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Q8BH61

- F13A_MOUSE

UniProt

Q8BH61 - F13A_MOUSE

Protein

Coagulation factor XIII A chain

Gene

F13a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin By similarity.By similarity

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-ABy similarity
    Active sitei315 – 3151PROSITE-ProRule annotation
    Active sitei374 – 3741PROSITE-ProRule annotation
    Active sitei397 – 3971PROSITE-ProRule annotation
    Metal bindingi437 – 4371CalciumBy similarity
    Metal bindingi439 – 4391CalciumBy similarity
    Metal bindingi486 – 4861CalciumBy similarity
    Metal bindingi491 – 4911CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: MGI

    GO - Biological processi

    1. blood coagulation Source: MGI
    2. peptide cross-linking Source: MGI

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coagulation factor XIII A chain (EC:2.3.2.13)
    Short name:
    Coagulation factor XIIIa
    Alternative name(s):
    Protein-glutamine gamma-glutamyltransferase A chain
    Transglutaminase A chain
    Gene namesi
    Name:F13a1
    Synonyms:F13a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1921395. F13a1.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity
    Note: Cytoplasmic in most tissues, but also secreted in the blood plasma.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Propeptidei2 – 3837Activation peptideBy similarityPRO_0000033648Add
    BLAST
    Chaini39 – 732694Coagulation factor XIII A chainPRO_0000033649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The activation peptide is released by thrombin.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ8BH61.
    PaxDbiQ8BH61.
    PRIDEiQ8BH61.

    PTM databases

    PhosphoSiteiQ8BH61.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BH61.
    BgeeiQ8BH61.
    CleanExiMM_F13A1.
    GenevestigatoriQ8BH61.

    Interactioni

    Subunit structurei

    Tetramer of two A chains and two B chains.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BH61.
    SMRiQ8BH61. Positions 7-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    GeneTreeiENSGT00740000115156.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiQ8BH61.
    KOiK03917.
    OMAiCEEDAVY.
    OrthoDBiEOG7WT40M.
    PhylomeDBiQ8BH61.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BH61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTPASTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLKDYLNVTA    50
    VHLFKERWDS NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF 100
    RVEYVIGRYP QENKGTYIPV PVVKELQSGK WGAKVIMNED RSVRLSVQSS 150
    PECIVGKFRM YVAVWTPYGI LRTRRDPETD TYILFNPWCE EDAVYLDDEK 200
    EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL YVMDKAEMDL 250
    SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300
    LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ 350
    MDIFLEEDGN VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP 400
    QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVFAEVNSDL VYITAKQDGT 450
    HVVEAVDATH IGKLIVTKQI GGDGMQDITD TYKFQEGQEE ERLALETALM 500
    YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF QNNSSNLYTI 550
    LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL 600
    EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT 650
    VEFTNPLKET LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV 700
    SGHRKLIASM TSDSLRHVYG ELDLQIQRRP TM 732
    Length:732
    Mass (Da):83,207
    Last modified:January 23, 2007 - v3
    Checksum:i47B338665D40C4D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51P → Q in BAC29414. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036403 mRNA. Translation: BAC29414.1.
    AK049092 mRNA. Translation: BAC33539.1.
    AK165311 mRNA. Translation: BAE38130.1.
    BC040274 mRNA. Translation: AAH40274.1.
    CCDSiCCDS26456.1.
    RefSeqiNP_001159863.1. NM_001166391.1.
    NP_083060.2. NM_028784.3.
    UniGeneiMm.235105.

    Genome annotation databases

    EnsembliENSMUST00000037491; ENSMUSP00000048667; ENSMUSG00000039109.
    ENSMUST00000164727; ENSMUSP00000128316; ENSMUSG00000039109.
    GeneIDi74145.
    KEGGimmu:74145.
    UCSCiuc007qcn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036403 mRNA. Translation: BAC29414.1 .
    AK049092 mRNA. Translation: BAC33539.1 .
    AK165311 mRNA. Translation: BAE38130.1 .
    BC040274 mRNA. Translation: AAH40274.1 .
    CCDSi CCDS26456.1.
    RefSeqi NP_001159863.1. NM_001166391.1.
    NP_083060.2. NM_028784.3.
    UniGenei Mm.235105.

    3D structure databases

    ProteinModelPortali Q8BH61.
    SMRi Q8BH61. Positions 7-729.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BH61.

    Proteomic databases

    MaxQBi Q8BH61.
    PaxDbi Q8BH61.
    PRIDEi Q8BH61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037491 ; ENSMUSP00000048667 ; ENSMUSG00000039109 .
    ENSMUST00000164727 ; ENSMUSP00000128316 ; ENSMUSG00000039109 .
    GeneIDi 74145.
    KEGGi mmu:74145.
    UCSCi uc007qcn.2. mouse.

    Organism-specific databases

    CTDi 2162.
    MGIi MGI:1921395. F13a1.

    Phylogenomic databases

    eggNOGi NOG80379.
    GeneTreei ENSGT00740000115156.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi Q8BH61.
    KOi K03917.
    OMAi CEEDAVY.
    OrthoDBi EOG7WT40M.
    PhylomeDBi Q8BH61.
    TreeFami TF324278.

    Miscellaneous databases

    ChiTaRSi F13A1. mouse.
    NextBioi 339898.
    PROi Q8BH61.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BH61.
    Bgeei Q8BH61.
    CleanExi MM_F13A1.
    Genevestigatori Q8BH61.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone, Cerebellum and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiF13A_MOUSE
    AccessioniPrimary (citable) accession number: Q8BH61
    Secondary accession number(s): Q3TNF9, Q8BIP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3