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Protein

Atlastin-1

Gene

Atl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81GTPBy similarity8
Nucleotide bindingi118 – 120GTPBy similarity3
Nucleotide bindingi217 – 218GTPBy similarity2
Nucleotide bindingi276 – 279GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-1 (EC:3.6.5.-)
Alternative name(s):
Spastic paraplegia 3A homolog
Gene namesi
Name:Atl1
Synonyms:Spg3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921241. Atl1.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
  • Cell projectionaxon By similarity

  • Note: Localizes to endoplasmic reticulum tubular network.1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 449CytoplasmicBy similarityAdd BLAST449
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471LumenalSequence analysis1
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 558CytoplasmicBy similarityAdd BLAST66

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909731 – 558Atlastin-1Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei395N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BH66.
MaxQBiQ8BH66.
PaxDbiQ8BH66.
PeptideAtlasiQ8BH66.
PRIDEiQ8BH66.

PTM databases

iPTMnetiQ8BH66.
PhosphoSitePlusiQ8BH66.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021066.
CleanExiMM_GBP3.
GenevisibleiQ8BH66. MM.

Interactioni

Subunit structurei

Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with SPAST; interaction is direct (By similarity). Interacts with REEP5, RTN3 and probably RTN4 (via the transmembrane region) (PubMed:19665976). Interacts with REEP1. Interacts with CPT1C. Interacts with ARL6IP1 (By similarity). Interacts with ZFYVE27 (PubMed:24668814).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BH66. 1 interactor.
MINTiMINT-4135323.
STRINGi10090.ENSMUSP00000021466.

Structurei

3D structure databases

ProteinModelPortaliQ8BH66.
SMRiQ8BH66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 309GB1/RHD3-type GAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni448 – 558Sufficient for membrane associationBy similarityAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili412 – 439Sequence analysisAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ8BH66.
KOiK17339.
OMAiHDYPNGD.
OrthoDBiEOG091G053P.
PhylomeDBiQ8BH66.
TreeFamiTF105251.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE
60 70 80 90 100
AALNRILLSQ AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV
110 120 130 140 150
GDYNEPLTGF SWRGGSERET TGIQIWSEVF LINKLDGKKV AVLLMDTQGT
160 170 180 190 200
FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ NVQEDDLQHL QLFTEYGRLA
210 220 230 240 250
MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL KVSGNQHEEL
260 270 280 290 300
QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL
310 320 330 340 350
IPWLLSPERL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA
360 370 380 390 400
TAEANNLAAV ATAKDTYNKK MEEVCGGDKP FLAPNDLQSK HLQLKEESVK
410 420 430 440 450
LFRGVKKMGG EEFSRRYLQQ LESEIDELYI QYIKHNDSKN IFHAARTPAT
460 470 480 490 500
LFVVIFITYV IAGVTGFIGL DIIASLCNMI MGLTLITLCT WAYIRYSGEY
510 520 530 540 550
RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLCHQ AFPAPKSEPT

QQPEKKKI
Length:558
Mass (Da):63,377
Last modified:March 1, 2003 - v1
Checksum:i4734A5D99A9171AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046919 mRNA. Translation: BAC32920.1.
AK050339 mRNA. Translation: BAC34198.1.
BC050784 mRNA. Translation: AAH50784.1.
AK083918 mRNA. Translation: BAC39062.1.
CCDSiCCDS36465.1.
RefSeqiNP_848743.1. NM_178628.5.
UniGeneiMm.474462.

Genome annotation databases

EnsembliENSMUST00000021466; ENSMUSP00000021466; ENSMUSG00000021066.
GeneIDi73991.
KEGGimmu:73991.
UCSCiuc007nsy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046919 mRNA. Translation: BAC32920.1.
AK050339 mRNA. Translation: BAC34198.1.
BC050784 mRNA. Translation: AAH50784.1.
AK083918 mRNA. Translation: BAC39062.1.
CCDSiCCDS36465.1.
RefSeqiNP_848743.1. NM_178628.5.
UniGeneiMm.474462.

3D structure databases

ProteinModelPortaliQ8BH66.
SMRiQ8BH66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH66. 1 interactor.
MINTiMINT-4135323.
STRINGi10090.ENSMUSP00000021466.

PTM databases

iPTMnetiQ8BH66.
PhosphoSitePlusiQ8BH66.

Proteomic databases

EPDiQ8BH66.
MaxQBiQ8BH66.
PaxDbiQ8BH66.
PeptideAtlasiQ8BH66.
PRIDEiQ8BH66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021466; ENSMUSP00000021466; ENSMUSG00000021066.
GeneIDi73991.
KEGGimmu:73991.
UCSCiuc007nsy.2. mouse.

Organism-specific databases

CTDi51062.
MGIiMGI:1921241. Atl1.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ8BH66.
KOiK17339.
OMAiHDYPNGD.
OrthoDBiEOG091G053P.
PhylomeDBiQ8BH66.
TreeFamiTF105251.

Miscellaneous databases

ChiTaRSiAtl1. mouse.
PROiQ8BH66.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021066.
CleanExiMM_GBP3.
GenevisibleiQ8BH66. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATLA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH66
Secondary accession number(s): Q8BJH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.