Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BH61

- F13A_MOUSE

UniProt

Q8BH61 - F13A_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Coagulation factor XIII A chain

Gene

F13a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-ABy similarity
Active sitei315 – 3151PROSITE-ProRule annotation
Active sitei374 – 3741PROSITE-ProRule annotation
Active sitei397 – 3971PROSITE-ProRule annotation
Metal bindingi437 – 4371CalciumBy similarity
Metal bindingi439 – 4391CalciumBy similarity
Metal bindingi486 – 4861CalciumBy similarity
Metal bindingi491 – 4911CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: MGI

GO - Biological processi

  1. blood coagulation Source: MGI
  2. peptide cross-linking Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13a1
Synonyms:F13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1921395. F13a1.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: Cytoplasmic in most tissues, but also secreted in the blood plasma.By similarity

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Propeptidei2 – 3837Activation peptideBy similarityPRO_0000033648Add
BLAST
Chaini39 – 732694Coagulation factor XIII A chainPRO_0000033649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The activation peptide is released by thrombin.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ8BH61.
PaxDbiQ8BH61.
PRIDEiQ8BH61.

PTM databases

PhosphoSiteiQ8BH61.

Expressioni

Gene expression databases

BgeeiQ8BH61.
CleanExiMM_F13A1.
ExpressionAtlasiQ8BH61. baseline and differential.
GenevestigatoriQ8BH61.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BH61.
SMRiQ8BH61. Positions 7-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ8BH61.
KOiK03917.
OMAiCEEDAVY.
OrthoDBiEOG7WT40M.
PhylomeDBiQ8BH61.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH61 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTPASTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLKDYLNVTA
60 70 80 90 100
VHLFKERWDS NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF
110 120 130 140 150
RVEYVIGRYP QENKGTYIPV PVVKELQSGK WGAKVIMNED RSVRLSVQSS
160 170 180 190 200
PECIVGKFRM YVAVWTPYGI LRTRRDPETD TYILFNPWCE EDAVYLDDEK
210 220 230 240 250
EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL YVMDKAEMDL
260 270 280 290 300
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL
310 320 330 340 350
LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ
360 370 380 390 400
MDIFLEEDGN VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP
410 420 430 440 450
QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVFAEVNSDL VYITAKQDGT
460 470 480 490 500
HVVEAVDATH IGKLIVTKQI GGDGMQDITD TYKFQEGQEE ERLALETALM
510 520 530 540 550
YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF QNNSSNLYTI
560 570 580 590 600
LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL
610 620 630 640 650
EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT
660 670 680 690 700
VEFTNPLKET LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV
710 720 730
SGHRKLIASM TSDSLRHVYG ELDLQIQRRP TM
Length:732
Mass (Da):83,207
Last modified:January 23, 2007 - v3
Checksum:i47B338665D40C4D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51P → Q in BAC29414. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036403 mRNA. Translation: BAC29414.1.
AK049092 mRNA. Translation: BAC33539.1.
AK165311 mRNA. Translation: BAE38130.1.
BC040274 mRNA. Translation: AAH40274.1.
CCDSiCCDS26456.1.
RefSeqiNP_001159863.1. NM_001166391.1.
NP_083060.2. NM_028784.3.
UniGeneiMm.235105.

Genome annotation databases

EnsembliENSMUST00000037491; ENSMUSP00000048667; ENSMUSG00000039109.
ENSMUST00000164727; ENSMUSP00000128316; ENSMUSG00000039109.
GeneIDi74145.
KEGGimmu:74145.
UCSCiuc007qcn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036403 mRNA. Translation: BAC29414.1 .
AK049092 mRNA. Translation: BAC33539.1 .
AK165311 mRNA. Translation: BAE38130.1 .
BC040274 mRNA. Translation: AAH40274.1 .
CCDSi CCDS26456.1.
RefSeqi NP_001159863.1. NM_001166391.1.
NP_083060.2. NM_028784.3.
UniGenei Mm.235105.

3D structure databases

ProteinModelPortali Q8BH61.
SMRi Q8BH61. Positions 7-729.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BH61.

Proteomic databases

MaxQBi Q8BH61.
PaxDbi Q8BH61.
PRIDEi Q8BH61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037491 ; ENSMUSP00000048667 ; ENSMUSG00000039109 .
ENSMUST00000164727 ; ENSMUSP00000128316 ; ENSMUSG00000039109 .
GeneIDi 74145.
KEGGi mmu:74145.
UCSCi uc007qcn.2. mouse.

Organism-specific databases

CTDi 2162.
MGIi MGI:1921395. F13a1.

Phylogenomic databases

eggNOGi NOG80379.
GeneTreei ENSGT00760000119108.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q8BH61.
KOi K03917.
OMAi CEEDAVY.
OrthoDBi EOG7WT40M.
PhylomeDBi Q8BH61.
TreeFami TF324278.

Miscellaneous databases

ChiTaRSi F13A1. mouse.
NextBioi 339898.
PROi Q8BH61.
SOURCEi Search...

Gene expression databases

Bgeei Q8BH61.
CleanExi MM_F13A1.
ExpressionAtlasi Q8BH61. baseline and differential.
Genevestigatori Q8BH61.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Cerebellum and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiF13A_MOUSE
AccessioniPrimary (citable) accession number: Q8BH61
Secondary accession number(s): Q3TNF9, Q8BIP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3