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Q8BH80

- Q8BH80_MOUSE

UniProt

Q8BH80 - Q8BH80_MOUSE

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Protein
Submitted name: Vesicle-associated membrane protein, associated protein B and C
Gene
Vapb, mCG_13760
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-tubulin binding Source: UniProtKB
  2. enzyme binding Source: UniProtKB
  3. protein heterodimerization activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. structural molecule activity Source: InterPro

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Ensembl
  2. cellular calcium ion homeostasis Source: Ensembl
  3. endoplasmic reticulum unfolded protein response Source: UniProtKB
  4. modulation by virus of host morphology or physiology Source: UniProtKB
  5. positive regulation of viral genome replication Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198151. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Vesicle-associated membrane protein, associated protein B and CImported
Submitted name:
Vesicle-associated membrane protein-associated protein BImported
Gene namesi
Name:VapbImported
ORF Names:mCG_13760Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1928744. Vapb.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8BH80.

Interactioni

Protein-protein interaction databases

MINTiMINT-4110487.
STRINGi10090.ENSMUSP00000064699.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000006947.
HOVERGENiHBG028551.
InParanoidiQ8BH80.
KOiK10707.
OMAiPHDIEIN.
OrthoDBiEOG7CK389.
TreeFamiTF317024.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamiPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiPS50202. MSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH80-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR    50
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA 150
PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK 200
AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
Length:243
Mass (Da):26,918
Last modified:March 1, 2003 - v1
Checksum:i4353D945931C41C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844849 Genomic DNA. No translation available.
AL845503 Genomic DNA. No translation available.
BC048231 mRNA. Translation: AAH48231.1.
BC057123 mRNA. Translation: AAH57123.1.
AK050632 mRNA. Translation: BAC34353.1.
AK081908 mRNA. Translation: BAC38368.1.
CH466551 Genomic DNA. Translation: EDL06655.1.
RefSeqiNP_062780.2. NM_019806.5.
UniGeneiMm.260456.

Genome annotation databases

EnsembliENSMUST00000067530; ENSMUSP00000064699; ENSMUSG00000054455.
GeneIDi56491.
KEGGimmu:56491.
UCSCiuc008oei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844849 Genomic DNA. No translation available.
AL845503 Genomic DNA. No translation available.
BC048231 mRNA. Translation: AAH48231.1 .
BC057123 mRNA. Translation: AAH57123.1 .
AK050632 mRNA. Translation: BAC34353.1 .
AK081908 mRNA. Translation: BAC38368.1 .
CH466551 Genomic DNA. Translation: EDL06655.1 .
RefSeqi NP_062780.2. NM_019806.5.
UniGenei Mm.260456.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4110487.
STRINGi 10090.ENSMUSP00000064699.

Protocols and materials databases

DNASUi 56491.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067530 ; ENSMUSP00000064699 ; ENSMUSG00000054455 .
GeneIDi 56491.
KEGGi mmu:56491.
UCSCi uc008oei.1. mouse.

Organism-specific databases

CTDi 9217.
MGIi MGI:1928744. Vapb.

Phylogenomic databases

GeneTreei ENSGT00390000006947.
HOVERGENi HBG028551.
InParanoidi Q8BH80.
KOi K10707.
OMAi PHDIEIN.
OrthoDBi EOG7CK389.
TreeFami TF317024.

Enzyme and pathway databases

Reactomei REACT_198151. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSi VAPB. mouse.
NextBioi 312774.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BH80.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view ]
Pfami PF00635. Motile_Sperm. 1 hit.
[Graphical view ]
PIRSFi PIRSF019693. VAMP-associated. 1 hit.
SUPFAMi SSF49354. SSF49354. 1 hit.
PROSITEi PS50202. MSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported and Olfactory epitheliumImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported and ThymusImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  14. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BH80_MOUSE
AccessioniPrimary (citable) accession number: Q8BH80
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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