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Q8BH80

- Q8BH80_MOUSE

UniProt

Q8BH80 - Q8BH80_MOUSE

Protein
Submitted name:

Vesicle-associated membrane protein, associated protein B and C

Gene

Vapb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta-tubulin binding Source: UniProtKB
    2. enzyme binding Source: UniProtKB
    3. protein heterodimerization activity Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB
    5. structural molecule activity Source: InterPro

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Ensembl
    2. cellular calcium ion homeostasis Source: Ensembl
    3. endoplasmic reticulum unfolded protein response Source: UniProtKB
    4. modulation by virus of host morphology or physiology Source: UniProtKB
    5. positive regulation of viral genome replication Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_198151. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Vesicle-associated membrane protein, associated protein B and CImported
    Submitted name:
    Vesicle-associated membrane protein-associated protein BImported
    Gene namesi
    Name:VapbImported
    ORF Names:mCG_13760Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1928744. Vapb.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB

    Expressioni

    Gene expression databases

    GenevestigatoriQ8BH80.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4110487.
    STRINGi10090.ENSMUSP00000064699.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000006947.
    HOVERGENiHBG028551.
    InParanoidiQ8BH80.
    KOiK10707.
    OMAiPHDIEIN.
    OrthoDBiEOG7CK389.
    TreeFamiTF317024.

    Family and domain databases

    Gene3Di2.60.40.360. 1 hit.
    InterProiIPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view]
    PfamiPF00635. Motile_Sperm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019693. VAMP-associated. 1 hit.
    SUPFAMiSSF49354. SSF49354. 1 hit.
    PROSITEiPS50202. MSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BH80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR    50
    RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
    DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA 150
    PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK 200
    AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
    Length:243
    Mass (Da):26,918
    Last modified:March 1, 2003 - v1
    Checksum:i4353D945931C41C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844849 Genomic DNA. No translation available.
    AL845503 Genomic DNA. No translation available.
    BC048231 mRNA. Translation: AAH48231.1.
    BC057123 mRNA. Translation: AAH57123.1.
    AK050632 mRNA. Translation: BAC34353.1.
    AK081908 mRNA. Translation: BAC38368.1.
    CH466551 Genomic DNA. Translation: EDL06655.1.
    RefSeqiNP_062780.2. NM_019806.5.
    UniGeneiMm.260456.

    Genome annotation databases

    EnsembliENSMUST00000067530; ENSMUSP00000064699; ENSMUSG00000054455.
    GeneIDi56491.
    KEGGimmu:56491.
    UCSCiuc008oei.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844849 Genomic DNA. No translation available.
    AL845503 Genomic DNA. No translation available.
    BC048231 mRNA. Translation: AAH48231.1 .
    BC057123 mRNA. Translation: AAH57123.1 .
    AK050632 mRNA. Translation: BAC34353.1 .
    AK081908 mRNA. Translation: BAC38368.1 .
    CH466551 Genomic DNA. Translation: EDL06655.1 .
    RefSeqi NP_062780.2. NM_019806.5.
    UniGenei Mm.260456.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4110487.
    STRINGi 10090.ENSMUSP00000064699.

    Protocols and materials databases

    DNASUi 56491.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067530 ; ENSMUSP00000064699 ; ENSMUSG00000054455 .
    GeneIDi 56491.
    KEGGi mmu:56491.
    UCSCi uc008oei.1. mouse.

    Organism-specific databases

    CTDi 9217.
    MGIi MGI:1928744. Vapb.

    Phylogenomic databases

    GeneTreei ENSGT00390000006947.
    HOVERGENi HBG028551.
    InParanoidi Q8BH80.
    KOi K10707.
    OMAi PHDIEIN.
    OrthoDBi EOG7CK389.
    TreeFami TF317024.

    Enzyme and pathway databases

    Reactomei REACT_198151. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    ChiTaRSi VAPB. mouse.
    NextBioi 312774.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8BH80.

    Family and domain databases

    Gene3Di 2.60.40.360. 1 hit.
    InterProi IPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view ]
    Pfami PF00635. Motile_Sperm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019693. VAMP-associated. 1 hit.
    SUPFAMi SSF49354. SSF49354. 1 hit.
    PROSITEi PS50202. MSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported and Olfactory epitheliumImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported and ThymusImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    14. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8BH80_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH80
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3