Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Atlastin-1

Gene

Atl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81GTPBy similarity8
Nucleotide bindingi118 – 120GTPBy similarity3
Nucleotide bindingi217 – 218GTPBy similarity2
Nucleotide bindingi276 – 279GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-1 (EC:3.6.5.-)
Alternative name(s):
Spastic paraplegia 3A homolog
Gene namesi
Name:Atl1
Synonyms:Spg3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921241 Atl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 449CytoplasmicBy similarityAdd BLAST449
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471LumenalSequence analysis1
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 558CytoplasmicBy similarityAdd BLAST66

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909731 – 558Atlastin-1Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei395N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BH66
MaxQBiQ8BH66
PaxDbiQ8BH66
PeptideAtlasiQ8BH66
PRIDEiQ8BH66

PTM databases

iPTMnetiQ8BH66
PhosphoSitePlusiQ8BH66

Expressioni

Gene expression databases

BgeeiENSMUSG00000021066
CleanExiMM_GBP3
ExpressionAtlasiQ8BH66 baseline and differential
GenevisibleiQ8BH66 MM

Interactioni

Subunit structurei

Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with SPAST; interaction is direct (By similarity). Interacts with REEP5, RTN3 and probably RTN4 (via the transmembrane region) (PubMed:19665976). Interacts with REEP1. Interacts with CPT1C. Interacts with ARL6IP1 (By similarity). Interacts with ZFYVE27 (PubMed:24668814).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216409, 1 interactor
IntActiQ8BH66, 1 interactor
MINTiQ8BH66
STRINGi10090.ENSMUSP00000021466

Structurei

3D structure databases

ProteinModelPortaliQ8BH66
SMRiQ8BH66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 309GB1/RHD3-type GAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni448 – 558Sufficient for membrane associationBy similarityAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili412 – 439Sequence analysisAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
ENOG410XR6Z LUCA
GeneTreeiENSGT00390000008959
HOGENOMiHOG000234332
HOVERGENiHBG062891
InParanoidiQ8BH66
KOiK17339
OMAiHLYHHAF
OrthoDBiEOG091G053P
PhylomeDBiQ8BH66
TreeFamiTF105251

Family and domain databases

InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02263 GBP, 1 hit
SUPFAMiSSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BH66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE
60 70 80 90 100
AALNRILLSQ AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV
110 120 130 140 150
GDYNEPLTGF SWRGGSERET TGIQIWSEVF LINKLDGKKV AVLLMDTQGT
160 170 180 190 200
FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ NVQEDDLQHL QLFTEYGRLA
210 220 230 240 250
MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL KVSGNQHEEL
260 270 280 290 300
QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL
310 320 330 340 350
IPWLLSPERL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA
360 370 380 390 400
TAEANNLAAV ATAKDTYNKK MEEVCGGDKP FLAPNDLQSK HLQLKEESVK
410 420 430 440 450
LFRGVKKMGG EEFSRRYLQQ LESEIDELYI QYIKHNDSKN IFHAARTPAT
460 470 480 490 500
LFVVIFITYV IAGVTGFIGL DIIASLCNMI MGLTLITLCT WAYIRYSGEY
510 520 530 540 550
RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLCHQ AFPAPKSEPT

QQPEKKKI
Length:558
Mass (Da):63,377
Last modified:March 1, 2003 - v1
Checksum:i4734A5D99A9171AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046919 mRNA Translation: BAC32920.1
AK050339 mRNA Translation: BAC34198.1
BC050784 mRNA Translation: AAH50784.1
AK083918 mRNA Translation: BAC39062.1
CCDSiCCDS36465.1
RefSeqiNP_848743.1, NM_178628.5
UniGeneiMm.474462

Genome annotation databases

EnsembliENSMUST00000021466; ENSMUSP00000021466; ENSMUSG00000021066
GeneIDi73991
KEGGimmu:73991
UCSCiuc007nsy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiATLA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH66
Secondary accession number(s): Q8BJH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health