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Q8BH59

- CMC1_MOUSE

UniProt

Q8BH59 - CMC1_MOUSE

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Protein

Calcium-binding mitochondrial carrier protein Aralar1

Gene
Slc25a12, Aralar1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi65 – 76121 By similarityAdd
BLAST
Calcium bindingi99 – 110122 By similarityAdd
BLAST
Calcium bindingi170 – 181123 By similarityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. L-aspartate transmembrane transporter activity Source: UniProtKB
  3. L-glutamate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. aspartate transport Source: UniProtKB
  2. L-glutamate transport Source: UniProtKB
  3. malate-aspartate shuttle Source: UniProtKB
  4. response to calcium ion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein Aralar1
Alternative name(s):
Mitochondrial aspartate glutamate carrier 1
Solute carrier family 25 member 12
Gene namesi
Name:Slc25a12
Synonyms:Aralar1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1926080. Slc25a12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei330 – 34718Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei391 – 41020Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei434 – 44714Helical; Name=3; Reviewed predictionAdd
BLAST
Transmembranei483 – 50220Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei522 – 53918Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei579 – 59820Helical; Name=6; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 677676Calcium-binding mitochondrial carrier protein Aralar1PRO_0000090599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BH59.
PaxDbiQ8BH59.
PRIDEiQ8BH59.

PTM databases

PhosphoSiteiQ8BH59.

Expressioni

Gene expression databases

BgeeiQ8BH59.
GenevestigatoriQ8BH59.

Interactioni

Protein-protein interaction databases

BioGridi219664. 4 interactions.
IntActiQ8BH59. 8 interactions.
MINTiMINT-1843325.

Structurei

3D structure databases

ProteinModelPortaliQ8BH59.
SMRiQ8BH59. Positions 19-285, 330-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 8546EF-hand 1Add
BLAST
Domaini86 – 12136EF-hand 2Add
BLAST
Domaini122 – 15635EF-hand 3Add
BLAST
Domaini157 – 19236EF-hand 4Add
BLAST
Repeati324 – 41693Solcar 1Add
BLAST
Repeati424 – 50885Solcar 2Add
BLAST
Repeati516 – 60489Solcar 3Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.
Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292991.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000180633.
HOVERGENiHBG005350.
InParanoidiA2BFG0.
KOiK15105.
OMAiFESVLCT.
OrthoDBiEOG70GMF1.
PhylomeDBiQ8BH59.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BH59-1 [UniParc]FASTAAdd to Basket

« Hide

MAVKVHTTKR GDPHELRNIF LQYASTEVDG EHYMTPEDFV QRYLGLYNDP    50
NSNPKIVQLL AGVADQTKDG LISYQEFLAF ESVLCAPDSM FIVAFQLFDK 100
SGNGEVTFEN VKEIFGQTII HHHIPFNWDC EFIRLHFGHN RKKHLNYVEF 150
TQFLQELQLE HARQAFALKD KSKSGMISGL DFSDVMVTIR SHMLTPFVEE 200
NLVSAAGGGT SHQVSFSYFN AFNSLLNNME LVRKIYSTLA GTRKDIEVTK 250
EEFAQSAIRY GQVTPLEIDI LYQLADLYNA SGRLTLADIE RIAPLAEGAL 300
PYNLAELQRQ QSPGLGRPIW LQIAESAYRF TLGSVAGAVG ATAVYPIDLV 350
KTRMQNQRGT GSVVGELMYK NSFDCFKKVL RYEGFFGLYR GLIPQLIGVA 400
PEKAIKLTVN DFVRDKFTKR DGSIPLPAEI LAGGCAGGSQ VIFTNPLEIV 450
KIRLQVAGEI TTGPRVSALN VLQDLGLFGL YKGAKACFLR DIPFSAIYFP 500
VYAHCKLLLA DENGRVGGIN LLTAGALAGV PAASLVTPAD VIKTRLQVAA 550
RAGQTTYSGV VDCFRKILRE EGPSAFWKGT AARVFRSSPQ FGVTLVTYEL 600
LQRWFYIDFG GLKPSGSEPT PKSRIADLPP ANPDHIGGYR LATATFAGIE 650
NKFGLYLPKF KSPSVAVAQP KAAAAAQ 677
Length:677
Mass (Da):74,570
Last modified:March 1, 2003 - v1
Checksum:i488ABC7EB8227571
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030595 mRNA. Translation: BAC27037.1.
AK083156 mRNA. Translation: BAC38787.1.
BX284624 Genomic DNA. Translation: CAM20071.1.
BC060505 mRNA. Translation: AAH60505.1.
CCDSiCCDS16113.1.
RefSeqiNP_766024.1. NM_172436.3.
UniGeneiMm.146696.
Mm.30928.

Genome annotation databases

EnsembliENSMUST00000151937; ENSMUSP00000122103; ENSMUSG00000027010.
GeneIDi78830.
KEGGimmu:78830.
UCSCiuc008kan.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030595 mRNA. Translation: BAC27037.1 .
AK083156 mRNA. Translation: BAC38787.1 .
BX284624 Genomic DNA. Translation: CAM20071.1 .
BC060505 mRNA. Translation: AAH60505.1 .
CCDSi CCDS16113.1.
RefSeqi NP_766024.1. NM_172436.3.
UniGenei Mm.146696.
Mm.30928.

3D structure databases

ProteinModelPortali Q8BH59.
SMRi Q8BH59. Positions 19-285, 330-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219664. 4 interactions.
IntActi Q8BH59. 8 interactions.
MINTi MINT-1843325.

PTM databases

PhosphoSitei Q8BH59.

Proteomic databases

MaxQBi Q8BH59.
PaxDbi Q8BH59.
PRIDEi Q8BH59.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000151937 ; ENSMUSP00000122103 ; ENSMUSG00000027010 .
GeneIDi 78830.
KEGGi mmu:78830.
UCSCi uc008kan.1. mouse.

Organism-specific databases

CTDi 8604.
MGIi MGI:1926080. Slc25a12.

Phylogenomic databases

eggNOGi NOG292991.
GeneTreei ENSGT00530000062944.
HOGENOMi HOG000180633.
HOVERGENi HBG005350.
InParanoidi A2BFG0.
KOi K15105.
OMAi FESVLCT.
OrthoDBi EOG70GMF1.
PhylomeDBi Q8BH59.
TreeFami TF313209.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

NextBioi 349608.
PROi Q8BH59.
SOURCEi Search...

Gene expression databases

Bgeei Q8BH59.
Genevestigatori Q8BH59.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.50.40.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Pituitary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCMC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH59
Secondary accession number(s): A2BFG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds calcium By similarity.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi