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Q8BH66

- ATLA1_MOUSE

UniProt

Q8BH66 - ATLA1_MOUSE

Protein

Atlastin-1

Gene

Atl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818GTPBy similarity
    Nucleotide bindingi118 – 1203GTPBy similarity
    Nucleotide bindingi217 – 2182GTPBy similarity
    Nucleotide bindingi276 – 2794GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB
    3. identical protein binding Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: UniProtKB
    2. endoplasmic reticulum organization Source: UniProtKB
    3. protein homooligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Atlastin-1 (EC:3.6.5.-)
    Alternative name(s):
    Spastic paraplegia 3A homolog
    Gene namesi
    Name:Atl1
    Synonyms:Spg3a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1921241. Atl1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB
    3. endoplasmic reticulum membrane Source: UniProtKB
    4. Golgi apparatus Source: UniProtKB
    5. Golgi cis cisterna Source: UniProtKB
    6. Golgi membrane Source: UniProtKB-SubCell
    7. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Atlastin-1PRO_0000190973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei23 – 231Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BH66.
    PaxDbiQ8BH66.
    PRIDEiQ8BH66.

    PTM databases

    PhosphoSiteiQ8BH66.

    Expressioni

    Gene expression databases

    BgeeiQ8BH66.
    CleanExiMM_GBP3.
    GenevestigatoriQ8BH66.

    Interactioni

    Subunit structurei

    Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with SPAST; interaction is direct By similarity. Interacts with REEP5, RTN3 and probably RTN4 (via the transmembrane region). Interacts with REEP1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8BH66. 1 interaction.
    MINTiMINT-4135323.
    STRINGi10090.ENSMUSP00000021466.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH66.
    SMRiQ8BH66. Positions 31-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 449449CytoplasmicBy similarityAdd
    BLAST
    Topological domaini471 – 4711LumenalSequence Analysis
    Topological domaini493 – 55866CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 309246GB1/RHD3-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni448 – 558111Sufficient for membrane associationBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili412 – 43928Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325148.
    GeneTreeiENSGT00390000008959.
    HOGENOMiHOG000234332.
    HOVERGENiHBG062891.
    InParanoidiQ8BH66.
    KOiK17339.
    OMAiHLYHHAF.
    OrthoDBiEOG7H4DTH.
    PhylomeDBiQ8BH66.
    TreeFamiTF105251.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02263. GBP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS51715. G_GB1_RHD3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BH66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE    50
    AALNRILLSQ AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV 100
    GDYNEPLTGF SWRGGSERET TGIQIWSEVF LINKLDGKKV AVLLMDTQGT 150
    FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ NVQEDDLQHL QLFTEYGRLA 200
    MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL KVSGNQHEEL 250
    QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL 300
    IPWLLSPERL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA 350
    TAEANNLAAV ATAKDTYNKK MEEVCGGDKP FLAPNDLQSK HLQLKEESVK 400
    LFRGVKKMGG EEFSRRYLQQ LESEIDELYI QYIKHNDSKN IFHAARTPAT 450
    LFVVIFITYV IAGVTGFIGL DIIASLCNMI MGLTLITLCT WAYIRYSGEY 500
    RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLCHQ AFPAPKSEPT 550
    QQPEKKKI 558
    Length:558
    Mass (Da):63,377
    Last modified:March 1, 2003 - v1
    Checksum:i4734A5D99A9171AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046919 mRNA. Translation: BAC32920.1.
    AK050339 mRNA. Translation: BAC34198.1.
    BC050784 mRNA. Translation: AAH50784.1.
    AK083918 mRNA. Translation: BAC39062.1.
    CCDSiCCDS36465.1.
    RefSeqiNP_848743.1. NM_178628.5.
    UniGeneiMm.474462.

    Genome annotation databases

    EnsembliENSMUST00000021466; ENSMUSP00000021466; ENSMUSG00000021066.
    GeneIDi73991.
    KEGGimmu:73991.
    UCSCiuc007nsy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046919 mRNA. Translation: BAC32920.1 .
    AK050339 mRNA. Translation: BAC34198.1 .
    BC050784 mRNA. Translation: AAH50784.1 .
    AK083918 mRNA. Translation: BAC39062.1 .
    CCDSi CCDS36465.1.
    RefSeqi NP_848743.1. NM_178628.5.
    UniGenei Mm.474462.

    3D structure databases

    ProteinModelPortali Q8BH66.
    SMRi Q8BH66. Positions 31-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BH66. 1 interaction.
    MINTi MINT-4135323.
    STRINGi 10090.ENSMUSP00000021466.

    PTM databases

    PhosphoSitei Q8BH66.

    Proteomic databases

    MaxQBi Q8BH66.
    PaxDbi Q8BH66.
    PRIDEi Q8BH66.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021466 ; ENSMUSP00000021466 ; ENSMUSG00000021066 .
    GeneIDi 73991.
    KEGGi mmu:73991.
    UCSCi uc007nsy.2. mouse.

    Organism-specific databases

    CTDi 51062.
    MGIi MGI:1921241. Atl1.

    Phylogenomic databases

    eggNOGi NOG325148.
    GeneTreei ENSGT00390000008959.
    HOGENOMi HOG000234332.
    HOVERGENi HBG062891.
    InParanoidi Q8BH66.
    KOi K17339.
    OMAi HLYHHAF.
    OrthoDBi EOG7H4DTH.
    PhylomeDBi Q8BH66.
    TreeFami TF105251.

    Miscellaneous databases

    ChiTaRSi ATL1. mouse.
    NextBioi 339480.
    PROi Q8BH66.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BH66.
    CleanExi MM_GBP3.
    Genevestigatori Q8BH66.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02263. GBP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS51715. G_GB1_RHD3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Liver and Spinal ganglion.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."
      Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
      Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH REEP5 AND RTN3.

    Entry informationi

    Entry nameiATLA1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH66
    Secondary accession number(s): Q8BJH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3