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Q8BH69

- SPS1_MOUSE

UniProt

Q8BH69 - SPS1_MOUSE

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Protein

Selenide, water dikinase 1

Gene
Sephs1, Sps1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Synthesizes selenophosphate from selenide and ATP.

Catalytic activityi

ATP + selenide + H2O = AMP + selenophosphate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei31 – 311 Reviewed prediction
Binding sitei32 – 321ATP By similarity
Sitei32 – 321Important for catalytic activity By similarity
Binding sitei87 – 871ATP By similarity
Binding sitei110 – 1101ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 693ATP By similarity
Nucleotide bindingi162 – 1643ATP; shared with dimeric partner By similarity
Nucleotide bindingi267 – 2737ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. selenide, water dikinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Selenium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenide, water dikinase 1 (EC:2.7.9.3)
Alternative name(s):
Selenium donor protein 1
Selenophosphate synthase 1
Gene namesi
Name:Sephs1
Synonyms:Sps1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923580. Sephs1.

Subcellular locationi

Cell membrane By similarity. Nucleus membrane By similarity

GO - Cellular componenti

  1. nuclear membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 392391Selenide, water dikinase 1PRO_0000127649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BH69.
PaxDbiQ8BH69.
PRIDEiQ8BH69.

PTM databases

PhosphoSiteiQ8BH69.

Expressioni

Gene expression databases

ArrayExpressiQ8BH69.
BgeeiQ8BH69.
CleanExiMM_SEPHS1.
GenevestigatoriQ8BH69.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ8BH69. 2 interactions.
MINTiMINT-4135416.

Structurei

3D structure databases

ProteinModelPortaliQ8BH69.
SMRiQ8BH69. Positions 6-377.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0709.
GeneTreeiENSGT00390000000950.
HOGENOMiHOG000219301.
HOVERGENiHBG001207.
InParanoidiQ8BH69.
KOiK01008.
OMAiYELDKNF.
OrthoDBiEOG7SR4MT.
PhylomeDBiQ8BH69.
TreeFamiTF313811.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR016188. PurM_N-like.
IPR004536. SelD.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
PIRSFiPIRSF036407. Selenphspht_syn. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH69-1 [UniParc]FASTAAdd to Basket

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MSTRESFNPE TYELDKSFRL TRFTELKGTG CKVPQDVLQK LLESLQENHF    50
QEDEQFLGAV MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG 100
RIACANVLSD LYAMGVTECD NMLMLLGVSN KMTDRERDKV IPLIIQGFKD 150
AAEEAGTSVT GGQTVLNPWI VLGGVATTVC QPNEFIMPDN AVPGDVLVLT 200
KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA MMNMARLNRT 250
AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA 300
AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ 350
AWIIGIVEKG NRTARIIDKP RIIEVAPQVA TQNVNPTPGA TS 392
Length:392
Mass (Da):42,907
Last modified:March 1, 2003 - v1
Checksum:i46627E6ADB3D593C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044971 mRNA. Translation: BAC32163.1.
AK053638 mRNA. Translation: BAC35456.1.
CCDSiCCDS15659.1.
RefSeqiNP_780609.4. NM_175400.6.
XP_006497372.1. XM_006497309.1.
UniGeneiMm.34329.

Genome annotation databases

EnsembliENSMUST00000027973; ENSMUSP00000027973; ENSMUSG00000026662.
ENSMUST00000115019; ENSMUSP00000110671; ENSMUSG00000026662.
GeneIDi109079.
KEGGimmu:109079.
UCSCiuc008ifb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044971 mRNA. Translation: BAC32163.1 .
AK053638 mRNA. Translation: BAC35456.1 .
CCDSi CCDS15659.1.
RefSeqi NP_780609.4. NM_175400.6.
XP_006497372.1. XM_006497309.1.
UniGenei Mm.34329.

3D structure databases

ProteinModelPortali Q8BH69.
SMRi Q8BH69. Positions 6-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BH69. 2 interactions.
MINTi MINT-4135416.

PTM databases

PhosphoSitei Q8BH69.

Proteomic databases

MaxQBi Q8BH69.
PaxDbi Q8BH69.
PRIDEi Q8BH69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027973 ; ENSMUSP00000027973 ; ENSMUSG00000026662 .
ENSMUST00000115019 ; ENSMUSP00000110671 ; ENSMUSG00000026662 .
GeneIDi 109079.
KEGGi mmu:109079.
UCSCi uc008ifb.1. mouse.

Organism-specific databases

CTDi 22929.
MGIi MGI:1923580. Sephs1.

Phylogenomic databases

eggNOGi COG0709.
GeneTreei ENSGT00390000000950.
HOGENOMi HOG000219301.
HOVERGENi HBG001207.
InParanoidi Q8BH69.
KOi K01008.
OMAi YELDKNF.
OrthoDBi EOG7SR4MT.
PhylomeDBi Q8BH69.
TreeFami TF313811.

Miscellaneous databases

ChiTaRSi SEPHS1. mouse.
NextBioi 361628.
PROi Q8BH69.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BH69.
Bgeei Q8BH69.
CleanExi MM_SEPHS1.
Genevestigatori Q8BH69.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR016188. PurM_N-like.
IPR004536. SelD.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00476. selD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.

Entry informationi

Entry nameiSPS1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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