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Q8BH61

- F13A_MOUSE

UniProt

Q8BH61 - F13A_MOUSE

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Protein

Coagulation factor XIII A chain

Gene
F13a1, F13a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin By similarity.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-A By similarity
Active sitei315 – 3151 By similarity
Active sitei374 – 3741 By similarity
Active sitei397 – 3971 By similarity
Metal bindingi437 – 4371Calcium By similarity
Metal bindingi439 – 4391Calcium By similarity
Metal bindingi486 – 4861Calcium By similarity
Metal bindingi491 – 4911Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: MGI

GO - Biological processi

  1. blood coagulation Source: MGI
  2. peptide cross-linking Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13a1
Synonyms:F13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1921395. F13a1.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: Cytoplasmic in most tissues, but also secreted in the blood plasma By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Propeptidei2 – 3837Activation peptide By similarityPRO_0000033648Add
BLAST
Chaini39 – 732694Coagulation factor XIII A chainPRO_0000033649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Glycosylationi614 – 6141N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The activation peptide is released by thrombin By similarity.

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ8BH61.
PaxDbiQ8BH61.
PRIDEiQ8BH61.

PTM databases

PhosphoSiteiQ8BH61.

Expressioni

Gene expression databases

ArrayExpressiQ8BH61.
BgeeiQ8BH61.
CleanExiMM_F13A1.
GenevestigatoriQ8BH61.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BH61.
SMRiQ8BH61. Positions 7-729.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
GeneTreeiENSGT00740000115156.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ8BH61.
KOiK03917.
OMAiCEEDAVY.
OrthoDBiEOG7WT40M.
PhylomeDBiQ8BH61.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH61-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTPASTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLKDYLNVTA    50
VHLFKERWDS NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF 100
RVEYVIGRYP QENKGTYIPV PVVKELQSGK WGAKVIMNED RSVRLSVQSS 150
PECIVGKFRM YVAVWTPYGI LRTRRDPETD TYILFNPWCE EDAVYLDDEK 200
EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL YVMDKAEMDL 250
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300
LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ 350
MDIFLEEDGN VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP 400
QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVFAEVNSDL VYITAKQDGT 450
HVVEAVDATH IGKLIVTKQI GGDGMQDITD TYKFQEGQEE ERLALETALM 500
YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF QNNSSNLYTI 550
LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL 600
EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT 650
VEFTNPLKET LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV 700
SGHRKLIASM TSDSLRHVYG ELDLQIQRRP TM 732
Length:732
Mass (Da):83,207
Last modified:January 23, 2007 - v3
Checksum:i47B338665D40C4D9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51P → Q in BAC29414. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036403 mRNA. Translation: BAC29414.1.
AK049092 mRNA. Translation: BAC33539.1.
AK165311 mRNA. Translation: BAE38130.1.
BC040274 mRNA. Translation: AAH40274.1.
CCDSiCCDS26456.1.
RefSeqiNP_001159863.1. NM_001166391.1.
NP_083060.2. NM_028784.3.
UniGeneiMm.235105.

Genome annotation databases

EnsembliENSMUST00000037491; ENSMUSP00000048667; ENSMUSG00000039109.
ENSMUST00000164727; ENSMUSP00000128316; ENSMUSG00000039109.
GeneIDi74145.
KEGGimmu:74145.
UCSCiuc007qcn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036403 mRNA. Translation: BAC29414.1 .
AK049092 mRNA. Translation: BAC33539.1 .
AK165311 mRNA. Translation: BAE38130.1 .
BC040274 mRNA. Translation: AAH40274.1 .
CCDSi CCDS26456.1.
RefSeqi NP_001159863.1. NM_001166391.1.
NP_083060.2. NM_028784.3.
UniGenei Mm.235105.

3D structure databases

ProteinModelPortali Q8BH61.
SMRi Q8BH61. Positions 7-729.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BH61.

Proteomic databases

MaxQBi Q8BH61.
PaxDbi Q8BH61.
PRIDEi Q8BH61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037491 ; ENSMUSP00000048667 ; ENSMUSG00000039109 .
ENSMUST00000164727 ; ENSMUSP00000128316 ; ENSMUSG00000039109 .
GeneIDi 74145.
KEGGi mmu:74145.
UCSCi uc007qcn.2. mouse.

Organism-specific databases

CTDi 2162.
MGIi MGI:1921395. F13a1.

Phylogenomic databases

eggNOGi NOG80379.
GeneTreei ENSGT00740000115156.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q8BH61.
KOi K03917.
OMAi CEEDAVY.
OrthoDBi EOG7WT40M.
PhylomeDBi Q8BH61.
TreeFami TF324278.

Miscellaneous databases

ChiTaRSi F13A1. mouse.
NextBioi 339898.
PROi Q8BH61.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BH61.
Bgeei Q8BH61.
CleanExi MM_F13A1.
Genevestigatori Q8BH61.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Cerebellum and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiF13A_MOUSE
AccessioniPrimary (citable) accession number: Q8BH61
Secondary accession number(s): Q3TNF9, Q8BIP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi