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Protein

F-box/LRR-repeat protein 4

Gene

Fbxl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 4
Alternative name(s):
F-box and leucine-rich repeat protein 4
Gene namesi
Name:Fbxl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140367. Fbxl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077191 – 621F-box/LRR-repeat protein 4Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ8BH70.
PRIDEiQ8BH70.

PTM databases

iPTMnetiQ8BH70.
PhosphoSitePlusiQ8BH70.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040410.
CleanExiMM_FBXL4.
ExpressionAtlasiQ8BH70. baseline and differential.
GenevisibleiQ8BH70. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042219.

Structurei

3D structure databases

ProteinModelPortaliQ8BH70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 332F-boxPROSITE-ProRule annotationAdd BLAST56
Repeati376 – 397LRR 1Add BLAST22
Repeati402 – 421LRR 2Add BLAST20
Repeati427 – 448LRR 3Add BLAST22
Repeati452 – 474LRR 4Add BLAST23
Repeati480 – 501LRR 5Add BLAST22
Repeati504 – 524LRR 6Add BLAST21
Repeati532 – 558LRR 7Add BLAST27
Repeati559 – 583LRR 8Add BLAST25
Repeati584 – 609LRR 9Add BLAST26

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000006948.
HOVERGENiHBG051588.
InParanoidiQ8BH70.
KOiK10270.
OMAiTMFYYIC.
OrthoDBiEOG091G06EZ.
PhylomeDBiQ8BH70.
TreeFamiTF323721.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPVFPMLTV LTMFYYMCLR RRARTATRGD MMNSHRTIVS NSRTSPLNAE
60 70 80 90 100
VVQYAKEVVD FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY
110 120 130 140 150
GTWWDQCPSA SLPFRRTPSS FQSQDYVELT FEQQVYPTAV HVLETYHPGA
160 170 180 190 200
VIRILACSAN PYSPNPPAEV RWEILWSERP MKVNASQARQ FKPCIKQINF
210 220 230 240 250
PTNLIRLEVN SSLLDYYTEL DAVVLHGTKD KPLLSLKTAL VDMNDLEDDD
260 270 280 290 300
YEEKDGCEMD ALNKKFSSAA LGDGPHNGYF DKLPYELIQL ILNHLSLPDL
310 320 330 340 350
CRLAQTCRLL HQHCCDPLQY IHLNLQPYWA RLDDTSLEFL QARCVLVQWL
360 370 380 390 400
NLSWTGNRGF ISVSGFSRFL KVCGSELVRL ELSCSHFLND TCLEVISEMC
410 420 430 440 450
PNLQDLNLSS CDKLPPQAFG HIAKLCSLKR LVLYRTKVEQ TALLSILNFC
460 470 480 490 500
AELQHLSLGS CVMIEDYDVI ASMIGAKCKN LRTLDLWRCK NITENGIAEL
510 520 530 540 550
ASGCVLLEEL DLGWCPTLQS STGCFVRLAR QLPNLQKLFL TANRSVCDTD
560 570 580 590 600
IEELASNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN
610 620
KAVLELNASF PKVFIKKSFT Q
Length:621
Mass (Da):70,269
Last modified:March 1, 2003 - v1
Checksum:i458544AD66711119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032391 mRNA. Translation: BAC27850.1.
AK051429 mRNA. Translation: BAC34636.1.
AL683854, AL772230 Genomic DNA. Translation: CAM18296.1.
AL772230, AL683854 Genomic DNA. Translation: CAM22633.1.
CCDSiCCDS18004.1.
RefSeqiNP_766576.1. NM_172988.4.
XP_006538016.1. XM_006537953.2.
UniGeneiMm.40708.

Genome annotation databases

EnsembliENSMUST00000039234; ENSMUSP00000042219; ENSMUSG00000040410.
GeneIDi269514.
KEGGimmu:269514.
UCSCiuc008sdo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032391 mRNA. Translation: BAC27850.1.
AK051429 mRNA. Translation: BAC34636.1.
AL683854, AL772230 Genomic DNA. Translation: CAM18296.1.
AL772230, AL683854 Genomic DNA. Translation: CAM22633.1.
CCDSiCCDS18004.1.
RefSeqiNP_766576.1. NM_172988.4.
XP_006538016.1. XM_006537953.2.
UniGeneiMm.40708.

3D structure databases

ProteinModelPortaliQ8BH70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042219.

PTM databases

iPTMnetiQ8BH70.
PhosphoSitePlusiQ8BH70.

Proteomic databases

PaxDbiQ8BH70.
PRIDEiQ8BH70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039234; ENSMUSP00000042219; ENSMUSG00000040410.
GeneIDi269514.
KEGGimmu:269514.
UCSCiuc008sdo.2. mouse.

Organism-specific databases

CTDi26235.
MGIiMGI:2140367. Fbxl4.

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000006948.
HOVERGENiHBG051588.
InParanoidiQ8BH70.
KOiK10270.
OMAiTMFYYIC.
OrthoDBiEOG091G06EZ.
PhylomeDBiQ8BH70.
TreeFamiTF323721.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ8BH70.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040410.
CleanExiMM_FBXL4.
ExpressionAtlasiQ8BH70. baseline and differential.
GenevisibleiQ8BH70. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 7 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL4_MOUSE
AccessioniPrimary (citable) accession number: Q8BH70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.