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Protein

Sesquipedalian-1

Gene

Fam109a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-1
Short name:
Ses1
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein A
Short name:
IPIP27A
Gene namesi
Name:Fam109a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442708. Fam109a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Sesquipedalian-1PRO_0000406046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BH49.
PaxDbiQ8BH49.
PRIDEiQ8BH49.

PTM databases

iPTMnetiQ8BH49.
PhosphoSiteiQ8BH49.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044134.
ExpressionAtlasiQ8BH49. baseline and differential.
GenevisibleiQ8BH49. MM.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B. Interaction with OCRL may be important for endosomal morphology and function (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062386.

Structurei

3D structure databases

ProteinModelPortaliQ8BH49.
SMRiQ8BH49. Positions 17-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 11397PHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi191 – 20313F&HAdd
BLAST

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH44. Eukaryota.
ENOG4111J7G. LUCA.
GeneTreeiENSGT00440000034671.
HOGENOMiHOG000046885.
HOVERGENiHBG061708.
InParanoidiQ8BH49.
OMAiTRARTYV.
OrthoDBiEOG091G0IU5.
PhylomeDBiQ8BH49.
TreeFamiTF326731.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BH49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSLAF YATCDAPVDN AGFLYKRGGR GTGSHRRWFV LRGNILFYFE
60 70 80 90 100
AEGSREPLGV ILLEGCTVEL VDAREEFAFA VRFAGGRSRP YVLAADSQAA
110 120 130 140 150
LEGWVKALSR ASFHYLRLVV RELEQQLAAM REGSPANALP ANPSPVLTQR
160 170 180 190 200
PKENGWVVWS TLPEQPSVAP QRPPPLPPRR RASAANGPLA SFAQLHARYG
210 220 230 240 250
LEVQALRDQW RGGQAGLASL EVPWHPGSAE TQTQDQPALR GHSGCKVLHV
260
FRSVEWPVCN PGSQGT
Length:266
Mass (Da):29,218
Last modified:March 1, 2003 - v1
Checksum:i4D0C3B71A5D23F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033618 mRNA. Translation: BAC28394.1.
AK039192 mRNA. Translation: BAC30272.1.
CH466529 Genomic DNA. Translation: EDL19707.1.
CH466529 Genomic DNA. Translation: EDL19708.1.
BC120681 mRNA. Translation: AAI20682.1.
BC120683 mRNA. Translation: AAI20684.1.
CCDSiCCDS19642.1.
RefSeqiNP_780683.1. NM_175474.3.
XP_006530367.1. XM_006530304.2.
UniGeneiMm.12654.

Genome annotation databases

EnsembliENSMUST00000056654; ENSMUSP00000062386; ENSMUSG00000044134.
ENSMUST00000198271; ENSMUSP00000143110; ENSMUSG00000044134.
GeneIDi231717.
KEGGimmu:231717.
UCSCiuc008zkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033618 mRNA. Translation: BAC28394.1.
AK039192 mRNA. Translation: BAC30272.1.
CH466529 Genomic DNA. Translation: EDL19707.1.
CH466529 Genomic DNA. Translation: EDL19708.1.
BC120681 mRNA. Translation: AAI20682.1.
BC120683 mRNA. Translation: AAI20684.1.
CCDSiCCDS19642.1.
RefSeqiNP_780683.1. NM_175474.3.
XP_006530367.1. XM_006530304.2.
UniGeneiMm.12654.

3D structure databases

ProteinModelPortaliQ8BH49.
SMRiQ8BH49. Positions 17-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062386.

PTM databases

iPTMnetiQ8BH49.
PhosphoSiteiQ8BH49.

Proteomic databases

MaxQBiQ8BH49.
PaxDbiQ8BH49.
PRIDEiQ8BH49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056654; ENSMUSP00000062386; ENSMUSG00000044134.
ENSMUST00000198271; ENSMUSP00000143110; ENSMUSG00000044134.
GeneIDi231717.
KEGGimmu:231717.
UCSCiuc008zkj.1. mouse.

Organism-specific databases

CTDi144717.
MGIiMGI:2442708. Fam109a.

Phylogenomic databases

eggNOGiENOG410IH44. Eukaryota.
ENOG4111J7G. LUCA.
GeneTreeiENSGT00440000034671.
HOGENOMiHOG000046885.
HOVERGENiHBG061708.
InParanoidiQ8BH49.
OMAiTRARTYV.
OrthoDBiEOG091G0IU5.
PhylomeDBiQ8BH49.
TreeFamiTF326731.

Miscellaneous databases

PROiQ8BH49.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044134.
ExpressionAtlasiQ8BH49. baseline and differential.
GenevisibleiQ8BH49. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSESQ1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.