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Protein

TIP41-like protein

Gene

Tiprl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
TIP41-like protein
Gene namesi
Name:Tiprl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915087. Tiprl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018541 – 271TIP41-like proteinAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106N6-acetyllysineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BH58.
MaxQBiQ8BH58.
PaxDbiQ8BH58.
PeptideAtlasiQ8BH58.
PRIDEiQ8BH58.

PTM databases

iPTMnetiQ8BH58.
PhosphoSitePlusiQ8BH58.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040843.
ExpressionAtlasiQ8BH58. baseline and differential.
GenevisibleiQ8BH58. MM.

Interactioni

Subunit structurei

Interacts with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BH58. 1 interactor.
MINTiMINT-4110476.
STRINGi10090.ENSMUSP00000037514.

Structurei

3D structure databases

ProteinModelPortaliQ8BH58.
SMRiQ8BH58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 271Interaction with PPP2CABy similarityAdd BLAST99

Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

eggNOGiKOG3224. Eukaryota.
ENOG410XT96. LUCA.
GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
HOVERGENiHBG053157.
InParanoidiQ8BH58.
KOiK17607.
OMAiACAQEWQ.
OrthoDBiEOG091G0II3.
PhylomeDBiQ8BH58.
TreeFamiTF105943.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIHGFQSSH QDFSFGPWKL TASKTHIMKS ADVEKLADEL HMPSLPEMMF
60 70 80 90 100
GDNVLRIQHG SGFGIEFNAT DALRCVNNYQ GMLKVACAEE WQESRTEGEH
110 120 130 140 150
SKEVIKPYDW TYTTDYKGTL LGESLKLKVV PTTDHIDTEK LKAREQIKFF
160 170 180 190 200
EEVLLFEDEL HDHGVSSLSV KIRVMPSSFF LLLRFFLRID GVLIRMNDTR
210 220 230 240 250
LYHEADKTYM LREYTSRESK IANLMHVPPS LFTEPNEISQ YLPIKEAVCE
260 270
KLVFPERIDP NPVDSQSTPS E
Length:271
Mass (Da):31,254
Last modified:March 1, 2003 - v1
Checksum:i49558C6DDE0E2A7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049119 mRNA. Translation: BAC33553.1.
AK049784 mRNA. Translation: BAC33919.1.
AK075774 mRNA. Translation: BAC35948.1.
BC002098 mRNA. Translation: AAH02098.1.
BC058250 mRNA. Translation: AAH58250.1.
CCDSiCCDS15441.1.
RefSeqiNP_663488.1. NM_145513.4.
UniGeneiMm.21520.

Genome annotation databases

EnsembliENSMUST00000043235; ENSMUSP00000037514; ENSMUSG00000040843.
GeneIDi226591.
KEGGimmu:226591.
UCSCiuc007diz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049119 mRNA. Translation: BAC33553.1.
AK049784 mRNA. Translation: BAC33919.1.
AK075774 mRNA. Translation: BAC35948.1.
BC002098 mRNA. Translation: AAH02098.1.
BC058250 mRNA. Translation: AAH58250.1.
CCDSiCCDS15441.1.
RefSeqiNP_663488.1. NM_145513.4.
UniGeneiMm.21520.

3D structure databases

ProteinModelPortaliQ8BH58.
SMRiQ8BH58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BH58. 1 interactor.
MINTiMINT-4110476.
STRINGi10090.ENSMUSP00000037514.

PTM databases

iPTMnetiQ8BH58.
PhosphoSitePlusiQ8BH58.

Proteomic databases

EPDiQ8BH58.
MaxQBiQ8BH58.
PaxDbiQ8BH58.
PeptideAtlasiQ8BH58.
PRIDEiQ8BH58.

Protocols and materials databases

DNASUi226591.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043235; ENSMUSP00000037514; ENSMUSG00000040843.
GeneIDi226591.
KEGGimmu:226591.
UCSCiuc007diz.2. mouse.

Organism-specific databases

CTDi261726.
MGIiMGI:1915087. Tiprl.

Phylogenomic databases

eggNOGiKOG3224. Eukaryota.
ENOG410XT96. LUCA.
GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
HOVERGENiHBG053157.
InParanoidiQ8BH58.
KOiK17607.
OMAiACAQEWQ.
OrthoDBiEOG091G0II3.
PhylomeDBiQ8BH58.
TreeFamiTF105943.

Miscellaneous databases

ChiTaRSiTiprl. mouse.
PROiQ8BH58.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040843.
ExpressionAtlasiQ8BH58. baseline and differential.
GenevisibleiQ8BH58. MM.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIPRL_MOUSE
AccessioniPrimary (citable) accession number: Q8BH58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.