_RCN3.
GenevestigatorQ8BH97.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio308862.
PROQ8BH97.
SOURCESearch...

Entry information

Entry nameRCN3_MOUSE
AccessionPrimary (citable) accession number: Q8BH97
Secondary accession number(s): Q58E50 expand/collapse secondary AC list , Q8R137, Q99K35, Q9CTD4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot