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Protein

Nuclear pore complex protein Nup107

Gene

Nup107

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup107
Alternative name(s):
107 kDa nucleoporin
Nucleoporin Nup107
Gene namesi
Name:Nup107
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143854. Nup107.

Subcellular locationi

  • Nucleus membrane By similarity
  • Nucleusnuclear pore complex By similarity
  • Chromosomecentromerekinetochore By similarity

  • Note: Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Nuclear pore complex protein Nup107PRO_0000204832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei11 – 111PhosphoserineCombined sources
Modified residuei46 – 461PhosphothreonineBy similarity
Modified residuei55 – 551PhosphothreonineBy similarity
Modified residuei57 – 571PhosphoserineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei65 – 651PhosphothreonineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BH74.
MaxQBiQ8BH74.
PaxDbiQ8BH74.
PeptideAtlasiQ8BH74.
PRIDEiQ8BH74.

PTM databases

iPTMnetiQ8BH74.
PhosphoSiteiQ8BH74.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052798.
CleanExiMM_NUP107.
ExpressionAtlasiQ8BH74. baseline and differential.
GenevisibleiQ8BH74. MM.

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR.By similarity

Protein-protein interaction databases

BioGridi222088. 55 interactions.
IntActiQ8BH74. 54 interactions.
MINTiMINT-4104188.
STRINGi10090.ENSMUSP00000063590.

Structurei

3D structure databases

ProteinModelPortaliQ8BH74.
SMRiQ8BH74. Positions 325-581, 668-925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nucleoporin Nup84/Nup107 family.Curated

Phylogenomic databases

eggNOGiKOG1964. Eukaryota.
ENOG410XRUG. LUCA.
GeneTreeiENSGT00390000012080.
HOGENOMiHOG000006750.
HOVERGENiHBG052677.
InParanoidiQ8BH74.
KOiK14301.
OMAiYLETNWT.
OrthoDBiEOG091G02HY.
PhylomeDBiQ8BH74.
TreeFamiTF324259.

Family and domain databases

InterProiIPR007252. Nup84_Nup100.
[Graphical view]
PANTHERiPTHR13003. PTHR13003. 1 hit.
PfamiPF04121. Nup84_Nup100. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSGFGGMS SPVIRDAEVT RTARKHSAHK RVLIQANQED NFGTATPRSQ
60 70 80 90 100
IIPRTPSSFR QPFVTPSSRS LLRHPDISYI LGTEGRSPRH TQSSGYLGNL
110 120 130 140 150
SMVTNLDDSN WAAAFSSQRL GLYTNTEHHS MTEDVNLSTV MLREDDPGEA
160 170 180 190 200
ASMSMFSDFL HSFLKHSSTT VFDLVEEYEN ICGSQVNILS KIVSRATPGL
210 220 230 240 250
QKFSKTASML WLLQQEMVTW RLLASLYRDR IQSSLEEENM FAIAGINASE
260 270 280 290 300
KMVVETLFQR DSLVRQSQLV VDWLESIAKD EIGEFSDNIE FYAKSVYWEN
310 320 330 340 350
TLHSLKQRQL LSHMGSTRPL VTELDPDAPI RQKLPLDDLD REDEVRLLKY
360 370 380 390 400
LFTLIRAGMT EEAQRLCKRC GQAWRAATLE GWKLYHDPNV NGGTELEPVE
410 420 430 440 450
GNPYRRIWKI SCWRMAEDEL FNKYERAIYA ALSGNLKQLL PVCDTWEDTV
460 470 480 490 500
WAYFRVMVDS LVEQEIRTSV MTQDDSEELP REYMEANWTL EKVFEELQAT
510 520 530 540 550
DKKRVLEENQ EHYHIVQKFL ILGDVDGLMD EFSKWLSKSG SSLPGHLLRF
560 570 580 590 600
MTHLILFLRT LGLQTKEEVS IEVLKTYIQL LISEKHTSLI AFYTCHLPQD
610 620 630 640 650
LAVAQYALFL EGVTEFEQRH QCLELAKEAD LDVATITKTV VENICKKDNG
660 670 680 690 700
EFSHHDLAPS LDTGTTEEDR LKIDVIDWLV FDPAQRAEAL RQGNAIMRKF
710 720 730 740 750
LALKKHEAAK EVFVKIPQDS IAEIYNQWEE QGMESPLPAE DDNAIREHLC
760 770 780 790 800
IRAYLEAHET FNEWFKHMNS APQKPTLLSQ ATFTEKVAYE HREKKYEMDH
810 820 830 840 850
NIWKGHLDAL TADVKEKMYN VLLFVDGGWM VDVREDAEDD PERTHQMVLL
860 870 880 890 900
RKLCLPMLCF LLHTILHSTG QYQECLQLAD MVSSERHKLY LVFSKEELRK
910 920
LLQKLRESSL MLLDQGLDPL GYEIQS
Length:926
Mass (Da):106,717
Last modified:March 1, 2003 - v1
Checksum:i4489666D13A1BD3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088069 mRNA. Translation: BAC40127.1.
AK088303 mRNA. Translation: BAC40270.1.
AK088625 mRNA. Translation: BAC40461.1.
BC004655 mRNA. Translation: AAH04655.1.
BC057591 mRNA. Translation: AAH57591.1.
CCDSiCCDS36068.1.
RefSeqiNP_598771.1. NM_134010.2.
UniGeneiMm.12568.

