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Q8BH69

- SPS1_MOUSE

UniProt

Q8BH69 - SPS1_MOUSE

Protein

Selenide, water dikinase 1

Gene

Sephs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Synthesizes selenophosphate from selenide and ATP.

    Catalytic activityi

    ATP + selenide + H2O = AMP + selenophosphate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei31 – 311Sequence Analysis
    Binding sitei32 – 321ATPBy similarity
    Sitei32 – 321Important for catalytic activityBy similarity
    Binding sitei87 – 871ATPBy similarity
    Binding sitei110 – 1101ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 693ATPBy similarity
    Nucleotide bindingi162 – 1643ATP; shared with dimeric partnerBy similarity
    Nucleotide bindingi267 – 2737ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein heterodimerization activity Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB
    4. selenide, water dikinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Selenium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Selenide, water dikinase 1 (EC:2.7.9.3)
    Alternative name(s):
    Selenium donor protein 1
    Selenophosphate synthase 1
    Gene namesi
    Name:Sephs1
    Synonyms:Sps1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1923580. Sephs1.

    Subcellular locationi

    Cell membrane By similarity. Nucleus membrane By similarity

    GO - Cellular componenti

    1. nuclear membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 392391Selenide, water dikinase 1PRO_0000127649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8BH69.
    PaxDbiQ8BH69.
    PRIDEiQ8BH69.

    PTM databases

    PhosphoSiteiQ8BH69.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BH69.
    BgeeiQ8BH69.
    CleanExiMM_SEPHS1.
    GenevestigatoriQ8BH69.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ8BH69. 2 interactions.
    MINTiMINT-4135416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH69.
    SMRiQ8BH69. Positions 6-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0709.
    GeneTreeiENSGT00390000000950.
    HOGENOMiHOG000219301.
    HOVERGENiHBG001207.
    InParanoidiQ8BH69.
    KOiK01008.
    OMAiYELDKNF.
    OrthoDBiEOG7SR4MT.
    PhylomeDBiQ8BH69.
    TreeFamiTF313811.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR016188. PurM_N-like.
    IPR004536. SelD.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036407. Selenphspht_syn. 1 hit.
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00476. selD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BH69-1 [UniParc]FASTAAdd to Basket

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    MSTRESFNPE TYELDKSFRL TRFTELKGTG CKVPQDVLQK LLESLQENHF    50
    QEDEQFLGAV MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG 100
    RIACANVLSD LYAMGVTECD NMLMLLGVSN KMTDRERDKV IPLIIQGFKD 150
    AAEEAGTSVT GGQTVLNPWI VLGGVATTVC QPNEFIMPDN AVPGDVLVLT 200
    KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA MMNMARLNRT 250
    AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA 300
    AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ 350
    AWIIGIVEKG NRTARIIDKP RIIEVAPQVA TQNVNPTPGA TS 392
    Length:392
    Mass (Da):42,907
    Last modified:March 1, 2003 - v1
    Checksum:i46627E6ADB3D593C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044971 mRNA. Translation: BAC32163.1.
    AK053638 mRNA. Translation: BAC35456.1.
    CCDSiCCDS15659.1.
    RefSeqiNP_780609.4. NM_175400.6.
    XP_006497372.1. XM_006497309.1.
    UniGeneiMm.34329.

    Genome annotation databases

    EnsembliENSMUST00000027973; ENSMUSP00000027973; ENSMUSG00000026662.
    ENSMUST00000115019; ENSMUSP00000110671; ENSMUSG00000026662.
    GeneIDi109079.
    KEGGimmu:109079.
    UCSCiuc008ifb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044971 mRNA. Translation: BAC32163.1 .
    AK053638 mRNA. Translation: BAC35456.1 .
    CCDSi CCDS15659.1.
    RefSeqi NP_780609.4. NM_175400.6.
    XP_006497372.1. XM_006497309.1.
    UniGenei Mm.34329.

    3D structure databases

    ProteinModelPortali Q8BH69.
    SMRi Q8BH69. Positions 6-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BH69. 2 interactions.
    MINTi MINT-4135416.

    PTM databases

    PhosphoSitei Q8BH69.

    Proteomic databases

    MaxQBi Q8BH69.
    PaxDbi Q8BH69.
    PRIDEi Q8BH69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027973 ; ENSMUSP00000027973 ; ENSMUSG00000026662 .
    ENSMUST00000115019 ; ENSMUSP00000110671 ; ENSMUSG00000026662 .
    GeneIDi 109079.
    KEGGi mmu:109079.
    UCSCi uc008ifb.1. mouse.

    Organism-specific databases

    CTDi 22929.
    MGIi MGI:1923580. Sephs1.

    Phylogenomic databases

    eggNOGi COG0709.
    GeneTreei ENSGT00390000000950.
    HOGENOMi HOG000219301.
    HOVERGENi HBG001207.
    InParanoidi Q8BH69.
    KOi K01008.
    OMAi YELDKNF.
    OrthoDBi EOG7SR4MT.
    PhylomeDBi Q8BH69.
    TreeFami TF313811.

    Miscellaneous databases

    ChiTaRSi SEPHS1. mouse.
    NextBioi 361628.
    PROi Q8BH69.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BH69.
    Bgeei Q8BH69.
    CleanExi MM_SEPHS1.
    Genevestigatori Q8BH69.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR016188. PurM_N-like.
    IPR004536. SelD.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036407. Selenphspht_syn. 1 hit.
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00476. selD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.

    Entry informationi

    Entry nameiSPS1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3