Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sesquipedalian-1

Gene

Fam109a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-1
Short name:
Ses1
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein A
Short name:
IPIP27A
Gene namesi
Name:Fam109a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442708 Fam109a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060461 – 266Sesquipedalian-1Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BH49
PaxDbiQ8BH49
PRIDEiQ8BH49

PTM databases

iPTMnetiQ8BH49
PhosphoSitePlusiQ8BH49

Expressioni

Gene expression databases

BgeeiENSMUSG00000044134
ExpressionAtlasiQ8BH49 baseline and differential
GenevisibleiQ8BH49 MM

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B. Interaction with OCRL may be important for endosomal morphology and function (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062386

Structurei

3D structure databases

ProteinModelPortaliQ8BH49
SMRiQ8BH49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 113PHPROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi191 – 203F&HAdd BLAST13

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated

Phylogenomic databases

eggNOGiENOG410IH44 Eukaryota
ENOG4111J7G LUCA
GeneTreeiENSGT00440000034671
HOGENOMiHOG000046885
HOVERGENiHBG061708
InParanoidiQ8BH49
OMAiTRARTYV
OrthoDBiEOG091G0IU5
PhylomeDBiQ8BH49
TreeFamiTF326731

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BH49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSLAF YATCDAPVDN AGFLYKRGGR GTGSHRRWFV LRGNILFYFE
60 70 80 90 100
AEGSREPLGV ILLEGCTVEL VDAREEFAFA VRFAGGRSRP YVLAADSQAA
110 120 130 140 150
LEGWVKALSR ASFHYLRLVV RELEQQLAAM REGSPANALP ANPSPVLTQR
160 170 180 190 200
PKENGWVVWS TLPEQPSVAP QRPPPLPPRR RASAANGPLA SFAQLHARYG
210 220 230 240 250
LEVQALRDQW RGGQAGLASL EVPWHPGSAE TQTQDQPALR GHSGCKVLHV
260
FRSVEWPVCN PGSQGT
Length:266
Mass (Da):29,218
Last modified:March 1, 2003 - v1
Checksum:i4D0C3B71A5D23F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033618 mRNA Translation: BAC28394.1
AK039192 mRNA Translation: BAC30272.1
CH466529 Genomic DNA Translation: EDL19707.1
CH466529 Genomic DNA Translation: EDL19708.1
BC120681 mRNA Translation: AAI20682.1
BC120683 mRNA Translation: AAI20684.1
CCDSiCCDS19642.1
RefSeqiNP_780683.1, NM_175474.3
XP_006530367.1, XM_006530304.3
UniGeneiMm.12654

Genome annotation databases

EnsembliENSMUST00000056654; ENSMUSP00000062386; ENSMUSG00000044134
ENSMUST00000198271; ENSMUSP00000143110; ENSMUSG00000044134
GeneIDi231717
KEGGimmu:231717
UCSCiuc008zkj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSESQ1_MOUSE
AccessioniPrimary (citable) accession number: Q8BH49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health