Genome annotation databases

EnsembliENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798.
GeneIDi103468.
KEGGimmu:103468.
UCSCiuc007hdo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088069 mRNA. Translation: BAC40127.1.
AK088303 mRNA. Translation: BAC40270.1.
AK088625 mRNA. Translation: BAC40461.1.
BC004655 mRNA. Translation: AAH04655.1.
BC057591 mRNA. Translation: AAH57591.1.
CCDSiCCDS36068.1.
RefSeqiNP_598771.1. NM_134010.2.
UniGeneiMm.12568.

3D structure databases

ProteinModelPortaliQ8BH74.
SMRiQ8BH74. Positions 325-581, 668-925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222088. 55 interactions.
IntActiQ8BH74. 54 interactions.
MINTiMINT-4104188.
STRINGi10090.ENSMUSP00000063590.

PTM databases

iPTMnetiQ8BH74.
PhosphoSiteiQ8BH74.

Proteomic databases

EPDiQ8BH74.
MaxQBiQ8BH74.
PaxDbiQ8BH74.
PeptideAtlasiQ8BH74.
PRIDEiQ8BH74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064848; ENSMUSP00000063590; ENSMUSG00000052798.
GeneIDi103468.
KEGGimmu:103468.
UCSCiuc007hdo.1. mouse.

Organism-specific databases

CTDi57122.
MGIiMGI:2143854. Nup107.

Phylogenomic databases

eggNOGiKOG1964. Eukaryota.
ENOG410XRUG. LUCA.
GeneTreeiENSGT00390000012080.
HOGENOMiHOG000006750.
HOVERGENiHBG052677.
InParanoidiQ8BH74.
KOiK14301.
OMAiYLETNWT.
OrthoDBiEOG091G02HY.
PhylomeDBiQ8BH74.
TreeFamiTF324259.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiNup107. mouse.
PROiQ8BH74.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052798.
CleanExiMM_NUP107.
ExpressionAtlasiQ8BH74. baseline and differential.
GenevisibleiQ8BH74. MM.

Family and domain databases

InterProiIPR007252. Nup84_Nup100.
[Graphical view]
PANTHERiPTHR13003. PTHR13003. 1 hit.
PfamiPF04121. Nup84_Nup100. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU107_MOUSE
AccessioniPrimary (citable) accession number: Q8BH74
Secondary accession number(s): Q99KH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.