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Protein

F-box/LRR-repeat protein 4

Gene

Fbxl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 4
Alternative name(s):
F-box and leucine-rich repeat protein 4
Gene namesi
Name:Fbxl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140367 Fbxl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077191 – 621F-box/LRR-repeat protein 4Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8BH70
PaxDbiQ8BH70
PRIDEiQ8BH70

PTM databases

iPTMnetiQ8BH70
PhosphoSitePlusiQ8BH70

Expressioni

Gene expression databases

BgeeiENSMUSG00000040410
CleanExiMM_FBXL4
ExpressionAtlasiQ8BH70 baseline and differential
GenevisibleiQ8BH70 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042219

Structurei

3D structure databases

ProteinModelPortaliQ8BH70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 332F-boxPROSITE-ProRule annotationAdd BLAST56
Repeati376 – 397LRR 1Add BLAST22
Repeati402 – 421LRR 2Add BLAST20
Repeati427 – 448LRR 3Add BLAST22
Repeati452 – 474LRR 4Add BLAST23
Repeati480 – 501LRR 5Add BLAST22
Repeati504 – 524LRR 6Add BLAST21
Repeati532 – 558LRR 7Add BLAST27
Repeati559 – 583LRR 8Add BLAST25
Repeati584 – 609LRR 9Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000006948
HOVERGENiHBG051588
InParanoidiQ8BH70
KOiK10270
OMAiTMFYYIC
OrthoDBiEOG091G06EZ
PhylomeDBiQ8BH70
TreeFamiTF323721

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 7 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPVFPMLTV LTMFYYMCLR RRARTATRGD MMNSHRTIVS NSRTSPLNAE
60 70 80 90 100
VVQYAKEVVD FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY
110 120 130 140 150
GTWWDQCPSA SLPFRRTPSS FQSQDYVELT FEQQVYPTAV HVLETYHPGA
160 170 180 190 200
VIRILACSAN PYSPNPPAEV RWEILWSERP MKVNASQARQ FKPCIKQINF
210 220 230 240 250
PTNLIRLEVN SSLLDYYTEL DAVVLHGTKD KPLLSLKTAL VDMNDLEDDD
260 270 280 290 300
YEEKDGCEMD ALNKKFSSAA LGDGPHNGYF DKLPYELIQL ILNHLSLPDL
310 320 330 340 350
CRLAQTCRLL HQHCCDPLQY IHLNLQPYWA RLDDTSLEFL QARCVLVQWL
360 370 380 390 400
NLSWTGNRGF ISVSGFSRFL KVCGSELVRL ELSCSHFLND TCLEVISEMC
410 420 430 440 450
PNLQDLNLSS CDKLPPQAFG HIAKLCSLKR LVLYRTKVEQ TALLSILNFC
460 470 480 490 500
AELQHLSLGS CVMIEDYDVI ASMIGAKCKN LRTLDLWRCK NITENGIAEL
510 520 530 540 550
ASGCVLLEEL DLGWCPTLQS STGCFVRLAR QLPNLQKLFL TANRSVCDTD
560 570 580 590 600
IEELASNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN
610 620
KAVLELNASF PKVFIKKSFT Q
Length:621
Mass (Da):70,269
Last modified:March 1, 2003 - v1
Checksum:i458544AD66711119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032391 mRNA Translation: BAC27850.1
AK051429 mRNA Translation: BAC34636.1
AL683854, AL772230 Genomic DNA Translation: CAM18296.1
AL772230, AL683854 Genomic DNA Translation: CAM22633.1
CCDSiCCDS18004.1
RefSeqiNP_766576.1, NM_172988.4
XP_006538016.1, XM_006537953.2
UniGeneiMm.40708

Genome annotation databases

EnsembliENSMUST00000039234; ENSMUSP00000042219; ENSMUSG00000040410
GeneIDi269514
KEGGimmu:269514
UCSCiuc008sdo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFBXL4_MOUSE
AccessioniPrimary (citable) accession number: Q8BH70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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