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Protein

TIP41-like protein

Gene

Tiprl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
TIP41-like protein
Gene namesi
Name:Tiprl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915087 Tiprl

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018541 – 271TIP41-like proteinAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106N6-acetyllysineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BH58
MaxQBiQ8BH58
PaxDbiQ8BH58
PeptideAtlasiQ8BH58
PRIDEiQ8BH58

PTM databases

iPTMnetiQ8BH58
PhosphoSitePlusiQ8BH58

Expressioni

Gene expression databases

BgeeiENSMUSG00000040843
ExpressionAtlasiQ8BH58 baseline and differential
GenevisibleiQ8BH58 MM

Interactioni

Subunit structurei

Interacts with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex (By similarity). Interacts with PPP4C and PPP4R2 (PubMed:26717153).By similarity1 Publication

Protein-protein interaction databases

IntActiQ8BH58, 1 interactor
MINTiQ8BH58
STRINGi10090.ENSMUSP00000037514

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi18 – 23Combined sources6
Helixi30 – 39Combined sources10
Beta strandi47 – 49Combined sources3
Beta strandi54 – 59Combined sources6
Beta strandi64 – 68Combined sources5
Helixi69 – 73Combined sources5
Beta strandi119 – 121Combined sources3
Beta strandi128 – 131Combined sources4
Beta strandi148 – 158Combined sources11
Helixi160 – 162Combined sources3
Beta strandi163 – 174Combined sources12
Beta strandi176 – 189Combined sources14
Turni190 – 192Combined sources3
Beta strandi193 – 204Combined sources12
Beta strandi208 – 220Combined sources13
Helixi221 – 223Combined sources3
Helixi229 – 233Combined sources5
Helixi235 – 238Combined sources4
Helixi239 – 241Combined sources3
Beta strandi244 – 253Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W0WX-ray3.80B/E/H/K12-259[»]
5W0XX-ray2.72A12-259[»]
ProteinModelPortaliQ8BH58
SMRiQ8BH58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 271Interaction with PPP2CABy similarityAdd BLAST99

Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

eggNOGiKOG3224 Eukaryota
ENOG410XT96 LUCA
GeneTreeiENSGT00390000006659
HOGENOMiHOG000213547
HOVERGENiHBG053157
InParanoidiQ8BH58
KOiK17607
OMAiKIANLMH
OrthoDBiEOG091G0II3
PhylomeDBiQ8BH58
TreeFamiTF105943

Family and domain databases

InterProiView protein in InterPro
IPR007303 TIP41-like
PANTHERiPTHR21021:SF16 PTHR21021:SF16, 1 hit
PfamiView protein in Pfam
PF04176 TIP41, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BH58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIHGFQSSH QDFSFGPWKL TASKTHIMKS ADVEKLADEL HMPSLPEMMF
60 70 80 90 100
GDNVLRIQHG SGFGIEFNAT DALRCVNNYQ GMLKVACAEE WQESRTEGEH
110 120 130 140 150
SKEVIKPYDW TYTTDYKGTL LGESLKLKVV PTTDHIDTEK LKAREQIKFF
160 170 180 190 200
EEVLLFEDEL HDHGVSSLSV KIRVMPSSFF LLLRFFLRID GVLIRMNDTR
210 220 230 240 250
LYHEADKTYM LREYTSRESK IANLMHVPPS LFTEPNEISQ YLPIKEAVCE
260 270
KLVFPERIDP NPVDSQSTPS E
Length:271
Mass (Da):31,254
Last modified:March 1, 2003 - v1
Checksum:i49558C6DDE0E2A7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049119 mRNA Translation: BAC33553.1
AK049784 mRNA Translation: BAC33919.1
AK075774 mRNA Translation: BAC35948.1
BC002098 mRNA Translation: AAH02098.1
BC058250 mRNA Translation: AAH58250.1
CCDSiCCDS15441.1
RefSeqiNP_663488.1, NM_145513.4
UniGeneiMm.21520

Genome annotation databases

EnsembliENSMUST00000043235; ENSMUSP00000037514; ENSMUSG00000040843
GeneIDi226591
KEGGimmu:226591
UCSCiuc007diz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTIPRL_MOUSE
AccessioniPrimary (citable) accession number: Q8BH58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health