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Q8BH59 (CMC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-binding mitochondrial carrier protein Aralar1
Alternative name(s):
Mitochondrial aspartate glutamate carrier 1
Solute carrier family 25 member 12
Gene names
Name:Slc25a12
Synonyms:Aralar1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length677 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Binds calcium By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 4 EF-hand domains.

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 677676Calcium-binding mitochondrial carrier protein Aralar1
PRO_0000090599

Regions

Transmembrane330 – 34718Helical; Name=1; Potential
Transmembrane391 – 41020Helical; Name=2; Potential
Transmembrane434 – 44714Helical; Name=3; Potential
Transmembrane483 – 50220Helical; Name=4; Potential
Transmembrane522 – 53918Helical; Name=5; Potential
Transmembrane579 – 59820Helical; Name=6; Potential
Domain40 – 8546EF-hand 1
Domain86 – 12136EF-hand 2
Domain122 – 15635EF-hand 3
Domain157 – 19236EF-hand 4
Repeat324 – 41693Solcar 1
Repeat424 – 50885Solcar 2
Repeat516 – 60489Solcar 3
Calcium binding65 – 76121 By similarity
Calcium binding99 – 110122 By similarity
Calcium binding170 – 181123 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BH59 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 488ABC7EB8227571

FASTA67774,570
        10         20         30         40         50         60 
MAVKVHTTKR GDPHELRNIF LQYASTEVDG EHYMTPEDFV QRYLGLYNDP NSNPKIVQLL 

        70         80         90        100        110        120 
AGVADQTKDG LISYQEFLAF ESVLCAPDSM FIVAFQLFDK SGNGEVTFEN VKEIFGQTII 

       130        140        150        160        170        180 
HHHIPFNWDC EFIRLHFGHN RKKHLNYVEF TQFLQELQLE HARQAFALKD KSKSGMISGL 

       190        200        210        220        230        240 
DFSDVMVTIR SHMLTPFVEE NLVSAAGGGT SHQVSFSYFN AFNSLLNNME LVRKIYSTLA 

       250        260        270        280        290        300 
GTRKDIEVTK EEFAQSAIRY GQVTPLEIDI LYQLADLYNA SGRLTLADIE RIAPLAEGAL 

       310        320        330        340        350        360 
PYNLAELQRQ QSPGLGRPIW LQIAESAYRF TLGSVAGAVG ATAVYPIDLV KTRMQNQRGT 

       370        380        390        400        410        420 
GSVVGELMYK NSFDCFKKVL RYEGFFGLYR GLIPQLIGVA PEKAIKLTVN DFVRDKFTKR 

       430        440        450        460        470        480 
DGSIPLPAEI LAGGCAGGSQ VIFTNPLEIV KIRLQVAGEI TTGPRVSALN VLQDLGLFGL 

       490        500        510        520        530        540 
YKGAKACFLR DIPFSAIYFP VYAHCKLLLA DENGRVGGIN LLTAGALAGV PAASLVTPAD 

       550        560        570        580        590        600 
VIKTRLQVAA RAGQTTYSGV VDCFRKILRE EGPSAFWKGT AARVFRSSPQ FGVTLVTYEL 

       610        620        630        640        650        660 
LQRWFYIDFG GLKPSGSEPT PKSRIADLPP ANPDHIGGYR LATATFAGIE NKFGLYLPKF 

       670 
KSPSVAVAQP KAAAAAQ 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus and Pituitary.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-68; 144-163; 174-190; 234-243; 245-259; 284-309; 330-351; 359-370; 382-403; 407-414; 454-482; 491-543; 552-565; 570-578; 587-622; 625-659 AND 662-671.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030595 mRNA. Translation: BAC27037.1.
AK083156 mRNA. Translation: BAC38787.1.
BX284624 Genomic DNA. Translation: CAM20071.1.
BC060505 mRNA. Translation: AAH60505.1.
RefSeqNP_766024.1. NM_172436.3.
UniGeneMm.146696.
Mm.30928.

3D structure databases

ProteinModelPortalQ8BH59.
SMRQ8BH59. Positions 14-223, 330-602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219664. 3 interactions.
IntActQ8BH59. 8 interactions.
MINTMINT-1843325.

PTM databases

PhosphoSiteQ8BH59.

Proteomic databases

PaxDbQ8BH59.
PRIDEQ8BH59.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000151937; ENSMUSP00000122103; ENSMUSG00000027010.
GeneID78830.
KEGGmmu:78830.
UCSCuc008kan.1. mouse.

Organism-specific databases

CTD8604.
MGIMGI:1926080. Slc25a12.

Phylogenomic databases

eggNOGNOG292991.
GeneTreeENSGT00530000062944.
HOGENOMHOG000180633.
HOVERGENHBG005350.
InParanoidA2BFG0.
KOK15105.
OMAAQTMSQI.
OrthoDBEOG70GMF1.
PhylomeDBQ8BH59.
TreeFamTF313209.

Gene expression databases

BgeeQ8BH59.
GenevestigatorQ8BH59.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
1.50.40.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio349608.
PROQ8BH59.
SOURCESearch...

Entry information

Entry nameCMC1_MOUSE
AccessionPrimary (citable) accession number: Q8BH59
Secondary accession number(s): A2BFG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot